Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition

scientific article published on 08 April 2015

Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP09694
P8608Fatcat IDrelease_coztulbbnff7fefpbvm5cyi6l4
P932PMC publication ID4894437
P698PubMed publication ID25853502

P50authorXuejun WangQ38361109
P2093author name stringXin Chen
Chong Zhao
Jinbao Liu
Xiaofen Li
Hongbiao Huang
Ningning Liu
Shouting Liu
Dan Zang
Yuning Liao
Xianping Shi
Peiquan Zhang
Xiaoying Lan
P2860cites workMule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosisQ24306444
AKT/PKB signaling: navigating downstreamQ24657857
Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphomaQ24672476
Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathwayQ24678660
X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complexQ27640955
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphomaQ27824784
Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingQ27860529
Stromal gene signatures in large-B-cell lymphomasQ28302107
In vitro and in vivo toxicity of garcinia or hydroxycitric Acid: a review.Q30420693
Organization and regulation of mitogen-activated protein kinase signaling pathwaysQ33333640
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteinsQ33345150
A phase 2 study of bortezomib in relapsed, refractory myelomaQ33348702
The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivoQ33896749
High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia.Q54621049
Rituximab: a review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemiaQ83362579
The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization.Q34276196
Physiological levels of ATP negatively regulate proteasome function.Q34376187
The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitorsQ34754412
Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823Q35045429
Immunochemotherapy: the new standard in aggressive non-Hodgkin's lymphoma in the elderlyQ35090607
Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progressionQ35663874
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NF-kB in development and progression of human cancerQ36108761
Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cellsQ36369816
Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.Q37109227
Engaging the lysosomal compartment to combat B cell malignanciesQ37286690
PI3K/Akt: getting it right mattersQ37310202
Old target new approach: an alternate NF-kappaB activation pathway via translation inhibitionQ37338854
Gambogic acid covalently modifies IkappaB kinase-beta subunit to mediate suppression of lipopolysaccharide-induced activation of NF-kappaB in macrophagesQ37341200
Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulationQ37610733
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humansQ38005203
Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibitionQ39435523
A novel inhibitor of focal adhesion signaling induces caspase-independent cell death in diffuse large B-cell lymphoma.Q39484336
A pivotal role for Mcl-1 in Bortezomib-induced apoptosisQ40102590
Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cellsQ40356831
Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cellsQ40534739
Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assayQ40547658
Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.Q40560316
IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cellsQ40778669
Gambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivoQ43675946
CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphomaQ43864036
Bortezomib sensitivity of acute myeloid leukemia CD34(+) cells can be enhanced by targeting the persisting activity of NF-κB and the accumulation of MCL-1.Q44623095
Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.Q45197519
Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutationQ46110608
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectdiffuse large B-cell lymphomaQ2626074
B-cell lymphomaQ4833719
gambogic acidQ105007431
P304page(s)9694
P577publication date2015-04-08
P1433published inScientific ReportsQ2261792
P1476titleGambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition
P478volume5

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Q43226621A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy
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