Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression

scientific article published on 10 October 2008

Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M709010200
P932PMC publication ID2602888
P698PubMed publication ID18849346

P50authorFelix BeuschleinQ37834705
Thomas ReinheckelQ56849298
P2093author name stringChristoph Peters
Vivian Hook
Thomas Toneff
Lydiane Funkelstein
Charles Mosier
Shin-Rong Hwang
Urs D Lichtenauer
P2860cites workPrecursor convertases in the secretory pathway, cytosol and extracellular milieuQ24322869
Carboxypeptidase EQ28283622
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An aminopeptidase activity in bovine pituitary secretory vesicles that cleaves the N-terminal arginine from beta-lipotropin60-65.Q34055726
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Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursorQ34634402
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Melanocortin system and eating disordersQ35173386
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.Q35234967
Complete structure of the porcine pro-opiomelanocortin mRNA derived from the nucleotide sequence of doned cDNAQ35693250
Biosynthesis and alternate targeting of the lysosomal cysteine protease cathepsin L.Q35952753
Pathophysiological dynamics of human ovarian surface epithelial cells in epithelial ovarian carcinogenesisQ35983656
Induction of integral membrane PAM expression in AtT-20 cells alters the storage and trafficking of POMC and PC1.Q36255780
Characterization of pro-opiocortin-converting activity in purified secretory granules from rat pituitary neurointermediate lobeQ36274772
Corticotropin-releasing factor stimulates phospholipid methylation and corticotropin secretion in mouse pituitary tumor cellsQ36316080
Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis.Q36323323
Proteases for processing proneuropeptides into peptide neurotransmitters and hormonesQ37053834
PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residuesQ37491584
Physiology of beta-endorphins. A close-up view and a review of the literatureQ40391645
Altered processing of pro-orphanin FQ/nociceptin and pro-opiomelanocortin-derived peptides in the brains of mice expressing defective prohormone convertase 2.Q43697190
Regulation of cellular alpha-MSH and beta-endorphin during stimulated secretion from intermediate pituitary cells: involvement of aspartyl and cysteine proteases in the control of cellular levels of alpha-MSH and beta-endorphinQ44105550
Regulation of ACTH levels in anterior pituitary cells during stimulated secretion: evidence for aspartyl and cysteine proteases in the cellular metabolism of ACTH.Q44535556
Biosynthesis of proopiomelanocortin-derived peptides in prohormone convertase 2 and 7B2 null miceQ44630408
Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretionQ44754448
Neuropeptide processing profile in mice lacking prohormone convertase-1.Q46393031
Secretory vesicle aminopeptidase B related to neuropeptide processing: molecular identification and subcellular localization to enkephalin- and NPY-containing chromaffin granulesQ46537906
Purification and characteristics of the candidate prohormone processing proteases PC2 and PC1/3 from bovine adrenal medulla chromaffin granulesQ46547246
The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic studyQ48449113
Unique cleavage specificity of 'prohormone thiol protease' related to proenkephalin processingQ72315500
Corticotropin releasing factor stimulates adrenocorticotropin and β-endorphin release from AtT-20 mouse pituitary tumor cellsQ72949163
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivoQ73077056
P433issue51
P407language of work or nameEnglishQ1860
P921main subjectendorphinsQ190528
P304page(s)35652-35659
P577publication date2008-10-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleMajor role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression
P478volume283

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cites work (P2860)
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