Turning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells

scientific article published on 16 March 2015

Turning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/JCB.25164
P932PMC publication ID4862620
P698PubMed publication ID25776852

P2093author name stringMelissa B Rogers
Tapan A Shah
Nadia N Shaikh
P2860cites workA large-scale analysis of mRNA polyadenylation of human and mouse genesQ24557438
miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1Q24657866
Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitroQ24675778
Coordinating tissue interactions: Notch signaling in cardiac development and diseaseQ26822995
Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosisQ28209599
Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2Q28591491
The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signalingQ28593888
HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesisQ30176413
Cloning and functional characterization of the 5'-flanking region of the human bone morphogenetic protein-2 geneQ30635527
Repressive BMP2 gene regulatory elements near the BMP2 promoterQ33653895
Epigenetic modifications and canonical wingless/int-1 class (WNT) signaling enable trans-differentiation of nonosteogenic cells into osteoblastsQ33931182
Transcriptional regulation of BMP2 expression by the PTH-CREB signaling pathway in osteoblastsQ33939715
Molecular evolution at the decapentaplegic locus in Drosophila.Q33969369
Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element.Q34103291
Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370.Q34275107
An autonomous BMP2 regulatory element in mesenchymal cellsQ34343759
Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.Q34353340
Epigenetic regulation of BMP2 by 1,25-dihydroxyvitamin D3 through DNA methylation and histone modificationQ34688816
Mycoplasma infection transforms normal lung cells and induces bone morphogenetic protein 2 expression by post-transcriptional mechanismsQ34721898
Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation.Q35077692
Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in miceQ35640633
Modulation of Bone Morphogenetic Protein (BMP) 2 gene expression by Sp1 transcription factorsQ35915965
An in vivo map of bone morphogenetic protein 2 post-transcriptional repression in the heartQ36145780
GATA-6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiationQ36234535
Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): comparison of the structures and promoter regions of BMP-2 and BMP-4 genesQ36732898
Dynamics and cellular localization of Bmp2, Bmp4, and Noggin transcription in the postnatal mouse skeletonQ36757294
Bone morphogenetic protein 2 transcripts in rapidly developing deer antler tissue contain an extended 5' non-coding region arising from a distal promoterQ36843152
Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesisQ37037233
c-Abl-dependent molecular circuitry involving Smad5 and phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2-induced osteogenesisQ37112666
Species-specific cis-regulatory elements in the 3'-untranslated region direct alternative polyadenylation of bone morphogenetic protein 2 mRNA.Q37141487
Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2.Q37156002
Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation.Q37906474
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.Q38304702
MicroRNA expression signature for Satb2-induced osteogenic differentiation in bone marrow stromal cellsQ38483578
Bone morphogenetic protein-focused strategies to induce cytotoxicity in lung cancer cellsQ38997362
Transcriptional repression of Bmp2 by p21(Waf1/Cip1) links quiescence to neural stem cell maintenanceQ39085673
Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblastsQ39266751
In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation.Q39300631
Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis.Q39345845
A conserved post-transcriptional BMP2 switch in lung cellsQ39708972
Hoxd13 binds in vivo and regulates the expression of genes acting in key pathways for early limb and skeletal patterning.Q39992638
Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol.Q40130225
Bone morphogenetic proteins-2 and -4 are involved in the retinoic acid-induced differentiation of embryonal carcinoma cellsQ40240703
Bone morphogenetic protein expression in human atherosclerotic lesions.Q40304303
Conservation of Bmp2 post-transcriptional regulatory mechanismsQ40516921
Osteoblast proliferation and maturation by bisphosphonatesQ40573161
BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loopQ40621832
NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitroQ40646195
Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transductionQ40676346
Regulation of the promoters for the human bone morphogenetic protein 2 and 4 genesQ40845725
Stimulation of bone formation in vitro and in rodents by statinsQ40914337
Bmp2 transcription in osteoblast progenitors is regulated by a distant 3' enhancer located 156.3 kilobases from the promoterQ41975562
Wnt3a stimulates Mepe, matrix extracellular phosphoglycoprotein, expression directly by the activation of the canonical Wnt signaling pathway and indirectly through the stimulation of autocrine Bmp-2 expression.Q42801437
Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells.Q44269091
Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytesQ44553793
An evolutionary and molecular analysis of Bmp2 expressionQ44752474
miR-140-5p suppresses BMP2-mediated osteogenesis in undifferentiated human mesenchymal stem cellsQ47861771
Transcriptional regulation of the Bmp2 gene. Retinoic acid induction in F9 embryonal carcinoma cells and Saccharomyces cerevisiaeQ47996305
Phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2 (BMP-2)-induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene in cardiomyocyte precursor cells.Q48006829
Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb.Q48086326
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effectQ48249566
miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells.Q50538051
Autoregulation of mouse BMP-2 gene transcription is directed by the proximal promoter element.Q51064172
Retinoic acid regulates programmed cell death through BMP signalling.Q52173225
Pro-inflammatory cytokine tumor necrosis factor-alpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulationQ79884998
A polymorphism in a conserved posttranscriptional regulatory motif alters bone morphogenetic protein 2 (BMP2) RNA:protein interactionsQ82646376
Bmp2 and Gata4 function additively to rescue heart tube development in the absence of retinoidsQ83324653
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectmorphogenesisQ815547
P304page(s)2127-2138
P577publication date2015-03-16
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titleTurning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells
P478volume116

Reverse relations

cites work (P2860)
Q39497817Bone morphogenetic protein 2 (BMP2) may contribute to partition of energy storage into visceral and subcutaneous fat depots
Q92035626Bone morphogenetic protein 2 is a depot-specific regulator of human adipogenesis
Q48286499Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles.
Q37020852Competing Repressive Factors Control Bone Morphogenetic Protein 2 (BMP2) in Mesenchymal Cells
Q30358100Effects of local delivery of BMP2, zoledronate and their combination on bone microarchitecture, biomechanics and bone turnover in osteoporotic rabbits
Q47153019Enhancement of Bone Marrow-Derived Mesenchymal Stem Cell Osteogenesis and New Bone Formation in Rats by Obtusilactone A.
Q55096315Expression and Dynamics of Podoplanin in Cultured Osteoblasts with Mechanostress and Mineralization Stimulus.
Q39144038How long bones grow children: Mechanistic paths to variation in human height growth
Q89522241Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling
Q41349109Increased microRNA-93-5p inhibits osteogenic differentiation by targeting bone morphogenetic protein-2.
Q38804309Local and targeted drug delivery for bone regeneration
Q92257469Modifications of Dental Implant Surfaces at the Micro- and Nano-Level for Enhanced Osseointegration
Q92932503Structural determinants and genetic modifications enhance BMP2 stability and extracellular secretion

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