New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders

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New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders is …
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scholarly articleQ13442814

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P356DOI10.4239/WJD.V6.I15.1285
P932PMC publication ID4635139
P698PubMed publication ID26557956
P5875ResearchGate publication ID283716950

P2093author name stringNigel Irwin
Peter R Flatt
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Use of glucagon-like peptide-1 receptor agonists and bone fractures: a meta-analysis of randomized clinical trials.Q54687755
Chronic Reduction of GIP Secretion Alleviates Obesity and Insulin Resistance Under High-Fat Diet ConditionsQ57591294
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Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor.Q64998688
Effects of Ingestion of Triglyceride or Galactose on Secretion of Gastric Inhibitory Polypeptide and on Responses to Intravenous Glucose in Normal and Diabetic SubjectsQ67317479
Gastric inhibitory polypeptide activates MAP kinase through the wortmannin-sensitive and -insensitive pathwaysQ73442906
Oxyntomodulin suppresses appetite and reduces food intake in humansQ79161514
Lack of tolerance development with long-term administration of PEGylated cholecystokininQ82974141
Comparison of stability, cellular, glucose-lowering and appetite supressing effects of oxyntomodulin analogues modified at the N-terminusQ85358566
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DPP IV inhibitor treatment attenuates bone loss and improves mechanical bone strength in male diabetic ratsQ87428531
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Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brainQ28256443
Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satietyQ28287902
GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1Q28289025
Optimal bone mechanical and material properties require a functional glucagon-like peptide-1 receptorQ28295907
Effects of glucose-dependent insulinotropic peptide on behaviorQ28504780
Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloidQ28565656
Cardiac function in mice lacking the glucagon-like peptide-1 receptorQ28586718
Cholecystokinin receptorsQ28608935
Effects of beta-cell rest on beta-cell function: a review of clinical and preclinical dataQ31144148
Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretionQ33529942
Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancyQ33753169
Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stressQ33812543
Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetesQ33873009
Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanismQ33924273
Receptors and effects of gut hormones in three osteoblastic cell linesQ33975451
The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucoseQ34014522
CholecystokininQ34096294
Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survivalQ34132510
Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in miceQ34316123
Glucose-dependent insulinotropic polypeptide (GIP) receptor deletion leads to reduced bone strength and quality.Q34357351
A meta-analysis of serious adverse events reported with exenatide and liraglutide: acute pancreatitis and cancer.Q34421364
Proglucagon-derived peptides: mechanisms of action and therapeutic potentialQ34452524
The murine glucagon-like peptide-1 receptor is essential for control of bone resorption.Q34585388
Gastrointestinal regulation of food intakeQ35251043
Glucose-dependent insulinotropic polypeptide (GIP): anti-diabetic and anti-obesity potential?Q35579570
Glucose-dependent insulinotropic polypeptide inhibits bone resorption in humansQ42464329
Deciphering metabolic messages from the gut drives therapeutic innovation: the 2014 Banting LectureQ42471846
Beneficial effects of a N-terminally modified GIP agonist on tissue-level bone material propertiesQ42805863
Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled studyQ43255700
Effects of chronic exposure of clonal β-cells to elevated glucose and free fatty acids on incretin receptor gene expression and secretory responses to GIP and GLP-1.Q43651347
Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytesQ43726354
Effects of cholecystokinin (CCK)-8, CCK-33, and gastric inhibitory polypeptide (GIP) on basal and meal-stimulated pancreatic hormone secretion in manQ43947295
The novel GLP-1-gastrin dual agonist, ZP3022, increases β-cell mass and prevents diabetes in db/db miceQ44704405
Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucoseQ44757149
Sulfonylurea induced beta-cell apoptosis in cultured human isletsQ45105959
Xenin-25[Lys13PAL]: a novel long-acting acylated analogue of xenin-25 with promising antidiabetic potentialQ45378064
Beneficial effects of (pGlu-Gln)-CCK-8 on energy intake and metabolism in high fat fed mice are associated with alterations of hypothalamic gene expressionQ45796873
Use of dipeptidyl peptidase-4 inhibitors for type 2 diabetes mellitus and risk of fracture.Q45918551
Design of a long acting peptide functioning as both a glucagon-like peptide-1 receptor agonist and a glucagon receptor antagonistQ46131933
Antidiabetic effects of sub-chronic activation of the GIP receptor alone and in combination with background exendin-4 therapy in high fat fed miceQ46203073
KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetesQ46218694
Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetesQ46226028
Dorothy Hodgkin Lecture 2008. Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesity-diabetes?Q46567054
Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trialQ46620662
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 studyQ46850405
Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose toleranceQ46942344
The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucoseQ46972113
Glucose-dependent insulinotropic peptide: differential effects on hepatic artery vs. portal vein endothelial cellsQ47280771
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodentsQ48246762
Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's diseaseQ48270990
Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive declineQ48379621
Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide™.Q48392292
Sequential induction of beta cell rest and stimulation using stable GIP inhibitor and GLP-1 mimetic peptides improves metabolic control in C57BL/KsJ db/db mice.Q35655010
Physiology of incretins in health and diseaseQ35760279
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitusQ35824086
Glucagon like peptide-1 receptor expression in the human thyroid glandQ36141532
Emerging DPP-4 inhibitors: focus on linagliptin for type 2 diabetesQ36520758
Gut hormones and appetite controlQ36820186
Combination therapy with GLP-1 receptor agonists and basal insulin: a systematic review of the literatureQ36872178
A critical analysis of the clinical use of incretin-based therapies: Are the GLP-1 therapies safe?Q36942123
Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications.Q37521930
The role of gut hormones in the regulation of body weight and energy homeostasisQ37535112
Do GLP-1-based therapies increase cancer risk?Q37577143
Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease?Q37779101
The safety and tolerability of GLP-1 receptor agonists in the treatment of type 2 diabetes: a reviewQ37864256
The gut endocrine system as a coordinator of postprandial nutrient homoeostasisQ38036016
A network meta-analysis to compare glycaemic control in patients with type 2 diabetes treated with exenatide once weekly or liraglutide once daily in comparison with insulin glargine, exenatide twice daily or placebo.Q38041660
Enteroendocrine hormone mimetics for the treatment of obesity and diabetesQ38142518
The role of incretin-based therapies in prediabetes: a reviewQ38199251
Cardiovascular actions of GLP-1 and incretin-based pharmacotherapy.Q38199984
Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: differences and similarities.Q38201586
Gastrointestinal hormones and their targetsQ38226510
Risk of bone fractures associated with glucagon-like peptide-1 receptor agonists' treatment: a meta-analysis of randomized controlled trialsQ38235219
Pharmacological characterization and antidiabetic activity of a long-acting glucagon-like peptide-1 analogue conjugated to an antithrombin III-binding pentasaccharide.Q38299362
Synergistic metabolic benefits of an exenatide analogue and cholecystokinin in diet-induced obese and leptin-deficient rodentsQ38304318
Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.Q38320627
Degradation, insulin secretion, glucose-lowering and GIP additive actions of a palmitate-derivatised analogue of xenin-25.Q38325630
Studying pancreatic risks caused by incretin-based therapies: is it a game? It's not a game!Q38601929
A novel GIP-oxyntomodulin hybrid peptide acting through GIP, glucagon and GLP-1 receptors exhibits weight reducing and anti-diabetic propertiesQ39177528
Comparison of independent and combined metabolic effects of chronic treatment with (pGlu-Gln)-CCK-8 and long-acting GLP-1 and GIP mimetics in high fat-fed miceQ39198588
Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?Q39499843
(D-Ser2)Oxm[mPEG-PAL]: a novel chemically modified analogue of oxyntomodulin with antihyperglycaemic, insulinotropic and anorexigenic actionsQ39663862
Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation.Q39732229
Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide functionQ40132400
Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*Q40329405
Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and dowQ40437409
Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase.Q40637074
Functional GIP receptors play a major role in islet compensatory response to high fat feeding in miceQ41420211
Mechanism of metabolic advantages after bariatric surgery: it's all gastrointestinal factors versus it's all food restriction.Q41945986
Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in miceQ41982493
GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in miceQ41984767
Coinfusion of low-dose GLP-1 and glucagon in man results in a reduction in food intakeQ42210115
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)1285-95
P577publication date2015-11-10
P1433published inWorld journal of diabetesQ27723539
P1476titleNew perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders
P478volume6

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cites work (P2860)
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