Critical immunological pathways are downregulated in APECED patient dendritic cells

scientific article published on 04 July 2008

Critical immunological pathways are downregulated in APECED patient dendritic cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00109-008-0374-7
P932PMC publication ID2685494
P698PubMed publication ID18600308
P5875ResearchGate publication ID5251630

P50authorLeena Peltonen-PalotieQ2399315
P2093author name stringIlkka Julkunen
Mari Strengell
Juha Saharinen
Ismo Ulmanen
Niko Sillanpää
Nora Pöntynen
P2860cites workGene ontology: tool for the unification of biologyQ23781406
Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cellsQ24307725
Chromosomal clustering of genes controlled by the aire transcription factorQ24527311
Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy proteinQ24539020
Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3Q24628750
Ensembl 2007Q24669862
Projection of an immunological self shadow within the thymus by the aire proteinQ28207164
Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responsesQ28616569
The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene productQ29618249
Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell toleranceQ33897693
Human T regulatory cells can use the perforin pathway to cause autologous target cell deathQ34551876
Dendritic cells in autoimmune diseases and neuroinflammatory disordersQ34626154
Immature, but not inactive: the tolerogenic function of immature dendritic cellsQ34842360
Molecular characterization of allospecific T suppressor and tolerogenic dendritic cells: reviewQ35979221
Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.Q36399327
What's new in the Aire?Q36843053
The cross-talk between dendritic and regulatory T cells: good or evil?Q36891471
Immunoregulatory dendritic cells to prevent and reverse new-onset Type 1 diabetes mellitusQ36897372
Dendritic cells and the immunopathogenesis of systemic lupus erythematosusQ36908788
Blot hybridisation analysis of genomic DNAQ40076874
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.Q40479586
Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineageQ40504697
Mechanisms of Vdelta1 gammadelta T cell activation by microbial componentsQ40553914
Immune complexes inhibit differentiation, maturation, and function of human monocyte-derived dendritic cells.Q42514349
Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasitesQ42595867
Streptococcus pyogenes activates human plasmacytoid and myeloid dendritic cellsQ44213289
The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cellsQ44368038
APECED-causing mutations in AIRE reveal the functional domains of the proteinQ44770511
Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cellsQ45345622
Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutationsQ45403313
Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of Th1-type cytokines and chemokines in human monocyte-derived dendritic cells.Q51035102
Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells.Q51579333
Expression of tissue-specific autoantigens in the hematopoietic cells leads to activation-induced cell death of autoreactive T cells in the secondary lymphoid organs.Q54701611
Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla.Q55032978
The cellular mechanism of Aire control of T cell tolerance.Q55041159
Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients.Q55057090
Migration of immature mouse DC across resting endothelium is mediated by ICAM-2 but independent of β2-integrins and murine DC-SIGN homologuesQ58199745
Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activationQ58807981
NADPH oxidase of human dendritic cells: Role inCandida albicans killing and regulation by interferons, dectin-1 and CD206Q58883557
Altered phenotype and function of dendritic cells in children with type 1 diabetesQ61714884
Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulatorQ61960529
Distinct clinical phenotype and immunoreactivity in Japanese siblings with autoimmune polyglandular syndrome type 1 (APS-1) associated with compound heterozygous novel AIRE gene mutationsQ74599811
Expression of AIRE gene in peripheral monocyte/dendritic cell lineageQ77526006
A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophyQ79485271
Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune responseQ80387717
P433issue10
P921main subjectimmunologyQ101929
patientQ181600
P1104number of pages14
P304page(s)1139-1152
P577publication date2008-07-04
P1433published inJournal of Molecular MedicineQ6295593
P1476titleCritical immunological pathways are downregulated in APECED patient dendritic cells
P478volume86

Reverse relations

cites work (P2860)
Q35931810Anticommensal Responses Are Associated with Regulatory T Cell Defect in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients.
Q26999696Autoimmune polyendocrine syndrome type 1: case report and review of literature
Q21296658Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy: insights into genotype-phenotype correlation
Q37974985Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy: known and novel aspects of the syndrome
Q33348588Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines
Q37837965Expression and function of the autoimmune regulator (Aire) gene in non-thymic tissue
Q21296698Expression of the autoimmune regulator gene and its relevance to the mechanisms of central and peripheral tolerance
Q37217551Human APECED; a Sick Thymus Syndrome?
Q61448759Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens
Q47442891Mode of Tolerance Induction and Requirement for Aire Are Governed by the Cell Types That Express Self-Antigen and Those That Present Antigen
Q46131966Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
Q58764531The Role of Autoimmune Regulator (AIRE) in Peripheral Tolerance
Q38367239The contribution of NF-κB signalling to immune regulation and tolerance
Q24648384Transcriptional regulation by AIRE: molecular mechanisms of central tolerance

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