E4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirus

scientific article published on 07 January 2009

E4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirus is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01972-08
P932PMC publication ID2648266
P698PubMed publication ID19129452

P50authorFelicia GoodrumQ57649749
P2093author name stringMichael A Thomas
David A Ornelles
Robin S Broughton
P2860cites workActivation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functionsQ22010220
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53Q24323169
Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteinsQ24527216
Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2Q24533404
Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2Q24535830
Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machineryQ24538586
Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteinsQ24622878
Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1Q24635316
Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeletonQ24685127
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene productQ28114879
PDZ domains and the organization of supramolecular complexesQ28209906
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKBQ28306356
Specificity and mechanism of action of some commonly used protein kinase inhibitorsQ28344791
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BADQ28592766
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexQ29041391
Cellular survival: a play in three AktsQ29547806
Rational design and characterization of a Rac GTPase-specific small molecule inhibitorQ29616494
Phosphoinositide kinasesQ29618047
Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replicationQ33649728
Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replicationQ33780662
p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infectionQ33785919
Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilinQ34171088
Quantitation of G0 and G1 phase cells in primary carcinomas. Antibody to M1 subunit of ribonucleotide reductase shows G1 phase restriction point blockQ34236717
Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: role of bone stromal cellsQ34340236
An adenovirus mutant that replicates selectively in p53-deficient human tumor cellsQ34399844
Recent lessons in gene expression, cell cycle control, and cell biology from adenovirusQ34469114
Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfectionQ34562704
Regulation of mRNA production by the adenoviral E1B 55-kDa and E4 Orf6 proteinsQ35127696
E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenovirusesQ35155212
Regulation of Tiam1-Rac signalling.Q35163913
Replicative oncolytic adenoviruses in multimodal cancer regimensQ35180181
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear exportQ35634994
The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycleQ35875344
Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.Q35883364
Inactivating intracellular antiviral responses during adenovirus infectionQ36318156
Functionally distinct monomers and trimers produced by a viral oncoproteinQ36318620
Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoproteinQ36410968
Control of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activityQ36484050
E4Orf6-E1B-55k-dependent degradation of de novo-generated adeno-associated virus type 5 Rep52 and capsid proteins employs a cullin 5-containing E3 ligase complexQ36498213
Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in ratsQ36634353
APOBEC-mediated viral restriction: not simply editing?Q36736677
Clinical trials with oncolytic adenovirus in ChinaQ36754441
Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoffQ36851240
The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAsQ36909556
Adenovirus type 5 early region 1b gene product is required for efficient shutoff of host protein synthesis.Q36914451
The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathwayQ37003173
Advances in the structural understanding of Vif proteinsQ37108363
Cytidine deaminases as a weapon against retroviruses and a new target for antiviral therapyQ37108598
Oncogenic potential of the adenovirus E4orf6 proteinQ37247046
Diverse roles for E4orf3 at late times of infection revealed in an E1B 55-kilodalton protein mutant backgroundQ37492831
Epstein-Barr virus nuclear protein EBNA-3C interacts with the human metastatic suppressor Nm23-H1: a molecular link to cancer metastasisQ38303570
Distinct requirements of adenovirus E1b55K protein for degradation of cellular substratesQ39963290
Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 proteinQ39982335
Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradationQ40140948
Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomesQ40384561
Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophagesQ40400107
E3 transcription unit of adenovirusQ40411741
Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteinsQ40423325
Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replicationQ40445488
Adenovirus E4-34kDa requires active proteasomes to promote late gene expressionQ40621055
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complexQ40717443
Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosisQ41563751
Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cellsQ41975913
Adenovirus E4 ORF3 protein inhibits the interferon-mediated antiviral responseQ42040593
Modulation of the metabolism and pharmacokinetics of 1-beta-D-arabinofuranosylcytosine by 1-beta-D-arabinofuranosyluracil in leukemic miceQ42197810
Adenovirus early region 4 and viral DNA synthesisQ42620900
The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.Q42812980
Rac1 prevents cisplatin-induced apoptosis through down-regulation of p38 activation in NIH3T3 cells.Q42815640
The ras-related GTPase rac1 regulates a proliferative pathway selectively utilized by G-protein coupled receptorsQ42825044
Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen speciesQ43506772
Interaction of adenoviral E4 and E1b products in late gene expressionQ44444174
Modified method of mammalian cell synchronization improves yield and degree of synchronizationQ44953098
China approves world's first oncolytic virus therapy for cancer treatmentQ45419325
Adenovirus overrides cellular checkpoints for protein translationQ46132694
Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteinsQ48082495
Analysis of adenovirus infections in synchronized cells.Q50950146
Adenovirus E4orf6 assembles with Cullin5-ElonginB-ElonginC E3 ubiquitin ligase through an HIV/SIV Vif-like BC-box to regulate p53Q64377210
Isolation of deletion and substitution mutants of adenovirus type 5Q64382239
P4510describes a project that usesImageQuantQ112270642
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
oncolytic virusQ1560099
P304page(s)2406-2416
P577publication date2009-01-07
P1433published inJournal of VirologyQ1251128
P1476titleE4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirus
P478volume83

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cites work (P2860)
Q39707314Adenovirus late-phase infection is controlled by a novel L4 promoter.
Q35488742Adenovirus replaces mitotic checkpoint controls
Q36071414Beyond Oncolytics: E1B55K-Deleted Adenovirus as a Vaccine Delivery Vector.
Q35021632Effects of the deletion of early region 4 (E4) open reading frame 1 (orf1), orf1-2, orf1-3 and orf1-4 on virus-host cell interaction, transgene expression, and immunogenicity of replicating adenovirus HIV vaccine vectors
Q39429511Impact of Autophagy in Oncolytic Adenoviral Therapy for Cancer
Q35734826Intracellular transport of recombinant adeno-associated virus vectors
Q37416907Intrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis.
Q33906116Oncolytic Viruses for Cancer Therapy: Overcoming the Obstacles
Q41699675Oncolytic Viruses-Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer
Q91776793Optimizing oncolytic virotherapy in cancer treatment
Q38201237Rho'ing in and out of cells: viral interactions with Rho GTPase signaling
Q64376883Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX
Q41919532Targeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses
Q33931595Targeting of p53-transcriptional dysfunction by conditionally replicating adenovirus is not limited by p53-homologues
Q38064834Tinkering with translation: protein synthesis in virus-infected cells

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