Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling

scientific article published on 19 April 2016

Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.8835
P932PMC publication ID5045402
P698PubMed publication ID27105493

P50authorIrene Oi-lin NgQ67487913
Terence Kin-Wah LeeQ73885432
Regina C L LoQ80738812
P2093author name stringAlan Ka-Lun Kai
Carmen Oi-Ning Leung
Kwan-Shuen Chan
Wing-Nga Mak
P2860cites workUpregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicityQ24292793
MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma.Q53261686
Analysis of SOX9 expression in colorectal cancer.Q54506833
Cancer stem cellsQ80312237
Human hepatocellular carcinomas with "Stemness"-related marker expression: keratin 19 expression and a poor prognosisQ82299264
Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cellsQ24320123
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APCQ24336321
Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factorsQ24676478
Frizzled7 as an emerging target for cancer therapyQ26849278
β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and TumorigenesisQ28087660
Sox9 and Hif-2α regulate TUBB3 gene expression and affect ovarian cancer aggressivenessQ28236570
Hypoxia and regulation of cancer cell stemnessQ33705149
Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinomaQ33976991
Slug and Sox9 cooperatively determine the mammary stem cell stateQ34030957
Hippo pathway activity influences liver cell fateQ34060093
Interactions between cancer stem cells and their niche govern metastatic colonizationQ34239769
beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance.Q34302259
SOXs in human prostate cancer: implication as progression and prognosis factors.Q34306308
Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad.Q34630557
Clinical significance of SOX9 in human non-small cell lung cancer progression and overall patient survivalQ35856469
Oncogenicity of the developmental transcription factor Sox9.Q36043468
Sox9 is required for prostate development and prostate cancer initiationQ36234048
Expression features of SOX9 associate with tumor progression and poor prognosis of hepatocellular carcinomaQ36299435
Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in miceQ36421780
SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/β-catenin activation in breast cancerQ36647355
Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinomaQ36755188
Cancer stem cells in the development of liver cancerQ36793453
Epigenetic regulation of SOX9 by the NF-κB signaling pathway in pancreatic cancer stem cellsQ37179115
SOX9: a stem cell transcriptional regulator of secreted niche signaling factorsQ37608199
Epigenetic signatures in stem cells and cancer stem cells.Q37961998
Liver tumor-initiating cells as a therapeutic target for hepatocellular carcinoma.Q38009569
SOX9 Overexpression Promotes Glioma Metastasis via Wnt/β-Catenin SignalingQ38906000
β-catenin activation in a novel liver progenitor cell type is sufficient to cause hepatocellular carcinoma and hepatoblastomaQ38993024
CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulationQ39512947
Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinomaQ40385782
The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site.Q40461728
Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cellsQ40843426
Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like propertiesQ42030667
Loss of TGF-β adaptor β2SP activates notch signaling and SOX9 expression in esophageal adenocarcinomaQ42557385
SOX9 regulates endocrine cell differentiation during human fetal pancreas development.Q51851391
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine.Q51894736
SOX9 regulates ERBB signalling in pancreatic cancer development.Q53229089
P433issue20
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)29371-29386
P577publication date2016-05-01
P1433published inOncotargetQ1573155
P1476titleSox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling
P478volume7

Reverse relations

cites work (P2860)
Q92554204A SOX9-AS1/miR-5590-3p/SOX9 positive feedback loop drives tumor growth and metastasis in hepatocellular carcinoma through the Wnt/β-catenin pathway
Q93004356Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside
Q53708414Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway.
Q48526220Deregulation of Frizzled Receptors in Hepatocellular Carcinoma.
Q64105262Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma
Q33276544Expression and Therapeutic Potential of SOX9 in Chordoma
Q98158767Extracellular ATP promotes breast cancer invasion and chemoresistance via SOX9 signaling
Q55080511Frizzled Receptors as Potential Therapeutic Targets in Human Cancers.
Q90308396In vitro transformation of primary human hepatocytes: Epigenetic changes and stemness properties
Q64055307Induction of tolerogenic dendritic cells by activated TGF-β/Akt/Smad2 signaling in RIG-I-deficient stemness-high human liver cancer cells
Q47095936Linc-ROR promotes esophageal squamous cell carcinoma progression through the derepression of SOX9.
Q98906859MYEOV increases HES1 expression and promotes pancreatic cancer progression by enhancing SOX9 transactivity
Q64106031Notch Inhibition Promotes Differentiation of Liver Progenitor Cells into Hepatocytes via Repression in Zebrafish
Q52585710Odd-skipped related 1 inhibits lung cancer proliferation and invasion by reducing Wnt signaling through the suppression of SOX9 and β-catenin.
Q64095213SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer
Q93016744SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance
Q47094928SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types.
Q91756222SOX9 promotes epithelial-mesenchymal transition via the Hippo-YAP signaling pathway in gastric carcinoma cells
Q52764125Small bowel carcinomas in celiac or Crohn's disease: distinctive histophenotypic, molecular and histogenetic patterns.
Q37692443Sox9 transcriptionally regulates Wnt signaling in intestinal epithelial stem cells in hypomethylated crypts in the diabetic state
Q50916178Tg737 acts as a key driver of invasion and migration in liver cancer stem cells and correlates with poor prognosis in patients with hepatocellular carcinoma.
Q97075825The Hepatic Sinusoid in Aging and Disease: Update and Advances From the 20th Liver Sinusoid Meeting
Q38604538Upregulation of GNL3 expression promotes colon cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway
Q38648415Variation of stemness markers expression in tumor nodules from synchronous multi-focal hepatocellular carcinoma - an immunohistochemical study.
Q48513742cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation.
Q64262257miR-135 regulated breast cancer proliferation and epithelial-mesenchymal transition acts by the Wnt/β-catenin signaling pathway
Q46735091β-Catenin Deficiency in Hepatocytes Aggravates Hepatocarcinogenesis Driven by Oncogenic β-Catenin and MET.

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