Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells

scientific article published on 19 April 2013

Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1289/EHP.1306528
P932PMC publication ID3702011
P698PubMed publication ID23603068
P5875ResearchGate publication ID236251742

P50authorTheodore A. SlotkinQ88773550
Frederic J SeidlerQ88773672
P2093author name stringJennifer Card
P2860cites workAssessment of chemical effects on neurite outgrowth in PC12 cells using high content screeningQ42809108
Modulation of neurotoxic behavior in F-344 rats by temporal disposition of benzo(a)pyreneQ43906475
Inhaled benzo(a)pyrene impairs long-term potentiation in the F1 generation rat dentate gyrusQ45217590
Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cellsQ45262406
Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal ratsQ46373582
Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifosQ46553074
Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal culturesQ46652083
Adverse neurodevelopmental effects of dexamethasone modeled in PC12 cells: identifying the critical stages and concentration thresholds for the targeting of cell acquisition, differentiation and viabilityQ47681892
Quantitative changes in DNA, RNA, and protein during prenatal and postnatal growth in the ratQ51244502
Modulation in the developmental expression profile of Sp1 subsequent to transplacental exposure of fetal rats to desorbed benzo[a]pyrene following maternal inhalation.Q52167122
Additive inhibitory action of chlorpyrifos and polycyclic aromatic hydrocarbons on acetylcholinesterase activity in vitro.Q52570746
Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal OutcomesQ72414034
Developmental neurotoxicity of perfluorinated chemicals modeled in vitroQ24654096
Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cellsQ24813250
Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic populationQ24813541
Developmental neurotoxicity of industrial chemicalsQ28279457
Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyreneQ28383834
Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickelQ28395180
Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city childrenQ28768066
Silver impairs neurodevelopment: studies in PC12 cellsQ33702906
Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifosQ34292224
Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cellsQ34603071
Regulation of the differentiation of PC12 pheochromocytoma cellsQ35032923
Glucocorticoids, hypothalamo-pituitary-adrenal (HPA) development, and life after birthQ35046443
Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategiesQ35842533
Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targetsQ35862603
Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cellsQ35971890
A summary of recent findings on birth outcomes and developmental effects of prenatal ETS, PAH, and pesticide exposuresQ36236140
Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cellsQ36291394
Environmental tobacco smoke as a source of polycyclic aromatic hydrocarbons in settled household dustQ40025207
Neuronal differentiation in PC12 cells is inhibited by chlorpyrifos and its metabolites: is acetylcholinesterase inhibition the site of action?Q40920286
Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cellsQ41016073
Benzo[a]pyrene impairs neurodifferentiation in PC12 cellsQ42599905
Early postnatal benzo(a)pyrene exposure in Sprague-Dawley rats causes persistent neurobehavioral impairments that emerge postnatally and continue into adolescence and adulthoodQ42726163
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectchlorpyrifosQ414915
dexamethasoneQ422252
P1104number of pages7
P304page(s)825-831
P577publication date2013-04-19
P1433published inEnvironmental Health PerspectivesQ1345904
P1476titleAdverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells
P478volume121

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cites work (P2860)
Q35739063Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors
Q46462780An investigation of the developmental neurotoxic potential of curcumol in PC12 cells
Q36935424Cognitive and Behavioral Impairments Evoked by Low-Level Exposure to Tobacco Smoke Components: Comparison with Nicotine Alone
Q36373946Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine
Q33707298Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene
Q48374066In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells
Q91683531The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]Pyrene: Effects on Cholinergic and Serotonergic Systems

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