Colorectal cancer carcinogenesis: a review of mechanisms

scientific article published on March 2016

Colorectal cancer carcinogenesis: a review of mechanisms is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID4850121
P698PubMed publication ID27144067

P2093author name stringKanwal Tariq
Kulsoom Ghias
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A CpG island methylator phenotype of colorectal cancer that is contiguous with conventional adenomas, but not serrated polypsQ34293192
Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidyQ34423165
The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancerQ34441849
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancerQ34461429
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The chromosomal instability pathway in colon cancerQ34570062
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MALAT1 promotes colorectal cancer cell proliferation/migration/invasion via PRKA kinase anchor protein 9.Q34718248
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TP53 and let-7a micro-RNA regulate K-Ras activity in HCT116 colorectal cancer cellsQ34926012
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Colon and endometrial cancers with mismatch repair deficiency can arise from somatic, rather than germline, mutationsQ34959257
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MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells.Q35008686
Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer.Q35013762
Over-expression of COX-2 mRNA in colorectal cancerQ35079511
Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer developmentQ35138248
P53 mutations occur more commonly than KRAS mutations in colorectal adenomaQ35173907
Aberrations of BUBR1 and TP53 gene mutually associated with chromosomal instability in human colorectal cancer.Q35293923
Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonistsQ35459134
Colorectal carcinomas with KRAS codon 12 mutation are associated with more advanced tumor stagesQ35579056
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The relationship between hypomethylation and CpG island methylation in colorectal neoplasiaQ35749254
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal CancerQ35762264
Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancersQ35810106
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Epigenetic regulation of microRNA expression in colorectal cancerQ39838959
The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-RasQ39860132
Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal CancerQ40847447
BRAF mutation-specific promoter methylation of FOX genes in colorectal cancerQ41056167
Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomasQ41603218
5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which resultQ41668069
miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancerQ42051478
Prevalence of somatic mutl homolog 1 promoter hypermethylation in Lynch syndrome colorectal cancerQ42175718
Telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancerQ43005462
Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instabilityQ43522906
Recurrence and variability of germline EPCAM deletions in Lynch syndrome.Q44080353
Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitroQ44206354
Somatic mutations in MLH1 and MSH2 are a frequent cause of mismatch-repair deficiency in Lynch syndrome-like tumorsQ44383505
A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis.Q44490075
Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instabilityQ44714286
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC geneQ45345254
Polymorphisms of the pri-miR-34b/c promoter and TP53 codon 72 are associated with risk of colorectal cancerQ45740901
MicroRNA signature in metastatic colorectal cancer patients treated with anti-EGFR monoclonal antibodiesQ45790076
Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer.Q46275729
Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancerQ46578998
Smad4 inactivation predicts for worse prognosis and response to fluorouracil-based treatment in colorectal cancerQ46676671
Three classes of genes mutated in colorectal cancers with chromosomal instabilityQ47652214
Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instabilityQ47704165
Germline epimutation of MLH1 in individuals with multiple cancersQ47817335
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancerQ48084125
Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancersQ51856604
Role of miR-143 targeting KRAS in colorectal tumorigenesisQ52591361
Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndromeQ53085005
Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumorsQ53258270
Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patientsQ53272678
Tumor heterogeneity revealed by KRAS, BRAF, and PIK3CA pyrosequencing: KRAS and PIK3CA intratumor mutation profile differences and their therapeutic implicationsQ54389429
Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.Q54632294
CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels.Q54797906
Variable 5-methylcytosine levels in human tumor cell lines and fresh pediatric tumor explants.Q55489110
Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissueQ56589628
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancerQ57240062
Large genomic rearrangements and germline epimutations in Lynch syndromeQ57671334
Modification of miR gene expression pattern in human colon cancer cells following exposure to 5-fluorouracil in vitroQ62061836
Hypomethylation of DNA from benign and malignant human colon neoplasmsQ69381419
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancersQ71167724
Allelic loss of chromosome 18q and prognosis in colorectal cancerQ72024722
Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndromeQ72657543
Hereditary colorectal cancerQ73088287
Infrequent somatic mutation of the adenomatous polyposis coli gene in aberrant crypt foci of human colon tissueQ77221792
Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instabilityQ77534962
Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2Q78532732
A new variant database for mismatch repair genes associated with Lynch syndromeQ79909235
Oncogenic mutations of PIK3CA in human cancersQ80826963
Genetic and epigenetic factors in regulation of microRNA in colorectal cancersQ84990760
MicroRNAs in cancerQ86065522
β-Catenin signaling dosage dictates tissue-specific tumor predisposition in Apc-driven cancerQ87418047
P433issue1
P921main subjectcolorectal cancerQ188874
carcinogenesisQ1637543
colorectal carcinomaQ25493920
P304page(s)120-135
P577publication date2016-03-01
P1433published inCancer Biology & MedicineQ26841841
P1476titleColorectal cancer carcinogenesis: a review of mechanisms
P478volume13

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