The endocannabinoid system: a new molecular target for the treatment of tobacco addiction.

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The endocannabinoid system: a new molecular target for the treatment of tobacco addiction. is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.2174/187152708786927859
P932PMC publication ID3821699
P698PubMed publication ID19128204
P5875ResearchGate publication ID23763084

P50authorBernard Le FollQ28480403
Paola FaddaQ59506111
Gianluigi TandaQ44736132
P2093author name stringSteven R Goldberg
Maria Scherma
Walter Fratta
Benoit Forget
P2860cites workLong term pharmacotherapy for obesity and overweight: updated meta-analysis.Q22242086
Nicotine receptor partial agonists for smoking cessationQ24242786
Nicotine receptor partial agonists for smoking cessationQ24246525
Brain monoglyceride lipase participating in endocannabinoid inactivationQ24533828
Cannabinoid receptor localization in brainQ24558751
2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptorQ24620096
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptorsQ24642509
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M currentQ24653442
The orphan receptor GPR55 is a novel cannabinoid receptorQ24670137
Marijuana and cannabinoid regulation of brain reward circuitsQ24671514
Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex.Q24681363
Addiction, dopamine, and the molecular mechanisms of memoryQ28142501
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneuronsQ28144567
Role of endogenous cannabinoids in synaptic signalingQ28185075
Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependenceQ28200994
Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cellsQ28212245
Cannabinoid CB1 receptors control conditioned drug seekingQ28259415
Allosteric modulation of the cannabinoid CB1 receptorQ28268355
Identification and functional characterization of brainstem cannabinoid CB2 receptorsQ28276972
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brainQ28290395
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptorsQ28292914
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amidesQ28295481
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout miceQ28343324
Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: reversal by D(1) antagonistsQ28348765
Limbic activation during cue-induced cocaine cravingQ28369526
Stress-induced craving and stress response in cocaine dependent individualsQ28374775
High reinforcing efficacy of nicotine in non-human primatesQ28469129
Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out miceQ28506626
The role of nicotinic receptor beta-2 subunits in nicotine discrimination and conditioned taste aversionQ28511348
Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nucleiQ28564628
Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of ratQ28583983
Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotineQ28589593
Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugsQ29301836
Isolation and structure of a brain constituent that binds to the cannabinoid receptorQ29547476
The molecular logic of endocannabinoid signallingQ29615356
Modulation of anxiety through blockade of anandamide hydrolysisQ29615902
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic studyQ29615905
The reinstatement model of drug relapse: history, methodology and major findingsQ29616241
Dopamine, learning and motivationQ29616245
International Union of Pharmacology. XXVII. Classification of cannabinoid receptorsQ29616832
Determination and characterization of a cannabinoid receptor in rat brainQ29618888
Formation and inactivation of endogenous cannabinoid anandamide in central neuronsQ29620558
Cannabinoid CB2 receptors: Immunohistochemical localization in rat brainQ30047898
Localization of drug reward mechanisms by intracranial injectionsQ35970774
Nicotine: from molecular mechanisms to behaviourQ36015617
Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction.Q36119168
The role of the cannabinoid system in nicotine addiction.Q36144660
Endocannabinoid signaling system and brain reward: emphasis on dopamineQ36152336
Nicotine as a typical drug of abuse in experimental animals and humans.Q36277268
Guidance for research and testing to reduce tobacco toxicant exposureQ36317922
Neural mechanisms of drug reinforcementQ36330262
Nicotine and nonnicotine factors in cigarette addictionQ36345893
Endocannabinoids in the central nervous system: from neuronal networks to behaviorQ36352196
Neuropharmacology and potential efficacy of new treatments for tobacco dependenceQ36376434
Tobacco addictionQ36519493
Brain nicotinic acetylcholine receptors: native subtypes and their relevance.Q36550823
Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous systemQ36607367
Discovery of the presence and functional expression of cannabinoid CB2 receptors in brainQ36653994
In vivo neurochemical effects induced by changes in endocannabinoid neurotransmissionQ36686455
The endocannabinoid system in brain reward processesQ36741861
Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversionsQ36830438
Independent presynaptic and postsynaptic mechanisms regulate endocannabinoid signaling at multiple synapses in the ventral tegmental area.Q36873051
Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependenceQ36950936
Hippocampal interneurons co-express transcripts encoding the alpha7 nicotinic receptor subunit and the cannabinoid receptor 1Q36952150
The neurobiology of tobacco addictionQ36966993
Endocannabinoid regulation of relapse mechanismsQ36970902
Allosterism and cannabinoid CB(1) receptors: the shape of things to comeQ37009188
Some effects of CB1 antagonists with inverse agonist and neutral biochemical propertiesQ37031056
The endocannabinoid system: emotion, learning and addictionQ37142237
Multiple roles for the endocannabinoid system during the earliest stages of life: pre- and postnatal developmentQ37143586
Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in ratsQ37146387
Blocking cannabinoid CB1 receptors for the treatment of nicotine dependence: insights from pre-clinical and clinical studiesQ37164812
Cannabinoid receptor 1 gene association with nicotine dependenceQ37322610
The endogenous cannabinoid system modulates nicotine reward and dependenceQ37353755
Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistryQ38331458
Preclinical assessment of abuse liability of drugsQ39635211
A psychomotor stimulant theory of addiction.Q39681407
Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamideQ48247701
Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory actionQ48309971
The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transportQ48315882
Cannabinoids modulate potassium current in cultured hippocampal neurons.Q48388103
The dopamine D-1 receptor antagonist SCH 23390 injected into the dorsolateral bed nucleus of the stria terminalis decreased cocaine reinforcement in the rat.Q48481302
Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in ratsQ48485540
Genetic dissociation of two behaviors associated with nicotine addiction: beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome.Q48510920
Nicotine activates and desensitizes midbrain dopamine neuronsQ48590165
Brain sites mediating the discriminative stimulus effects of nicotine in ratsQ48950640
Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys.Q51375099
Stimulation of in vivo dopamine transmission in the bed nucleus of stria terminalis by reinforcing drugs.Q51375624
Long-term potentiation of excitatory inputs to brain reward areas by nicotine.Q51381056
Expression of Fos protein in various rat brain areas following acute nicotine and diazepam.Q51571790
Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area.Q51627333
Control of behavior by intravenous nicotine injections in laboratory animals.Q51850356
Computerised therapy for psychiatric disorders.Q51901557
Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats.Q52016680
Reinstatement and spontaneous recovery of nicotine seeking in rats.Q52195387
Nicotine self-administration in rats: strain and nicotine pre-exposure effects on acquisition.Q52197424
Nicotine reinstatement of nicotine self-administration after long-term extinction.Q52200047
Nicotine-induced place preferences following prior nicotine exposure in rats.Q52220497
Discriminative stimulus effects of nicotine in rats trained under different schedules of reinforcement.Q52248899
Plasma nicotine and cotinine levels following intravenous nicotine self-administration in rats.Q52277162
Nicotine as a reinforcer in human subjects and laboratory animals.Q52278630
Persistent behavior at high rates maintained by intravenous self-administration of nicotine.Q52292036
EndocannabinoidsQ55282369
Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled studyQ60209721
Stimuli associated with drug injections as events that control behaviorQ67520426
Rodent model of nicotine abstinence syndromeQ67591174
Genetic influence on smoking--a study of male twinsQ68022601
Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent processQ71693466
Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamideQ71743278
Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brainQ71988975
Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterizationQ72631582
Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxyl ic acid phenylamide (CP-272871)Q73011648
Conditioned cued recovery of responding following prolonged withdrawal from self-administered cocaine in rats: an animal model of relapseQ73554155
The pedunculopontine tegmental nucleus and the role of cholinergic neurons in nicotine self-administration in the rat: a correlative neuroanatomical and behavioral studyQ73572188
A comparison of the effects of nicotine on dopamine and non-dopamine neurons in the rat ventral tegmental area: an in vitro electrophysiological studyQ73661239
Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areasQ73689123
Presynaptic nicotinic receptors modulating dopamine release in the rat striatumQ73689125
No association between (AAT)n repeats in the cannabinoid receptor gene (CNR1) and heroin abuse in a Chinese populationQ73816360
The alpha4beta2 agonist SIB 1765F, but not the alpha7 agonist AR-R 17779, cross-sensitises to the psychostimulant effects of nicotineQ74043409
Stress-induced relapse to heroin and cocaine seeking in rats: a reviewQ74248968
Tobacco dependence treatments: review and prospectusQ74610223
Effects of isoarecolone, a nicotinic receptor agonist in rodent models of nicotine dependenceQ80167784
Interaction of nicotine with dopaminergic mechanisms assessed through drug discrimination and rotational behaviour in ratsQ82900089
Pharmacotherapeutic targeting of the endocannabinoid signaling system: drugs for obesity and the metabolic syndrome.Q30366778
Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms, biological actions and synaptic plasticity.Q30493991
Cannabinoids: reward, dependence, and underlying neurochemical mechanisms--a review of recent preclinical dataQ30807024
Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens.Q31813503
Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuseQ31863511
Overview of nicotinic receptors and their roles in the central nervous systemQ32076973
Dysregulation of the endocannabinoid system in obesityQ33345484
Pain modulation by release of the endogenous cannabinoid anandamideQ33421146
Nicotinic receptors in the brain. Links between molecular biology and behavior.Q33872186
Role of dopamine in the behavioural actions of nicotine related to addictionQ33894548
Alteration of the behavioral effects of nicotine by chronic caffeine exposure.Q33933548
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapsesQ33940688
Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology.Q33951646
Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbensQ34032832
A missense mutation in human fatty acid amide hydrolase associated with problem drug use.Q34032872
Brain monoamine oxidase A inhibition in cigarette smokersQ34063791
US public health service clinical practice guideline: treating tobacco use and dependence.Q34072032
Genes and addictionQ34076144
The fatty acid amide hydrolase (FAAH).Q34098981
Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoidsQ34166712
Conditioned place preference: what does it add to our preclinical understanding of drug reward?Q34188090
Assembly and subunit diversity of nicotinic acetylcholine receptorsQ34217965
Nicotine induces conditioned place preferences over a large range of doses in rats.Q34402486
Evidence for novel cannabinoid receptorsQ34415409
Modulation of transmitter release via presynaptic cannabinoid receptorsQ34430714
Pharmacology of cannabinoid CB1 and CB2 receptors.Q34442847
Use of knock-out mice to determine the molecular basis for the actions of nicotineQ34478329
The genetic epidemiology of smokingQ34478414
Involvement of the endocannabinoid system in drug addictionQ34495242
Cellular mechanisms of nicotine addictionQ34498016
Cue dependency of nicotine self-administration and smoking.Q34498025
Nicotine dependence: studies with a laboratory modelQ34498036
Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitorsQ34532228
Neurobiology of relapse to heroin and cocaine seeking: a reviewQ34547387
Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe studyQ34556870
Non-nicotinic therapies for smoking cessation.Q34599269
Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation.Q34605939
Cannabinoid addiction: behavioral models and neural correlates.Q34616145
Treatment of tobacco dependence: integrating recent progress into practiceQ34715360
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous systemQ34745063
Cellular and synaptic mechanisms of nicotine addictionQ35000325
The genetic determinants of smokingQ35124903
Twin concordance for a binary trait. II. Nested analysis of ever-smoking and ex-smoking traits and unnested analysis of a "committed-smoking" traitQ35200130
Nicotine as a modulator of behavior: beyond the inverted U.Q35216455
Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addictionQ35541262
Neuroadaptive effects of active versus passive drug administration in addiction research.Q35579511
Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropionQ35613704
Current pharmacological treatments for nicotine dependenceQ35629258
Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbensQ35682043
The endocannabinoid system and its therapeutic exploitationQ35876026
Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence.Q35938826
Cannabinoids and gene expression during brain development.Q35950914
Second-order schedules: extended sequences of behavior controlled by brief environmental stimuli associated with drug self-administrationQ40263092
The scientific case that nicotine is addictive.Q40510452
Pharmacology of nicotine and its therapeutic use in smoking cessation and neurodegenerative disordersQ40955351
Factors associated with participation, attrition, and outcome in a smoking cessation program at the workplaceQ41295074
Molecular Aspects of Cannabinoid ReceptorsQ41519833
The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in ratsQ41962278
Behavioural and biochemical evidence for interactions between Delta 9-tetrahydrocannabinol and nicotine.Q42154370
Activation of multiple transcription factor genes by tetrahydrocannabinol in rat forebrainQ42281865
Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistryQ42471010
A comparison of delta 9-THC and anandamide induced c-fos expression in the rat forebrainQ42539487
Cannabinoid receptor gene (CNR1): association with i.v. drug use.Q42550174
Cannabinoid CB1 receptors are involved in motivational effects of nicotine in ratsQ42661076
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's diseaseQ43504648
Characterizing concerns about post-cessation weight gain: results from a national survey of women smokersQ43549140
Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminalsQ43574291
Evidence for a new G protein-coupled cannabinoid receptor in mouse brain.Q43641975
A common profile of prefrontal cortical activation following exposure to nicotine- or chocolate-associated contextual cuesQ43715532
Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus.Q43742950
GABA mechanisms in the pedunculopontine tegmental nucleus influence particular aspects of nicotine self-administration selectively in the rat.Q43794898
Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoidsQ44051647
Preferential stimulation of dopamine release in the nucleus accumbens by opiates, alcohol, and barbiturates: studies with transcerebral dialysis in freely moving ratsQ44086486
Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence.Q44182704
Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaineQ44189376
SR141716, a central cannabinoid (CB(1)) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in ratsQ44190296
Reconciling conflicting findings regarding postcessation weight concerns and success in smoking cessationQ44229738
Nicotine maintains robust self-administration in rats on a limited-access scheduleQ44290531
Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptorQ44303656
Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanismQ44346123
Classically conditioned responses in opioid and cocaine dependence: a role in relapse?Q44348701
A dopamine-mu1 opioid link in the rat ventral tegmentum shared by palatable food (Fonzies) and non-psychostimulant drugs of abuse.Q44350045
Subsecond dopamine release promotes cocaine seeking.Q44398175
The endogenous cannabinoid anandamide inhibits alpha7 nicotinic acetylcholine receptor-mediated responses in Xenopus oocytesQ44453346
Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus.Q44545264
Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors.Q44723162
Dopamine operates as a subsecond modulator of food seeking.Q44762650
Nicotine serves as an effective reinforcer of intravenous drug-taking behavior in human cigarette smokersQ44784239
Neuroscience of addictionQ44880443
CNR1 variation modulates risk for drug and alcohol dependenceQ44896757
The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in miceQ44916561
Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuseQ45004332
Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal: reversal by the cannabinoid (CB1) receptor antagonist, rimonabant (SR141716).Q45006435
The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]racloprideQ45047801
Rimonabant, a CB1 antagonist, blocks nicotine-conditioned place preferences.Q45108517
Acetaldehyde enhances acquisition of nicotine self-administration in adolescent ratsQ45117312
Neuroscience. What genes tell us about nicotine addictionQ45140704
Delta9-tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in miceQ45153251
The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activityQ45171657
Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation.Q45173372
Endogenous cannabinoid signalingQ46128123
(AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population.Q46385269
Altered Fos expression in neural pathways underlying cue-elicited drug seeking in the rat.Q46425139
Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A.Q46499076
Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptorsQ46586967
beta2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 miceQ46679002
Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemiaQ46807918
Endogenous cannabinoid anandamide inhibits nicotinic acetylcholine receptor function in mouse thalamic synaptosomesQ46808737
The cannabinoid antagonist AM251 attenuates nicotine self-administration and nicotine-seeking behaviour in ratsQ46870466
Individual differences in nicotine dependence, withdrawal symptoms, and sex predict transient fMRI-BOLD responses to smoking cuesQ46911648
A neutral CB1 receptor antagonist reduces weight gain in rat.Q46932962
Are weight concerns predictive of smoking cessation? A prospective analysisQ47308290
Understanding the relations between smoking and body weight and their importance to smoking cessation and relapseQ47420228
Cigarette smoking and alcohol use in Finland and Sweden: a cross-national twin studyQ47585426
Nicotine-induced limbic cortical activation in the human brain: a functional MRI studyQ47704131
Cortico-limbic circuitry for conditioned nicotine-seeking behavior in rats involves endocannabinoid signalingQ48142913
Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotineQ48205587
P433issue5
P921main subjectendocannabinoid systemQ368952
P304page(s)468-481
P577publication date2008-11-01
P1433published inCNS and Neurological DisordersQ15724632
P1476titleThe endocannabinoid system: a new molecular target for the treatment of tobacco addiction
P478volume7