Transcription factor Bcl11b sustains iNKT1 and iNKT2 cell programs, restricts iNKT17 cell program, and governs iNKT cell survival

scientific article published on 21 June 2016

Transcription factor Bcl11b sustains iNKT1 and iNKT2 cell programs, restricts iNKT17 cell program, and governs iNKT cell survival is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1073/PNAS.1521846113
P932PMC publication ID4941433
P698PubMed publication ID27330109

P50authorDerek B Sant'AngeloQ89209234
P2093author name stringDorina Avram
Mohammad Nizam Uddin
Mark L Brantly
Dil Afroz Sultana
Mariana E Kirst
Jonathan J Cho
Danielle Califano
Kyle J Lorentsen
P2860cites workThe BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functionsQ24650707
The transcription factor PLZF directs the effector program of the NKT cell lineageQ24654999
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramidesQ28254991
NKT cells derive from double-positive thymocytes that are positively selected by CD1dQ28508188
Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytesQ41763674
E and Id proteins influence invariant NKT cell sublineage differentiation and proliferationQ42002425
An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11bQ42227980
Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development.Q42791608
Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursorsQ46553571
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cellsQ47765721
A thymic precursor to the NK T cell lineageQ95783850
Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytesQ28584907
The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cellsQ28585176
Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiationQ28588268
BCL11B is required for positive selection and survival of double-positive thymocytesQ28590236
Bcl11b is required for differentiation and survival of αβ T lymphocytesQ28592191
The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineageQ30434352
Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11bQ34044451
Sea-level fingerprinting as a direct test for the source of global meltwater pulse IA.Q34118671
CD1d-unrestricted NKT cells are endowed with a hybrid function far superior than that of iNKT cellsQ34144149
Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel diseaseQ35237502
The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation.Q35568453
Bcl11b is essential for group 2 innate lymphoid cell developmentQ35671246
The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their developmentQ35671263
Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signalingQ35856488
Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid CellsQ36311181
CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.Q36362981
Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytesQ36365532
A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stageQ36370202
Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer stainingQ36370359
Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector FunctionQ36371748
The transcriptional repressor NKAP is required for the development of iNKT cellsQ36737300
Reprogramming of T cells to natural killer-like cells upon Bcl11b deletionQ36772386
Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell populationQ36837547
Critical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation.Q37018987
The role of invariant natural killer T cells in microbial immunityQ37292523
Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cellsQ37298525
Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansionQ37334414
NKT cells as an ideal anti-tumor immunotherapeuticQ37352756
Diverting T helper cell trafficking through increased plasticity attenuates autoimmune encephalomyelitis.Q37410601
Development of PLZF-expressing innate T cellsQ37831694
Biology of CD1- and MR1-restricted T cellsQ38185462
The multifaceted roles of Bcl11b in thymic and peripheral T cells: impact on immune diseasesQ38240342
A committed precursor to innate lymphoid cellsQ39031358
Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.Q41005207
P433issue27
P407language of work or nameEnglishQ1860
P304page(s)7608-7613
P577publication date2016-06-21
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleTranscription factor Bcl11b sustains iNKT1 and iNKT2 cell programs, restricts iNKT17 cell program, and governs iNKT cell survival
P478volume113

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cites work (P2860)
Q52560201Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma.
Q92924396Bcl11b prevents fatal autoimmunity by promoting Treg cell program and constraining innate lineages in Treg cells
Q58097749Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16
Q55423756Invariant Natural Killer T Cell Subsets—More Than Just Developmental Intermediates.
Q39168836TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells
Q41204682The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1.
Q37334885Transcription Factor Bcl11b Controls Effector and Memory CD8 T cell Fate Decision and Function during Poxvirus Infection
Q49574395Unraveling Natural Killer T-Cells Development

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