Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function

scientific article published on January 2009

Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1593/NEO.81006
P932PMC publication ID2606115
P698PubMed publication ID19107228
P5875ResearchGate publication ID23688896

P2093author name stringBum-Joon Park
Nam-Chul Ha
Su-Jin Lee
Sun-Hye Lee
Yongbin Xu
Ho Sung Kang
Yeon Sang Jung
P2860cites workTransforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathwaysQ44508741
Oncogene-induced senescence as an initial barrier in lymphoma developmentQ46634165
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.Q47745236
AIMP3 haploinsufficiency disrupts oncogene-induced p53 activation and genomic stability.Q53343862
MDM2 gene amplification in metastatic osteosarcomaQ70521330
Infrequency of MDM2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomasQ72657594
p53 Mutation and MDM2 amplification in human soft tissue sarcomasQ72968853
Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomasQ73784542
Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stressQ24301523
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transitionQ24305416
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4aQ24324559
p53, the cellular gatekeeper for growth and divisionQ27860990
Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational statusQ28143274
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cellsQ28143877
A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoterQ28190014
Targeting RAS signalling pathways in cancer therapyQ28201363
Flavonols and pancreatic cancer risk: the multiethnic cohort studyQ28240121
Divorcing ARF and p53: an unsettled caseQ28258356
Mutant KRAS in the initiation of pancreatic cancerQ28272767
The transcriptional repressor Snail promotes mammary tumor recurrenceQ28272823
The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATRQ28512723
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expressionQ28595042
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?Q29547559
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomasQ29616243
Restoration of p53 function leads to tumour regression in vivoQ29618727
p53 ubiquitination: Mdm2 and beyondQ29619502
Nucleolar Arf sequesters Mdm2 and activates p53Q29620244
A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescenceQ30699339
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.Q33889383
Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformationQ34688909
Ras signalling and apoptosisQ34746668
Snail in the frame of malignant tumor recurrenceQ35605788
Oncogene-induced senescence pathways weave an intricate tapestryQ36718786
ATM and ATR: components of an integrated circuitQ36741134
A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicinQ38797735
p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivoQ39676073
Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.Q40432782
Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2: two mechanisms that cooperatively increase p53 function in colon cancer cellsQ40520938
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular contextQ40637553
Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.Q40845331
Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cellsQ44095249
P433issue1
P304page(s)22-31, 6p following 31
P577publication date2009-01-01
P1433published inNeoplasiaQ2962042
P1476titleBlocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function
P478volume11

Reverse relations

cites work (P2860)
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