The function of RhoGTPases in axon ensheathment and myelination

scientific article

The function of RhoGTPases in axon ensheathment and myelination is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1002/GLIA.20752
P932PMC publication ID2615182
P698PubMed publication ID18803320
P5875ResearchGate publication ID23268434

P50authorUeli SuterQ28606521
Joao RelvasQ43115278
P2093author name stringM Laura Feltri
P2860cites workPhosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphologyQ57987174
Association of Frabin with the Actin Cytoskeleton Is Essential for Microspike Formation through Activation of Cdc42 Small G ProteinQ58550187
Mitotic Schwann cells in developing nerve: Their changes in shape, fine structure, and axon relationshipsQ69681283
Axonal interactions regulate Schwann cell apoptosis in developing peripheral nerve: neuregulin receptors and the role of neuregulinsQ71554050
Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cellsQ73424194
GTPases and phosphatidylinositol 3-kinase are critical for insulin-like growth factor-I-mediated Schwann cell motilityQ73829221
Axonal regulation of Schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activityQ73870801
Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cellsQ83005031
Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDIQ24292355
Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10Q24295273
Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architectureQ24299320
Rocks: multifunctional kinases in cell behaviourQ24303641
p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by FynQ24303948
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPasesQ24304128
ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migrationQ24648256
Homozygosity mapping of autosomal recessive demyelinating Charcot-Marie-Tooth neuropathy (CMT4H) to a novel locus on chromosome 12p11.21-q13.11Q24673964
Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4Q24676494
Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4HQ24676752
Rho GTPases in cell biologyQ27860969
LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complexQ27919650
Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarityQ27939243
Regulation and functions of Rho-associated kinaseQ28138022
Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.Q28507503
Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors.Q52206462
Cell type-specific functions of Rho GTPases revealed by gene targeting in mice.Q53583432
Nerve growth factor induces proliferation of PC12 cells through Cdc42.Q53654104
Rho GTPases and their effector proteinsQ56690400
An in vitro study on the involvement of LINGO-1 and Rho GTPases in Nogo-A regulated differentiation of oligodendrocyte precursor cellsQ57361239
Cdc42 and Rac1 Signaling Are Both Required for and Act Synergistically in the Correct Formation of Myelin Sheaths in the CNSQ57510566
Rho Regulates Membrane Transport in the Endocytic Pathway to Control Plasma Membrane Specialization in Oligodendroglial CellsQ57983952
Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1Q28513718
A rat G protein-coupled receptor selectively expressed in myelin-forming cellsQ28569876
Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migrationQ28579777
Neuregulin-1 type III determines the ensheathment fate of axonsQ28585039
WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelinationQ28585142
LINGO-1 negatively regulates myelination by oligodendrocytesQ28588853
Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelinationQ28756758
Rho GTPases and their effector proteinsQ29547740
An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1Q29614256
Guanine nucleotide exchange factors for Rho GTPases: turning on the switchQ29618403
Rho GTPases in neuronal morphogenesisQ29620432
Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membraneQ30443407
FAK is required for axonal sorting by Schwann cellsQ30480416
Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarityQ30487982
Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation.Q30708317
Rho guanine dissociation inhibitors: pivotal molecules in cellular signallingQ33703466
Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathwayQ33717551
The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migrationQ33936040
Flipping the switch: the structural basis for signaling through the CRIB motifQ34019126
Rho family GTPases: more than simple switchesQ34040276
Multiple roles for Cdc42 in cell regulationQ34180632
Oligophrenin 1 (OPHN1) gene mutation causes syndromic X-linked mental retardation with epilepsy, rostral ventricular enlargement and cerebellar hypoplasiaQ34205653
Integrins regulate Rac targeting by internalization of membrane domainsQ34295045
Rho-family GTPases: it's not only Rac and Rho (and I like it).Q34305856
Evidence that a major site of expression of the RHO-GTPASE activating protein, oligophrenin-1, is peripheral myelin.Q34306464
The origin and development of glial cells in peripheral nervesQ34447586
Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPasesQ34515430
Charcot-Marie-Tooth type 4B demyelinating neuropathy: deciphering the role of MTMR phosphatasesQ34690650
Schwann cell-specific ablation of laminin gamma1 causes apoptosis and prevents proliferationQ34806340
Rho GTPase-activating proteins in cell regulationQ35024821
Disease mechanisms in inherited neuropathiesQ35209953
Roles of Rho-family GTPases in cell polarisation and directional migrationQ35547373
Actin polymerization: riding the waveQ35676555
PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulationQ35952627
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system developmentQ36118630
Laminins and their receptors in Schwann cells and hereditary neuropathiesQ36164129
The geometry of peripheral myelin sheaths during their formation and growth in rat sciatic nervesQ36192451
A Rac switch regulates random versus directionally persistent cell migrationQ36320639
Coordinate control of axon defasciculation and myelination by laminin-2 and -8.Q36321400
Conditional disruption of beta 1 integrin in Schwann cells impedes interactions with axonsQ36324660
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spinesQ36498526
Pathomechanisms of mutant proteins in Charcot-Marie-Tooth diseaseQ36507183
Axonal regulation of myelination by neuregulin 1.Q36589639
New developments in the biological functions of lysophospholipidsQ36599952
Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPasesQ36938760
ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinasesQ36954083
Phosphoinositides and Charcot-Marie-tooth disease: new keys to old questionsQ36983739
Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cellsQ37088822
Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behaviorQ37295867
Rho-dependent regulation of cell spreading by the tetraspan membrane protein Gas3/PMP22.Q38612581
N-WASP regulates extension of filopodia and processes by oligodendrocyte progenitors, oligodendrocytes, and Schwann cells-implications for axon ensheathment at myelinationQ40150333
Cdc42 promotes G1 progression through p70 S6 kinase-mediated induction of cyclin E expressionQ42169248
P0-Cre transgenic mice for inactivation of adhesion molecules in Schwann cellsQ42480759
Role of N-cadherin in Schwann cell precursors of growing nerves.Q42499157
Formation of a beta1 integrin signaling complex in Schwann cells is independent of rho.Q42528418
Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascadeQ42807716
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.Q42823880
Lysophosphatidic acid promotes survival and differentiation of rat Schwann cellsQ43580480
Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes.Q44684981
Initiation of neuropathic pain requires lysophosphatidic acid receptor signalingQ44934799
S1P and LPA trigger Schwann cell actin changes and migration.Q44951512
RhoA, RhoB, RhoC, Rac1, Cdc42, and Tc10 mRNA levels in spinal cord, sensory ganglia, and corticospinal tract neurons and long-lasting specific changes following spinal cord injuryQ45286570
The polarity protein Par-3 directly interacts with p75NTR to regulate myelinationQ46887211
Neuregulin and laminin stimulate phosphorylation of the NF2 tumor suppressor in Schwann cells by distinct protein kinase A and p21-activated kinase-dependent pathwaysQ46902773
RhoA and Rac1 GTPases mediate the dynamic rearrangement of actin in peripheral glia.Q47072127
Rho kinase regulates schwann cell myelination and formation of associated axonal domains.Q47717786
The relationships between interphase Schwann cells and axons before myelination: A quantitative electron microscopic studyQ47914936
Loss of X-linked mental retardation gene oligophrenin1 in mice impairs spatial memory and leads to ventricular enlargement and dendritic spine immaturityQ48386718
Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination.Q48467646
Expression of Rho-family GTPases (Rac, cdc42, RhoA) and their association with p-21 activated kinase in adult rat peripheral nerveQ48874872
Phosphorylation of the NF2 tumor suppressor in Schwann cells is mediated by Cdc42-Pak and requires paxillin binding.Q50704352
Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS.Q50795071
P433issue14
P921main subjectmyelinationQ14876135
P304page(s)1508-1517
P577publication date2008-11-01
P1433published inGliaQ15716658
P1476titleThe function of RhoGTPases in axon ensheathment and myelination
P478volume56

Reverse relations

cites work (P2860)
Q38916443A novel mutation in FGD4/FRABIN causes Charcot Marie Tooth disease type 4H in patients from a consanguineous Tunisian family.
Q38122225Akt/mTOR signalling in myelination
Q21144864An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs
Q38070879Axonal regulation of Schwann cell ensheathment and myelination.
Q50481135CD82 blocks cMet activation and overcomes hepatocyte growth factor effects on oligodendrocyte precursor differentiation.
Q37580149Chapter 2: Development of the peripheral nerve.
Q33936216Common genetic variants and gene expression associated with white matter microstructure in the human brain
Q57287898Evolvability of the actin cytoskeleton in oligodendrocytes during central nervous system development and aging
Q53306821Fibroblast-derived tenascin-C promotes Schwann cell migration through β1-integrin dependent pathway during peripheral nerve regeneration.
Q51920312Gelsolin is required for macrophage recruitment during remyelination of the peripheral nervous system.
Q39367129Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy
Q37722638Impaired geranylgeranyltransferase-I regulation reduces membrane-associated Rho protein levels in aged mouse brain
Q27329703Intrinsic migratory properties of cultured Schwann cells based on single-cell migration assay
Q30540349Lck tyrosine kinase mediates β1-integrin signalling to regulate Schwann cell migration and myelination
Q33824976Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration
Q34295163MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells
Q97649728Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge
Q42132669Modulation of RhoGTPases improves the behavioral phenotype and reverses astrocytic deficits in a mouse model of Rett syndrome.
Q36942808Molecular mechanisms of inherited demyelinating neuropathies
Q58795841Mutations in dock1 disrupt early Schwann cell development
Q58183071Myelin and Axon Pathology in a Long-Term Study ofPMP22-Overexpressing Mice
Q30515379Myosin II is a negative regulator of oligodendrocyte morphological differentiation
Q35210805N-WASP is required for membrane wrapping and myelination by Schwann cells
Q38648687N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination.
Q38309247Neuropathologic characterization of INF2-related Charcot-Marie-Tooth disease: evidence for a Schwann cell actinopathy.
Q38254331Non-redundant function of dystroglycan and β1 integrins in radial sorting of axons
Q36530065Polarization and myelination in myelinating glia
Q33671359Poly(ADP-ribosylation) is present in murine sciatic nerve fibers and is altered in a Charcot-Marie-Tooth-1E neurodegenerative model
Q41977319Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors
Q37860720Rho GTPases as regulators of morphological neuroplasticity
Q41387997Rho GTPases as therapeutic targets in cancer (Review).
Q64118485Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves
Q38468684Schwann Cells: Development and Role in Nerve Repair
Q30502106Schwannomin/merlin promotes Schwann cell elongation and influences myelin segment length
Q47832358Targeted deletion of RIC8A in mouse neural precursor cells interferes with the development of the brain, eyes, and muscles.
Q35902777The RNA-binding protein human antigen R controls global changes in gene expression during Schwann cell development.
Q37309492The protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development
Q42486077The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool.
Q48327147Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination
Q37318020Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development