Identification of TBK1 and IKKε, the non-canonical IκB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes

scientific article published on 16 April 2016

Identification of TBK1 and IKKε, the non-canonical IκB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.LEUKRES.2016.04.012
P932PMC publication ID4899189
P698PubMed publication ID27123832

P2093author name stringLi Chen
Hua Cheng
Huan Zhang
Shao-Hui Cai
P2860cites workThe HTLV-1 Tax interactomeQ21093224
Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cellsQ28270680
NF-kappaB: linking inflammation and immunity to cancer development and progressionQ29614597
Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaQ29615115
HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomainsQ33794114
Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinasesQ33797174
HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cellsQ34270849
Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the diseaseQ34274473
The autophagy molecule Beclin 1 maintains persistent activity of NF-κB and Stat3 in HTLV-1-transformed T lymphocytesQ36087310
Transcriptional and post-transcriptional gene regulation of HTLV-1.Q36254862
Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair responseQ36254875
HTLV gene regulation: because size matters, transcription is not enoughQ37470581
TBK1 mediates crosstalk between the innate immune response and autophagyQ37922423
Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancerQ37995693
IκB kinase ε (IKKε): a therapeutic target in inflammation and cancerQ38075370
Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular cloneQ39594099
All roads lead to IKKepsilonQ40118983
HTLV-1 Tax protein recruitment into IKKε and TBK1 kinase complexes enhances IFN-I expression.Q41587571
Metabolism and anti-human immunodeficiency virus-1 activity of 2-halo-2',3'-dideoxyadenosine derivativesQ42211960
The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbetaQ45755453
HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB.Q52591266
P921main subjectHuman T-lymphotropic virus 1Q1280388
P304page(s)37-44
P577publication date2016-04-16
P1433published inLeukemia ResearchQ15716445
P1476titleIdentification of TBK1 and IKKε, the non-canonical IκB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes
P478volume46

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cites work (P2860)
Q64277776Curbing Lipids: Impacts ON Cancer and Viral Infection
Q57284121Decreased RORC expression and downstream signaling in HTLV-1-associated Adult T-cell Lymphoma/Leukemia uncovers an antiproliferative IL17 link: a potential target for immunotherapy?
Q91846149Dual TBK1/IKKɛ inhibitor amlexanox attenuates the severity of hepatotoxin-induced liver fibrosis and biliary fibrosis in mice
Q64243483Essential Roles for the Non-Canonical IκB Kinases in Linking Inflammation to Cancer, Obesity, and Diabetes
Q92579583Expression and prognostic role of IKBKE and TBK1 in stage I non-small cell lung cancer
Q52728051HTLV Deregulation of the NF-κB Pathway: An Update on Tax and Antisense Proteins Role.
Q39168834Pharmacological Potential and Synthetic Approaches of Imidazo[4,5-b]pyridine and Imidazo[4,5-c]pyridine Derivatives
Q58737053Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
Q91831967The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65RelA-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability

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