Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity.

scientific article published on 17 March 2013

Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.MCN.2013.03.002
P932PMC publication ID3715571
P698PubMed publication ID23511190

P50authorMarina A MaksimovaQ85763514
P2093author name stringChristopher W Cowan
Eric N Olson
Kimberly M Huber
Rhonda Bassel-Duby
Tong Zang
P2860cites workRepeated stress alters dendritic spine morphology in the rat medial prefrontal cortexQ30492445
Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortexQ31965180
NMDA receptor subunits: diversity, development and diseaseQ33950711
Development of long-term dendritic spine stability in diverse regions of cerebral cortexQ33986592
Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndromeQ34200046
The psychiatric presentation of fragile x: evolution of the diagnosis and treatment of the psychiatric comorbidities of fragile X syndromeQ34213731
Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal sliceQ34311517
Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortexQ34433739
Circuit and plasticity defects in the developing somatosensory cortex of FMR1 knock-out mice.Q34778657
Cocaine regulates MEF2 to control synaptic and behavioral plasticityQ34818266
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo.Q35247785
Mechanisms of synapse assembly and disassemblyQ35558414
Neural activity and the dynamics of central nervous system developmentQ35719203
Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.Q35949697
Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translationQ36189503
FMRP RNA targets: identification and validationQ36228088
The MEF2D transcription factor mediates stress-dependent cardiac remodeling in miceQ36249548
Transsynaptic signaling by activity-dependent cleavage of neuroligin-1.Q37198461
From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and functionQ37279404
The state of synapses in fragile X syndromeQ37387721
The role of glial cells in synapse eliminationQ37950632
Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2.Q40372504
MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.Q40817289
Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice.Q41844282
Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densitiesQ42042937
Generating green fluorescent mice by germline transmission of green fluorescent ES cellsQ42819708
Development of vesicle pools during maturation of hippocampal synapses.Q43875561
Presynaptic FMR1 genotype influences the degree of synaptic connectivity in a mosaic mouse model of fragile X syndrome.Q45192998
Biolistic transfection of cultured organotypic brain slices.Q45992976
Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampusQ46152163
Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout miceQ46185789
Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation.Q46932828
Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation.Q48232839
Development of rat CA1 neurones in acute versus organotypic slices: role of experience in synaptic morphology and activity.Q48246019
The transcription factor MEF2 directs developmental visually driven functional and structural metaplasticity.Q48358652
MEF2 negatively regulates learning-induced structural plasticity and memory formationQ48411990
Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term DepressionQ60141744
Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturationQ71978735
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiationQ24305050
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95Q24306675
The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BPQ24314573
Fragile X syndrome: loss of local mRNA regulation alters synaptic development and functionQ24608468
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autismQ24631425
Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivoQ24644531
A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome.Q24644826
Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2CQ24649105
MEF2: a calcium-dependent regulator of cell division, differentiation and deathQ28215798
From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndromeQ28247567
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse numberQ28297899
MEF2C transcription factor controls chondrocyte hypertrophy and bone developmentQ28505927
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and functionQ28507026
In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survivalQ28508411
Postsynaptic Neuroligin1 regulates presynaptic maturationQ28508958
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroliginQ28572335
Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy imagesQ28755127
Rayburst sampling, an algorithm for automated three-dimensional shape analysis from laser scanning microscopy imagesQ29028421
Regional differences in synaptogenesis in human cerebral cortexQ29616105
A robust and high-throughput Cre reporting and characterization system for the whole mouse brainQ29616609
Experience-dependent structural synaptic plasticity in the mammalian brainQ29619661
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouseQ29620355
P4510describes a project that usesImageJQ1659584
P304page(s)39-49
P577publication date2013-03-17
P1433published inMolecular and Cellular NeuroscienceQ6895985
P1476titlePostsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity
P478volume56

Reverse relations

cites work (P2860)
Q98773451An essential role for MEF2C in the cortical response to loss of sleep in mice
Q47547973Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes
Q35762766Autism spectrum disorder and epilepsy: Disorders with a shared biology
Q27320813Autism-Associated Chromatin Regulator Brg1/SmarcA4 Is Required for Synapse Development and Myocyte Enhancer Factor 2-Mediated Synapse Remodeling
Q88535420Dendritic Spine Elimination: Molecular Mechanisms and Implications
Q41691925Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D
Q38550206Immune mediators in the brain and peripheral tissues in autism spectrum disorder
Q37564195Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models
Q48343073Impaired presynaptic long-term potentiation in the anterior cingulate cortex of Fmr1 knock-out mice.
Q36299874Inducible knockout of Mef2a, -c, and -d from nestin-expressing stem/progenitor cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo
Q30370553MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.
Q37128147MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease
Q37603793Postsynaptic FMRP promotes the pruning of cell-to-cell connections among pyramidal neurons in the L5A neocortical network
Q38326506Serotonin dysregulation in Fragile X Syndrome: implications for treatment
Q35572532Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome.
Q36318358Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models