Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells

scientific article published on 05 December 2008

Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1289/EHP.0800251
P8608Fatcat IDrelease_ba336def7nfgpe3cgfz32flalm
P932PMC publication ID2679603
P698PubMed publication ID19440498
P5875ResearchGate publication ID24425641

P50authorTheodore A. SlotkinQ88773550
Frederic J SeidlerQ88773672
P2860cites workComparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicityQ24547922
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Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthoodQ28387172
Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickelQ28387502
Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickelQ28395180
Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamilyQ28395997
Organophosphorus pesticides: do they all have the same mechanism of toxicity?Q29615471
Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathionQ30484602
Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinonQ30491985
Ethanol, oxidative stress, reactive aldehydes, and the fetusQ33333822
Developmental cholinotoxicants: nicotine and chlorpyrifosQ33608802
Prevalence of fetal exposure to environmental toxins as determined by meconium analysisQ33962016
Roles of molecular chaperones in the nervous systemQ34067828
Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifosQ34292224
Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphatesQ34331472
Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency.Q34579240
Causes of oxidative stress in the pre- and perinatal periodQ34591238
Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cellsQ34603071
The neurobiology of autismQ34699035
Chlorpyrifos, parathion, and their oxons bind to and desensitize a nicotinic acetylcholine receptor: relevance to their toxicities.Q52559630
The "stress" of being bornQ70037446
Agonist-stimulated calcium transients in PC12 cells are affected differentially by cadmium and nickelQ71860980
Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen speciesQ73111301
Regulation of the differentiation of PC12 pheochromocytoma cellsQ35032923
Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibitionQ35113105
Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinonQ35636257
Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targetsQ35862603
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Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cellsQ35971890
Insecticide urinary metabolites in nonoccupationally exposed populationsQ36270180
Developmental diazinon neurotoxicity in rats: later effects on emotional responseQ36477388
Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systemsQ36490835
Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthoodQ36569670
Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitroQ36725915
Interactions between methamphetamine and environmental stress: role of oxidative stress, glutamate and mitochondrial dysfunctionQ36817237
Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cellsQ37113546
The role of glutamate neurotoxicity in hypoxic-ischemic neuronal deathQ37585239
Brain regional heterogeneity and toxicological mechanisms of organophosphates and carbamatesQ37658753
Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiationQ38314836
Gene expression profiles of the rat brain both immediately and 3 months following acute sarin exposureQ38317370
Metals and free radicals in neurodegenerationQ40599315
Neuronal differentiation in PC12 cells is inhibited by chlorpyrifos and its metabolites: is acetylcholinesterase inhibition the site of action?Q40920286
Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cellsQ41016073
Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro modelQ42128564
Prenatal exposure to the pesticide dieldrin or the GABA(A) receptor antagonist bicuculline differentially alters expression of GABA(A) receptor subunit mRNAs in fetal rat brainstemQ42542197
In vitro and in vivo induction of heat shock (stress) protein (Hsp) gene expression by selected pesticidesQ42554258
Developmental neurotoxicity of chlorpyrifos: targeting glial cellsQ42729938
Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cellsQ43812555
Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cellsQ44085638
Behavioral and neurochemical effects induced by pyrethroid-based mosquito repellent exposure in rat offsprings during prenatal and early postnatal periodQ44169165
Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degenerationQ44494831
Block of neuronal nicotinic acetylcholine receptors by organophosphate insecticidesQ45041250
Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthionQ45138907
Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifosQ46553074
Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combinationQ46553092
Corticosterone and dexamethasone potentiate cytotoxicity associated with oxygen-glucose deprivation in organotypic cerebellar slice culturesQ46719241
Concentrations of selective metabolites of organophosphorus pesticides in the United States populationQ46820302
Copper, manganese, zinc, nickel, cadmium and lead in human foetal tissuesQ48193141
NMDA antagonists exert distinct effects in experimental organophosphate or carbamate poisoning in miceQ48342946
Prenatal exposure to neurotoxicants dieldrin or lindane alters tert-butylbicyclophosphorothionate binding to GABA(A) receptors in fetal rat brainstemQ48463101
Direct actions of anticholinesterases on the neuronal nicotinic acetylcholine receptor channelsQ48592373
Dieldrin toxicosis: fetotoxicosis, tissue concentrations, and microscopic and ultrastructural changes in guinea pigs.Q48789839
The organophosphate sarin, at low concentrations, inhibits the evoked release of GABA in rat hippocampal slices.Q51415851
Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?Q52167210
In vitro and in vivo effects of chlorpyrifos on glutathione peroxidase and catalase in developing rat brain.Q52168615
The toxicity of organophosphate compounds towards cultured PC12 cells.Q52544690
In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides.Q52546874
P433issue4
P921main subjectnickelQ744
chlorpyrifosQ414915
neurotoxicityQ3338704
toxic encephalopathyQ7830379
P304page(s)587-596
P577publication date2008-12-05
P1433published inEnvironmental Health PerspectivesQ1345904
P1476titleOxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells
P478volume117

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cites work (P2860)
Q35739063Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors
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