Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis.

scientific article published on 27 January 2011

Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/JN.00866.2010
P698PubMed publication ID21273318
P5875ResearchGate publication ID49791082

P50authorChristian HölscherQ37831053
Victor A. GaultQ39188087
P2093author name stringBernard Thorens
Emilie Faivre
P2860cites workMolecular cloning, functional expression, and signal transduction of the GIP‐receptor cloned from a human insulinomaQ24314426
Cell biology of Ca2+-triggered exocytosisQ26269905
Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brainQ28256443
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetesQ28273497
Effects of glucose-dependent insulinotropic peptide on behaviorQ28504780
Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloidQ28565656
Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): cellular localization, lesion-affected expression, and impaired regenerative axonal growthQ28575395
Biology of incretins: GLP-1 and GIPQ29617302
GIP biology and fat metabolismQ33832917
The entero-insular axis in type 2 diabetes--incretins as therapeutic agentsQ34312081
Fluoxetine targets early progenitor cells in the adult brainQ34611258
Gastric inhibitory polypeptide: the neglected incretin revisitedQ34758871
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptorsQ36056970
The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents.Q36763267
New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer's disease?Q37302369
Low dose radiation overcomes diabetes-induced suppression of hippocampal neuronal cell proliferation in ratsQ37313368
One-trial object recognition in rats and mice: methodological and theoretical issues.Q37671063
Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease.Q37718840
Role of the glucose-dependent insulinotropic polypeptide and its receptor in the central nervous system: therapeutic potential in neurological diseases.Q37767353
Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretiQ38356895
Immunohistochemical distribution of glucose-dependent insulinotropic polypeptide in the adult rat brainQ40211872
The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37).Q41583407
Stable agonist of glucose-dependent insulinotropic polypeptide (GIP) restores pancreatic beta cell glucose responsiveness but not glucose intolerance in aging mice.Q42488586
Active immunization with glucose-dependent insulinotropic polypeptide vaccine influences brain function and behaviour in ratsQ42665926
Seizures induced by GABAB-receptor blockade in early-life induced long-term GABA(B) receptor hypofunction and kindling facilitation.Q47825120
Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat dietQ48254911
Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's diseaseQ48270990
Synaptic release rather than failure in the conditioning pulse results in paired-pulse facilitation during minimal synaptic stimulation in the rat hippocampal CA1 neuronesQ48863392
Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation.Q49040662
Applications of the Morris water maze in the study of learning and memoryQ56442716
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectsynaptic plasticityQ1551556
knockout mouseQ1364740
neurogenesisQ1456827
P304page(s)1574-1580
P577publication date2011-01-27
P1433published inJournal of NeurophysiologyQ1709863
P1476titleGlucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis.
P478volume105

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cites work (P2860)
Q50422191A novel GLP-1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease.
Q96127896A unique hybrid characteristic having both pro- and anti-inflammatory phenotype transformed by repetitive low-dose lipopolysaccharide in C8-B4 microglia
Q47656370Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure
Q27334336Autologous transplantation of intestine-isolated glia cells improves neuropathology and restores cognitive deficits in β amyloid-induced neurodegeneration
Q36471528Blast traumatic brain injury-induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon-like peptide-1 receptor agonist, exendin-4.
Q39485182Central GIP signaling stimulates peripheral GIP release and promotes insulin and pancreatic polypeptide secretion in nonhuman primates
Q47343467Clostridium butyricum exerts a neuroprotective effect in a mouse model of traumatic brain injury via the gut-brain axis.
Q51362307Evaluation of the long-term effects of gastric inhibitory polypeptide-ovalbumin conjugates on insulin resistance, metabolic dysfunction, energy balance and cognition in high-fat-fed mice.
Q89880144GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease-A Systematic Review
Q34339666GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis
Q40129940Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: The Women's Interagency HIV Study.
Q38122432Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory
Q37424923Glucose-Dependent Insulinotropic Polypeptide Ameliorates Mild Traumatic Brain Injury-Induced Cognitive and Sensorimotor Deficits and Neuroinflammation in Rats
Q92854769Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake
Q33603384Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas
Q34736763Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline.
Q26765470Incretin-Based Therapy for Prevention of Diabetic Vascular Complications
Q48488584Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer's Disease.
Q36421280Neural stem cells in the diabetic brain
Q36997912Neuroprotective effects of D-Ala(2)GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model
Q26777654New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders
Q37601299Perioperative hyperglycemia is associated with postoperative neurocognitive disorders after cardiac surgery
Q26774021Potentials of incretin-based therapies in dementia and stroke in type 2 diabetes mellitus
Q36554957Temporal and Regional Expression of Glucose-Dependent Insulinotropic Peptide and Its Receptor in Spinal Cord Injured Rats
Q60920688The Regulation of Peripheral Metabolism by Gut-Derived Hormones
Q33580451Transcriptional analysis of apoptotic cerebellar granule neurons following rescue by gastric inhibitory polypeptide
Q64074975Wheel Running Improves Motor Function and Spinal Cord Plasticity in Mice With Genetic Absence of the Corticospinal Tract