scholarly article | Q13442814 |
P50 | author | Claudia Peitzsch | Q64008641 |
Anna Dubrovska | Q51121511 | ||
P2093 | author name string | Monica Cojoc | |
Franziska Trautmann | |||
Gennady D Telegeev | |||
Leo Polishchuk | |||
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The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway | Q28145398 | ||
Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth | Q28203327 | ||
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Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. | Q28274091 | ||
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer | Q28274188 | ||
Exploring the role of cancer stem cells in radioresistance | Q28282037 | ||
Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing's sarcoma | Q28284358 | ||
G-protein-coupled receptor expression, function, and signaling in macrophages | Q36800734 | ||
Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis | Q36831102 | ||
Concomitant CXCR4 and CXCR7 Expression Predicts Poor Prognosis in Renal Cancer | Q63247785 | ||
Hypoxic radiosensitization: adored and ignored | Q36935082 | ||
Chemokines and their receptors: drug targets in immunity and inflammation | Q36947059 | ||
NF-κB regulates radioresistance mediated by β1-integrin in three-dimensional culture of breast cancer cells | Q36974768 | ||
Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors | Q37017121 | ||
Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells | Q37034391 | ||
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. | Q37089440 | ||
Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: comradeship and hostility | Q37142751 | ||
HGF upregulates CXCR4 expression in gliomas via NF-kappaB: implications for glioma cell migration | Q37158288 | ||
New insights on the role of CXCR4 in cancer metastasis | Q37181856 | ||
Integrins in prostate cancer progression | Q37182177 | ||
CXCL12 increases human neural progenitor cell proliferation through Akt-1/FOXO3a signaling pathway | Q37184400 | ||
The role of CXC chemokines and their receptors in cancer. | Q37200003 | ||
High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma | Q37222638 | ||
CXCL12/CXCR4 signalling in neuronal cell migration. | Q37222938 | ||
CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cells | Q37344836 | ||
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients | Q37360176 | ||
Cancer stem cells, hypoxia and metastasis | Q37403294 | ||
Functional diversity of SDF-1 splicing variants | Q37415245 | ||
Matrix metalloproteinase and G protein coupled receptors: co-conspirators in the pathogenesis of autoimmune disease and cancer | Q37439490 | ||
CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer. | Q37649217 | ||
Radiation enhancement of metastasis: a review | Q37717380 | ||
Hypoxia and hypoxia inducible factors in cancer stem cell maintenance | Q37768064 | ||
CXCR4 and cancer | Q37769282 | ||
Pharmacological modulation of chemokine receptor function. | Q37893687 | ||
Development of novel CXCR4-based therapeutics | Q37979306 | ||
CXCR4 inhibitors: tumor vasculature and therapeutic challenges. | Q37989227 | ||
Stromal-Cell-Derived Factor-1 (SDF-1)/CXCL12 as Potential Target of Therapeutic Angiogenesis in Critical Leg Ischaemia | Q37998467 | ||
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links | Q38007261 | ||
Molecular pathways: emerging pathways mediating growth, invasion, and metastasis of tumors progressing in an irradiated microenvironment. | Q38021451 | ||
CXCR7 impact on CXCL12 biology and disease. | Q38059938 | ||
Halting metastasis through CXCR4 inhibition | Q38065037 | ||
The role of the CXCR4 cell surface chemokine receptor in glioma biology | Q38089686 | ||
Discovery of the cancer stem cell related determinants of radioresistance. | Q38119636 | ||
HGF induces CXCR4 and CXCL12-mediated tumor invasion through Ets1 and NF-kappaB. | Q38311506 | ||
CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12. | Q38321879 | ||
CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrins | Q38567609 | ||
CXCR4 regulates growth of both primary and metastatic breast cancer | Q28296113 | ||
Low doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesis | Q28474555 | ||
CXCR4 expression in prostate cancer progenitor cells | Q28480904 | ||
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development | Q28512895 | ||
Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats | Q28569530 | ||
Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression | Q28679187 | ||
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion | Q29547317 | ||
G proteins: transducers of receptor-generated signals | Q29547519 | ||
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 | Q29615241 | ||
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease | Q29616432 | ||
Seven-transmembrane receptors | Q29619896 | ||
Cancer stem cells: models and concepts | Q29620611 | ||
Heterogeneity in cancer: cancer stem cells versus clonal evolution | Q29622839 | ||
Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling | Q30014843 | ||
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy. | Q30487339 | ||
CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway | Q30574876 | ||
αV integrin induces multicellular radioresistance in human nasopharyngeal carcinoma via activating SAPK/JNK pathway | Q31066931 | ||
Chemokine receptor expression profiles in nasopharyngeal carcinoma and their association with metastasis and radiotherapy | Q33256512 | ||
Dynamic regulation of ROCK in tumor cells controls CXCR4-driven adhesion events | Q33629153 | ||
CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression | Q33672265 | ||
The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype | Q33674720 | ||
Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors | Q33844796 | ||
Calcium mobilization triggered by the chemokine CXCL12 regulates migration in wounded intestinal epithelial monolayers | Q33855209 | ||
Prognostic value of radiobiological hypoxia during fractionated irradiation for local tumor control | Q33887017 | ||
Beyond desensitization: physiological relevance of arrestin-dependent signaling. | Q33890802 | ||
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha | Q33968025 | ||
Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers | Q33979799 | ||
Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation | Q34052833 | ||
Chemokine receptor homo- or heterodimerization activates distinct signaling pathways | Q34079612 | ||
CXCL12 (SDF-1)/CXCR4 pathway in cancer | Q34116260 | ||
Epigenetic changes of CXCR4 and its ligand CXCL12 as prognostic factors for sporadic breast cancer | Q34119133 | ||
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation. | Q34178157 | ||
Clinicopathologic significance of HIF-1α, CXCR4, and VEGF expression in colon cancer | Q34189559 | ||
Heterotrimeric G-protein betagamma-dimers in growth and differentiation | Q34226052 | ||
Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12. | Q34231598 | ||
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models | Q34241451 | ||
Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma. | Q51825255 | ||
Foxo3a is essential for maintenance of the hematopoietic stem cell pool. | Q51960990 | ||
Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias. | Q52575669 | ||
The chemokine receptor CXCR4 as a novel independent prognostic marker for node-positive breast cancer patients. | Q53175932 | ||
Chemokines in vascular remodeling. | Q53555481 | ||
Targeting of c-kit+ haematopoietic progenitor cells prevents hypoxic pulmonary hypertension. | Q54646705 | ||
Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophy. | Q54672725 | ||
The prognostic role of a gene signature from tumorigenic breast-cancer cells. | Q55042952 | ||
CXCR4-positive subset of glioma is enriched for cancer stem cells. | Q55463539 | ||
SDF-1α/CXCR4 Axis Is Instrumental in Neointimal Hyperplasia and Recruitment of Smooth Muscle Progenitor Cells | Q56921714 | ||
c-Src/Histone Deacetylase 3 Interaction Is Crucial for Hepatocyte Growth Factor Dependent Decrease of CXCR4 Expression in Highly Invasive Breast Tumor Cells | Q57374777 | ||
CXCR4 Expression Predicts Patient Outcome and Recurrence Patterns after Hepatic Resection for Colorectal Liver Metastases | Q57823384 | ||
Pathways Implicated in Stem Cell Migration: The SDF-1/CXCR4 Axis | Q62590293 | ||
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules | Q34320910 | ||
CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients | Q34370179 | ||
Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis | Q34418159 | ||
Wnt5a promotes ewing sarcoma cell migration through upregulating CXCR4 expression | Q34449657 | ||
TGFbeta/TNF(alpha)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype | Q35085542 | ||
Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system | Q35091583 | ||
Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis | Q35131138 | ||
The bicyclam AMD3100 story | Q35158014 | ||
Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers | Q35169094 | ||
In vitro generation of human cells with cancer stem cell properties | Q35196349 | ||
CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration. | Q35213405 | ||
Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma | Q35750964 | ||
Understanding cancer stem cell heterogeneity and plasticity. | Q35796886 | ||
The significance of cancer cell expression of the chemokine receptor CXCR4. | Q35832343 | ||
The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer | Q35858991 | ||
CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion | Q35875566 | ||
Expression of chemokine receptors on circulating tumor cells in patients with solid tumors | Q35916031 | ||
G-protein signaling: back to the future | Q36061579 | ||
CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling | Q36075168 | ||
The evolving concept of cancer and metastasis stem cells | Q36145729 | ||
Functions of CXCL12 and CXCR4 in breast cancer | Q36208303 | ||
Co-expression of CXCR4 and CD133 proteins is associated with poor prognosis in stage II-III colon cancer patients | Q36225000 | ||
Significance of CXCR4, phosphorylated STAT3 and VEGF-A expression in resected non-small cell lung cancer | Q36230718 | ||
Extracellular matrix alters PDGF regulation of fibroblast integrins | Q36236430 | ||
Inhibition of stromal CXCR4 impairs development of lung metastases. | Q36250217 | ||
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment | Q36306137 | ||
Hematopoietic stem cell derived carcinoma-associated fibroblasts: a novel origin | Q36358017 | ||
The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. | Q36376700 | ||
Matrix metalloproteinases: changing roles in tumor progression and metastasis | Q36422976 | ||
FOXO factors: a matter of life and death | Q36429676 | ||
Stromal fibroblasts in cancer: a novel tumor-promoting cell type | Q36553020 | ||
The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis. | Q36561662 | ||
Regulation of CXCR4 signaling | Q36684219 | ||
The expressions of MIF and CXCR4 protein in tumor microenvironment are adverse prognostic factors in patients with esophageal squamous cell carcinoma. | Q36758659 | ||
Correlation between Chemokine Receptor CXCR4 Expression and Prognostic Factors in Patients with Prostate Cancer | Q38776802 | ||
CXC chemokine receptor 4 is essential for maintenance of renal cell carcinoma-initiating cells and predicts metastasis. | Q39158412 | ||
Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070. | Q39174058 | ||
Inhibition of TGF-β/Smad signaling by BAMBI blocks differentiation of human mesenchymal stem cells to carcinoma-associated fibroblasts and abolishes their protumor effects | Q39266430 | ||
CXCR4 inhibition with AMD3100 sensitizes prostate cancer to docetaxel chemotherapy | Q39284720 | ||
Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells | Q39369977 | ||
Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells | Q39389192 | ||
The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network | Q39514879 | ||
Chemokines stimulate bidirectional migration of human mesenchymal stem cells across bone marrow endothelial cells | Q39554635 | ||
Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells. | Q39597276 | ||
Combination therapy targeting both tumor-initiating and differentiated cell populations in prostate carcinoma | Q39622809 | ||
HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells. | Q39703370 | ||
Vesnarinone downregulates CXCR4 expression via upregulation of Krüppel-like factor 2 in oral cancer cells | Q39813978 | ||
Hepatic stellate cells promote liver metastasis of colon cancer cells by the action of SDF-1/CXCR4 axis. | Q39827208 | ||
TNF-alpha mediates SDF-1 alpha-induced NF-kappa B activation and cytotoxic effects in primary astrocytes | Q39946851 | ||
Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells | Q39976240 | ||
CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone | Q40003028 | ||
CXCR4 chemokine receptor engagement modifies integrin dependent adhesion of renal carcinoma cells | Q40092108 | ||
Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion | Q40213967 | ||
Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells | Q40221505 | ||
Identification and expression of novel isoforms of human stromal cell-derived factor 1. | Q40289913 | ||
Up-regulation of CXCR4 expression in PC-3 cells by stromal-derived factor-1alpha (CXCL12) increases endothelial adhesion and transendothelial migration: role of MEK/ERK signaling pathway-dependent NF-kappaB activation | Q40355298 | ||
CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation | Q40390514 | ||
Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation | Q40416189 | ||
CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells. | Q40439589 | ||
Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis | Q40548697 | ||
Expression of functional CXCR4 by muscle satellite cells and secretion of SDF-1 by muscle-derived fibroblasts is associated with the presence of both muscle progenitors in bone marrow and hematopoietic stem/progenitor cells in muscles. | Q40648297 | ||
Evaluation of SDF-1/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry | Q40681253 | ||
Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation | Q40699131 | ||
The chemokine receptor CXCR4 enhances integrin-mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow. | Q40762163 | ||
The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells. | Q40780948 | ||
Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. | Q40916348 | ||
Characterization of the migration of lung and blood T cells in response CXCL12 in a three-dimensional matrix | Q42152773 | ||
The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis | Q42411644 | ||
High chemokine receptor CXCR4 level in triple negative breast cancer specimens predicts poor clinical outcome | Q42454953 | ||
The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling | Q42719191 | ||
CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche | Q42833135 | ||
A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer | Q43009321 | ||
SDF-1/CXCR4-mediated migration of transplanted bone marrow stromal cells toward areas of heart myocardial infarction through activation of PI3K/Akt | Q43152356 | ||
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. | Q43283510 | ||
The effect of local control on metastatic dissemination in carcinoma of the prostate: long-term results in patients treated with 125I implantation | Q43688225 | ||
Myocardial CXCR4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarction | Q44168224 | ||
Distant metastases after irradiation alone in carcinoma of the uterine cervix | Q44169375 | ||
Impaired chemokine-induced migration during T-cell development in the absence of Jak 3. | Q44899122 | ||
Akt activation, but not extracellular signal-regulated kinase activation, is required for SDF-1alpha/CXCR4-mediated migration of epitheloid carcinoma cells | Q46438810 | ||
A small molecule CXCR4 antagonist inhibits neointima formation and smooth muscle progenitor cell mobilization after arterial injury | Q47438278 | ||
CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas | Q48361474 | ||
CXCR4 is a major chemokine receptor on glioma cells and mediates their survival | Q48464729 | ||
P275 | copyright license | Creative Commons Attribution-NonCommercial 3.0 Unported | Q18810331 |
P6216 | copyright status | copyrighted | Q50423863 |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 1347-1361 | |
P577 | publication date | 2013-09-30 | |
P1433 | published in | OncoTargets and Therapy | Q7092081 |
P1476 | title | Emerging targets in cancer management: role of the CXCL12/CXCR4 axis | |
P478 | volume | 6 |
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