Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation

scientific article published on 24 April 2012

Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.NTT.2012.04.008
P932PMC publication ID3404226
P698PubMed publication ID22546817

P50authorTheodore A. SlotkinQ88773550
Frederic J SeidlerQ88773672
P2860cites workTranscriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cellsQ37113546
Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cellsQ37185608
The role of development and duration of exposure to the embryotoxicity of diazinonQ38459521
Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicantsQ39684720
Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cellsQ39987295
Embryotoxicity and genotoxicity of nickelQ40202825
Effects of the PKC inhibitor PD 406976 on cell cycle progression, proliferation, PKC isozymes and apoptosis in glioma and SVG-transformed glial cellsQ40432925
Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cellsQ41016073
Cell cycle arrest of proliferating neuronal cells by serum deprivation can result in either apoptosis or differentiation.Q41556728
Developmental neurotoxicity of environmental agents in the neonate.Q41618755
Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivoQ41949474
Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro modelQ42128564
Neonatal lesions of the basal forebrain cholinergic neurons result in abnormal cortical developmentQ42514940
Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cellsQ43812555
Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degenerationQ44494831
Decreased susceptibility of differentiated PC12 cells to oxidative challenge: relationship to cellular redox and expression of apoptotic protease activator factor-1.Q46475085
Copper, manganese, zinc, nickel, cadmium and lead in human foetal tissuesQ48193141
Prenatal exposure to neurotoxicants dieldrin or lindane alters tert-butylbicyclophosphorothionate binding to GABA(A) receptors in fetal rat brainstemQ48463101
Inhibition of protein kinase C prevents Purkinje cell death but does not affect axonal regeneration.Q48620798
Dieldrin toxicosis: fetotoxicosis, tissue concentrations, and microscopic and ultrastructural changes in guinea pigs.Q48789839
Agonist-stimulated calcium transients in PC12 cells are affected differentially by cadmium and nickelQ71860980
Gene ontology: tool for the unification of biologyQ23781406
Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cellsQ24813250
PesticidesQ28254296
Developmental neurotoxicity of industrial chemicalsQ28279457
Nerve growth factor-stimulated calcium uptake into PC12 cells: uniqueness of the channel and evidence for phosphorylationQ28316175
Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickelQ28387502
Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivoQ28393707
Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickelQ28395180
Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamilyQ28395997
Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitroQ28397594
Silver impairs neurodevelopment: studies in PC12 cellsQ33702906
Cholinergic regulation of cortical development and plasticity. New twists to an old story.Q33758926
Apoptosis and the nervous systemQ33806940
Testing methods for developmental neurotoxicity of environmental chemicalsQ33876820
Vulnerable processes of nervous system development: a review of markers and methods.Q33905413
Mechanisms of programmed cell death in the developing brainQ33944933
Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: Effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cellsQ34103892
Disruption of CREB function in brain leads to neurodegenerationQ34124865
Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifosQ34292224
Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphatesQ34331472
Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cellsQ34603071
Neurotoxicity testing: a discussion of in vitro alternativesQ34942010
Regulation of the differentiation of PC12 pheochromocytoma cellsQ35032923
Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinonQ35636257
Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targetsQ35862603
Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systemsQ35933418
The role of cell death genes during developmentQ36440068
Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitroQ36725915
Undertaking positive control studies as part of developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpointsQ36903350
P433issue4
P304page(s)395-402
P577publication date2012-04-24
P1433published inNeurotoxicology and TeratologyQ15097918
P1476titleDoes mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation
P478volume34

Reverse relations

cites work (P2860)
Q43618232Effect of exposure to diazinon on adult rat's brain
Q37128325Lactobacillus Casei Decreases Organophosphorus Pesticide Diazinon Cytotoxicity in Human HUVEC Cell Line
Q28397348Research Review: Environmental exposures, neurodevelopment, and child mental health - new paradigms for the study of brain and behavioral effects