GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice

scientific article published on 16 January 2009

GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice is …
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scholarly articleQ13442814

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P356DOI10.2337/DB08-1193
P932PMC publication ID2661586
P698PubMed publication ID19151200
P5875ResearchGate publication ID46872367

P50authorDaniel J. DruckerQ19966099
P2093author name stringLaurie L Baggio
R Mark Henkelman
Yu-Qing Zhou
Kiwon Ban
M Abdul Momen
Mansoor Husain
Al-Muktafi Sadi
Ali M Riazi
Mohammad Hossein Noyan-Ashraf
P2860cites workGlucagon-like peptide-1 receptor is involved in learning and neuroprotectionQ28202403
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Simultaneous evaluation of infarct size and cardiac function in intact mice by contrast-enhanced cardiac magnetic resonance imaging reveals contractile dysfunction in noninfarcted regions early after myocardial infarctionQ30432987
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Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition poreQ34327908
Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heartQ36151679
Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarctionQ36370540
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Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathwaysQ42165735
Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats.Q43349026
Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytesQ43726354
Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase--dependent pathway is cardioprotectiveQ43909380
Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardiumQ44512663
Elafin-overexpressing mice have improved cardiac function after myocardial infarctionQ44704940
Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusionQ44774818
One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.Q44865459
Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathyQ45020436
Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injuryQ45199143
Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathyQ46604606
Dietary approaches to positively influence fetal determinants of adult healthQ46851302
Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat heartsQ46952887
Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetesQ47296454
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytesQ48014037
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failureQ62383757
In vivo survival and function of transplanted rat cardiomyocytesQ70934703
Regulation of bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes: association with changes in mitochondrial membrane potentialQ73175884
Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in ratsQ73195050
Tumor necrosis factor-alpha induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytesQ73573637
Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic miceQ74236314
Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failureQ79437872
Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload stateQ79923829
Comprehensive transthoracic cardiac imaging in mice using ultrasound biomicroscopy with anatomical confirmation by magnetic resonance imagingQ80007972
Myocardial ischaemia-reperfusion injury is attenuated by intact glucagon like peptide-1 (GLP-1) in the in vitro rat heart and may involve the p70s6K pathwayQ80414128
Glucagon-like peptide-1 limits myocardial stunning following brief coronary occlusion and reperfusion in conscious caninesQ80542636
Age-related differences in postinfarct left ventricular rupture and remodelingQ80669914
Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemia-reperfusion injury in rat heartQ81538720
Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndromeQ81681212
Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart modelQ81730896
Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular functionQ95821951
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectmyocardial infarctionQ12152
liraglutideQ2526479
P304page(s)975-983
P577publication date2009-01-16
P1433published inDiabetesQ895262
P1476titleGLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
P478volume58

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