Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients

scientific article published on 14 December 2011

Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00395-011-0233-5
P932PMC publication ID3252036
P698PubMed publication ID22167343
P5875ResearchGate publication ID51876422

P50authorJessica A SipkensQ130284857
P2093author name stringSuat Simsek
Floris P van Alphen
Victor W M van Hinsbergh
Casper G Schalkwijk
Jaap D van Buul
Hans W M Niessen
Ivana Kholová
Paul A J Krijnen
Christof Meischl
Alexander B A Vonk
Nynke E Hahn
Umit Baylan
P2860cites workDipeptidyl peptidase IV and related enzymes in cell biology and liver disordersQ28116286
Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veinsQ28507544
Thrombopoietin modulates cardiac contractility in vitro and contributes to myocardial depressing activity of septic shock serumQ28581675
The many faces of tissue factorQ33711050
Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in miceQ33750640
Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction.Q34299156
No-reflow phenomenonQ34517875
Neuropeptide Y: a novel mechanism for ischemic angiogenesisQ35066249
Tissue factor and thrombin mediate myocardial ischemia-reperfusion injuryQ35073959
The multifunctional or moonlighting protein CD26/DPPIV.Q35089114
Effect of PAR2 in regulating TNF-α and NAD(P)H oxidase in coronary arterioles in type 2 diabetic miceQ35128047
No-reflow phenomenon and prognosis in patients with acute myocardial infarctionQ36577567
Imaging microvascular obstruction and its clinical significance following acute myocardial infarctionQ36666471
Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of actionQ36751470
Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stressQ37100768
Coronary microembolization: from bedside to bench and back to bedsideQ37626321
TNFalpha in atherosclerosis, myocardial ischemia/reperfusion and heart failureQ37771751
Prevention and treatment of microvascular obstruction-related myocardial injury and coronary no-reflow following percutaneous coronary intervention: a systematic approachQ37774756
The role of endothelial interleukin-8/NADPH oxidase 1 axis in sepsisQ39697418
Neuropeptide Y induces ischemic angiogenesis and restores function of ischemic skeletal musclesQ39774393
Direct relationship between levels of TNF-alpha expression and endothelial dysfunction in reperfusion injuryQ40358563
Alterations in tumor necrosis factor-induced endothelial cell procoagulant activity by hyperthermiaQ40540907
Tissue factor and factor VIIa receptor/ligand interactions induce proinflammatory effects in macrophages.Q40918403
Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis.Q42138675
Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathwaysQ42165735
Mitochondrial reactive oxygen species: a common pathway for PAR1- and PAR2-mediated tissue factor induction in human endothelial cellsQ42602246
Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A.Q43071459
The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA.Q43140566
Peroxisome proliferator-activated receptor-gamma activation attenuates cardiac fibrosis in type 2 diabetic rats: the effect of rosiglitazone on myocardial expression of receptor for advanced glycation end products and of connective tissue growth facQ43245112
Blockade of NF-kappaB by pyrrolidine dithiocarbamate attenuates myocardial inflammatory response and ventricular dysfunction following coronary microembolization induced by homologous microthrombi in ratsQ43262789
Coronary occlusion: cause or consequence of acute myocardial infarction?Q44827749
Antagonism of selectin function attenuates microvascular platelet deposition and platelet-mediated myocardial injury after transient ischemiaQ45226110
Inhibition of dipeptidyl peptidase 4 regulates microvascular endothelial growth induced by inflammatory cytokinesQ45721715
Guggulsterone, an anti-inflammatory phytosterol, inhibits tissue factor and arterial thrombosisQ46294089
Exogenous superoxide mediates pro-oxidative, proinflammatory, and procoagulatory changes in primary endothelial cell culturesQ46743274
The extent of microvascular damage during myocardial contrast echocardiography is superior to other known indexes of post-infarct reperfusion in predicting left ventricular remodeling: results of the multicenter AMICI study.Q46780250
Recombinant human, active site-blocked factor VIIa reduces infarct size and no-reflow phenomenon in rabbitsQ47241260
Different enzyme activities in coronary capillary endothelial cells.Q50532021
PDGF-CC induces tissue factor expression: role of PDGF receptor alpha/beta.Q54462813
Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, pre-diabetic rats.Q54632091
Thrombogenicity of vascular cells. Comparison between endothelial cells isolated from different sources and smooth muscle cells and fibroblastsQ68795347
A negative blood-clotting factor lining the vesselsQ70241658
Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusionQ70908026
Dipeptidyl peptidase IV inhibits the polymerization of fibrin monomersQ71451365
C-reactive protein colocalizes with complement in human hearts during acute myocardial infarctionQ71971756
Vascular endothelial growth factor-stimulated endothelial cells promote adhesion and activation of plateletsQ73281199
F11-receptor (F11R/JAM) mediates platelet adhesion to endothelial cells: role in inflammatory thrombosisQ78505148
Differential functions of tissue factor in the trans-activation of cellular signalling pathwaysQ79396021
N(epsilon)-(carboxymethyl)lysine depositions in intramyocardial blood vessels in human and rat acute myocardial infarction: a predictor or reflection of infarction?Q80265058
Microparticles from apoptotic monocytes induce transient platelet recruitment and tissue factor expression by cultured human vascular endothelial cells via a redox-sensitive mechanismQ81445961
Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuationQ83022905
The basement membrane of intramyocardial capillaries is thickened in patients with acute myocardial infarctionQ84388623
DPP4 deficiency preserves cardiac function via GLP-1 signaling in rats subjected to myocardial ischemia/reperfusionQ84543059
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)233
P577publication date2011-12-14
P1433published inBasic Research in CardiologyQ2453360
P1476titleLoss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients
P478volume107

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cites work (P2860)
Q39337755Activated platelet chemiluminescence and presence of CD45+ platelets in patients with acute myocardial infarction.
Q38195527Antiatherothrombotic effects of dipeptidyl peptidase inhibitors
Q47258313Cardioprotection--time to take into account clinical complexity: the case of antiplatelet agents : editorial to "two classes of anti-platelet drugs reduce anatomical infarct size in monkey hearts" by Xi-Ming Yang et al.
Q37611715Cardiovascular Benefits of Native GLP-1 and its Metabolites: An Indicator for GLP-1-Therapy Strategies
Q34383575Cardiovascular impact of drugs used in the treatment of diabetes
Q48254834DPP-4 inhibitors repress NLRP3 inflammasome and interleukin-1beta via GLP-1 receptor in macrophages through protein kinase C pathway
Q39040954DPP-4 inhibitors repress foam cell formation by inhibiting scavenger receptors through protein kinase C pathway
Q38413395DPP4 in cardiometabolic disease: recent insights from the laboratory and clinical trials of DPP4 inhibition.
Q38118157Dipeptidyl peptidase-4 inhibitors and their effects on the cardiovascular system
Q45897317Dipeptidyl peptidases in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis.
Q37065219Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus
Q52356627Infectious myocarditis: the role of the cardiac vasculature.
Q94950741Is DPP4 inhibition a comrade or adversary in COVID-19 Infection
Q28084374Mononuclear cells and vascular repair in HHT
Q37522403Plasma DPP4 activity is associated with no-reflow and major bleeding events in Chinese PCI-treated STEMI patients
Q41094907Plasma dipeptidyl-peptidase-4 activity is associated with left ventricular systolic function in patients with ST-segment elevation myocardial infarction
Q48136973Possible mechanisms of direct cardiovascular impact of GLP-1 agonists and DPP4 inhibitors.
Q58797884Reduced post-operative DPP4 activity associated with worse patient outcome after cardiac surgery
Q34029715The nonglycemic actions of dipeptidyl peptidase-4 inhibitors
Q38121545The role of DPP4 activity in cardiovascular districts: in vivo and in vitro evidence