Regulation of CXCR4 signaling

scientific article published on 10 November 2006

Regulation of CXCR4 signaling is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BBAMEM.2006.11.002
P932PMC publication ID1952230
P698PubMed publication ID17169327
P5875ResearchGate publication ID6631325

P2093author name stringJeffrey L Benovic
John M Busillo
P2860cites workBeta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexesQ22008730
Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7Q22009482
Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalizationQ22010658
beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4Q22011146
HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorQ22242268
beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2Q22253360
Involvement of chemokine receptors in breast cancer metastasisQ24290909
CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4Q24298867
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4Q24299260
Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptorsQ24304933
Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1Q24310870
Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytesQ24324518
Expression of functional CXCR4 chemokine receptors on human colonic epithelial cellsQ24563114
Role for CCR5Delta32 protein in resistance to R5, R5X4, and X4 human immunodeficiency virus type 1 in primary CD4+ cellsQ24608200
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient miceQ24681021
Infection of cells expressing CXCR4 mutants lacking N-glycosylation at the N-terminal extracellular domain is enhanced for R5X4-dualtropic human immunodeficiency virus type-1.Q24794092
Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinomaQ24803472
HIV and the chemokine system: 10 years laterQ27473020
Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptorQ27758437
Worms gang up on bacteriaQ27860588
The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathwayQ28145398
International union of pharmacology. XXII. Nomenclature for chemokine receptorsQ28145705
Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine familyQ28199376
CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesionQ28209329
Transduction of receptor signals by beta-arrestinsQ28246395
Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entryQ28255297
Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expressionQ28265800
Cancer and the chemokine networkQ28269751
Genomic organization and promoter characterization of human CXCR4 geneQ28271622
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tractQ28504884
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar developmentQ28512895
A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivoQ28592009
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprintsQ29547321
Chemokines: a new classification system and their role in immunityQ29615663
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1Q29616092
The biology of chemokines and their receptorsQ29619170
Molecular dynamics simulations on SDF-1alpha: binding with CXCR4 receptorQ30332403
Characterization of recombinant human CXCR4 in insect cells: role of extracellular domains and N-glycosylation in ligand bindingQ30772032
Optimal inhibition of X4 HIV isolates by the CXC chemokine stromal cell-derived factor 1 alpha requires interaction with cell surface heparan sulfate proteoglycansQ30989372
Molecular characterization of the tumor microenvironment in breast cancerQ31095898
Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytesQ32159654
Identification of CXCR4 domains that support coreceptor and chemokine receptor functionsQ33643223
N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolatesQ33804016
Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolatesQ33817249
Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signalingQ33819399
Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptorQ33819496
Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4.Q33873478
Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers.Q40474872
CXCR4-mediated adhesion and MMP-9 secretion in head and neck squamous cell carcinomaQ40516360
N-linked glycosylation in the CXCR4 N-terminus inhibits binding to HIV-1 envelope glycoproteinsQ40548357
Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signalingQ40569053
Regulation of CXCR4 receptor dimerization by the chemokine SDF-1alpha and the HIV-1 coat protein gp120: a fluorescence resonance energy transfer (FRET) studyQ40579902
Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cellsQ40601255
Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.Q40601346
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.Q40633683
The molecular biology of leukocyte chemoattractant receptorsQ40661169
Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptorQ40689812
Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cellsQ40692637
Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancerQ40696855
Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activationQ40699131
Proteoglycans guide SDF-1-induced migration of hematopoietic progenitor cells.Q40714333
The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entryQ40729017
The chemokine stromal cell-derived factor-1 alpha modulates alpha 4 beta 7 integrin-mediated lymphocyte adhesion to mucosal addressin cell adhesion molecule-1 and fibronectinQ40733877
Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sortingQ40773765
Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studiesQ40781201
Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cellsQ40804004
Transcriptional down-regulation of CXC chemokine receptor 4 induced by impaired association of transcription regulator YY1 with c-Myc in human herpesvirus 6-infected cellsQ40833898
Monocyte chemotactic protein-1 receptor CCR2B is a glycoprotein that has tyrosine sulfation in a conserved extracellular N-terminal regionQ40846584
Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progressionQ40853389
Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes.Q40893812
SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells.Q40919059
Differential regulation of CXCR4 and CCR5 endocytosisQ41012960
Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivityQ41049440
Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) geneQ41312923
Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell linesQ41328166
Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12)Q41907503
G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunitsQ42104261
Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.Q42807023
Marked structural and functional heterogeneity in CXCR4: separation of HIV-1 and SDF-1alpha responsesQ42817463
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.Q42823593
The synthetic peptide WKYMVm attenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1.Q43600788
Epithelial cancer cell migration: a role for chemokine receptors?Q43657321
Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entryQ43694761
Up-regulation of HIV coreceptor CXCR4 expression in human T lymphocytes is mediated in part by a cAMP-responsive elementQ43903183
CXCR4 function requires membrane cholesterol: implications for HIV infectionQ43950699
Tyrosine-sulfated peptides functionally reconstitute a CCR5 variant lacking a critical amino-terminal regionQ44106148
Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1 alpha-mediated chemotaxis of human cord blood CD34+ progenitor cellsQ44241973
CXCR4 heterogeneity in primary cells: possible role of ubiquitination.Q44253586
Interleukin-8-mediated heterologous receptor internalization provides resistance to HIV-1 infectivity. Role of signal strength and receptor desensitizationQ44320725
Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.Q44645796
Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradientQ45029569
Characterization of the stromal cell-derived factor-1alpha-heparin complexQ38306497
Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activityQ38920578
Molecular analysis of CD26-mediated signal transduction in T cellsQ39091438
USF/c-Myc enhances, while Yin-Yang 1 suppresses, the promoter activity of CXCR4, a coreceptor for HIV-1 entry.Q39269765
HTLV type I Tax activation of the CXCR4 promoter by association with nuclear respiratory factor 1.Q39269773
A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infectionQ39290210
Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptorQ39315677
Spontaneous and ligand-induced trafficking of CXC-chemokine receptor 4.Q39511604
Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4.Q39546246
Specific interaction of CXCR4 with CD4 and CD8alpha: functional analysis of the CD4/CXCR4 interaction in the context of HIV-1 envelope glycoprotein-mediated membrane fusionQ40261449
G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transferQ40281519
Identification and expression of novel isoforms of human stromal cell-derived factor 1.Q40289913
Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells.Q40291702
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptorQ40396846
CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.Q40439589
Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxQ40440548
Enhanced function with decreased internalization of carboxy-terminus truncated CXCR4 responsible for WHIM syndromeQ40444352
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.Q34064133
Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophagesQ34098669
Structure, function, and inhibition of chemokinesQ34110896
Lymphocyte traffic control by chemokinesQ34139610
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency diseaseQ34190328
CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivoQ34357222
CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cellsQ34397166
Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axisQ34418159
Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.Q34447967
Dimerization: an emerging concept for G protein-coupled receptor ontogeny and functionQ34504071
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptorQ34562493
The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) miceQ34926717
The ins and outs of G protein-coupled receptor traffickingQ35183866
WHIM syndrome: a genetic disorder of leukocyte traffickingQ35581707
Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha.Q35786830
The significance of cancer cell expression of the chemokine receptor CXCR4.Q35832343
A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains.Q35868457
CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesionQ35875566
Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasisQ36175129
WHIM syndrome: a defect in CXCR4 signalingQ36223651
Emerging drug targets for antiretroviral therapyQ36237524
Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.Q36276570
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironmentQ36306137
B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1alpha chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4.Q36368196
A coordinated change in chemokine responsiveness guides plasma cell movementsQ36369352
Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesisQ36370653
Regulation of the chemokine receptor CXCR4 by hypoxiaQ36371842
Involvement of chemokine receptors in organ-specific metastasisQ36455122
Regulation of angiogenesis by hypoxia-inducible factor 1.Q36485190
Anti-HIV therapy: Current and future directionsQ36512922
Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4.Q36612087
Silencing of CXCR4 blocks breast cancer metastasisQ37074006
Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cellsQ37147052
Dynamic reorganization of chemokine receptors, cholesterol, lipid rafts, and adhesion molecules to sites of CD4 engagementQ45303209
Entry of R5X4 and X4 human immunodeficiency virus type 1 strains is mediated by negatively charged and tyrosine residues in the amino-terminal domain and the second extracellular loop of CXCR4.Q45741936
Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activitiesQ45742231
Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1.Q46044632
Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodiesQ46853172
GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo.Q47286150
Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomasQ47376060
Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasisQ47850242
Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivoQ47895026
Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndromeQ47937615
Endothelial cells differentially express functional CXC-chemokine receptor-4 (CXCR-4/fusin) under the control of autocrine activity and exogenous cytokinesQ47939485
CXCR4 is a major chemokine receptor on glioma cells and mediates their survivalQ48464729
TNF-alpha down-regulates CXCR4 expression in primary murine astrocytesQ49106823
Differential MMP and TIMP production by human marrow and peripheral blood CD34(+) cells in response to chemokines.Q50758433
The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor.Q51063481
Cytokines and cell surface molecules independently induce CXCR4 expression on CD4+ CCR7+ human memory T cells.Q52026146
Chemokines and the arrest of lymphocytes rolling under flow conditions.Q52040689
CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion.Q52834072
The chemokine receptor CXCR4 is regulated by DNA methylation in pancreatic cancer.Q54684328
The fundamental role of epigenetic events in cancerQ56421597
Constitutive Agonist-independent CCR5 Oligomerization and Antibody-mediated Clustering Occurring at Physiological Levels of ReceptorsQ56648631
Glycosaminoglycans Mediate Cell Surface Oligomerization of ChemokinesQ57019212
WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12Q57218463
Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftmentQ61942738
Maturation decreases responsiveness of human bone marrow B lineage cells to stromal-derived factor 1 (SDF-1)Q73114085
NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4Q73256626
Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesisQ73281156
Stromal cell-derived factor-1 as a chemoattractant for follicular center lymphoma B cellsQ73692588
Solution studies of recombinant human stromal-cell-derived factor-1Q73700556
Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalizationQ73836239
Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokinesQ74167839
The role of receptor kinases and arrestins in G protein-coupled receptor regulationQ74578170
A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastomaQ74601897
TCR activation inhibits chemotaxis toward stromal cell-derived factor-1: evidence for reciprocal regulation between CXCR4 and the TCRQ77787509
Heterologous desensitization of T cell functions by CCR5 and CXCR4 ligands: inhibition of cellular signaling, adhesion and chemotaxisQ78720018
CXC chemokine receptor 4 expression and function in human anaplastic thyroid cancer cellsQ78767913
Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilizationQ80884356
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomersQ81168337
Chemokines and cancerQ83278273
Chemokine control of HIV-1 infectionQ95809785
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)952-963
P577publication date2006-11-10
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleRegulation of CXCR4 signaling
P478volume1768

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cites work (P2860)
Q359924887th annual European Antibody Congress 2011: November 29-December 1, 2011, Geneva, Switzerland.
Q61448715A Flow Cytometry-Based Approach for the Isolation and Characterization of Neural Stem Cell Primary Cilia
Q42321604A bivalent promoter contributes to stress-induced plasticity of CXCR4 in Ewing sarcoma
Q91276895A feed-forward loop between nuclear translocation of CXCR4 and HIF-1α promotes renal cell carcinoma metastasis
Q34089069A novel CXCR4-selective high-affinity fluorescent probe and its application in competitive binding assays
Q39661306Activation of the JNK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on CXCR4 and CD74
Q36054360Analysis of Chemokine Receptor Trafficking by Site-Specific Biotinylation
Q49241180Asymmetrical ligand-induced cross-regulation of chemokine (C-X-C motif) receptor 4 by α1-adrenergic receptors at the heteromeric receptor complex.
Q28285887Attenuation of CXCR4 responses by CCL18 in acute lymphocytic leukemia B cells
Q99635214Automated Synthesis of Fluorine-18 Labeled CXCR4 Ligand via the Conjugation with Nicotinic Acid N-Hydroxysuccinimide Ester (6-[18F]SFPy)
Q92099049BETP degradation simultaneously targets acute myelogenous leukemia stem cells and the microenvironment
Q34986779Baclofen and other GABAB receptor agents are allosteric modulators of the CXCL12 chemokine receptor CXCR4.
Q35830988Basal and steroid hormone-regulated expression of CXCR4 in human endometrium and endometriosis
Q47664682Biological/pathological functions of the CXCL12/CXCR4/CXCR7 axes in the pathogenesis of bladder cancer
Q38345580Biology, prognosis, and therapy of Waldenström Macroglobulinemia
Q50049701Biomarker discovery for renal cancer stem cells.
Q93052244Blocking of the CXCR4-CXCL12 Interaction Inhibits the Migration of Chicken B Cells Into the Bursa of Fabricius
Q51405629Bone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis.
Q38125795Bone marrow neoplastic niche in leukemia
Q37368106Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis
Q24302660CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin
Q58756005CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
Q26859215CXCL12 chemokine and GABA neurotransmitter systems crosstalk and their putative roles
Q38311811CXCL12/CXCR4 axis in the pathogenesis of acute lymphoblastic leukemia (ALL): a possible therapeutic target.
Q34357718CXCL12/CXCR4 axis triggers the activation of EGF receptor and ERK signaling pathway in CsA-induced proliferation of human trophoblast cells
Q49541054CXCL12/CXCR4/CXCR7 Chemokine Axis in the Central Nervous System: Therapeutic Targets for Remyelination in Demyelinating Diseases.
Q35806963CXCL14 and MCP1 are potent trophic factors associated with cell migration and angiogenesis leading to higher regenerative potential of dental pulp side population cells
Q50888759CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic β-adrenergic response.
Q37344836CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cells
Q46009370CXCR4 and mobilization of hematopoietic precursors.
Q26781915CXCR4 in breast cancer: oncogenic role and therapeutic targeting
Q45990007CXCR4-SERINE339 regulates cellular adhesion, retention and mobilization, and is a marker for poor prognosis in acute myeloid leukemia.
Q37001222CXCR4-targeted therapy inhibits VEGF expression and chondrosarcoma angiogenesis and metastasis.
Q38209118CXCR4: a virus's best friend?
Q33711863CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7.
Q50871275CXCR7 influences the migration of B cells during maturation.
Q35213405CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration.
Q34416235Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular α₁-adrenergic receptor function
Q104073726Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment
Q90489394Chemokine receptor 4 (CXCR4) blockade enhances resistance to bacterial internalization in RAW264.7 cells and AMD3100, a CXCR4 antagonist, attenuates susceptibility to Brucella abortus 544 infection in a murine model
Q35791692Chemokine receptor CXCR4 expression and lung cancer prognosis: a meta-analysis
Q33822327Chemokine receptor CXCR4 regulates CaMKII/CREB pathway in spinal neurons that underlies cancer-induced bone pain
Q35138504Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors
Q34231598Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12.
Q45325496Chemokines and Chemokine Receptors: Accomplices for Human Immunodeficiency Virus Infection and Latency
Q37721300Chemokines and their receptors in the allergic airway inflammatory process.
Q51033302Chitosan nanoparticle-delivered siRNA reduces CXCR4 expression and sensitizes breast cancer cells to cisplatin.
Q38657644Chloroquine-Modified Hydroxyethyl Starch as a Polymeric Drug for Cancer Therapy
Q91018292Circulating tumour cells and their association with bone metastases in patients with neuroendocrine tumours
Q64257480Clathrin Heavy Chain Knockdown Impacts CXCR4 Signaling and Post-translational Modification
Q37820947Collective cell migration of the cephalic neural crest: the art of integrating information
Q34075713Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica
Q33565687Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors
Q28080830Concise Review: CXCR4/CXCL12 Signaling in Immature Hematopoiesis--Lessons From Pharmacological and Genetic Models
Q37834097Conformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies
Q38799530Construction and Quantitative Validation of Chicken CXCR4 Expression Reporter
Q54367289Coupling factor 6 attenuates CXCR4 expression through the HIF-1α and c-Src pathways and promotes endothelial apoptosis and inflammation.
Q38217835Current molecular imaging positron emitting radiotracers in oncology
Q90402524Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch
Q37373794Cysteine (C)-X-C Receptor 4 Regulates NADPH Oxidase-2 During Oxidative Stress in Prostate Cancer Cells
Q89517868DPP4 Inhibition, NPY1-36, PYY1-36, SDF-1α, and a Hypertensive Genetic Background Conspire to Augment Cell Proliferation and Collagen Production: Effects That Are Abolished by Low Concentrations of 2-Methoxyestradiol
Q33654957Decreased expression of CXCR4 chemokine receptor in bone marrow after chemotherapy in patients with non-Hodgkin lymphomas is a good prognostic factor
Q33590761Deletion of CXCR4 in cardiomyocytes exacerbates cardiac dysfunction following isoproterenol administration
Q40002560Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis
Q38490396Development and trafficking function of haematopoietic stem cells and myeloid cells during fetal ontogeny
Q40014256Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag.
Q37067760Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation
Q37125106Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists
Q33765419Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
Q34654975Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
Q37153084Disrupting the CXCL12/CXCR4 axis disturbs the characteristics of glioblastoma stem-like cells of rat RG2 glioblastoma
Q33494281Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration
Q37527802Downregulation of CXCL12 signaling and altered hematopoietic stem and progenitor cell trafficking in a murine model of acute Anaplasma phagocytophilum infection
Q37384979Downregulation of CXCR4 Expression and Functionality After Zoledronate Exposure in Canine Osteosarcoma
Q36334083Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
Q47114899Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics.
Q35718010Dual targeting of the chemokine receptors CXCR4 and ACKR3 with novel engineered chemokines
Q37185272Dynamic chemotherapy-induced upregulation of CXCR4 expression: a mechanism of therapeutic resistance in pediatric AML.
Q33911801Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development
Q33621893Dysplasia of Granulocytes in a Patient with HPV Disease, Recurrent Infections, and B Lymphopenia: A Novel Variant of WHIM Syndrome?
Q35742364Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma
Q36282884Effect of human cytomegalovirus (HCMV) US27 on CXCR4 receptor internalization measured by fluorogen-activating protein (FAP) biosensors
Q33829364Effects of the chemokine CXCL12 and combined internalization of its receptors CXCR4 and CXCR7 in human MCF-7 breast cancer cells.
Q38334389Effects of the polymorphisms of Mx1, BAT2 and CXCL12 genes on immunological traits in pigs
Q38010726Embryonic development of hematopoietic stem cells: implications for clinical use.
Q35201347Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
Q89106795Emerging roles of atypical chemokine receptor 3 (ACKR3) in normal development and physiology
Q37225329Emerging targets in cancer management: role of the CXCL12/CXCR4 axis
Q38872070Endocytic Trafficking of HIV gp120 is Mediated by Dynamin and Plays a Role in gp120 Neurotoxicity
Q27008073Endocytic trafficking of chemokine receptors
Q89093864Endocytosis is required for CXC chemokine receptor type 4 (CXCR4)-mediated Akt activation and antiapoptotic signaling
Q38163509Endothelialization of implanted cardiovascular biomaterial surfaces: the development from in vitro to in vivo
Q47820841Enhanced migration and CXCR4 over-expression in fibroblasts with telomerase reconstitution.
Q36406895Evidence that β7 Integrin Regulates Hematopoietic Stem Cell Homing and Engraftment Through Interaction with MAdCAM-1.
Q37547939Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis
Q42452080Expression of CXCR4 is associated with progression and invasion in patients with nasal-surface basal cell carcinoma.
Q34408178Expression of the chemokine receptor CXCR4 in human hepatocellular carcinoma and its role in portal vein tumor thrombus
Q38693302Extracellular Ubiquitin: Role in Myocyte Apoptosis and Myocardial Remodeling
Q37272076Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4
Q28289847Extracellular ubiquitin: immune modulator and endogenous opponent of damage-associated molecular pattern molecules
Q35140322Filamin A interaction with the CXCR4 third intracellular loop regulates endocytosis and signaling of WT and WHIM-like receptors
Q53242934Functional and structural consequences of chemokine (C-X-C motif) receptor 4 activation with cognate and non-cognate agonists.
Q42117966Functional consequences of perturbed CXCL12 signal processing: analyses of immature hematopoiesis in GRK6-deficient mice
Q92547985Functional mimetic of the G-protein coupled receptor CXCR4 on a soluble antibody scaffold
Q30438828Functional reconstitution of the human chemokine receptor CXCR4 with G(i)/G (o)-proteins in Sf9 insect cells
Q51090373G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of β-Arrestin.
Q89575141GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation
Q57401085Gated Mesoporous Silica Nanoparticles Using a Double-Role Circular Peptide for the Controlled and Target-Preferential Release of Doxorubicin in CXCR4-Expresing Lymphoma Cells
Q37653020Genetics on a WHIM.
Q37001216Granulocyte colony-stimulating factor inhibits CXCR4/SDF-1α signaling and overcomes stromal-mediated drug resistance in the HL-60 cell line
Q42687594Gα13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation
Q36141492HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha
Q89995898HIV-1 Protein gp120 Induces Mouse Lung Fibroblast-to-Myofibroblast Transdifferentiation via CXCR4 Activation
Q40109819Harnessing CXCR4 antagonists in stem cell mobilization, HIV infection, ischemic diseases, and oncology.
Q38770505Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α.
Q42173784Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization
Q35279688Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.
Q34755795Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.
Q61811965High CXCR4 expression impairs rituximab response and the prognosis of R-CHOP-treated diffuse large B-cell lymphoma patients
Q36608727Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration
Q48672266How the human spermatozoa sense the oocyte: a new role of SDF1-CXCR4 signalling
Q46789730Human Cytomegalovirus UL111A and US27 gene products enhance the CXCL12/CXCR4 signaling axis via distinct mechanisms
Q39884805Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells
Q35869939IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes
Q27011420Immunohistochemical expression of CXCR4 on breast cancer and its clinical significance
Q28472108Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor
Q64081689In vivo topology converts competition for cell-matrix adhesion into directional migration
Q37332423Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro
Q37714248Inhibiting metastatic breast cancer cell migration via the synergy of targeted, pH-triggered siRNA delivery and chemokine axis blockade
Q30437935Inhibition of gluconeogenesis in primary hepatocytes by stromal cell-derived factor-1 (SDF-1) through a c-Src/Akt-dependent signaling pathway
Q36627752Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model
Q36327374Initial assessment of the role of CXC chemokine receptor 4 after polytrauma
Q41786672Integrating chemotaxis and contact-inhibition during collective cell migration: Small GTPases at work
Q40058610Interaction of chemokine receptor CXCR4 in monomeric and dimeric state with its endogenous ligand CXCL12: coarse-grained simulations identify differences.
Q37432097International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors
Q60949707Isotype Specific Assembly of B Cell Antigen Receptors and Synergism With Chemokine Receptor CXCR4
Q92764624Knockout of LASP1 in CXCR4 expressing CML cells promotes cell persistence, proliferation and TKI resistance
Q24647565Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling
Q38828335Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progression
Q28658170MLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism
Q37801577Mechanisms of HIV envelope-induced T lymphocyte apoptosis
Q39126530Mechanisms of Regulation of the Chemokine-Receptor Network.
Q35181510Mesenchymal stromal cell secretome up-regulates 47 kDa CXCR4 expression, and induce invasiveness in neuroblastoma cell lines
Q40298036MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias
Q89360303MicroRNA-9 inhibits growth and invasion of head and neck cancer cells and is a predictive biomarker of response to plerixafor, an inhibitor of its target CXCR4
Q39861422Microarray coupled to quantitative RT-PCR analysis of androgen-regulated genes in human LNCaP prostate cancer cells
Q36445393Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4.
Q37810088Mobilization of hematopoietic stem cells into the peripheral blood
Q33963030Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification
Q50423780Molecular Regulation of Sprouting Angiogenesis
Q33502767Molecular cloning, characterization, and expression analysis of the CXCR4 gene from Turbot: Scophthalmus maximus
Q28566402Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons
Q35137542Multiplex detection of homo- and heterodimerization of g protein-coupled receptors by proximity biotinylation
Q49343068Multisystem multitasking by CXCL12 and its receptors CXCR4 and ACKR3.
Q55077069Myocardial Ischemia and Mobilization of Circulating Progenitor Cells.
Q36043738NMR metabolomics of MTLn3E breast cancer cells identifies a role for CXCR4 in lipid and choline regulation.
Q37641792Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo.
Q36413901Nef-M1, a peptide antagonist of CXCR4, inhibits tumor angiogenesis and epithelial‑to‑mesenchymal transition in colon and breast cancers
Q39022058Negative regulation of chemokine receptor signaling and B-cell chemotaxis by p66Shc.
Q24612339Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model
Q37050877New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle.
Q34713289Novel role for NFAT3 in ERK-mediated regulation of CXCR4
Q30010172Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.
Q38808628Oncogenic roles and drug target of CXCR4/CXCL12 axis in lung cancer and cancer stem cell
Q34471041Overexpression of chemokine ligand 7 is associated with the progression of canine transmissible venereal tumor.
Q24603099PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers
Q42920116Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists
Q37588378Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer
Q58701453Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3
Q48624133Pathogenesis, diagnosis and therapeutic strategies in WHIM syndrome immunodeficiency.
Q27487954Persistent fetal infection with bovine viral diarrhea virus differentially affects maternal blood cell signal transduction pathways
Q54986974Pharmacological blockage of the CXCR4-CXCL12 axis in endometriosis leads to contrasting effects in proliferation, migration, and invasion.
Q38620904Pharmacological modulation of C-X-C motif chemokine receptor 4 influences development of acute respiratory distress syndrome after lung ischemia-reperfusion injury.
Q89782379Phosphorylation-Dependent Differences in CXCR4-LASP1-AKT1 Interaction between Breast Cancer and Chronic Myeloid Leukemia
Q38285805Pim kinases in hematological malignancies: where are we now and where are we going?
Q92541764Ping-Pong-Tumor and Host in Pancreatic Cancer Progression
Q46174161Plasma malondialdehyde levels and CXCR4 expression in peripheral blood cells of breast cancer patients.
Q36486011Plasma stromal cell-derived factor 1α/CXCL12 level predicts long-term adverse cardiovascular outcomes in patients with coronary artery disease.
Q33818848Plasminogen regulates cardiac repair after myocardial infarction through its noncanonical function in stem cell homing to the infarcted heart
Q36970380Polymer-DNA Nanoparticle-Induced CXCR4 Overexpression Improves Stem Cell Engraftment and Tissue Regeneration in a Mouse Hindlimb Ischemia Model
Q34087051Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia.
Q37977191Putative roles for phospholipase Cη enzymes in neuronal Ca2+ signal modulation.
Q47697210RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling
Q35185336ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells
Q37287538ROS-mediated regulation of CXCR4 in cancer.
Q40748467RTN3 Regulates the Expression Level of Chemokine Receptor CXCR4 and is Required for Migration of Primordial Germ Cells
Q50534081Redirection to the bone marrow improves T cell persistence and antitumor functions.
Q37536210Regulated expression of CXCR4 constitutive active mutants revealed the up-modulated chemotaxis and up-regulation of genes crucial for CXCR4 mediated homing and engraftment of hematopoietic stem/progenitor cells
Q52720171Regulation of Tumor Progression by Programmed Necrosis.
Q39506215Role of CXC chemokine receptor type 4 as a lactoferrin receptor
Q33414625SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury
Q34080818SDF-1alpha is a potent inducer of HIV-1-Specific CD8+ T-cell chemotaxis, but migration of CD8+ T cells is impaired at high viral loads
Q47121177SDF-1α (Stromal Cell-Derived Factor 1α) Induces Cardiac Fibroblasts, Renal Microvascular Smooth Muscle Cells, and Glomerular Mesangial Cells to Proliferate, Cause Hypertrophy, and Produce Collagen
Q35916526Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells
Q42637522Sequence analysis, characterization and mRNA distribution of channel catfish (Ictalurus punctatus Rafinesque, 1818) chemokine (C-X-C motif) receptor 4 (CXCR4) cDNA.
Q41865415Signaling properties of the human chemokine receptors CXCR4 and CXCR7 by cellular electric impedance measurements
Q47177038Single-molecule imaging reveals dimerization/oligomerization of CXCR4 on plasma membrane closely related to its function
Q30432989Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling
Q37961327Stem cells as the root of pancreatic ductal adenocarcinoma.
Q37413713Strain differences in behavioral and cellular responses to perinatal hypoxia and relationships to neural stem cell survival and self-renewal: Modeling the neurovascular niche.
Q50186474Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4.
Q41978128Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-β3 and phospholipase C-γ1 for distinct cellular responses
Q37998467Stromal-Cell-Derived Factor-1 (SDF-1)/CXCL12 as Potential Target of Therapeutic Angiogenesis in Critical Leg Ischaemia
Q92619665Structural and Biological Characterizations of Novel High-Affinity Fluorescent Probes with Overlapped and Distinctive Binding Regions on CXCR4
Q35626054Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction
Q48531686Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists
Q41527702Synthesis of pyridine derivatives as potential antagonists of chemokine receptor type 4.
Q39155781TRAIL-induced miR-146a expression suppresses CXCR4-mediated human breast cancer migration
Q38791259Targeted Imaging of the Atypical Chemokine Receptor 3 (ACKR3/CXCR7) in Human Cancer Xenografts.
Q47850217Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy
Q35312229The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions
Q36213484The CXCL12/CXCR4 Signaling Pathway: A New Susceptibility Factor in Human Papillomavirus Pathogenesis
Q24312062The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction
Q92149775The Effects of the CXCR4 Antagonist, AMD3465, on Human Retinal Vascular Endothelial Cells (hRVECs) in a High Glucose Model of Diabetic Retinopathy
Q34121692The Epstein-Barr virus-encoded G protein-coupled receptor BILF1 hetero-oligomerizes with human CXCR4, scavenges Gαi proteins, and constitutively impairs CXCR4 functioning
Q46361858The Human Blood-Brain Barrier Internalizes Cryptococcus neoformans via the EphA2-Tyrosine Kinase Receptor.
Q54109145The Orphan G Protein-coupled Receptor 75 Signaling is Activated by the Chemokine CCL5.
Q28258028The PIM kinases in hematological cancers
Q90050404The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases
Q48201727The SDF-1 3'A genetic variation is correlated with elevated intra-tumor tissue and circulating concentration of CXCL12 in glial tumors: a study on Iranian anaplastic astrocytoma and glioblastoma multiforme patients.
Q28728119The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells
Q54346075The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia.
Q37888712The bone marrow microenvironment and leukemia: biology and therapeutic targeting
Q37016290The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders?
Q35172606The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR.
Q39508591The induction of CXCR4 expression in human osteoblast-like cells (MG63) by CoCr particles is regulated by the PLC-DAG-PKC pathway
Q53639793The role of SDF-1 in homing of human adipose-derived stem cells.
Q62019365The unique structural and functional features of CXCL12
Q39556699The up-regulation of Myb may help mediate EGCG inhibition effect on mouse lung adenocarcinoma
Q37977482The use of chemokine receptor agonists in stem cell mobilization
Q33725587Thermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes
Q92511538Transcriptome Analysis Reveals Distinct Responses to Physiologic versus Toxic Manganese Exposure in Human Neuroblastoma Cells
Q36124735Transgene expression study of CXCR4 active mutants. Potential prospects in up-modulation of homing and engraftment efficiency of hematopoietic stem/progenitor cells.
Q36765097Ubiquitin and stromal cell-derived factor-1α in bronchoalveolar lavage fluid after burn and inhalation injury
Q39590023Ubiquitin receptor binding and signaling in primary human leukocytes
Q92681960Ubiquitination and SUMOylation in HIV Infection: Friends and Foes
Q39850663Ubiquitination of chemokine receptors
Q33784472Using nanoBRET and CRISPR/Cas9 to monitor proximity to a genome-edited protein in real-time
Q40722797WHIM Syndrome Caused by Waldenström's Macroglobulinemia-Associated Mutation CXCR4 (L329fs).
Q54708512WHIM syndrome and oral squamous cell carcinoma.
Q36079791WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4.
Q37168887WHIM syndrome: congenital immune deficiency disease
Q54593987[CXCR4, a therapeutic target in rare immunodeficiencies?].
Q38907008miR-146a controls CXCR4 expression in a pathway that involves PLZF and can be used to inhibit HIV-1 infection of CD4(+) T lymphocytes
Q28646005miRNA-133 augments coelomocyte phagocytosis in bacteria-challenged Apostichopus japonicus via targeting the TLR component of IRAK-1 in vitro and in vivo
Q36638961p21Cip1 modulates arterial wound repair through the stromal cell-derived factor-1/CXCR4 axis in mice.
Q41628550α1-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells.
Q39241548β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4.
Q104501867β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling

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