Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus

scientific article published on 14 June 2013

Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00395-013-0365-X
P932PMC publication ID3731771
P698PubMed publication ID23764734
P5875ResearchGate publication ID237821536

P50authorAdam GoodwillQ56535651
Johnathan D TuneQ77481052
Kieren J MatherQ90465787
Eli D CasaliniQ117266924
Zachary C BerwickQ117266925
Steven P MoberlyQ117266926
P2093author name stringGary D Hutchins
Meredith K Owen
Mark A Green
Yen Ng
Robert V Considine
Kevin M Perry
Robin L Chisholm
P2860cites workGlucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase.Q54627651
PET imaging of oxidative metabolism abnormalities in sympathetically denervated canine myocardiumQ77729118
Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failureQ79437872
Glucagon-like peptide-1 limits myocardial stunning following brief coronary occlusion and reperfusion in conscious caninesQ80542636
Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemia-reperfusion injury in rat heartQ81538720
Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart modelQ81730896
GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) miceQ85538281
Heart disease and stroke statistics--2012 update: a report from the American Heart AssociationQ29547909
Heart of the matter: coronary dysfunction in metabolic syndromeQ30404992
Single dose GLP-1-Tf ameliorates myocardial ischemia/reperfusion injuryQ33925948
Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated?Q34207237
The biology of incretin hormonesQ34499706
Glucagon-like peptide-1 increases myocardial glucose uptake via p38alpha MAP kinase-mediated, nitric oxide-dependent mechanisms in conscious dogs with dilated cardiomyopathyQ34786386
Implementation of GLP-1 based therapy of type 2 diabetes mellitus using DPP-IV inhibitorsQ35098627
Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patientsQ35654597
Equivalence of arterial and venous blood for [11C]CO2-metabolite analysis following intravenous administration of 1-[11C]acetate and 1-[11C]palmitateQ36206257
Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham heart studyQ36807441
Mechanisms of coronary dysfunction in obesity and insulin resistanceQ36871760
Chronic glucagon-like peptide-1 infusion sustains left ventricular systolic function and prolongs survival in the spontaneously hypertensive, heart failure-prone rat.Q37322877
Myocardial fatty acid metabolism in health and diseaseQ37677921
The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: an updateQ37970585
Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heartQ38317335
Exenatide reduces final infarct size in patients with ST-segment-elevation myocardial infarction and short-duration of ischemiaQ38473330
Signalling pathways activated by glucagon-like peptide-1 (7-36) amide in the rat heart and their role in protection against ischaemia.Q38610870
The metabolic syndrome and total and cardiovascular disease mortality in middle-aged menQ39513420
Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failureQ41267217
Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathwaysQ42165735
Intracoronary glucagon-like peptide 1 preferentially augments glucose uptake in ischemic myocardium independent of changes in coronary flow.Q42357170
A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cellsQ42996825
Glucagon-like peptide-1 (GLP-1) attenuates post-resuscitation myocardial microcirculatory dysfunctionQ43116787
Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytesQ43726354
Interrelations between coronary artery pressure, myocardial metabolism and coronary blood flowQ44044009
The glucagon-like peptide-1 receptor--or not?Q44489452
Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusionQ44774818
Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young womenQ44880994
Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathyQ45020436
Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injuryQ45199143
Simultaneous measurement of myocardial oxygen consumption and blood flow using [1-carbon-11]acetate.Q46334306
Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathyQ46604606
AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heartQ46716866
Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat heartsQ46952887
Postconditioning with glucagon like peptide-2 reduces ischemia/reperfusion injury in isolated rat hearts: role of survival kinases and mitochondrial KATP channelsQ47620961
Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients.Q51550359
Quantitative evaluation of regional substrate metabolism in the human heart by positron emission tomography.Q51610167
Exenatide alters myocardial glucose transport and uptake depending on insulin resistance and increases myocardial blood flow in patients with type 2 diabetes.Q53163778
P433issue4
P921main subjecttype 2 diabetesQ3025883
obesityQ12174
P304page(s)365
P577publication date2013-06-14
P1433published inBasic Research in CardiologyQ2453360
P1476titleImpaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus
P478volume108

Reverse relations

cites work (P2860)
Q37611715Cardiovascular Benefits of Native GLP-1 and its Metabolites: An Indicator for GLP-1-Therapy Strategies
Q33993725Cardiovascular and hemodynamic effects of glucagon-like peptide-1.
Q39106973Cardiovascular consequences of metabolic syndrome.
Q38857056Cardiovascular effects of anti-diabetes drugs
Q26823085Cardiovascular effects of glucagon-like peptide 1 (GLP-1) receptor agonists
Q90312782Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection vs. Insulin Alone in Type 2 Diabetes
Q38372787Effect of liraglutide on myocardial glucose uptake and blood flow in stable chronic heart failure patients: A double-blind, randomized, placebo-controlled LIVE sub-study
Q41878782Exendin-4 attenuates adverse cardiac remodelling in streptozocin-induced diabetes via specific actions on infiltrating macrophages
Q37510130GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats
Q38797077Glucagon-Like Peptide 1 Receptor Activation Augments Cardiac Output and Improves Cardiac Efficiency in Obese Swine After Myocardial Infarction
Q34653078Glucagon-like peptide-1 (7-36) but not (9-36) augments cardiac output during myocardial ischemia via a Frank-Starling mechanism.
Q38218639Impact of glucagon-like peptide-1 on myocardial glucose metabolism revisited
Q41853657Influence of GLP-1 on myocardial glucose metabolism in healthy men during normo- or hypoglycemia
Q49630529Is it time to reassess the role of myocardial metabolic modulation for the treatment of heart failure?
Q50026330Liraglutide protects cardiac function in diabetic rats through the PPARα pathway
Q38589032Mechanisms for the cardiovascular effects of glucagon-like peptide-1.
Q35973848Metabolic Syndrome Abolishes Glucagon-Like Peptide 1 Receptor Agonist Stimulation of SERCA in Coronary Smooth Muscle
Q50084370Multiorgan, Multimodality Imaging in Cardiometabolic Disease
Q37468729Obesity alters molecular and functional cardiac responses to ischemia/reperfusion and glucagon-like peptide-1 receptor agonism.
Q34785887PEGylated exendin-4, a modified GLP-1 analog exhibits more potent cardioprotection than its unmodified parent molecule on a dose to dose basis in a murine model of myocardial infarction
Q30392463Saturated high-fat diet-induced obesity increases adenylate cyclase of myocardial β-adrenergic system and does not compromise cardiac function
Q34994502Selective targeting of glucagon-like peptide-1 signalling as a novel therapeutic approach for cardiovascular disease in diabetes

Search more.