The multifaceted roles of Bcl11b in thymic and peripheral T cells: impact on immune diseases

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The multifaceted roles of Bcl11b in thymic and peripheral T cells: impact on immune diseases is …
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scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1400930
P932PMC publication ID4135393
P698PubMed publication ID25128552
P5875ResearchGate publication ID264830552

P2093author name stringDorina Avram
Danielle Califano
P2860cites workDisruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouseQ24290693
BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytesQ24294962
COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding proteinQ24534913
CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target geneQ24646255
Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptorsQ24650527
Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repressionQ24650557
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cellsQ24655629
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
Neuronal subtype-specific genes that control corticospinal motor neuron development in vivoQ28507231
Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomasQ28508746
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytesQ28584907
BCL11B is required for positive selection and survival of double-positive thymocytesQ28590236
Development and maintenance of regulatory T cellsQ38092234
Transcriptional control of regulatory T-cell differentiationQ38204700
Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiationQ39325698
Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytesQ41763674
TNF-α-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanomaQ42008502
An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11bQ42227980
Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cellsQ45345520
Transcriptional regulator Id2 mediates CD8+ T cell immunity.Q46760945
GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice.Q50542419
IFN-γ-producing and IL-17-producing γδ T cells differentiate at distinct developmental stages in murine fetal thymus.Q50691450
The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.Q50977520
An essential developmental checkpoint for production of the T cell lineage.Q51905187
The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selectionQ81483894
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell developmentQ85350477
Bcl11b is required for differentiation and survival of αβ T lymphocytesQ28592191
Expression of TCR alpha beta partly rescues developmental arrest and apoptosis of alpha beta T cells in Bcl11b-/- miceQ28592452
A far downstream enhancer for murine Bcl11b controls its T-cell specific expressionQ28685472
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Q29619324
Regulatory T cells: mechanisms of differentiation and functionQ29620731
Coordinated regulation of transcription factor Bcl11b activity in thymocytes by the mitogen-activated protein kinase (MAPK) pathways and protein sumoylationQ30417770
A dual function of Bcl11b/Ctip2 in hippocampal neurogenesisQ30465746
Glycolipid antigen processing for presentation by CD1d molecules.Q31832878
Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathwayQ33288223
Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2.Q33854381
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fateQ33908130
Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11bQ34044451
Helper T cell diversity and plasticityQ34255017
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cellsQ34383385
BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoterQ34441819
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cellsQ34556464
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunityQ34596060
The Fezf2-Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortexQ34804095
Plasticity of CD4+ T cell lineage differentiation.Q34982725
A critical role for TCF-1 in T-lineage specification and differentiationQ35165548
Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel diseaseQ35237502
The many faces of Th17 cellsQ35596984
Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.Q35807613
Making memory at birth: understanding the differentiation of natural killer T cellsQ35870831
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells.Q36229615
Transcription factor Foxp3 and its protein partners form a complex regulatory networkQ36250037
Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytesQ36365532
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin developmentQ36565839
Reprogramming of T cells to natural killer-like cells upon Bcl11b deletionQ36772386
T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiationQ36967375
BCL11B is a general transcriptional repressor of the HIV-1 long terminal repeat in T lymphocytes through recruitment of the NuRD complexQ37088793
BCL11B enhances TCR/CD28-triggered NF-kappaB activation through up-regulation of Cot kinase gene expression in T-lymphocytesQ37091336
Flow Cytometry Analysis of Transcription Factors in T LymphocytesQ37210735
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cellsQ37394198
Diverting T helper cell trafficking through increased plasticity attenuates autoimmune encephalomyelitis.Q37410601
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)2059-2065
P577publication date2014-09-01
P1433published inJournal of ImmunologyQ3521441
P1476titleThe multifaceted roles of Bcl11b in thymic and peripheral T cells: impact on immune diseases
P478volume193

Reverse relations

cites work (P2860)
Q59135590A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment
Q57787120Aortic stiffness, pressure and flow pulsatility and target organ damage
Q30787663Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment
Q30855603Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network
Q35671246Bcl11b is essential for group 2 innate lymphoid cell development
Q52560201Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma.
Q92924396Bcl11b prevents fatal autoimmunity by promoting Treg cell program and constraining innate lineages in Treg cells
Q58097749Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16
Q64212113Causal Gene Regulatory Network Modeling and Genomics: Second-Generation Challenges
Q60926402Classification of triple-negative breast cancers based on Immunogenomic profiling
Q38320682Forging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control
Q58794691Functional characterization of common BCL11B gene desert variants suggests a lymphocyte-mediated association of BCL11B with aortic stiffness
Q99365874How transcription factors drive choice of the T cell fate
Q26995456Investigating Evolutionary Conservation of Dendritic Cell Subset Identity and Functions
Q29147572Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B
Q93085956Programming for T-lymphocyte fates: modularity and mechanisms
Q37015302Protein Kinase C-Mediated Phosphorylation of BCL11B at Serine 2 Negatively Regulates Its Interaction with NuRD Complexes during CD4+ T-Cell Activation
Q49910540SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia
Q51183547SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells.
Q35671263The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
Q37334885Transcription Factor Bcl11b Controls Effector and Memory CD8 T cell Fate Decision and Function during Poxvirus Infection
Q36311181Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells
Q37086432Transcription factor Bcl11b sustains iNKT1 and iNKT2 cell programs, restricts iNKT17 cell program, and governs iNKT cell survival
Q38810888Views on helper/cytotoxic lineage choice from a bottom-up approach

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