Molecular biomarkers in gastro-esophageal cancer: recent developments, current trends and future directions.

scientific article published on 11 July 2018

Molecular biomarkers in gastro-esophageal cancer: recent developments, current trends and future directions. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1105486033
P356DOI10.1186/S12935-018-0594-Z
P932PMC publication ID6042434
P698PubMed publication ID30008616

P50authorFrancesca BattaglinQ54963247
Alberto PucciniQ55590284
Heinz-Josef LenzQ89668545
P2093author name stringMadiha Naseem
P2860cites workHER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practiceQ26741253
Potential biomarkers for esophageal cancerQ26749416
Genomic and epigenomic heterogeneity in molecular subtypes of gastric cancerQ26774509
MicroRNAs in cancer: from developmental genes in worms to their clinical application in patientsQ26865275
Genomic assays for Epstein-Barr virus-positive gastric adenocarcinomaQ27024034
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trialQ27851578
Lapatinib plus paclitaxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN--a randomized, phase III studyQ27853010
Global cancer statistics, 2012Q27860501
Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical applicationQ28079309
Comprehensive molecular characterization of gastric adenocarcinomaQ28244985
The two histological main types of gastric carcinoma: diffuse and so called intestinal-type carcinoma: an attempt at a histo-clinical classificationQ29618627
Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III studyQ29620647
Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trialQ29620687
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trialQ29620917
HER2 screening data from ToGA: targeting HER2 in gastric and gastroesophageal junction cancerQ30837184
Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GATSBY): an international randomised, open-label, adaptive, phase 2/3 studyQ33440401
Biomarkers of Primary Resistance to Trastuzumab in HER2-Positive Metastatic Gastric Cancer Patients: the AMNESIA Case-Control Study.Q50058854
HER2 copy number of circulating tumour DNA functions as a biomarker to predict and monitor trastuzumab efficacy in advanced gastric cancerQ50064802
Impact of genomic alterations on lapatinib treatment outcome and cell-free genomic landscape during HER2 therapy in HER2-positive gastric cancer patientsQ50160878
Oncogenic mutations in gastric cancer with microsatellite instability.Q51538176
HER2 loss in HER2-positive gastric or gastroesophageal cancer after trastuzumab therapy: Implication for further clinical research.Q51541370
Liquid biopsy provides new insights into gastric cancer.Q52620413
Outlooks on Epstein-Barr virus associated gastric cancer.Q52720624
Prognosis of metastatic gastric and gastroesophageal junction cancer by HER2 status: a European and USA International collaborative analysis.Q53128686
Evaluation of altered expression of miR-9 and miR-106a as an early diagnostic approach in gastric cancer.Q53176896
HER2 expression variability between primary gastric cancers and corresponding lymph node metastases.Q53527417
Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome.Q54578578
HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population: clinicopathologic analysis with proposed approach to HER2 assessment.Q54587084
Clinical value of ctDNA in upper-GI cancers: A systematic review and meta-analysis.Q54989505
Discordances in HER2 status between primary gastric cancer and corresponding metastatic sites.Q55066506
Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas: association with poor outcomeQ79522451
Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patientsQ81353699
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genesQ83831946
Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trialQ84078596
Epstein-Barr virus-associated gastric cancer reveals intratumoral heterogeneity of PIK3CA mutationsQ33608197
The novel negative checkpoint regulator VISTA is expressed in gastric carcinoma and associated with PD-L1/PD-1: A future perspective for a combined gastric cancer therapy?Q33632116
Distribution of somatic mutations of cancer-related genes according to microsatellite instability status in Korean gastric cancerQ33833750
MicroRNAs as potential biomarkers for gastric cancerQ34168445
Causes and consequences of microsatellite instability in gastric carcinogenesis.Q34589660
Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis.Q35108424
Preexisting oncogenic events impact trastuzumab sensitivity in ERBB2-amplified gastroesophageal adenocarcinomaQ35145369
Epstein-barr virus in gastro-esophageal adenocarcinomas - single center experiences in the context of current literatureQ35218805
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinibQ35666332
Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and DifferencesQ35763725
Epstein-Barr Virus MicroRNA Expression Increases Aggressiveness of Solid MalignanciesQ35777091
The ErbB receptors and their ligands in cancer: an overview.Q36108987
Prognostic value of diffuse versus intestinal histotype in patients with gastric cancer: a systematic review and meta-analysis.Q36303653
Establishment of patient-derived gastric cancer xenografts: a useful tool for preclinical evaluation of targeted therapies involving alterations in HER-2, MET and FGFR2 signaling pathwaysQ36307708
Clinicopathological characteristics of RHOA mutations in a Central European gastric cancer cohortQ36475722
Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trialQ36892840
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexityQ36918993
Trends in esophageal adenocarcinoma incidence and mortality.Q37096847
Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patientsQ37135262
HER2 in gastric cancer: a new prognostic factor and a novel therapeutic targetQ37149210
Evaluation of Angiopoietin-2 as a biomarker in gastric cancer: results from the randomised phase III AVAGAST trialQ37174690
Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinomaQ37190164
Biomarker analyses in REGARD gastric/GEJ carcinoma patients treated with VEGFR2-targeted antibody ramucirumabQ37335124
Oncogenic pathway combinations predict clinical prognosis in gastric cancer.Q37357165
Long non-coding RNA expression profile in human gastric cancer and its clinical significancesQ37360311
Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targetingQ37404956
Circulating miRNA profile in esophageal adenocarcinomaQ37447965
Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited: Urgent Need for StandardizationQ37488484
Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markersQ37537123
Gastric Cancer Genomics: Advances and Future Directions.Q37673604
MicroRNAs and pharmacogenomicsQ37736453
Targeting MET in cancer: rationale and progressQ37978193
Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trialQ38099726
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.Q38307191
Characterization and validation of potential therapeutic targets based on the molecular signature of patient-derived xenografts in gastric cancerQ50057702
Update on Epstein-Barr virus and gastric cancer (review).Q38336778
A Systematic Review of Esophageal MicroRNA Markers for Diagnosis and Monitoring of Barrett's EsophagusQ38634473
Long noncoding RNAs as potential biomarkers in gastric cancer: Opportunities and challengesQ38636282
HER2 Heterogeneity in Gastroesophageal Cancer Detected by Testing Biopsy and Resection Specimens.Q38637319
PD-1 and PD-L1 as emerging therapeutic targets in gastric cancer: current evidenceQ38649562
Clinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Cancer Genome Atlas Project.Q38659483
FGFR a promising druggable target in cancer: Molecular biology and new drugs.Q38692628
Molecular classification of gastric cancerQ38727880
Immunotherapy for gastric cancers: emerging role and future perspectivesQ38738652
Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.Q38748208
New agents on the horizon in gastric cancerQ38759129
The Evolving Role of Checkpoint Inhibitors in the Management of Gastroesophageal CancerQ38788032
Lapatinib in Combination With Capecitabine Plus Oxaliplatin in Human Epidermal Growth Factor Receptor 2-Positive Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma: TRIO-013/LOGiC--A Randomized Phase III Trial.Q38936367
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancerQ38997289
HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology.Q39007646
Predictive biomarkers along gastric cancer pathogenetic pathwaysQ39170872
HER2 Status in Gastric and Gastroesophageal Junction Cancer: Results of the Large, Multinational HER-EAGLE StudyQ39525000
Trastuzumab in gastric cancerQ39864629
EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy numberQ40105232
HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells.Q40201364
Early miR-223 Upregulation in Gastroesophageal Carcinogenesis.Q40250083
HER2 Status in Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma for Entry to the TRIO-013/LOGiC Trial of LapatinibQ40490620
FGFR2 in gastric cancer: protein overexpression predicts gene amplification and high H-index predicts poor survivalQ40733626
Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.Q41038524
Circulating tumor DNA functions as an alternative for tissue to overcome tumor heterogeneity in advanced gastric cancerQ41595482
Targeting microRNAs with small molecules: from dream to realityQ41827839
HER2 status in gastro-oesophageal adenocarcinomas assessed by two rabbit monoclonal antibodies (SP3 and 4B5) and two in situ hybridization methods (FISH and SISH)Q41880900
Exomics and immunogenics: Bridging mutational load and immune checkpoints efficacyQ41983246
Molecular classification of esophagogastric junction carcinoma correlated with prognosisQ42283228
Microsatellite instability status predicts response to anti-PD-1/PD-L1 therapy regardless the histotype: A comment on recent advancesQ42353279
Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric CancerQ43142381
Effect of HER2 on prognosis and benefit from peri-operative chemotherapy in early oesophago-gastric adenocarcinoma in the MAGIC trialQ43712233
HER2 in resected gastric cancer: Is there prognostic value?Q44578051
Modulation of lymphocyte regulation for cancer therapy: a phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma.Q44783161
CpG island methylation status in gastric carcinoma with and without infection of Epstein-Barr virusQ45416558
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.Q46108181
Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma.Q46129222
The role of miRNA and lncRNA in gastric cancerQ47117573
Liquid biopsies in gastrointestinal malignancies: when is the big day?Q47372761
Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer.Q47584566
Safety and Antitumor Activity of the Anti-Programmed Death-1 Antibody Pembrolizumab in Patients With Advanced Esophageal CarcinomaQ47632392
A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or gene amplificationQ47695585
Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trialQ47745009
PTEN loss and level of HER2 amplification is associated with trastuzumab resistance and prognosis in HER2-positive gastric cancerQ47838777
Pembrolizumab for treatment of advanced gastric and gastroesophageal junction adenocarcinomaQ47864236
Epigenetic biomarkers in gastrointestinal cancers: The current state and clinical perspectivesQ49663292
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectbiomarkerQ864574
P304page(s)99
P577publication date2018-07-11
P1433published inCancer Cell InternationalQ1829859
P1476titleMolecular biomarkers in gastro-esophageal cancer: recent developments, current trends and future directions.
P478volume18

Reverse relations

cites work (P2860)
Q90247887A novel positive feedback loop of linc02042 and c-Myc mediated by YBX1 promotes tumorigenesis and metastasis in esophageal squamous cell carcinoma
Q89879114HER2 Heterogeneity in Personalized Therapy of Gastro-Oesophageal Malignancies: An Overview by Different Methodologies
Q61445358Long noncoding RNA PXN-AS1-L promotes non-small cell lung cancer progression via regulating PXN
Q93082677MALAT1 promotes gastric adenocarcinoma through the MALAT1/miR-181a-5p/AKT3 axis
Q64101409Towards precision medicine: advances in 5-hydroxymethylcytosine cancer biomarker discovery in liquid biopsy
Q64101703WISP2 exhibits its potential antitumor activity via targeting ERK and E-cadherin pathways in esophageal cancer cells

Search more.