[(64) Cu]-labelled trastuzumab: optimisation of labelling by DOTA and NODAGA conjugation and initial evaluation in mice

scientific article published on 24 April 2015

[(64) Cu]-labelled trastuzumab: optimisation of labelling by DOTA and NODAGA conjugation and initial evaluation in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JLCR.3287
P932PMC publication ID5029596
P698PubMed publication ID25906708
P5875ResearchGate publication ID275357490

P50authorNic GillingsQ26388661
Søren HeisselQ58930977
Andreas KjærQ39183738
Peter HøjrupQ40022709
Paul R. HansenQ54936624
P2093author name stringChristina Schjoeth-Eskesen
Carsten Haagen Nielsen
P2860cites workOptimized preparation and preliminary evaluation of [64Cu]–DOTA–trastuzumab for targeting ErbB2/Neu expressionQ57567743
Biodistribution and dosimetry of pretargeted monoclonal antibody 2D12.5 and Y-Janus-DOTA in BALB/c mice with KHJJ mouse adenocarcinomaQ73836705
Monoclonal antibody pharmacokinetics and pharmacodynamicsQ81951721
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trialQ27851578
Monoclonal antibodies for copper-64 PET dosimetry and radioimmunotherapyQ35124411
A comparison of 111In- or 64Cu-DOTA-trastuzumab Fab fragments for imaging subcutaneous HER2-positive tumor xenografts in athymic mice using microSPECT/CT or microPET/CT.Q35650526
Trastuzumab and breast cancer: developments and current statusQ36540576
Monitoring therapeutic response of human ovarian cancer to 17-DMAG by noninvasive PET imaging with (64)Cu-DOTA-trastuzumabQ36680209
89Zr-Radiolabeled Trastuzumab Imaging in Orthotopic and Metastatic Breast TumorsQ37148669
A human, compact, fully functional anti-ErbB2 antibody as a novel antitumour agent.Q37355464
H6phospa-trastuzumab: bifunctional methylenephosphonate-based chelator with 89Zr, 111In and 177Lu.Q37412579
Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical researchQ37478003
Monoclonal antibodies in diagnosis and therapyQ37755851
Clinical pharmacokinetics of therapeutic monoclonal antibodiesQ37770555
Matching chelators to radiometals for radiopharmaceuticalsQ38156660
Comparison of DOTA and NODAGA as chelators for (64)Cu-labeled immunoconjugatesQ38933889
Comparison of bifunctional chelates for (64)Cu antibody imagingQ39692454
Imaging and biodistribution of Her2/neu expression in non-small cell lung cancer xenografts with Cu-labeled trastuzumab PET.Q39729571
A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistributionQ39855359
Radiolabeling of trastuzumab with 177Lu via DOTA, a new radiopharmaceutical for radioimmunotherapy of breast cancer.Q39855377
Preclinical characterisation of 111In-DTPA-trastuzumab.Q40491931
Progression and treatment of HER2-positive breast cancerQ43189081
An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA.Q43582043
64Cu-DOTA-trastuzumab PET imaging in patients with HER2-positive breast cancerQ44650607
Development and characterization of clinical-grade 89Zr-trastuzumab for HER2/neu immunoPET imagingQ44944204
Biodistribution of 89Zr-trastuzumab and PET imaging of HER2-positive lesions in patients with metastatic breast cancerQ48252174
Indium-111-labeled trastuzumab scintigraphy in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer.Q48532937
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecttrastuzumabQ412616
P304page(s)227-233
P577publication date2015-04-24
P1433published inJournal of Labelled Compounds and RadiopharmaceuticalsQ3186923
P1476title[(64) Cu]-labelled trastuzumab: optimisation of labelling by DOTA and NODAGA conjugation and initial evaluation in mice
P478volume58

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cites work (P2860)
Q90233040Comparison between Fractionated Dose and Single Dose of Cu-64 Trastuzumab Therapy in the NCI-N87 Gastric Cancer Mouse Model
Q38693617MANOTA: a promising bifunctional chelating agent for copper-64 immunoPET.
Q52990593New synthesis of phenyl-isothiocyanate C-functionalised cyclams. Bioconjugation and (64)Cu phenotypic PET imaging studies of multiple myeloma with the te2a derivative.
Q89529826Radiolabelled Peptides for Positron Emission Tomography and Endoradiotherapy in Oncology
Q91725280Site-specifically labeled 89Zr-DFO-trastuzumab improves immuno-reactivity and tumor uptake for immuno-PET in a subcutaneous HER2-positive xenograft mouse model
Q102388853Towards integration of 64Cu-DOTA-trastuzumab PET-CT and MRI with mathematical modeling to predict response to neoadjuvant therapy in HER2 + breast cancer

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