Emerging targets in cancer management: role of the CXCL12/CXCR4 axis

scientific article published on 30 September 2013

Emerging targets in cancer management: role of the CXCL12/CXCR4 axis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2147/OTT.S36109
P932PMC publication ID3794844
P698PubMed publication ID24124379

P50authorClaudia PeitzschQ64008641
Anna DubrovskaQ51121511
P2093author name stringMonica Cojoc
Franziska Trautmann
Gennady D Telegeev
Leo Polishchuk
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CXCL12 increases human neural progenitor cell proliferation through Akt-1/FOXO3a signaling pathwayQ37184400
The role of CXC chemokines and their receptors in cancer.Q37200003
High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinomaQ37222638
CXCL12/CXCR4 signalling in neuronal cell migration.Q37222938
CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cellsQ37344836
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patientsQ37360176
Cancer stem cells, hypoxia and metastasisQ37403294
Functional diversity of SDF-1 splicing variantsQ37415245
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CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer.Q37649217
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CXCR4 and cancerQ37769282
Pharmacological modulation of chemokine receptor function.Q37893687
Development of novel CXCR4-based therapeuticsQ37979306
CXCR4 inhibitors: tumor vasculature and therapeutic challenges.Q37989227
Stromal-Cell-Derived Factor-1 (SDF-1)/CXCL12 as Potential Target of Therapeutic Angiogenesis in Critical Leg IschaemiaQ37998467
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular linksQ38007261
Molecular pathways: emerging pathways mediating growth, invasion, and metastasis of tumors progressing in an irradiated microenvironment.Q38021451
CXCR7 impact on CXCL12 biology and disease.Q38059938
Halting metastasis through CXCR4 inhibitionQ38065037
The role of the CXCR4 cell surface chemokine receptor in glioma biologyQ38089686
Discovery of the cancer stem cell related determinants of radioresistance.Q38119636
HGF induces CXCR4 and CXCL12-mediated tumor invasion through Ets1 and NF-kappaB.Q38311506
CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12.Q38321879
CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrinsQ38567609
CXCR4 regulates growth of both primary and metastatic breast cancerQ28296113
Low doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesisQ28474555
CXCR4 expression in prostate cancer progenitor cellsQ28480904
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar developmentQ28512895
Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in ratsQ28569530
Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progressionQ28679187
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretionQ29547317
G proteins: transducers of receptor-generated signalsQ29547519
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1Q29615241
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and diseaseQ29616432
Seven-transmembrane receptorsQ29619896
Cancer stem cells: models and conceptsQ29620611
Heterogeneity in cancer: cancer stem cells versus clonal evolutionQ29622839
Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signalingQ30014843
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.Q30487339
CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathwayQ30574876
αV integrin induces multicellular radioresistance in human nasopharyngeal carcinoma via activating SAPK/JNK pathwayQ31066931
Chemokine receptor expression profiles in nasopharyngeal carcinoma and their association with metastasis and radiotherapyQ33256512
Dynamic regulation of ROCK in tumor cells controls CXCR4-driven adhesion eventsQ33629153
CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expressionQ33672265
The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotypeQ33674720
Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumorsQ33844796
Calcium mobilization triggered by the chemokine CXCL12 regulates migration in wounded intestinal epithelial monolayersQ33855209
Prognostic value of radiobiological hypoxia during fractionated irradiation for local tumor controlQ33887017
Beyond desensitization: physiological relevance of arrestin-dependent signaling.Q33890802
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alphaQ33968025
Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteersQ33979799
Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiationQ34052833
Chemokine receptor homo- or heterodimerization activates distinct signaling pathwaysQ34079612
CXCL12 (SDF-1)/CXCR4 pathway in cancerQ34116260
Epigenetic changes of CXCR4 and its ligand CXCL12 as prognostic factors for sporadic breast cancerQ34119133
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.Q34178157
Clinicopathologic significance of HIF-1α, CXCR4, and VEGF expression in colon cancerQ34189559
Heterotrimeric G-protein betagamma-dimers in growth and differentiationQ34226052
Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12.Q34231598
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse modelsQ34241451
Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma.Q51825255
Foxo3a is essential for maintenance of the hematopoietic stem cell pool.Q51960990
Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias.Q52575669
The chemokine receptor CXCR4 as a novel independent prognostic marker for node-positive breast cancer patients.Q53175932
Chemokines in vascular remodeling.Q53555481
Targeting of c-kit+ haematopoietic progenitor cells prevents hypoxic pulmonary hypertension.Q54646705
Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophy.Q54672725
The prognostic role of a gene signature from tumorigenic breast-cancer cells.Q55042952
CXCR4-positive subset of glioma is enriched for cancer stem cells.Q55463539
SDF-1α/CXCR4 Axis Is Instrumental in Neointimal Hyperplasia and Recruitment of Smooth Muscle Progenitor CellsQ56921714
c-Src/Histone Deacetylase 3 Interaction Is Crucial for Hepatocyte Growth Factor Dependent Decrease of CXCR4 Expression in Highly Invasive Breast Tumor CellsQ57374777
CXCR4 Expression Predicts Patient Outcome and Recurrence Patterns after Hepatic Resection for Colorectal Liver MetastasesQ57823384
Pathways Implicated in Stem Cell Migration: The SDF-1/CXCR4 AxisQ62590293
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granulesQ34320910
CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patientsQ34370179
Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axisQ34418159
Wnt5a promotes ewing sarcoma cell migration through upregulating CXCR4 expressionQ34449657
TGFbeta/TNF(alpha)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotypeQ35085542
Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous systemQ35091583
Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasisQ35131138
The bicyclam AMD3100 storyQ35158014
Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markersQ35169094
In vitro generation of human cells with cancer stem cell propertiesQ35196349
CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration.Q35213405
Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myelomaQ35750964
Understanding cancer stem cell heterogeneity and plasticity.Q35796886
The significance of cancer cell expression of the chemokine receptor CXCR4.Q35832343
The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancerQ35858991
CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesionQ35875566
Expression of chemokine receptors on circulating tumor cells in patients with solid tumorsQ35916031
G-protein signaling: back to the futureQ36061579
CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signallingQ36075168
The evolving concept of cancer and metastasis stem cellsQ36145729
Functions of CXCL12 and CXCR4 in breast cancerQ36208303
Co-expression of CXCR4 and CD133 proteins is associated with poor prognosis in stage II-III colon cancer patientsQ36225000
Significance of CXCR4, phosphorylated STAT3 and VEGF-A expression in resected non-small cell lung cancerQ36230718
Extracellular matrix alters PDGF regulation of fibroblast integrinsQ36236430
Inhibition of stromal CXCR4 impairs development of lung metastases.Q36250217
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironmentQ36306137
Hematopoietic stem cell derived carcinoma-associated fibroblasts: a novel originQ36358017
The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood.Q36376700
Matrix metalloproteinases: changing roles in tumor progression and metastasisQ36422976
FOXO factors: a matter of life and deathQ36429676
Stromal fibroblasts in cancer: a novel tumor-promoting cell typeQ36553020
The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis.Q36561662
Regulation of CXCR4 signalingQ36684219
The expressions of MIF and CXCR4 protein in tumor microenvironment are adverse prognostic factors in patients with esophageal squamous cell carcinoma.Q36758659
Correlation between Chemokine Receptor CXCR4 Expression and Prognostic Factors in Patients with Prostate CancerQ38776802
CXC chemokine receptor 4 is essential for maintenance of renal cell carcinoma-initiating cells and predicts metastasis.Q39158412
Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070.Q39174058
Inhibition of TGF-β/Smad signaling by BAMBI blocks differentiation of human mesenchymal stem cells to carcinoma-associated fibroblasts and abolishes their protumor effectsQ39266430
CXCR4 inhibition with AMD3100 sensitizes prostate cancer to docetaxel chemotherapyQ39284720
Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cellsQ39369977
Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cellsQ39389192
The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG networkQ39514879
Chemokines stimulate bidirectional migration of human mesenchymal stem cells across bone marrow endothelial cellsQ39554635
Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells.Q39597276
Combination therapy targeting both tumor-initiating and differentiated cell populations in prostate carcinomaQ39622809
HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells.Q39703370
Vesnarinone downregulates CXCR4 expression via upregulation of Krüppel-like factor 2 in oral cancer cellsQ39813978
Hepatic stellate cells promote liver metastasis of colon cancer cells by the action of SDF-1/CXCR4 axis.Q39827208
TNF-alpha mediates SDF-1 alpha-induced NF-kappa B activation and cytotoxic effects in primary astrocytesQ39946851
Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cellsQ39976240
CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in boneQ40003028
CXCR4 chemokine receptor engagement modifies integrin dependent adhesion of renal carcinoma cellsQ40092108
Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasionQ40213967
Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cellsQ40221505
Identification and expression of novel isoforms of human stromal cell-derived factor 1.Q40289913
Up-regulation of CXCR4 expression in PC-3 cells by stromal-derived factor-1alpha (CXCL12) increases endothelial adhesion and transendothelial migration: role of MEK/ERK signaling pathway-dependent NF-kappaB activationQ40355298
CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activationQ40390514
Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivationQ40416189
CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.Q40439589
Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasisQ40548697
Expression of functional CXCR4 by muscle satellite cells and secretion of SDF-1 by muscle-derived fibroblasts is associated with the presence of both muscle progenitors in bone marrow and hematopoietic stem/progenitor cells in muscles.Q40648297
Evaluation of SDF-1/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometryQ40681253
Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activationQ40699131
The chemokine receptor CXCR4 enhances integrin-mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow.Q40762163
The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells.Q40780948
Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells.Q40916348
Characterization of the migration of lung and blood T cells in response CXCL12 in a three-dimensional matrixQ42152773
The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesisQ42411644
High chemokine receptor CXCR4 level in triple negative breast cancer specimens predicts poor clinical outcomeQ42454953
The chemokine receptor CXCR7 functions to regulate cardiac valve remodelingQ42719191
CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic nicheQ42833135
A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancerQ43009321
SDF-1/CXCR4-mediated migration of transplanted bone marrow stromal cells toward areas of heart myocardial infarction through activation of PI3K/AktQ43152356
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha.Q43283510
The effect of local control on metastatic dissemination in carcinoma of the prostate: long-term results in patients treated with 125I implantationQ43688225
Myocardial CXCR4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarctionQ44168224
Distant metastases after irradiation alone in carcinoma of the uterine cervixQ44169375
Impaired chemokine-induced migration during T-cell development in the absence of Jak 3.Q44899122
Akt activation, but not extracellular signal-regulated kinase activation, is required for SDF-1alpha/CXCR4-mediated migration of epitheloid carcinoma cellsQ46438810
A small molecule CXCR4 antagonist inhibits neointima formation and smooth muscle progenitor cell mobilization after arterial injuryQ47438278
CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomasQ48361474
CXCR4 is a major chemokine receptor on glioma cells and mediates their survivalQ48464729
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)1347-1361
P577publication date2013-09-30
P1433published inOncoTargets and TherapyQ7092081
P1476titleEmerging targets in cancer management: role of the CXCL12/CXCR4 axis
P478volume6

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