Cardiovascular Benefits of Native GLP-1 and its Metabolites: An Indicator for GLP-1-Therapy Strategies

scientific article published on 30 January 2017

Cardiovascular Benefits of Native GLP-1 and its Metabolites: An Indicator for GLP-1-Therapy Strategies is …
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scholarly articleQ13442814

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P356DOI10.3389/FPHYS.2017.00015
P932PMC publication ID5276855
P698PubMed publication ID28194113

P2093author name stringQinghua Wang
Juan Zheng
Ali Fathi
Junfeng Li
Harry K Lau
Susanne Wang
P2860cites workCloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptorQ24318252
GLP-1 and cardioprotection: from bench to bedsideQ27024984
Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brainQ28256443
DPPIV inhibitors extend GLP-2 mediated tumour promoting effects on intestinal cancer cellsQ28257599
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitusQ28297680
Alogliptin after acute coronary syndrome in patients with type 2 diabetesQ28297690
Novel GLP-1 Fusion Chimera as Potent Long Acting GLP-1 Receptor AgonistQ28475510
Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoformsQ28535415
Cardiac function in mice lacking the glucagon-like peptide-1 receptorQ28586718
Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiencyQ28740948
Biology of incretins: GLP-1 and GIPQ29617302
GLP-1 (7-36) amide restores myocardial insulin sensitivity and prevents the progression of heart failure in senescent beaglesQ30411123
GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscleQ30418716
Role of smooth muscle cells in the initiation and early progression of atherosclerosisQ30438867
Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditureQ30478488
Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in miceQ33750640
Effects of high-fat diet and the anti-diabetic drug metformin on circulating GLP-1 and the relative number of intestinal L-cellsQ33898060
The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha.Q33932817
Bariatric surgery and long-term cardiovascular events.Q34030064
GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressureQ34336097
The biology of incretin hormonesQ34499706
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 DiabetesQ34540403
Glucagon-like peptide-1 (7-36) but not (9-36) augments cardiac output during myocardial ischemia via a Frank-Starling mechanism.Q34653078
Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 DiabetesQ34670462
Long-term consequences of type 2 diabetes mellitus: economic impact on society and managed careQ34984643
Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6).Q34986024
Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patientsQ35654597
GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese MiceQ35769544
Glucagon-like peptide-1(9-36)amide metabolite inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese miceQ47403266
Antihypertrophic effects of combined inhibition of the renin-angiotensin system (RAS) and neutral endopeptidase (NEP) in progressive, tachycardia-induced experimental heart failureQ48408264
Sitagliptin reduces plaque macrophage content and stabilises arteriosclerotic lesions in Apoe (-/-) mice.Q50509855
Supplemental hydrogen sulphide protects transplant kidney function and prolongs recipient survival after prolonged cold ischaemia-reperfusion injury by mitigating renal graft apoptosis and inflammation.Q50896244
Differential effects of glucagon-like peptide-1 on microvascular recruitment and glucose metabolism in short- and long-term insulin resistance.Q51307758
A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice.Q51362571
GLP-1-derived nonapeptide GLP-1(28-36)amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytes.Q51381163
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.Q53886146
Exendin-4 protects endothelial cells from lipoapoptosis by PKA, PI3K, eNOS, p38 MAPK, and JNK pathways.Q54454763
Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarctionQ58447894
Clinical efficacy of bariatric surgery versus liraglutide in patients with type 2 diabetes and severe obesity: a 12-month retrospective evaluationQ60312974
Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor.Q64998688
Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1(7-36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptidesQ70942068
Regulation and Differential Expression of Neutral Endopeptidase 24.11 in Human Endothelial CellsQ71959170
Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failureQ79437872
Beneficial effects of GLP-1 on endothelial function in humans: dampening by glyburide but not by glimepirideQ80825411
Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemia-reperfusion injury in rat heartQ81538720
Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces intimal thickening after vascular injuryQ83151449
Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptorQ84187312
[Effects of glucagon-like peptide 1(9-36) on endothelial nitric oxide synthase in human umbilical vein endothelial cells]Q85912555
Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic MiceQ86916012
Impact of GLP-1 receptor agonists on blood pressure, heart rate and hypertension among patients with type 2 diabetes: A systematic review and network meta-analysisQ35769898
Cell-surface peptidasesQ35818705
Circulation and degradation of GIP and GLP-1.Q36012469
Liraglutide and Cardiovascular Outcomes in Type 2 DiabetesQ36050559
The Effect of Sitagliptin on Carotid Artery Atherosclerosis in Type 2 Diabetes: The PROLOGUE Randomized Controlled TrialQ36063048
Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model miceQ36331561
Predicted structure of agonist-bound glucagon-like peptide 1 receptor, a class B G protein-coupled receptorQ36471233
Cardiovascular biology of the incretin systemQ36484283
Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection.Q36836773
Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetesQ36850966
Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitusQ37065219
Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studiesQ37172727
Endothelial permeability in vitro and in vivo: protective actions of ANP and omapatrilat in experimental atherosclerosisQ37209666
Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.Q37635255
Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgery.Q37687612
Minireview: update on incretin biology: focus on glucagon-like peptide-1.Q37715583
The structure and function of the glucagon-like peptide-1 receptor and its ligandsQ37939244
Optimising cardioprotection during myocardial ischaemia: targeting potential intracellular pathways with glucagon-like peptide-1Q38177382
GLP-1: a mediator of the beneficial metabolic effects of bariatric surgery?Q38307449
The regulation of function, growth and survival of GLP-1-producing L-cellsQ38659256
Effects of dipeptidyl peptidase-4 inhibitors on blood pressure in patients with type 2 diabetes: A systematic review and meta-analysisQ38673335
7. Approaches to Glycemic TreatmentQ38676991
Association of low GLP-1 with oxidative stress is related to cardiac disease and outcome in patients with type 2 diabetes mellitus: a pilot studyQ38919256
GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody.Q39030156
Evidence for paracrine/autocrine regulation of GLP-1-producing cellsQ39103643
Cardioprotective effects of exenatide against oxidative stress-induced injuryQ39104148
Glucagon-like peptide-1 activates endothelial nitric oxide synthase in human umbilical vein endothelial cellsQ39234083
Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cellsQ39277813
Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cellsQ39304557
Glucagon-like peptide-1 (GLP-1) and its split products GLP-1(9-37) and GLP-1(28-37) stabilize atherosclerotic lesions in apoe⁻/⁻ miceQ39309484
Antiapoptotic effects of GLP-1 in murine HL-1 cardiomyocytesQ39600857
The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cellsQ39774031
Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4.Q39778606
Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction.Q39990285
Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cellsQ40592531
Glucagon-Like Peptide-1 Receptor Activation Does not Affect Re-Endothelialization but Reduces Intimal Hyperplasia via Direct Effects on Smooth Muscle Cells in a Nondiabetic Model of Arterial InjuryQ40947688
Possible involvement of GLP-1(9-36) in the regional haemodynamic effects of GLP-1(7-36) in conscious ratsQ41809232
Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse modelQ41826601
GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in miceQ41984767
Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesisQ42022343
Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathwaysQ42165735
Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathwayQ42594418
Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytesQ42824310
A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cellsQ42996825
Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A.Q43071459
Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor.Q43155141
Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissueQ43237616
Study rationale and design of ADVANCE: action in diabetes and vascular disease--preterax and diamicron MR controlled evaluationQ43763511
Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group studyQ43919658
Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db miceQ44145661
In vitro metabolism of the glucagon-like peptide-1 (GLP-1)-derived metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in mouse and human hepatocytesQ44317184
Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injuryQ44321259
Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusionQ44774818
Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathyQ45020436
Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injuryQ45199143
Prediction of the risk of cardiovascular mortality using a score that includes glucose as a risk factor. The DECODE StudyQ45232445
Endothelial dysfunction induced by triglycerides is not restored by exenatide in rat conduit arteries ex vivo.Q45930780
Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium: GLP-1R mediated effects in human myocardium.Q45954775
LOX-1, a bridge between GLP-1R and mitochondrial ROS generation in human vascular smooth muscle cellsQ46353648
Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetesQ46381951
Effects of intravenous glucagon-like peptide-1 on glucose control and hemodynamics after coronary artery bypass surgery in patients with type 2 diabetesQ46415493
GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP.Q46426083
Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathyQ46604606
Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig.Q46605092
Blood pressure-lowering effects of GLP-1 receptor agonists exenatide and liraglutide: a meta-analysis of clinical trialsQ46637270
GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptideQ46637836
Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro formQ46778176
Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 yearsQ46870991
The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetesQ46872862
GLP-1-derived nonapeptide GLP-1(28-36)amide inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese miceQ47377801
P304page(s)15
P577publication date2017-01-30
P1433published inFrontiers in PhysiologyQ2434141
P1476titleCardiovascular Benefits of Native GLP-1 and its Metabolites: An Indicator for GLP-1-Therapy Strategies
P478volume8

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cites work (P2860)
Q47899237Effects of Glucagon-Like Peptide-1 on Oxidative Stress and Nrf2 Signaling
Q60044940GLP-1RAs in type 2 diabetes: mechanisms that underlie cardiovascular effects and overview of cardiovascular outcome data
Q90737641Impact of Glucose-Lowering Medications on Cardiovascular and Metabolic Risk in Type 2 Diabetes
Q33679277Novel GLP-1 Analog Supaglutide Reduces HFD-Induced Obesity Associated with Increased Ucp-1 in White Adipose Tissue in Mice
Q47180841Preoperative weight loss with glucagon-like peptide-1 receptor agonist treatment predicts greater weight loss achieved by the combination of medical weight management and bariatric surgery in patients with type 2 diabetes: A longitudinal analysis.

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