Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression

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Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M809266200
P932PMC publication ID2670142
P698PubMed publication ID19204000

P50authorJay RappaportQ89690562
Shohreh AminiQ115282246
Carine MichielsQ28833495
Luis Del ValleQ59160314
P2093author name stringBassel E Sawaya
Kamel Khalili
Thersa Sweet
Shongshan Fan
Satish L Deshmane
Ruma Mukerjee
Inna Rom
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Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB siteQ28286400
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Antioxidants and dipyridamole inhibit HIV-1 gp120-induced free radical-based oxidative damage to human monocytoid cellsQ73947924
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Interplay between HIV-1 Vpr and Sp1 modulates p21(WAF1) gene expression in human astrocytesQ80432998
HIV-associated dementia, mitochondrial dysfunction, and oxidative stressQ81110651
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunitQ28298336
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expressionQ34104247
Oxidative stress and neuroAIDS: triggers, modulators and novel antioxidants.Q34284896
Estrogen attenuates gp120- and tat1-72-induced oxidative stress and prevents loss of dopamine transporter functionQ34461323
Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioningQ35677054
Novel nuclear import of Vpr promoted by importin alpha is crucial for human immunodeficiency virus type 1 replication in macrophages.Q35857586
Hypoxia and the regulation of mitogen-activated protein kinases: gene transcription and the assessment of potential pharmacologic therapeutic interventionsQ35864105
Reactive oxygen species and the mitochondrial signaling pathway of cell deathQ35971626
Novel markers of oxidative stress in actively progressive HIV dementiaQ35972808
Toxicity and roles of reactive oxygen speciesQ36230425
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Tat protein of human immunodeficiency virus type 1 represses expression of manganese superoxide dismutase in HeLa cellsQ36481470
Mitochondrial reactive oxygen species are required for hypoxic HIF alpha stabilization.Q36647216
The signaling mechanism of ROS in tumor progressionQ36679538
Hypoxia-inducible factors: central regulators of the tumor phenotypeQ36701590
Pathological apoptosis in the developing brainQ36799186
Mitochondria and reactive oxygen species in renal cancer.Q36804989
The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseasesQ36846729
Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1alpha through a nuclear factor-kappaB-dependent pathwayQ39890706
A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxiaQ40106826
Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cellsQ40118264
HIV-1 Vpr causes neuronal apoptosis and in vivo neurodegeneration.Q40149510
A novel antioxidant N-acetylcysteine amide prevents gp120- and Tat-induced oxidative stress in brain endothelial cellsQ40272008
Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses.Q40273686
p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes.Q40360359
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chainQ40795310
Cooperative interaction between HIV-1 regulatory proteins Tat and Vpr modulates transcription of the viral genomeQ40863490
HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B.Q41086835
Sensitization of the HIV-1-LTR upon long term low dose oxidative stress.Q41168762
Establishment of human microglial cell lines after transfection of primary cultures of embryonic microglial cells with the SV40 large T antigenQ41313592
Cooperative actions of HIV-1 Vpr and p53 modulate viral gene transcriptionQ42459014
Reactive oxygen species generated by glia are responsible for neuron death induced by human immunodeficiency virus-glycoprotein 120 in vitro.Q43823530
HIV-Tat protein induces oxidative and inflammatory pathways in brain endotheliumQ44251296
Down-regulation of Jab1, HIF-1alpha, and VEGF by Moloney murine leukemia virus-ts1 infection: a possible cause of neurodegenerationQ45394264
Neuronal apoptosis induced by HIV-1 Tat protein and TNF-alpha: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia.Q47931417
HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stressQ48313745
MH2 domain of Smad3 reduces HIV-1 Tat-induction of cytokine secretionQ48511851
Oxidative damage induced by the injection of HIV-1 Tat protein in the rat striatumQ48877809
Association of p65 and C/EBPbeta with HIV-1 LTR modulates transcription of the viral promoter.Q51583631
The dose-dependent H2O2 stress response promotes increased survival for Schizosaccharomyces pombe cells expressing HIV-1 Vpr.Q53582168
P433issue17
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
HIVQ15787
P304page(s)11364-11373
P577publication date2009-02-09
P1433published inJournal of Biological ChemistryQ867727
P1476titleActivation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression
P478volume284

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