Regulation of the differentiation of PC12 pheochromocytoma cells

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Regulation of the differentiation of PC12 pheochromocytoma cells is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1289/EHP.8980127
P932PMC publication ID1567620
P698PubMed publication ID2647474
P5875ResearchGate publication ID20507695

P2093author name stringGuroff G
Fujita K
Lazarovici P
P2860cites workBinding of nerve growth factor to its receptorQ70176128
Epidermal growth factor receptor expression during morphological differentiation of pheochromocytoma cells, induced by nerve growth factor or dibutyryl cyclic AMPQ70183145
Nerve growth factor-inducible large external (NILE) glycoprotein: studies of a central and peripheral neuronal markerQ70242112
Expression and structure of the human NGF receptorQ24295226
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factorQ24561804
Gene transfer and molecular cloning of the rat nerve growth factor receptorQ28288106
Long-term, heterologous down-regulation of the epidermal growth factor receptor in PC12 cells by nerve growth factorQ28578723
Nerve growth factor enhances expression of neuron-glia cell adhesion molecule in PC12 cellsQ28580540
Regulation of protein kinase activities in PC12 pheochromocytoma cellsQ33881180
The internalization of nerve growth factor by high-affinity receptors on pheochromocytoma PC12 cells.Q33930204
Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissuesQ33940309
Molecular cloning of a gene sequence regulated by nerve growth factorQ34192247
Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMPQ34626064
Alteration of cellular adhesion by nerve growth factorQ35053463
Immunological distinction between acetylcholine receptor and the alpha-bungarotoxin-binding component on sympathetic neuronsQ35058992
Storage and release of acetylcholine by a clonal cell lineQ35062636
Cholinergic metabolism and synapse formation by a rat nerve cell lineQ35065203
Nerve growth factor modulates the drug sensitivity of neurotransmitter release from PC-12 cellsQ35598146
Protein kinase C as a component of a nerve growth factor-sensitive phosphorylation system in PC12 cellsQ35598893
Nerve growth factor rapidly induces c-fos mRNA in PC12 rat pheochromocytoma cellsQ35614658
Nerve growth factor-mediated induction of tyrosine hydroxylase in a clonal pheochromocytoma cell lineQ35992344
Primary cultures of dissociated sympathetic neurons. I. Establishment of long-term growth in culture and studies of differentiated propertiesQ36195625
Rapid, sequential changes in surface morphology of PC12 pheochromocytoma cells in response to nerve growth factorQ36200932
Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factorQ36204451
Regulation of acetylcholinesterase by nerve growth factor in the pheochromocytoma PC12 cell lineQ70261678
Synapsin I in PC12 cells. I. Characterization of the phosphoprotein and effect of chronic NGF treatmentQ70337558
Content and release of neurotensin in PC12 pheochromocytoma cell cultures: modulation by dexamethasone and nerve growth factorQ70438069
Alterations of lipid metabolism in response to nerve growth factorQ70517387
Nerve growth factor has both mitogenic and antimitogenic activityQ70541240
Nerve growth factor receptors on PC12 cells: evidence for two receptor classes with differing cytoskeletal associationQ70664526
Interaction of GM1 ganglioside with PC12 pheochromocytoma cells: serum- and NGF-dependent effects on neuritic growth (and proliferation)Q70679274
Regulation of acetylcholinesterase activity by nerve growth factor. Role of transcription and dissociation from effects on proliferation and neurite outgrowthQ70797578
Neuropeptide Y (NPY) in PC12 phaeochromocytoma cultures: responses to dexamethasone and nerve growth factorQ70814008
Increased Levels of Neuron‐Specific Enolase in PC 12 Pheochromocytoma Cells as a Result of Nerve Growth Factor TreatmentQ70913743
Isolation and partial amino acid sequence analysis of nerve growth factor from the guinea pig prostateQ70978940
Ca2+ transmembrane fluxes and nerve growth factor action on a clonal cell line of rat phaeochromocytomaQ71128343
A clonal rat pheochromocytoma cell line possesses synthesizing ability of gamma-aminobutyric acid together with catecholamine and acetylcholineQ71131850
Storage of dopamine and acetylcholine in granules of PC12, a clonal pheochromocytoma cell lineQ71178112
The effects of nerve growth factor on acetylcholinesterase and its multiple forms in cultures of rat PC12 pheochromocytoma cells: increased total specific activity and appearance of the 16 S molecular formQ71211224
Somatostatin-like immunoreactivity is expressed in neural crest culturesQ71259200
The molecular organization of adrenal chromaffin granulesQ71374039
Nicotine stimulates secretion of both catecholamines and acetylcholinesterase from cultured adrenal chromaffin cellsQ71690022
Tumor promoter modulation of epidermal growth factor- and nerve growth factor-induced adhesion and growth factor binding of PC-12 pheochromocytoma cellsQ72084759
The induction of ornithine decarboxylase by nerve growth factor and epidermal growth factor in PC12 cellsQ72093278
Reversible dissociation of the mouse nerve growth factor protein into different subunitsQ72106948
Effects of 12-0-Tetradecanoylphorbol-13-acetate (TPA) on rat pheochromocytoma (PC12) cells: interactions with epidermal growth factor and nerve growth factorQ72109163
Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptorsQ72406213
The modulation of neurotransmitter synthesis by steroid hormones and insulinQ72424281
Relationship between activation and phosphorylation of tyrosine hydroxylase by 56 mm K+ in PC12 cells in cultureQ72585104
Increased phosphorylation of specific nuclear proteins in superior cervical ganglia and PC12 cells in response to nerve growth factorQ72620654
Nerve growth factor mediates phosphorylation of specific proteinsQ72875238
Possible muscarinic regulation of catecholamine secretion mediated by cyclic GMP in isolated bovine adrenal chromaffin cellsQ72897499
Two types of potassium channels in the PC12 cell lineQ72901669
Identification of a nerve growth factor receptor protein in sympathetic ganglia membranes by affinity labelingQ72908995
The action of nerve growth factor and dibutyryl adenosine cyclic 3':5'- monophosphate on rat pheochromocytoma reveals distinct stages in the mechanisms underlying neurite outgrowthQ72909301
In vitro experiments on the effects of mouse sarcomas 180 and 37 on the spinal and sympathetic ganglia of the chick embryoQ73392340
Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryoQ75702642
Comparison of pheochromocytes with ganglion cells and neuroblasts grown in vitro. An electron microscopic and histochemical studyQ93702232
Changes in the expression of beta and gamma actins during differentiation of PC12 cellsQ70151543
A possible involvement of cytoplasmic Ca2+ in sodium dependency of neurite outgrowth of rat pheochromocytoma PC12 cellsQ70168318
Conversion of nerve growth factor-receptor complexes to a slowly dissociating, Triton X-100 insoluble state by anti nerve growth factor antibodiesQ70174097
Heparin modulation of the neurotropic effects of acidic and basic fibroblast growth factors and nerve growth factor on PC12 cellsQ70175497
Synapsin I in PC12 cells. II. Evidence for regulation by NGF of phosphorylation at a novel siteQ70175952
Pit formation and rapid changes in surface morphology of sympathetic neurons in response to nerve growth factorQ36205005
Regulation of a high molecular weight microtubule-associated protein in PC12 cells by nerve growth factorQ36206571
Ionic responses and growth stimulation induced by nerve growth factor and epidermal growth factor in rat pheochromocytoma (PC12) cellsQ36207405
Differential inhibition of nerve growth factor and epidermal growth factor effects on the PC12 pheochromocytoma lineQ36210059
Nerve growth factor- and epidermal growth factor-stimulated phosphorylation of a PC12 cytoskeletally associated protein in situQ36211938
Regulation of microtubule composition and stability during nerve growth factor-promoted neurite outgrowthQ36213118
PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factorQ36214656
Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinasesQ36215329
Co-expression of cytokeratins and neurofilament proteins in a permanent cell line: cultured rat PC12 cells combine neuronal and epithelial featuresQ36215843
Nerve growth factor inhibits the synthesis of a single-stranded DNA binding protein in pheochromocytoma cells (clone PC12).Q36266341
Physiological and morphological studies of rat pheochromocytoma cells (PC12) chemically fused and grown in cultureQ36361602
Mobility, clustering, and transport of nerve growth factor in embryonal sensory cells and in a sympathetic neuronal cell lineQ36393915
Nerve growth factor receptors on PC12 cells: ligand-induced conversion from low- to high-affinity statesQ36402511
PURIFICATION OF A NERVE-GROWTH PROMOTING PROTEIN FROM THE MOUSE SALIVARY GLAND AND ITS NEURO-CYTOTOXIC ANTISERUM.Q36431961
DESTRUCTION OF THE SYMPATHETIC GANGLIA IN MAMMALS BY AN ANTISERUM TO A NERVE-GROWTH PROTEIN.Q36432342
The nerve growth factor: purification as a 30,000-molecular-weight proteinQ36446136
A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.Q36472744
Regulation of tyrosine hydroxylase mRNA by glucocorticoid and cyclic AMP in a rat pheochromocytoma cell line. Isolation of a cDNA clone for tyrosine hydroxylase mRNAQ36588527
Clonal variants of PC12 pheochromocytoma cells with defects in cAMP-dependent protein kinases induce ornithine decarboxylase in response to nerve growth factor but not to adenosine agonistsQ36892015
Mutants of PC12 Cells with Altered Cyclic AMP ResponsesQ36948583
Nerve growth factor-induced transformation of immature chromaffin cells in vivo into sympathetic neurons: effect of antiserum to nerve growth factorQ37320573
Nerve growth factor in the nucleus: interaction with receptors on the nuclear membraneQ37320737
Cellular localization of the molecular forms of acetylcholinesterase in rat pheochromocytoma PC12 cells treated with nerve growth factor.Q37388509
Ethanol regulates calcium channels in clonal neural cells.Q37396130
Peripheral-type benzodiazepines influence ornithine decarboxylase levels and neurite outgrowth in PC12 cellsQ37526744
Nerve growth factor rapidly induces ornithine decarboxylase mRNA in PC12 rat pheochromocytoma cellsQ37530227
Induction of the proto-oncogene fos by nerve growth factorQ37553567
Nerve growth factor promotes cholinergic development in brain striatal culturesQ37556010
Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organsQ37580834
Nerve growth factor-induced fiber outgrowth from isolated rat adrenal chromaffin cells: impairment by glucocorticoidsQ37591312
Evidence for RNA synthesis-dependent and -independent pathways in stimulation of neurite outgrowth by nerve growth factorQ37596585
Short-latency local actions of nerve growth factor at the growth coneQ37611147
Chromosomal locations of the human and mouse genes for precursors of epidermal growth factor and the beta subunit of nerve growth factorQ37674900
Multiple calcium channels and neuronal functionQ38170255
Selective enzyme induction in a nerve growth factor-responsive pheochromocytoma cell line (PC 12)Q39510309
Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell lineQ39649794
Alterations in the surface properties of cells responsive to nerve growth factorQ40154010
Short-term regulation of catecholamine biosynthesis in a nerve growth factor responsive clonal line of rat pheochromocytoma cellsQ40166762
Nerve growth factor-mediated selective induction of ornithine decarboxylase in rat pheochromocytoma; a cyclic amp-independent processQ40178128
Human beta-nerve growth factor gene sequence highly homologous to that of mouseQ40236820
Modulation of protein synthesis by nerve growth factorQ40245727
The heterogeneity of nerve growth factor receptorsQ40290438
Nerve growth factor-recent developments and perspectivesQ40571517
Nerve growth factor-induced reduction in epidermal growth factor responsiveness and epidermal growth factor receptors in PC12 cells: An aspect of cell differentiationQ40720264
Tetanus toxin: a cell surface marker for neurones in cultureQ40897523
Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factorQ41340059
Regulation of neural cell adhesion molecule expression on cultured mouse Schwann cells by nerve growth factorQ41340935
Nerve growth factor enhances the level of the protein kinase C substrate B-50 in pheochromocytoma PC12 cellsQ41451602
Rapid stimulation by nerve growth factor of amino acid uptake by clonal PC12 pheochromocytoma cellsQ41499124
The role of cAMP in nerve growth factor-promoted neurite outgrowth in PC12 cellsQ41499753
Clonal variants of PC12 pheochromocytoma cells with altered response to nerve growth factorQ41549514
Properties of the nerve growth factor receptor of a clonal line of rat pheochromocytoma (PC12) cellsQ41621733
Neurite outgrowth and protein synthesis by PC12 cells as a function of substratum and nerve growth factorQ41624050
Nerve growth factor influences sodium ion extrusion from chick embryonic dorsal root ganglionic neuronsQ41723682
NGF stimulates incorporation of fucose or glucosamine into an external glycoprotein in cultured rat PC12 pheochromocytoma cellsQ41882026
Activation of muscarinic receptors in PC12 cells. Correlation between cytosolic Ca2+ rise and phosphoinositide hydrolysisQ41997939
Changes in the phosphorylation and distribution of vinculin during nerve growth factor induced neurite outgrowthQ41999565
Rapid activation of tyrosine hydroxylase in response to nerve growth factorQ42242282
Characterization of substance P and somatostatin receptors on adrenal chromaffin cells using structural analoguesQ42448561
?- and ?-receptor control of catecholamine secretion from isolated adrenal medulla cellsQ42452488
Gangliosides stimulate neurite outgrowth and induce tubulin mRNA accumulation in neural cellsQ42461179
The protein kinase C activator phorbol-12-myristate-13-acetate enhances cyclic AMP accumulation in pheochromocytoma cellsQ42507981
Pharmacological profile of adenosine A2 receptor in PC12 cellsQ42508882
Calcium-dependent nerve growth factor-stimulated hydrolysis of phosphoinositides in PC12 cellsQ42509666
Purification and mechanism of activation of a nerve growth factor-sensitive S6 kinase from PC12 cells.Q42511737
Morphologic and cytochemical properties of a clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factorQ42802296
Neuritic growth from a new subline of PC12 pheochromocytoma cells: cyclic AMP mimics the action of nerve growth factorQ42820088
Activation of muscarinic receptors in PC12 cells. Stimulation of Ca2+ influx and redistributionQ42853003
Two receptor classes for epidermal growth factor on pheochromocytoma cells, distinguishable by temperature, lectins, and tumor promotersQ43484547
Functional acetylcholine receptor in PC12 cells reacts with a monoclonal antibody to brain nicotinic receptorsQ43501913
Nerve growth factor enhances the synthesis, phosphorylation, and metabolic stability of neurofilament proteins in PC12 cellsQ43502614
The Action of Adenosine Analogs on PC12 CellsQ43531548
Isolation of human nerve growth factor from placental tissueQ67015888
Sodium and calcium fluxes in a clonal nerve cell lineQ67018254
Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cellsQ67018448
Purification of the receptor for nerve growth factor from A875 melanoma cells by affinity chromatographyQ67267804
Characterization of antisera raised against cultured rat sympathetic neuronsQ67270164
Atypical distribution of asymmetric acetylcholinesterase in mutant PC12 pheochromocytoma cells lacking a cell surface heparan sulfate proteoglycanQ67289798
Simultaneous visualization of the binding of nerve growth factor and epidermal growth factor to single rat pheochromocytoma (PC12) cells through indirect immunohistofluorescenceQ67290511
Relationship between NGF-mediated volume increase and “priming effect” in fast and slow reacting clones of PC12 pheochromocytoma cellsQ67294336
Nerve growth factor-induced decrease in the cell-free phosphorylation of a soluble protein in PC12 cellsQ67295450
Purification, characterization, and partial amino acid sequence of nerve growth factor from cobra venomQ67434206
alpha-Bungarotoxin binding and cholinergic receptor function on a rat sympathetic nerve lineQ67715067
K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cellsQ68259333
Early rise of cytosolic Ca2+ induced by NGF in PC12 and chromaffin cellsQ68807544
NIF (neurite-inducing factor): a novel peptide inducing neurite formation in PC12 cellsQ68859173
Differential regulation of peptide and catecholamine characters in cultured sympathetic neuronsQ68948419
Tumor promoter phorbol myristate acetate inhibits Ca2+ influx through voltage-gated Ca2+ channels in two secretory cell lines, PC12 and RINm5FQ68950185
Inactivation of 45Ca2+ uptake by prior depolarization of PC12 cellsQ68956157
Properties of the apamin-sensitive Ca2+-activated K+ channel in PC12 pheochromocytoma cells which hyper-produce the apamin receptorQ68966107
Enkephalin and substance P modulate synaptic properties of chick ciliary ganglion neurons in cell cultureQ68969514
The effect of nerve growth factor on the development of sodium channels in PC12 cellsQ68987617
Ca2+/calmodulin-dependent phosphorylation of elongation factor 2Q68989080
Interaction of calmodulin inhibitors and protein kinase C inhibitors with voltage-dependent calcium channelsQ68990562
Ethanol-induced component of 45Ca2+ uptake in PC12 cells is sensitive to Ca2+ channel modulating drugsQ68993574
Effects of ethanol on 45Ca2+ uptake in synaptosomes and in PC12 cellsQ68998521
Nerve growth factor potentiates the agonist-stimulated accumulation of inositol phosphates in PC-12 pheochromocytoma cellsQ69021517
Magnesium-dependent attachment and neurite outgrowth by PC12 cells on collagen and laminin substrataQ69022212
Cell-free detection and characterization of a novel nerve growth factor-activated protein kinase in PC12 cellsQ69025760
Extracellular matrix derived from astrocytes stimulates neuritic outgrowth from PC12 cells in vitroQ69203755
Morphological properties and membrane channels of the growth cones induced in PC12 cells by nerve growth factorQ69381283
Cooperative regulation of neurotensin content in PC12 pheochromocytoma cell cultures: effects of nerve growth factor, dexamethasone, and activators of adenylate cyclaseQ69519003
Epinephrine synthesis in the PC12 pheochromocytoma cell lineQ69617335
Characterization of adenosine receptors in the PC12 pheochromocytoma cell line using radioligand binding: evidence for A-2 selectivityQ69696599
Differentiation of PC12 pheochromocytoma cells by sodium butyrateQ69745193
Partial purification and characterization of a nerve growth factor-sensitive kinase and its substrate from PC12 cellsQ69833379
Nerve growth factor and other agents mediate phosphorylation and activation of tyrosine hydroxylase. A convergence of multiple kinase activitiesQ69866745
Regulation of tyrosine hydroxylase phosphorylation in PC12 pheochromocytoma cells by elevated K+ and nerve growth factor. Evidence for different mechanisms of actionQ69867429
Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cellsQ69874602
Control of Thy-1 glycoprotein expression in cultures of PC12 cellsQ69901377
Inhibition of calcium flux and calcium channel antagonist binding in the PC12 neural cell line by phorbol esters and protein kinase CQ69996129
The effect of fibroblast growth factor on PC12 cellsQ70079580
Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiationQ70104566
Nerve growth factor-induced increase in the cell-free phosphorylation of a nuclear protein in PC12 cellsQ70111682
Phosphorylation of nerve growth factor receptor proteins in sympathetic neurons and PC12 cells. In vitro phosphorylation by the cAMP-independent protein kinase FA/GSK-3Q70148138
Regulation of the multiple forms of dopamine beta-hydroxylase by nerve growth factor, dexamethasone, and dibutyryl cyclic AMP in the PC12 pheochromocytoma cell lineQ70149185
PC12 variants deficient in catecholamine transportQ43654735
Nerve growth factor does not activate Na+/H+ exchange in PC12 pheochromocytoma cellsQ43665352
Nerve growth factor induces specific enkephalin binding sites in a nerve cell lineQ43733948
Probable identity of NILE glycoprotein and the high-molecular-weight component of L1 antigenQ43847741
PC12 adhesion and neurite formation on selected substrates are inhibited by some glycosaminoglycans and a fibronectin-derived tetrapeptideQ43859995
Nuclear localization of a lactic dehydrogenase with single-stranded DNA-binding properties.Q43904581
Release, storage and uptake of catecholamines by a clonal cell line of nerve growth factor (NGF) responsive pheochromocytoma cellsQ43974691
Mechanism of biosynthesis of soluble and membrane-bound forms of dopamine beta-hydroxylase in PC12 pheochromocytoma cellsQ43996945
Monensin depletes PC12 pheochromocytoma cells of catecholamines and of chromaffin-type granulesQ44087657
Nerve growth factor increases the number of functional Na channels and induces TTX-resistant Na channels in PC12 pheochromocytoma cells.Q44149781
Calcium-dependent activation of glycogen phosphorylase in rat pheochromocytoma PC12 cells by nerve growth factorQ44323479
Regulation of nerve growth factor action on Nsp100 phosphorylation in PC12h cells by calciumQ44408567
Protein kinase C mediated regulation of calcium channels in PC-12 pheochromocytoma cellsQ44455073
A single Mr approximately 103,000 125I-beta-nerve growth factor-affinity-labeled species represents both the low and high affinity forms of the nerve growth factor receptorQ44510146
Neuritogenic and metabolic effects of individual gangliosides and their interaction with nerve growth factor in cultures of neuroblastoma and pheochromocytomaQ44661863
Glucocorticoid stimulation of dopamine production in PC12 cells on extracellular matrix and plasticQ44729899
Nerve Growth Factor and InsulinQ46305123
Dorsal root ganglion neurons are destroyed by exposure in utero to maternal antibody to nerve growth factorQ46362940
The Isolation of the Mouse Nerve Growth Factor Protein in a High Molecular Weight Form*Q47406466
Effects of a nerve-growth factor, embryo age and metabolic inhibitors on growth of fibres and on synthesis of ribonucleic acid and protein in embryonic sympathetic gangliaQ47735981
Release of [3H]norepinephrine from a clonal line of pheochromocytoma cells (PC12) by nicotinic cholinergic stimulationQ48243801
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptorsQ48307334
Nerve growth factor and gangliosides stimulate the release of glycoproteins from PC12 pheochromocytoma cellsQ48369089
Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factorQ48399039
PC12 neurite regeneration and long-term maintenance in the absence of exogenous nerve growth factor in response to contact with Schwann cellsQ48554153
Nerve growth factor increases choline acetyltransferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neuronsQ48555966
Phospholipases elevate cyclic AMP levels and promote neurite extension in a clonal nerve cell line.Q48667041
Biochemical properties of the nerve growth factor-inducible large external (NILE) glycoprotein.Q48708284
Structural features of the nerve growth factor inducible large external glycoprotein of PC12 pheochromocytoma cells and brain.Q48709217
Nerve growth factor-mediated induction of tyrosine hydroxylase and of neurite outgrowth in cultures of bovine adrenal chromaffin cells: Dependence on developmental stageQ52287099
Beta nerve growth factor binding to PC12 cells. Association kinetics and cooperative interactions.Q52428749
Voltage-dependent activation and inactivation of calcium channels in PC12 cells. Correlation with neurotransmitter release.Q52592457
Nerve growth factor-mediated stimulation of tyrosine hydroxylase activity in a clonal rat pheochromocytoma cell lineQ52833979
Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines.Q53542393
Two types of transglutaminase in the PC12 pheochromocytoma cell line. Stimulation by sodium butyrate.Q53875695
Nerve growth factor-mediated induction of choline acetyltransferase in PC12 cells: evaluation of the site of action of nerve growth factor and the involvement of lysosomal degradation products of nerve growth factor.Q53906637
The distribution of nerve growth factor in the male sex organs of mammals.Q53962534
Slow EPSP and the depolarizing action of noradrenaline on sympathetic preganglionic neurons.Q54405029
Activated N-ras gene induces neuronal differentiation of PC12 rat pheochromocytoma cells.Q54421458
Cell surface Thy-1-cross-reactive glycoprotein in cultured PC12 cells: modulation by nerve growth factor and association with the cytoskeleton.Q54456017
Induction of neurite outgrowth in the IMR-32 human neuroblastoma cell line by nerve growth factor.Q55490611
The effect of nerve growth factor on undifferentiated glioma cells.Q55490747
Nerve growth factor-induced increase in saxitoxin binding to rat PC12 pheochromocytoma cellsQ58450180
Synthesis, storage and release of acetylcholine by a noradrenergic pheochromocytoma cell lineQ59057925
A second messenger required for nerve growth factor biological activity?Q59061153
Induction of ornithine decarboxylase by nerve growth factor dissociated from effects on survival and neurite outgrowthQ59064971
Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogeneQ59073572
Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell lineQ59094087
Regulation of muscarinic ligand binding sites by nerve growth factor in PC12 phaeochromocytoma cellsQ59094089
Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21Q59094093
Synthesis and content of a DNA-binding protein with lactic dehydrogenase activity are reduced by nerve growth factor in the neoplastic cell line PC12Q60658536
P921main subjectcellQ7868
nerve tissue proteinQ6996861
peptideQ172847
cell differentiationQ210861
phaeochromocytomaQ536269
nerve growth factorsQ98072643
P1104number of pages16
P304page(s)127-142
P577publication date1989-03-01
P1433published inEnvironmental Health PerspectivesQ1345904
P1476titleRegulation of the differentiation of PC12 pheochromocytoma cells
P478volume80

Reverse relations

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Q34940280In vitro techniques for the assessment of neurotoxicity
Q30450313Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation
Q42501982Induction of peptidylglycine alpha-hydroxylating monooxygenase activity by nerve growth factor in PC12 cells
Q42520534Inhibition of neuronal cyclin-dependent kinase-5 by staurosporine and purine analogs is independent of activation by Munc-18.
Q38301804Involvement of JunD in transcriptional activation of the orphan receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells
Q43654475Involvement of cAMP in nerve growth factor-triggered p35/Cdk5 activation and differentiation in PC12 cells.
Q42111178Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells
Q67552403Isoprenylation and carboxylmethylation in small GTP-binding proteins of pheochromocytoma (PC-12) cells
Q40241179K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses
Q28573139Knockdown of dystrophin Dp71 impairs PC12 cells cycle: localization in the spindle and cytokinesis structures implies a role for Dp71 in cell division
Q35027709LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization
Q38943759Low fucose containing bacterial polysaccharide facilitate mitochondria-dependent ROS-induced apoptosis of human lung epithelial carcinoma via controlled regulation of MAPKs-mediated Nrf2/Keap1 homeostasis signaling.
Q48361736Methylmercury decreases NGF-induced TrkA autophosphorylation and neurite outgrowth in PC12 cells
Q48479929NGF gene expression in dividing and non-dividing cells from AAV-derived constructs
Q47676649NGF induces transient but not sustained activation of ERK in PC12 mutant cells incapable of differentiating
Q44780952Nerve growth factor binding sites on hepatic parenchymal cells
Q44784052Nerve growth factor pretreatment attenuates oxygen and glucose deprivation-induced c-Jun amino-terminal kinase 1 and stress-activated kinases p38alpha and p38beta activation and confers neuroprotection in the pheochromocytoma PC12 Model
Q37541110Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene
Q48795477Nerve growth factor up-regulates the N-methyl-D-aspartate receptor subunit 1 promoter in PC12 cells
Q73514875Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway
Q36797999Neurobehavioural and molecular changes induced by methylmercury exposure during development
Q50117414Neuroprotective Effects of Bioactive Compounds and MAPK Pathway Modulation in "Ischemia"-Stressed PC12 Pheochromocytoma Cells.
Q43981154Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia
Q34292224Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos
Q35636257Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon
Q33527544Normalization with genes encoding ribosomal proteins but not GAPDH provides an accurate quantification of gene expressions in neuronal differentiation of PC12 cells
Q37244862Nucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genes
Q38164458Opportunities for live cell FT-infrared imaging: macromolecule identification with 2D and 3D localization
Q37308667Optimality conditions for cell-fate heterogeneity that maximize the effects of growth factors in PC12 cells
Q26825787Organic electrode coatings for next-generation neural interfaces
Q39726152Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells
Q37185608Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells
Q39633639Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss
Q33740035PC12 cells differentiate into chromaffin cell-like phenotype in coculture with adrenal medullary endothelial cells
Q67469303Pardaxin-Stimulated Calcium Uptake in PC12 Cells is Blocked by Cadmium and is not Mediated by L-Type Calcium Channels
Q39690163Polylysine-modified PEG-based hydrogels to enhance the neuro-electrode interface
Q38793863Probing the response of human osteoblasts following exposure to sympathetic neuron-like PC-12 cells in a 3D coculture model
Q44328529Protective effects of flavonoids on the cytotoxicity of linoleic acid hydroperoxide toward rat pheochromocytoma PC12 cells
Q39987295Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells
Q47955607Rapid transport of neural intermediate filament protein
Q42455330Reactive oxygen species, apoptosis and altered NGF-induced signaling in PC12 pheochromocytoma cells cultured in elevated glucose: an in vitro cellular model for diabetic neuropathy
Q33283987Real-time assessment of three-dimensional cell aggregation in rotating wall vessel bioreactors in vitro
Q38345251Regulation of the neural-specific gene VGF in PC12 cells. Identification of transcription factors interacting with NGF-responsive elements
Q71874668Repression of preprotachykinin-A promoter activity is mediated by a proximal promoter element
Q36529776Retinoic acid stimulates the differentiation of PC12 cells that are deficient in cAMP-dependent protein kinase
Q28395180Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel
Q74034559Searching for depolarization-induced genes that modulate synaptic plasticity and neurotrophin-induced genes that mediate neuronal differentiation
Q74558339Simulated microgravity conditions enhance differentiation of cultured PC12 cells towards the neuroendocrine phenotype
Q71689551Staurosporine induces neurite outgrowth in neuronal hybrids (PC12EN) lacking NGF receptors
Q36828641Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells
Q46046946Synchrotron infrared measurements of protein phosphorylation in living single PC12 cells during neuronal differentiation.
Q36725915Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro
Q24290251Tau promoter confers neuronal specificity and binds Sp1 and AP-2
Q40001677Temporal and functional dynamics of the transcriptome during nerve growth factor-induced differentiation.
Q36531148The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells
Q52574996The effects of carbaryl and trichlorphon on differentiating mouse N2a neuroblastoma cells.
Q28573510The p53 transcriptional target gene wnt7b contributes to NGF-inducible neurite outgrowth in neuronal PC12 cells
Q26862632The plasminogen activation system and the regulation of catecholaminergic function
Q42471328Tissue-specific alternative mRNA splicing of phenylethanolamine N-methyltransferase (PNMT) during development by intron retention
Q52980630Tl(I) and Tl(III) alter the expression of EGF-dependent signals and cyclins required for pheochromocytoma (PC12) cell-cycle resumption and progression.
Q41679842Toxic and transcriptional responses of PC12 cells to soluble tungsten alloy surrogates
Q38235510Transcriptional down-regulation of epidermal growth factor (EGF) receptors by nerve growth factor (NGF) in PC12 cells.
Q39684720Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants
Q37113546Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells
Q50524871Tricresyl phosphate inhibits the formation of axon-like processes and disrupts neurofilaments in cultured mouse N2a and rat PC12 cells.
Q37142287Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells.
Q42128564Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model

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