PD-L1 expression in colorectal cancer defines three subsets of tumor immune microenvironments.

scientific article published on 12 January 2018

PD-L1 expression in colorectal cancer defines three subsets of tumor immune microenvironments. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.24196
P8608Fatcat IDrelease_fxc54id6xfbmdkg5wzbzzphkne
P932PMC publication ID5823560
P698PubMed publication ID29492219

P2093author name stringGianluigi Giannelli
Vito Guerra
Anna Maria Valentini
Maria Lucia Caruso
Federica Di Pinto
Filomena Cariola
Michele Pirrelli
P2860cites workCostimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic targetQ24559442
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancerQ24685406
The blockade of immune checkpoints in cancer immunotherapyQ27860852
The emerging role of immunotherapy in colorectal cancerQ28067898
Biomarkers for immune therapy in colorectal cancer: mismatch-repair deficiency and othersQ28072468
PD-L1 and Survival in Solid Tumors: A Meta-AnalysisQ28084090
PD-1 and its ligands in tolerance and immunityQ28131650
Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancerQ28245751
PD-1 Blockade in Tumors with Mismatch-Repair DeficiencyQ28262647
A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancerQ28289377
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patientsQ29617771
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapyQ29617774
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escapeQ29620881
Immunosuppressive strategies that are mediated by tumor cellsQ29636247
Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instabilityQ33786764
Increased intratumoral neutrophil in colorectal carcinomas correlates closely with malignant phenotype and predicts patients' adverse prognosisQ34147688
Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studiesQ34362289
PTEN loss increases PD-L1 protein expression and affects the correlation between PD-L1 expression and clinical parameters in colorectal cancerQ34778769
Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway.Q34809019
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpointsQ34943776
Tissue expression of PD-L1 mediates peripheral T cell tolerance.Q36228541
The PD-1-PD-L pathway in immunological toleranceQ36405777
Colorectal cancer carcinogenesis: a review of mechanismsQ36849645
Variability in Immunohistochemical Detection of Programmed Death Ligand 1 (PD-L1) in Cancer Tissue Types.Q36939402
Immunoscore encompassing CD3+ and CD8+ T cell densities in distant metastasis is a robust prognostic marker for advanced colorectal cancer.Q37697218
Role of PD-L1 expression as a biomarker for GEP neuroendocrine neoplasm grading.Q38610333
Microsatellite Instability as a Biomarker for PD-1 BlockadeQ38735093
Molecular and Biochemical Aspects of the PD-1 Checkpoint PathwayQ38996832
Neutrophils recruit regulatory T-cells into tumors via secretion of CCL17--a new mechanism of impaired antitumor immunityQ39026688
Neutrophils as active regulators of the immune system in the tumor microenvironmentQ39164353
Immune Checkpoints as a Target for Colorectal Cancer Treatment.Q39387816
Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment.Q39930421
PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytesQ40745198
Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite InstabilityQ40850728
Immune checkpoint blockade in microsatellite instable colorectal cancers: Back to the clinicQ41593422
Characterisation of PD-L1-positive subsets of microsatellite-unstable colorectal cancersQ42275171
Immunotherapy resistance: the answers lie ahead - not in front - of us.Q42320552
Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma.Q42721528
Morphology of sporadic colorectal cancer with DNA replication errorsQ43087650
Presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinomaQ43282875
Intratumoral IL-17⁺ cells and neutrophils show strong prognostic significance in intrahepatic cholangiocarcinomaQ44698673
Impact of immune parameters on long-term survival in metastatic renal cell carcinomaQ44811646
Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanomaQ45054030
PD-L1 protein expression in tumour cells and immune cells in mismatch repair protein-deficient and -proficient colorectal cancer: the foundation study using the SP142 antibody and whole section immunohistochemistryQ47781498
Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomasQ48942904
Medullary-type poorly differentiated adenocarcinoma of the large bowel: a distinct clinicopathologic entity characterized by microsatellite instability and improved survival.Q50757104
Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study.Q50876217
Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma.Q53281128
Clinical impact of programmed cell death ligand 1 expression in colorectal cancer.Q54269172
Multipopulation analysis of polymorphisms in five mononucleotide repeats used to determine the microsatellite instability status of human tumors.Q54628312
IL-18 Induces PD-1-Dependent Immunosuppression in CancerQ57556330
New monoclonal antibodies against B-cell antigens: Possible new strategies for diagnosis of primary cutaneous B-cell lymphomasQ58482097
PD-1: an inhibitory immunoreceptor involved in peripheral toleranceQ73807451
Intratumoral neutrophils: a poor prognostic factor for hepatocellular carcinoma following resectionQ82641830
Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significanceQ82793374
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
P304page(s)8584-8596
P577publication date2018-01-12
P1433published inOncotargetQ1573155
P1476titlePD-L1 expression in colorectal cancer defines three subsets of tumor immune microenvironments.
P478volume9

Reverse relations

cites work (P2860)
Q89610924Combination Therapy with Radiation and PARP Inhibition Enhances Responsiveness to Anti-PD-1 Therapy in Colorectal Tumor Models
Q63729383Immunoprofiles of colorectal cancer from Lynch syndrome
Q60961676Increased nerve twigs in small intestinal mucosa with programmed cell death-ligand 1 and somatostatin receptor type 2A expression in recurrent Crohn disease: A case report
Q91394247Low miR200c expression in tumor budding of invasive front predicts worse survival in patients with localized colon cancer and is related to PD-L1 overexpression
Q92875307Mechanisms of immunogenicity in colorectal cancer
Q92035014Molecular alterations and PD-L1 expression in non-ampullary duodenal adenocarcinoma: Associations among clinicopathological, immunophenotypic and molecular features
Q98159002PD-L1 expression increased by IFN-γ via JAK2-STAT1 signaling and predicts a poor survival in colorectal cancer
Q92721786PD-L1 expression, CD8+ and CD4+ lymphocyte rate are predictive of pathological complete response after neoadjuvant chemoradiotherapy for squamous cell cancer of the thoracic esophagus
Q92839298Screening of MSI detection loci and their heterogeneity in East Asian colorectal cancer patients
Q64268768The density of Tbet+ tumor-infiltrating T lymphocytes reflects an effective and druggable preexisting adaptive antitumor immune response in colorectal cancer, irrespective of the microsatellite status
Q92684094Tumor microenvironment immune types in gastric cancer are associated with mismatch repair however, not HER2 status

Search more.