Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development

scientific article published on 14 March 2012

Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development is …
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scholarly articleQ13442814

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P356DOI10.1099/VIR.0.041186-0
P932PMC publication ID3755519
P698PubMed publication ID22422068
P5875ResearchGate publication ID221708940

P50authorMichael NonnemacherQ55273616
Satinder DahiyaQ59296143
P2093author name stringBrian Wigdahl
P2860cites workMyeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cellsQ36399936
Type I interferon induces inhibitory 16-kD CCAAT/ enhancer binding protein (C/EBP)beta, repressing the HIV-1 long terminal repeat in macrophages: pulmonary tuberculosis alters C/EBP expression, enhancing HIV-1 replicationQ36401561
Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathwaysQ36499676
CCAAT/enhancer binding protein (C/EBP) sites are required for HIV-1 replication in primary macrophages but not CD4(+) T cells.Q36556421
Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR.Q36699534
HIV-1 matrix protein: a mysterious regulator of the viral life cycleQ36702218
Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter.Q36710904
Chromatin-associated regulation of HIV-1 transcription: implications for the development of therapeutic strategiesQ36813044
Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolatesQ36882975
Regulation of HIV-1 latency by T-cell activation.Q36887625
HIV-1 Tat RNA silencing suppressor activity is conserved across kingdoms and counteracts translational repression of HIV-1.Q37062107
Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infectionQ37066263
Suppression of HIV-1 replication by microRNA effectorsQ37133970
APOBEC proteins and intrinsic resistance to HIV-1 infectionQ37140468
Transcriptional restriction of human immunodeficiency virus type 1 gene expression in undifferentiated primary monocytesQ37145340
Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell deathQ37183208
Cellular reservoirs of HIV-1 and their role in viral persistenceQ37196089
HIV interactions with monocytes and dendritic cells: viral latency and reservoirsQ37229398
Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophagesQ37273948
HIV-1 Vpr enhances viral burden by facilitating infection of tissue macrophages but not nondividing CD4+ T cellsQ36370102
CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBPbeta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infectionQ36371384
HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expressionQ21245193
Global landscape of HIV-human protein complexesQ24300336
Identification of host proteins required for HIV infection through a functional genomic screenQ24306298
The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcriptionQ24307870
The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signalingQ24322710
Comparison of human immunodeficiency virus (HIV)-specific infection-enhancing and -inhibiting antibodies in AIDS patientsQ24538755
Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 VprQ24543218
Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanismQ24594703
Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acidQ24596282
CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cellsQ24633405
Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoterQ24634457
Crystal structure of HIV-1 Tat complexed with human P-TEFbQ24634569
Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral productionQ24682936
HIV-1 nef suppression by virally encoded microRNAQ24803620
Dual role of TRBP in HIV replication and RNA interference: viral diversion of a cellular pathway or evasion from antiviral immunity?Q24816505
Changes in microRNA expression profiles in HIV-1-transfected human cellsQ25257532
Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replicationQ27497968
DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongationQ28139929
Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycansQ28140638
Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNAQ28203201
A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replicationQ28245811
Controlling the elongation phase of transcription with P-TEFbQ28255518
Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1Q28261598
Repression of MHC class I gene promoter activity by two-exon Tat of HIVQ28269206
Role of viral regulatory and accessory proteins in HIV-1 replicationQ28280802
Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humansQ28345408
The glucocorticoid receptor type II complex is a target of the HIV-1 vpr gene productQ28368083
Deep sequencing of virus-infected cells reveals HIV-encoded small RNAsQ42118138
Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activityQ42157622
Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replicationQ42282677
Induction of Sp1 phosphorylation and NF-kappa B-independent HIV promoter domain activity in T lymphocytes stimulated by okadaic acidQ42485695
Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription.Q42755157
Maximal HIV-1 replication in alveolar macrophages during tuberculosis requires both lymphocyte contact and cytokinesQ42944655
HIV-1 LTR C/EBP binding site sequence configurations preferentially encountered in brain lead to enhanced C/EBP factor binding and increased LTR-specific activityQ43716009
Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART.Q43792135
Addition of cyclophosphamide to antiretroviral therapy does not diminish the cellular reservoir in HIV-infected persons.Q44010197
Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 inductionQ44483444
Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetateQ44535607
HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infectionQ45345418
Early viral brain invasion in iatrogenic human immunodeficiency virus infectionQ45868985
Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagementQ46142126
Transient-mediated fate determination in a transcriptional circuit of HIV.Q50642600
Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencingQ50768291
Targets for human encoded microRNAs in HIV genesQ57076044
The HIV-1 Nef protein has a dual role in T cell receptor signaling in infected CD4+ T lymphocytesQ57565041
Stable changes in CD4+ T lymphocyte miRNA expression after exposure to HIV-1Q58377824
Effects of integration and replication on transcription of the HIV-1 long terminal repeatQ72571845
Macrophages as a source of HIV during opportunistic infectionsQ73427586
CCAAT/enhancer binding proteins are not required for HIV-1 entry but regulate proviral transcription by recruiting coactivators to the long-terminal repeat in monocytic cellsQ74587983
HIV-1 matrix protein p17 binds to monocytes and selectively stimulates MCP-1 secretion: role of transcriptional factor AP-1Q80089462
Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune responseQ81770906
HIV-Nef and AIDS pathogenesis: are we barking up the wrong tree?Q84602577
HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral disseminationQ28474374
Epigenetic regulation of HIV-1 latency by cytosine methylationQ28475636
Ribo-gnome: the big world of small RNAsQ29615681
Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replicationQ29616375
HIV-1 integration in the human genome favors active genes and local hotspotsQ29618457
HIV-1 accessory proteins--ensuring viral survival in a hostile environmentQ29619538
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infectionQ29619738
HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interactionQ30159721
Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentivirusesQ30391530
"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescenceQ30488246
Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein deliveryQ31577177
OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regionsQ31814830
Extracellular HIV-1 virus protein R causes a large inward current and cell death in cultured hippocampal neurons: implications for AIDS pathologyQ32068509
Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversityQ33220546
HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANTQ33265220
NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat siteQ33266806
The Ebola virus VP35 protein is a suppressor of RNA silencingQ33288729
HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTRQ33292464
Interfering RNA and HIV: reciprocal interferencesQ33372109
miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1Q33400321
The SET complex acts as a barrier to autointegration of HIV-1Q33415459
Isolation of a cellular factor that can reactivate latent HIV-1 without T cell activationQ33425135
Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infectionQ33476165
CpG methylation controls reactivation of HIV from latencyQ33495565
Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activationQ33508788
Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineageQ33587139
Regulation of SIV mac 239 basal long terminal repeat activity and viral replication in macrophages: functional roles of two CCAAT/enhancer-binding protein beta sites in activation and interferon beta-mediated suppressionQ33593821
Association of Tat with Promoters of PTEN and PP2A Subunits Is Key to Transcriptional Activation of Apoptotic Pathways in HIV-Infected CD4+ T CellsQ33700607
The macrophage in HIV-1 infection: from activation to deactivation?Q33810779
Vpr-host interactions during HIV-1 viral life cycleQ33828332
A re-examination of global suppression of RNA interference by HIV-1.Q33840754
Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cellsQ33851786
Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineageQ33864438
Combinatorial latency reactivation for HIV-1 subtypes and variantsQ33877492
Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.Q33886004
Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exonQ33889326
Cellular microRNA and P bodies modulate host-HIV-1 interactionsQ37391014
Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybridQ37406083
Chromatin dynamics associated with HIV-1 Tat-activated transcriptionQ37589012
Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesisQ37596477
The capsid protein of human immunodeficiency virus: interactions of HIV-1 capsid with host protein factorsQ37613764
Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategiesQ37644561
Curing HIV: Pharmacologic approaches to target HIV-1 latencyQ37645582
Macrophage signaling in HIV-1 infectionQ37728093
HIV-1 matrix protein p17: a candidate antigen for therapeutic vaccines against AIDS.Q37785252
Analysis of the roles of HIV-derived microRNAsQ37816443
Epigenetic regulation of HIV latencyQ37829626
A simian immunodeficiency virus macaque model of highly active antiretroviral treatment: viral latency in the periphery and the central nervous systemQ37829628
Macrophages and HIV-1.Q37898469
The mouse is out of the bag: insights and perspectives on HIV-1-infected humanized mouse modelsQ37900419
Mechanisms of RNA interference in the HIV-1-host cell interplay.Q37907829
Interactions between prostaglandins, leukotrienes and HIV-1: possible implications for the central nervous systemQ37974980
High-affinity interaction between HIV-1 Vpr and specific sequences that span the C/EBP and adjacent NF-kappaB sites within the HIV-1 LTR correlate with HIV-1-associated dementia.Q38341208
Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2.Q38356666
HIV-1 Vpr binding to HIV-1 LTR C/EBP cis-acting elements and adjacent regions is sequence-specific.Q38356699
Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo.Q39270892
Human immunodeficiency virus type 1 tat protein activates transcription factor NF-kappaB through the cellular interferon-inducible, double-stranded RNA-dependent protein kinase, PKRQ39595632
Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restrictionQ39712159
The NS3 protein of rice hoja blanca virus complements the RNAi suppressor function of HIV-1 Tat.Q39883609
Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expressionQ39885717
SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitroQ39902859
Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latencyQ39933477
Nucleocapsid mutations turn HIV-1 into a DNA-containing virus.Q40009476
TAT-Hsp40 inhibits oxidative stress-mediated cytotoxicity via the inhibition of Hsp70 ubiquitination.Q40015511
Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-1-treated human monocytes: an ultrastructural studyQ40130110
Brain-derived human immunodeficiency virus-1 Tat exerts differential effects on LTR transactivation and neuroimmune activationQ40132386
Suppression of microRNA-silencing pathway by HIV-1 during virus replicationQ40166750
Human immunodeficiency virus type 1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytesQ40280905
Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signalingQ40339753
A role for LEDGF/p75 in targeting HIV DNA integrationQ40346940
Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophagesQ40358843
Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cellsQ40435387
Regulation of human immunodeficiency virus 1 transcription by nef microRNA.Q40456215
HIV-1 Tat interactions with p300 and PCAF transcriptional coactivators inhibit histone acetylation and neurotrophin signaling through CREB.Q40478718
Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expressionQ40507650
A signaling role of histone-binding proteins and INHAT subunits pp32 and Set/TAF-Ibeta in integrating chromatin hypoacetylation and transcriptional repression.Q40557365
Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid raftsQ40572781
HIV-1 Vpr displays natural protein-transducing properties: implications for viral pathogenesis.Q40690555
Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1.Q41868116
Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulenceQ41929326
Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytesQ41994305
Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latencyQ42100247
Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytesQ33895074
Emergence of a complex relationship between HIV-1 and the microRNA pathwayQ34025960
Role of chromatin in HIV-1 transcriptional regulationQ34033128
Hydroxyurea in the treatment of HIV infection: clinical efficacy and safety concernsQ34206910
Structural and functional studies of CCAAT/enhancer binding sites within the human immunodeficiency virus type 1 subtype C LTR.Q34387337
Step out of the groove: epigenetic gene control systems and engineered transcription factorsQ34531990
Expression of a protein phosphatase 1 inhibitor, cdNIPP1, increases CDK9 threonine 186 phosphorylation and inhibits HIV-1 transcriptionQ34537015
The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuitQ34544409
Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapyQ34588169
Hematopoietic stem/precursor cells as HIV reservoirs.Q34610023
Hexamethylbisacetamide remodels the human immunodeficiency virus type 1 (HIV-1) promoter and induces Tat-independent HIV-1 expression but blunts cell activationQ34647406
Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairmentQ34671618
Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytesQ34695803
Discrepancies between protease inhibitor concentrations and viral load in reservoirs and sanctuary sites in human immunodeficiency virus-infected patientsQ34725556
Histone deacetylase inhibitors and HIV latencyQ34816844
HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic interventionQ34957142
Gene expression profiles of HIV-1-infected glia and brain: toward better understanding of the role of astrocytes in HIV-1-associated neurocognitive disordersQ35022812
HIV Tat, its TARgets and the control of viral gene expressionQ35088029
Inhibition of PP2A by LIS1 increases HIV-1 gene expressionQ35098682
Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier.Q35114694
Regulation of HIV-1 gene transcription: from lymphocytes to microglial cellsQ35213780
MicroRNAs and human retrovirusesQ35226238
Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.Q35266342
Latently-infected CD4+ T cells are enriched for HIV-1 Tat variants with impaired transactivation activityQ35761152
Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patientsQ35799435
Interplay between HIV-1 infection and host microRNAsQ35823730
Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.Q35826285
Role of β-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes.Q35826464
Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency.Q35832979
The HIV-1 virion-associated protein vpr is a coactivator of the human glucocorticoid receptorQ35834594
Recombinant human immunodeficiency virus type 1 genomes with tat unconstrained by overlapping reading frames reveal residues in Tat important for replication in tissue culture.Q35866513
Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infectionQ36225040
siRNA-mediated transcriptional gene silencing: the potential mechanism and a possible role in the histone codeQ36325641
P433issuePt 6
P407language of work or nameEnglishQ1860
P304page(s)1151-1172
P577publication date2012-03-14
P1433published inJournal of General VirologyQ6295245
P1476titleDeployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development
P478volume93