Deficient mismatch repair system in patients with sporadic advanced colorectal cancer

scientific article published on January 2009

Deficient mismatch repair system in patients with sporadic advanced colorectal cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.BJC.6604867
P932PMC publication ID2634718
P698PubMed publication ID19165197
P5875ResearchGate publication ID23934307

P50authorNicoline HoogerbruggeQ56436866
P2093author name stringC J A Punt
M Koopman
J H J M van Krieken
M J L Ligtenberg
N F Antonini
G A M Kortman
L Mekenkamp
P2860cites workUbiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesisQ22122362
Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancerQ24614511
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of CanadaQ27860904
ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancerQ28270163
A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancerQ28289377
Systematic review of microsatellite instability and colorectal cancer prognosisQ28303189
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell linesQ29620526
The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomasQ34020549
Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trialQ34581085
Role of DNA mismatch repair defects in the pathogenesis of human cancerQ35085461
Mismatch repair proficiency and in vitro response to 5-fluorouracilQ35129256
Microsatellite instability and the clinicopathological features of sporadic colorectal cancerQ35363901
Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndromeQ35598109
Conventional and tissue microarray immunohistochemical expression analysis of mismatch repair in hereditary colorectal tumorsQ35748966
BAT-26 and BAT-40 instability in colorectal adenomas and carcinomas and germline polymorphismsQ35787161
New options and old dilemmas in the treatment of patients with advanced colorectal cancerQ35887568
Patients with an unexplained microsatellite instable tumour have a low risk of familial cancerQ36609603
Classification of colorectal cancer based on correlation of clinical, morphological and molecular featuresQ36699559
Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use.Q36826562
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screeningQ37066133
Human colon cancer cells surviving high doses of cisplatin or oxaliplatin in vitro are not defective in DNA mismatch repair proteinsQ38287337
Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancerQ38449001
Allelic imbalance and microsatellite instability in resected Duke's D colorectal cancerQ38475125
Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines.Q40582817
Microsatellite instability is a predictive marker for survival benefit from adjuvant chemotherapy in a population-based series of stage III colorectal carcinomaQ40620362
Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 statusQ40706999
The role of DNA mismatch repair in platinum drug resistanceQ41155820
Clues to the pathogenesis of familial colorectal cancerQ42622043
Predictive and prognostic value of microsatellite instability in patients with advanced colorectal cancer treated with a fluoropyrimidine and oxaliplatin containing first-line chemotherapy. A report of the AIO Colorectal Study GroupQ43894713
High-frequency microsatellite instability predicts better chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV sporadic colorectal cancer after palliative bowel resectionQ44141769
Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level.Q44274945
The World Health Organization's histologic classification of gastrointestinal tumors. A commentary on the second editionQ45001869
High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategiesQ46522716
Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trialQ46570394
Microsatellite instability and colorectal cancer prognosis.Q46831092
Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instabilityQ47704165
CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability.Q53390493
Prognostic significance of microsatellite instability in sporadic colorectal cancer.Q53639179
Microsatellite instability as a prognostic factor in resected colorectal cancer liver metastases.Q54694611
Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer.Q54703703
Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite InstabilityQ56589885
Better survival rates in patients with MLH1-associated hereditary colorectal cancerQ57567998
A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting Highlights and Bethesda GuidelinesQ57978042
Prognostic Factors and Analysis of Microsatellite Instability in Resected Pulmonary Metastases From Colorectal CarcinomaQ60609635
Frequency of hereditary colorectal carcinomaQ69807271
Genomic instability in colorectal cancer: relationship to clinicopathological variables and family historyQ72657539
Tumor microsatellite instability and clinical outcome in young patients with colorectal cancerQ73345126
Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumorsQ77639637
Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCRQ80421961
Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancerQ80557773
Interpretation of immunohistochemistry for mismatch repair proteins is only reliable in a specialized settingQ81737843
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpatientQ181600
colorectal cancerQ188874
DNA mismatch repairQ2984243
colorectal carcinomaQ25493920
P304page(s)266-273
P577publication date2009-01-01
P1433published inBritish Journal of CancerQ326309
P1476titleDeficient mismatch repair system in patients with sporadic advanced colorectal cancer
P478volume100

Reverse relations

cites work (P2860)
Q37203399A phase I clinical study of immunotherapy for advanced colorectal cancers using carcinoembryonic antigen-pulsed dendritic cells mixed with tetanus toxoid and subsequent IL-2 treatment
Q36494964A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency
Q91584700A subset of patients with MSS/MSI-low-colorectal cancer showed increased CD8(+) TILs together with up-regulated IFN-γ
Q43206841ABC-Transporter Expression Does Not Correlate with Response to Irinotecan in Patients with Metastatic Colorectal Cancer
Q52371842Accelerating Therapeutic Development through Innovative Trial Design in Colorectal Cancer.
Q37815610Adjuvant colon cancer chemotherapy: where we are and where we'll go.
Q97525750Anti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistance
Q53440447Association between mismatch repair gene and irinotecan-based chemotherapy in metastatic colon cancer.
Q90023691Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial
Q90604757Automated Quantitation of CD8-positive T Cells Predicts Prognosis in Colonic Adenocarcinoma With Mucinous, Signet Ring Cell, or Medullary Differentiation Independent of Mismatch Repair Protein Status
Q58806091Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint inhibition
Q37114675Biomarker in Colorectal Cancer.
Q91754859Biomarker-guided therapy for colorectal cancer: strength in complexity
Q64881806Biomarkers for Immune Checkpoint Inhibitor-Mediated Tumor Response and Adverse Events.
Q37132680Biomarkers in advanced colorectal cancer: challenges in translating clinical research into practice
Q99580038CD8+ tumor-infiltrating lymphocytes within the primary tumor of patients with synchronous de novo metastatic colorectal carcinoma do not track with survival
Q64113851CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids
Q38828624Cancer vaccines in colon and rectal cancer over the last decade: lessons learned and future directions
Q54581789Case report: impressive response to pembrolizumab in a patient with mismatch-repair deficient metastasized colorectal cancer and bulky disease.
Q37602291Chemotherapy, which drugs and when
Q35088103Chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent
Q38636430Clinical Applications of Immunotherapy Combination Methods and New Opportunities for the Future.
Q52659178Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer.
Q91904761Clinical Implications of Mismatch Repair Status in Patients With High-risk Stage II Colon Cancer
Q37631539Clinical Significance and Prognostic Relevance of Microsatellite Instability in Sporadic Colorectal Cancer Patients.
Q92514791Clinicopathologic features and prognostic value of KRAS, NRAS and BRAF mutations and DNA mismatch repair status: A single-center retrospective study of 1,834 Chinese patients with Stage I-IV colorectal cancer
Q34005870Clinicopathological features and outcome in advanced colorectal cancer patients with synchronous vs metachronous metastases.
Q89868154Colon Cancer: A Clinician's Perspective in 2019
Q28647615Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach
Q57178427Colorectal Liver Metastases: Does the Future of Precision Medicine Lie in Genetic Testing?
Q91682267Colorectal metastasis to the gallbladder mimicking a primary gallbladder malignancy: histopathological and molecular characteristics
Q55071626Combined microsatellite instability and BRAF gene status as biomarkers for adjuvant chemotherapy in stage III colorectal cancer.
Q64915364Comparison of immunological characteristics between paired mismatch repair-proficient and -deficient colorectal cancer patients.
Q37710549Comparison of the Mismatch Repair System between Primary and Metastatic Colorectal Cancers Using Immunohistochemistry.
Q92709364Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
Q91704285Comprehensive routine diagnostic screening to identify predictive mutations, gene amplifications, and microsatellite instability in FFPE tumor material
Q91876747Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients
Q57022679Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy
Q45242086Correlating programmed death ligand 1 (PD-L1) expression, mismatch repair deficiency, and outcomes across tumor types: implications for immunotherapy.
Q57806327Cost-effectiveness of immune checkpoint inhibitors for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer
Q64083490Cross-platform Data Analysis Reveals a Generic Gene Expression Signature for Microsatellite Instability in Colorectal Cancer
Q91830988Current and emerging biomarkers in metastatic colorectal cancer
Q39172118Current companion diagnostics in advanced colorectal cancer; getting a bigger and better piece of the pie
Q42086309Current progress in immunotherapy for pancreatic cancer
Q91584739Cyclin-dependent kinase 9 expression and its association with CD8+ T cell infiltration in microsatellite-stable colorectal cancer
Q41634316DNA mismatch repair and BRAF status in colorectal cancer: Interest for the therapeutic management?
Q26796491Deficient mismatch repair: Read all about it (Review)
Q35462738EMAST is associated with a poor prognosis in microsatellite instable metastatic colorectal cancer
Q40062688Effect of Modified Vaccinia Ankara-5T4 and Low-Dose Cyclophosphamide on Antitumor Immunity in Metastatic Colorectal Cancer: A Randomized Clinical Trial.
Q37061363Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers
Q38786707From tumour heterogeneity to advances in precision treatment of colorectal cancer
Q34568317Genomic landscape of metastatic colorectal cancer
Q60939319How the V600E Mutation Defines a Distinct Subgroup of Colorectal Cancer: Molecular and Clinical Implications
Q40383388Immune checkpoints and immunotherapy for colorectal cancer
Q53111596Immunotherapy for Colorectal Cancer.
Q39218636Immunotherapy for colorectal cancer: where are we heading?
Q48103017Immunotherapy regimens for metastatic colorectal carcinomas
Q37842126Implementing prognostic and predictive biomarkers in CRC clinical trials
Q26772272Implications of mismatch repair-deficient status on management of early stage colorectal cancer
Q51732351Improving diagnosis, prognosis and prediction by using biomarkers in CRC patients (Review).
Q57758070Integrated Analysis of Molecular and Clinical Prognostic Factors in Stage II/III Colon Cancer
Q36089548Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver Resection.
Q35045790KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients
Q40040773Maintenance treatment with capecitabine and bevacizumab versus observation in metastatic colorectal cancer: updated results and molecular subgroup analyses of the phase 3 CAIRO3 study
Q89782419Microsatellite Instability and MMR Genes Abnormalities in Canine Mammary Gland Tumors
Q92645700Microsatellite instability and protein expression of MLH1 and MSH2 genes in young Mexican patients less than 50 years of age diagnosed with colorectal cancer
Q34616565Microsatellite instability in colorectal cancer-the stable evidence
Q83835402Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications
Q37929008Microsatellite instability in metastatic colorectal cancer: a review of pathology, response to chemotherapy and clinical outcome
Q38895750Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade
Q90117036Mismatch Repair Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
Q38741029Mismatch repair deficiency testing in clinical practice
Q37696965Mismatch repair deficient colorectal cancer in the era of personalized treatment
Q38654591Mismatch repair deficient metastatic colon cancer and urothelial cancer: A case report of sequential immune checkpoint therapy.
Q34362289Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies
Q91718987Mismatch repair status between primary colorectal tumor and metastatic tumor, a retrospective consistent study
Q35578034Mitochondrial microsatellite instability in patients with metastatic colorectal cancer
Q36813582Molecular Biomarkers in the Personalized Treatment of Colorectal Cancer.
Q39308037Molecular biomarkers for an early diagnosis, effective treatment and prognosis of colorectal cancer: Current updates
Q36836733Molecular dissection of microsatellite instable colorectal cancer
Q38938329Molecular markers of prognosis and therapeutic targets in metastatic colorectal cancer.
Q35836592Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications
Q33813216Multicenter retrospective analysis of metastatic colorectal cancer (CRC) with high-level microsatellite instability (MSI-H).
Q57494108Multidisciplinary team intervention associated with improved survival for patients with colorectal adenocarcinoma with liver or lung metastasis
Q38727912New Therapeutic Opportunities Based on DNA Mismatch Repair and BRAF Status in Metastatic Colorectal Cancer
Q50876217Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study.
Q87857715Nivolumab in the treatment of microsatellite instability high metastatic colorectal cancer
Q33765195Optimization of a pentaplex panel for MSI analysis without control DNA in a Brazilian population: correlation with ancestry markers.
Q88413794Outcome of Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Mayo Clinic Experience
Q28262647PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
Q54290348Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability.
Q26738655Predictive Biomarkers in Colorectal Cancer: From the Single Therapeutic Target to a Plethora of Options
Q38847613Prognostic Implication of KRAS Status after Hepatectomy for Colorectal Liver Metastases Varies According to Primary Colorectal Tumor Location.
Q58583909Prognostic Value of Mismatch Repair Genes for Patients With Colorectal Cancer: Meta-Analysis
Q35583987Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery
Q34982575Prognostic impact of deficient DNA mismatch repair in patients with stage III colon cancer from a randomized trial of FOLFOX-based adjuvant chemotherapy
Q37132721Prognostic value of colorectal cancer biomarkers.
Q92494955Pseudo progression in heterogeneity of right-sided metastatic colon carcinoma during nivolumab therapy: A case report
Q84836911RBSP3 is frequently altered in premalignant cervical lesions: clinical and prognostic significance
Q89807855Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study
Q37593573Reactivation of dormant anti-tumor immunity - a clinical perspective of therapeutic immune checkpoint modulation
Q41105389Recent developments in the treatment of metastatic colorectal cancer.
Q53081522Recent progress in Lynch syndrome and other familial colorectal cancer syndromes.
Q36413276Reduced rate of copy number aberrations in mucinous colorectal carcinoma
Q33794933Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers
Q28080176Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer
Q48160519Role of family history and tumor location on prognosis of patients with colorectal cancer and synchronous metastases
Q92954872SATB2 and CDX2 are prognostic biomarkers in DNA mismatch repair protein deficient colon cancer
Q64114423Selecting treatment options in refractory metastatic colorectal cancer
Q55242470Shorter survival in adolescent and young adult patients, compared to adult patients, with stage IV colorectal cancer in Japan.
Q52691832Strategies for Increasing Pancreatic Tumor Immunogenicity.
Q100526092Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era
Q35224176Systematic review of the predictive effect of MSI status in colorectal cancer patients undergoing 5FU-based chemotherapy
Q38961110Targeted Therapies in Elderly Patients with Metastatic Colorectal Cancer: A Review of the Evidence.
Q92306520Targeted Therapy in Metastatic Colorectal Cancer: Current Standards and Novel Agents in Review
Q43233321The effect of DNA mismatch repair (MMR) status on oxaliplatin-based first-line chemotherapy as in recurrent or metastatic colon cancer.
Q51737468The significance of microsatellite instability in colorectal cancer after controlling for clinicopathological factors.
Q102061305Tumor-derived mutations in postoperative plasma of colorectal cancer with microsatellite instability
Q52643529Updates on immunotherapy for colorectal cancer.
Q28075719Validation of biomarkers to predict response to immunotherapy in cancer: Volume I - pre-analytical and analytical validation

Search more.