Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

scientific article published on 24 March 2013

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NG.2591
P932PMC publication ID3678719
P698PubMed publication ID23525077
P5875ResearchGate publication ID236076959

P50authorTodd GolubQ7812388
Rameen BeroukhimQ88043871
Adam J BassQ89556844
Scott L CarterQ90591598
Andrey SivachenkoQ104846634
Robert OnofrioQ114385358
Shuji OginoQ18055035
Eric LanderQ970550
Candace GuiducciQ29840635
Gad GetzQ32646381
Kristian CibulskisQ32646400
Daniel AuclairQ32646543
Carrie SougnezQ28321195
Tony E GodfreyQ57487924
Chip StewartQ61305792
David G BeerQ87761086
Gordon SaksenaQ32646626
Douglas VoetQ32646808
Stacey GabrielQ32649203
Aaron McKennaQ32650112
Andrew C. ChangQ37621533
P2093author name stringYu Imamura
Alex H Ramos
Austin M Dulak
Erica Shefler
Michael S Lawrence
Lin Lin
Zhongren Zhou
James D Luketich
Arjun Pennathur
Santhoshi Bandla
Jules Lin
Petar Stojanov
Shouyong Peng
Steven E Schumacher
Cameron Fox
Rishindra Reddy
Kristin Thompson
Rodney Landrenau
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DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1Q28182421
Epidemiology and pathogenesis of esophageal cancerQ28213313
PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signalingQ28253621
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulatorsQ28267500
Comprehensive genomic characterization of squamous cell lung cancersQ28274701
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell linesQ28275084
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencingQ28275103
Rac activation and inactivation control plasticity of tumor cell movementQ28299776
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinaseQ38330900
ERBB2 kinase domain mutation in the lung squamous cell carcinomaQ38513518
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.Q39372073
Mapping of homozygous deletions in verified esophageal adenocarcinoma cell lines and xenograftsQ39443467
A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4.Q40549606
Expression of seven main Rho family members in gastric carcinomaQ40587668
Human mutation rate associated with DNA replication timingQ42085559
A multiethnic population-based study of smoking, alcohol and body size and risk of adenocarcinomas of the stomach and esophagus (United States).Q43741084
Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesisQ46839636
Mutations of BRAF and KRAS2 in the development of Barrett's adenocarcinomaQ47264599
Clinicopathologic and molecular profiles of microsatellite unstable Barrett Esophagus-associated adenocarcinoma.Q51489470
p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations.Q52858385
Requirement for Rac1 in a K-ras induced lung cancer in the mouse.Q53329326
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.Q53606400
Lack of EGFR gene mutations in exons 19 and 21 in esophageal (Barrett's) adenocarcinomas.Q54562020
Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomasQ73117116
Induction of chromosomal gene mutations in Escherichia coli by direct incorporation of oxidatively damaged nucleotides. New evaluation method for mutagenesis by damaged DNA precursors in vivoQ74473358
The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidenceQ81290009
Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagusQ82100207
Gefitinib-sensitizing mutations in esophageal carcinomaQ83364741
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genesQ83831946
Discovering motifs in ranked lists of DNA sequencesQ33279806
Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in the risk for the development of distal gastric cancer.Q33282920
p53 in esophageal adenocarcinoma: a critical reassessment of mutation frequency and identification of 72Arg as the dominant allele.Q33304991
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Sequence analysis of mutations and translocations across breast cancer subtypesQ34032470
SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia.Q34140542
Absolute quantification of somatic DNA alterations in human cancerQ34271693
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samplesQ34327021
SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesisQ35216353
ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancersQ35501591
Junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147.Q35723623
Rho GTPase expression in tumourigenesis: evidence for a significant linkQ36126283
Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesisQ36205151
Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinomaQ36322862
E-cadherin gene mutations are rare in adenocarcinomas of the oesophagusQ36620473
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusionQ37242449
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.Q37250634
Barrett esophagus: an updateQ37762151
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectwhole genome sequencingQ2068526
adenocarcinomaQ356033
P304page(s)478-486
P577publication date2013-03-24
P1433published inNature GeneticsQ976454
P1476titleExome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
P478volume45

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Q35145369Preexisting oncogenic events impact trastuzumab sensitivity in ERBB2-amplified gastroesophageal adenocarcinoma
Q38677878Prevalence and Significance of HMGA2 Expression in Esophageal Adenocarcinoma.
Q34734133Profiling of exome mutations associated with progression of HBV-related hepatocellular carcinoma.
Q64235429Prognostic impact of family history of cancer in Southern Chinese patients with esophageal squamous cell cancer
Q35203134Protein domain-level landscape of cancer-type-specific somatic mutations
Q60309641Quantification of somatic mutation flow across individual cell division events by lineage sequencing
Q59912703Quantitative proteomic profiling of primary cancer-associated fibroblasts in oesophageal adenocarcinoma
Q35051834RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer
Q38752935RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas
Q38714000RNA sequencing of esophageal adenocarcinomas identifies novel fusion transcripts, including NPC1-MELK, arising from a complex chromosomal rearrangement.
Q37389361Rapid conversion of chronic myeloid leukemia to chronic myelomonocytic leukemia in a patient on imatinib therapy.
Q26769014Reactivation of telomerase in cancer
Q33589301Recent advances in preoperative management of esophageal adenocarcinoma
Q40211104Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma
Q37536791Reduced genomic tumor heterogeneity after neoadjuvant chemotherapy is related to favorable outcome in patients with esophageal adenocarcinoma
Q46268209Reduced mutation rate in exons due to differential mismatch repair
Q41472107Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis
Q37215328Research advances in esophageal diseases: bench to bedside
Q35067345Retrospective review using targeted deep sequencing reveals mutational differences between gastroesophageal junction and gastric carcinomas
Q33825098Ribosomal DNA copy number loss and sequence variation in cancer
Q98210339Risk factors for precancerous lesions of esophageal squamous cell carcinoma in high-risk areas of rural China: A population-based screening study
Q38839797Risk stratification of Barrett's oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study.
Q34348631Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.
Q42284390Role of protein kinases CK1α and CK2 in multiple myeloma: regulation of pivotal survival and stress-managing pathways
Q42127711Rosai-Dorfman Disease Harboring an Activating KRAS K117N Missense Mutation.
Q38904246Runx3 in Immunity, Inflammation and Cancer
Q92675551STAG Mutations in Cancer
Q26998657SWI/SNF chromatin remodeling complexes and cancer
Q89285948Screening and Surveillance for Barrett's Esophagus: Is It Cost-Effective?
Q35085793SeqBench: integrated solution for the management and analysis of exome sequencing data.
Q27026253Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction
Q29547191Signatures of mutational processes in human cancer
Q36159205Simul-seq: combined DNA and RNA sequencing for whole-genome and transcriptome profiling
Q35218771Smad4 loss in esophageal adenocarcinoma is associated with an increased propensity for disease recurrence and poor survival
Q34409666Strategies to improve outcomes in esophageal adenocarcinoma.
Q51048878Strategy for prevention of cancers of the esophagus.
Q43226865Structural Analysis of the Pin1-CPEB1 interaction and its potential role in CPEB1 degradation.
Q27929935Structural integrity of centromeric chromatin and faithful chromosome segregation requires Pat1
Q51832891Studying Cancer Evolution in Barrett's Esophagus and Esophageal Adenocarcinoma.
Q54976655Subtypes of Barrett's oesophagus and oesophageal adenocarcinoma based on genome-wide methylation analysis.
Q26852061Surgery in the era of the 'omics revolution
Q37059872Surrogate Markers: Lessons from the Next Gen?
Q28085367Systematic review and meta-analysis of immunohistochemical prognostic biomarkers in resected oesophageal adenocarcinoma
Q91623094Systems Biology Analyses Show Hyperactivation of Transforming Growth Factor-β and JNK Signaling Pathways in Esophageal Cancer
Q36081375TAK1-regulated expression of BIRC3 predicts resistance to preoperative chemoradiotherapy in oesophageal adenocarcinoma patients
Q37256055TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism
Q35021377TET proteins and the control of cytosine demethylation in cancer
Q45314404TGFBR1 LBD Mutants in Cancer
Q50288851TGFBR2 does not recruit TGFBR1 LBD Mutants
Q34219975TGM2: a cell surface marker in esophageal adenocarcinomas.
Q46036182TP53, PIK3CA, FBXW7 and KRAS Mutations in Esophageal Cancer Identified by Targeted Sequencing.
Q35634450Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms
Q38634870Targeted next-generation sequencing of commonly mutated genes in esophageal adenocarcinoma patients with long-term survival
Q49961144Targeted therapies for targeted populations: Anti-EGFR treatment for EGFR amplified gastroesophageal adenocarcinoma
Q38856729Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges
Q38157714Targeting the protein-protein interaction between IRS1 and mutant p110α for cancer therapy
Q64993592Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Q37524048Temporal and spatial evolution of somatic chromosomal alterations: a case-cohort study of Barrett's esophagus
Q38132057The '-omics' revolution and oesophageal adenocarcinoma
Q34505489The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival
Q39440077The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma
Q60921528The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens
Q60960098The Potential Clinical Utility of Circulating Tumor DNA in Esophageal Adenocarcinoma: From Early Detection to Therapy
Q38969484The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.
Q41084526The Transcriptional Landscape of p53 Signalling Pathway
Q40374172The biological significance of methylome differences in human papilloma virus associated head and neck cancer
Q53087702The cancer genome: from structure to function.
Q34467243The chromatin regulator Brpf1 regulates embryo development and cell proliferation
Q37488137The degree of segmental aneuploidy measured by total copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma
Q33910495The dynamic exome: acquired variants as individuals age.
Q38831655The emerging role of immunotherapy in gastric and esophageal adenocarcinoma
Q38195175The emerging roles of ARID1A in tumor suppression
Q39179722The enigmatic oncogene and tumor suppressor-like properties of RAD54B: Insights into genome instability and cancer
Q39183864The genetics of gastroesophageal adenocarcinoma and the use of circulating cell free DNA for disease detection and monitoring
Q36225715The genomic landscape of juvenile myelomonocytic leukemia
Q34389892The genomic landscape of oesophagogastric junctional adenocarcinoma
Q93014579The genomics of oxidative DNA damage, repair, and resulting mutagenesis
Q41992804The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium
Q91341661The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic
Q58617586The many lives of KATs - detectors, integrators and modulators of the cellular environment
Q36656549The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening
Q96639903The mutREAD method detects mutational signatures from low quantities of cancer DNA
Q38687715The prognostic value of TP53 mutations in oesophageal adenocarcinoma: a systematic review and meta-analysis
Q35818437The role of intracellular calcium for the development and treatment of neuroblastoma
Q58484627Therapeutic approaches to gastroesophageal junction adenocarcinomas
Q98944980Towards personalized induction therapy for esophageal adenocarcinoma: organoids derived from endoscopic biopsy recapitulate the pre-treatment tumor
Q35929463Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy
Q30239109Translating genomic profiling to gastrointestinal cancer treatment
Q58426138Tumors of the upper aerodigestive tract
Q94392976UEG Week 2015 Oral Presentations
Q38840433Understanding mutagenesis through delineation of mutational signatures in human cancer
Q38684349Update on Gastroesophageal Adenocarcinoma Targeted Therapies
Q36355920Upfront molecular testing in patients with advanced gastro-esophageal cancer: Is it time yet?
Q57797057WWOX, the FRA16D gene: a target of and a contributor to genomic instability
Q90710914Wee1 Kinase Inhibitor AZD1775 Effectively Sensitizes Esophageal Cancer to Radiotherapy
Q37610120Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers
Q38307191Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
Q58118126Whole-genome sequencing of esophageal adenocarcinoma in Chinese patients reveals distinct mutational signatures and genomic alterations
Q38748225Whole-genome sequencing of nine esophageal adenocarcinoma cell lines
Q36015250Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma
Q64240600p53 overexpression is a prognosticator of poor outcome in esophageal cancer
Q55317227siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth.

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