The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC.

scientific article published on 20 January 2009

The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1476-5381.2008.00050.X
P932PMC publication ID2697671
P698PubMed publication ID19154420
P5875ResearchGate publication ID23802283

P50authorNeill J LiptrottQ39489163
Andrew OwenQ39489259
Jean G SathishQ58424510
P2093author name stringD J Back
S H Khoo
P G Bray
M Penny
P2860cites workThe human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactionsQ24310512
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampinQ28211706
Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomesQ28239777
Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytesQ28254139
Effect of tumor necrosis factor-alpha and interferon-gamma on intestinal P-glycoprotein expression, activity, and localization in Caco-2 cellsQ33202588
P-glycoprotein in autoimmune diseasesQ33360575
Microheterogeneity of alpha 1 acid glycoprotein in rheumatoid arthritis: dependent on disease duration?Q33565293
Potential role of ABC transporters as a detoxification system at the blood-CSF barrier.Q33981559
Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axisQ34418159
Secretion of peptides and proteins lacking hydrophobic signal sequences: the role of adenosine triphosphate-driven membrane translocatorsQ35486614
Differential Th1/Th2 cytokine patterns in chronic arthritis: interferon gamma is highly expressed in synovium of rheumatoid arthritis compared with seronegative spondyloarthropathiesQ35549213
Protein binding in antiretroviral therapiesQ35571186
The changes in the T helper 1 (Th1) and T helper 2 (Th2) cytokine balance during HIV-1 infection are indicative of an allergic response to viral proteins that may be reversed by Th2 cytokine inhibitors and immune response modifiers--a review and hypQ35636412
Down regulation of multidrug resistance protein-1 expression in patients with early rheumatoid arthritis exposed to methotrexate as a first disease-modifying antirheumatic drug.Q35637979
Cytochrome P450 enzymes: novel options for cancer therapeutics.Q35693756
HIV-1 induced AIDS is an allergy and the allergen is the Shed gp120--a review, hypothesis, and implicationsQ35841997
Intracellular pharmacokinetics of antiretroviral agentsQ36054598
Role of P-glycoprotein in statin drug interactionsQ36634221
Cytokine gene polymorphisms, cancer susceptibility, and prognosisQ36689627
P-glycoprotein: so many ways to turn it on.Q37044372
Differences in the pharmacokinetics of protease inhibitors between healthy volunteers and HIV-infected personsQ37447683
Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4.Q37583423
Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liverQ38322847
CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo.Q39583317
Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levelsQ40177451
Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5.Q40282075
Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes.Q41172472
Effect of 5637-conditioned medium and recombinant cytokines on P-glycoprotein expression in a human GM-CSF-dependent leukemic myeloid cell lineQ41290791
Induction of mdr1b mRNA and P-glycoprotein expression by tumor necrosis factor alpha in primary rat hepatocyte culturesQ42459607
Guide to Receptors and Channels (GRAC), 3rd editionQ43088119
Synovial fluid from patients with rheumatoid arthritis inhibits neutrophil apoptosis: role of adenosine and proinflammatory cytokinesQ44209336
Variability in activity of hepatic CYP3A4 in patients infected with HIV.Q44874904
Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA.Q45145266
Variations of CYP3A activity induced by antiretroviral treatment in HIV-1 infected patientsQ45229364
Alterations in gastric acidity in patients infected with human immunodeficiency virusQ45769106
An assessment of P-glycoprotein expression and activity in peripheral blood lymphocytes of transplant candidatesQ46420437
Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme inductionQ46616703
Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP.Q46801300
Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytesQ46985668
Counter-regulatory effects of procalcitonin and indoxyl sulphate on net albumin secretion by cultured rat hepatocytesQ47924950
Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell linesQ48124580
Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrierQ48355279
P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation.Q53954128
High expression of the multidrug resistance-associated protein (MRP) in chronic and prolymphocytic leukaemia.Q54194573
Detection of ABCC2, CYP2B6 and CYP3A4 in human peripheral blood mononuclear cells using flow cytometryQ58073774
Detection and quantification of minority HIV isolates harbouring the D30N mutation by real-time PCR amplificationQ58073790
Factors impacting the expression of membrane-bound proteins in lymphocytes from HIV-positive subjectsQ58073794
Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liverQ60787038
Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritisQ71160288
Microheterogeneity of alpha 1-acid glycoprotein in early and established rheumatoid arthritisQ72023236
[Multi-drug resistance in the treatments of autoimmune diseases]Q79317505
Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancerQ80546801
Overcoming drug resistance induced by P-glycoprotein on lymphocytes in patients with refractory rheumatoid arthritisQ80693015
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)497-508
P577publication date2009-01-20
P1433published inBritish Journal of PharmacologyQ919631
P1476titleThe impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC
P478volume156

Reverse relations

cites work (P2860)
Q37595188ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer
Q89441164Alcohol and Cocaine Exposure Modulates ABCB1 and ABCG2 Transporters in Male Alcohol-Preferring Rats
Q36708715Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS
Q38409261Camellia sinensis in asymptomatic hyperuricemia: A meta-analysis of tea or tea extract effects on uric acid levels
Q28468505Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection
Q28081272Drug transporters in tissues and cells relevant to sexual transmission of HIV: Implications for drug delivery
Q38514821Effect of cocoa products and flavanols on platelet aggregation in humans: a systematic review.
Q38087565Effect of flavonoids on circulating levels of TNF-α and IL-6 in humans: a systematic review and meta-analysis.
Q42283286Effect of peginterferon alfa-2a (40KD) on cytochrome P450 isoenzyme activity
Q52677743Evaluation of Potential Disease-Mediated Drug-Drug Interaction in Patients With Moderate-to-Severe Atopic Dermatitis Receiving Dupilumab.
Q35016654Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction
Q40204531Hepatic organoids for microfluidic drug screening
Q35749503Immunological response as a source to variability in drug metabolism and transport
Q83496835Impact of interleukin-10 gene polymorphisms on tacrolimus dosing requirements in Chinese liver transplant patients during the early posttransplantation period
Q37310533Inflammation and Immune Regulation as Potential Drug Targets in Antidepressant Treatment.
Q38740792Inflammation and pharmacokinetics: potential implications for HIV-infection
Q35708089Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings
Q37232200Interactions between tenofovir and nevirapine in CD4+ T cells and monocyte-derived macrophages restrict their intracellular accumulation.
Q38216941Interference of flavonoids with fluorescent intracellular probes: methodological implications in the evaluation of the oxidative burst by flow cytometry
Q38803026Isoniazid clearance is impaired among human immunodeficiency virus/tuberculosis patients with high levels of immune activation
Q33862472Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans.
Q92053598Perturbation Theory Machine Learning Modeling of Immunotoxicity for Drugs Targeting Inflammatory Cytokines and Study of the Antimicrobial G1 Using Cytometric Bead Arrays
Q36694926Phase I clinical trial combining imatinib mesylate and IL-2 in refractory cancer patients: IL-2 interferes with the pharmacokinetics of imatinib mesylate
Q56966090Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients
Q46169240Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation.
Q34529127Raltegravir is a substrate for SLC22A6: a putative mechanism for the interaction between raltegravir and tenofovir
Q44363021Regulation of drug transporter mRNA expression by interferon-γ in primary human hepatocytes
Q37604385Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines
Q34705514Schistosome ABC multidrug transporters: From pharmacology to physiology
Q28553833Staphylococcus aureus and Lipopolysaccharide Modulate Gene Expressions of Drug Transporters in Mouse Mammary Epithelial Cells Correlation to Inflammatory Biomarkers
Q38054629The generation, detection, and effects of reactive drug metabolites
Q35609414The human P-glycoprotein transporter enhances the type I interferon response to Listeria monocytogenes infection
Q37836908The role of cytokines in the regulation of drug disposition: extended functional pleiotropism?
Q40621078Therapeutic protein-drug interactions: plausible mechanisms and assessment strategies

Search more.