Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II

scientific article published on December 15, 1992

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1992PNAS...8911920D
P356DOI10.1073/PNAS.89.24.11920
P953full work available at URLhttps://europepmc.org/articles/PMC50669
https://europepmc.org/articles/PMC50669?pdf=render
P932PMC publication ID50669
P698PubMed publication ID1465419
P5875ResearchGate publication ID21691138

P50authorWilliam DynanQ88524515
P2093author name stringH. Lu
A. Dvir
S. R. Peterson
M. W. Knuth
P2860cites workIsolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndromeQ24558767
A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase IIQ24614481
A DNA-activated protein kinase from HeLa cell nucleiQ24633308
Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase IIQ27932567
CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiaeQ27934743
A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase IIQ28119106
Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoterQ28253961
cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigenQ28278340
Cloning of a human gene encoding the general transcription initiation factor IIBQ28292676
The human U1 snRNA promoter correctly initiates transcription in vitro and is activated by PSE1Q28621556
Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerasesQ29617053
The C-terminal repeat domain of RNA polymerase II largest subunit is essential in vivo but is not required for accurate transcription initiation in vitroQ33576282
Mutations in RNA polymerase II enhance or suppress mutations in GAL4.Q33850755
Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. wt. heat-shock protein in animal cell extractsQ33930822
An RNA polymerase II transcription factor has an associated DNA-dependent ATPase (dATPase) activity strongly stimulated by the TATA region of promotersQ34306436
Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigenQ35131599
The C-terminal domain of the largest subunit of RNA polymerase II of Saccharomyces cerevisiae, Drosophila melanogaster, and mammals: a conserved structure with an essential functionQ35619254
Analysis of the mechanism of interaction of simian Ku protein with DNAQ35788212
Use of monoclonal antibodies for the characterization of novel DNA-binding proteins recognized by human autoimmune seraQ36349787
Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complexQ36774375
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigenQ36774702
Genetic analysis of the repetitive carboxyl-terminal domain of the largest subunit of mouse RNA polymerase IIQ36780765
A carboxyl-terminal-domain kinase associated with RNA polymerase II transcription factor delta from rat liverQ37151396
A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II.Q37537860
Mechanism of promoter selection by RNA polymerase II: mammalian transcription factors alpha and beta gamma promote entry of polymerase into the preinitiation complexQ37548660
The small subunit of transcription factor IIF recruits RNA polymerase II into the preinitiation complexQ37617495
Nuclear proteins TREF1 and TREF2 bind to the transcriptional control element of the transferrin receptor gene and appear to be associated as a heterodimerQ38343243
Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlapQ40684049
Transcription-dependent structural changes in the C-terminal domain of mammalian RNA polymerase subunit IIa/o.Q41305990
Identification of phosphorylation sites in the repetitive carboxyl-terminal domain of the mouse RNA polymerase II largest subunit.Q41695825
CTD kinase associated with yeast RNA polymerase II initiation factor b.Q44229085
Inhibition of in vivo and in vitro transcription by monoclonal antibodies prepared against wheat germ RNA polymerase II that react with the heptapeptide repeat of eukaryotic RNA polymerase II.Q44259355
Phosphorylation of RNA polymerase IIA occurs subsequent to interaction with the promoter and before the initiation of transcriptionQ46409988
Promoter-dependent transcription by RNA polymerase II using immobilized enzyme complexesQ46825216
Cloning of a subunit of yeast RNA polymerase II transcription factor b and CTD kinaseQ48158311
Promoter-dependent phosphorylation of RNA polymerase II by a template-bound kinase. Association with transcriptional initiationQ52236882
Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2Q58997292
RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signalsQ59076397
Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase IIQ59098636
The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIaQ64378924
HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complexQ64379078
Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNAQ67728079
RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitroQ67782272
DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeatsQ68074474
Phosphorylation causes a conformational change in the carboxyl-terminal domain of the mouse RNA polymerase II largest subunitQ68187252
On the mechanisms of ku protein binding to DNAQ68211245
Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disordersQ68858908
Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase IIQ69222476
A protein kinase from wheat germ that phosphorylates the largest subunit of RNA polymerase IIQ69323019
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits a HeLa protein kinase that phosphorylates an RNA polymerase II-derived peptideQ69973755
Mechanism of interaction between Ku protein and DNAQ70144316
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
nuclear antigensQ76742702
P304page(s)11920-11924
P577publication date1992-12-01
1992-12-15
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleKu autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II
P478volume89

Reverse relations

cites work (P2860)
Q7276837710th International Conference on Methods in Protein Structure Analysis. September 8-13, 1994, Snowbird, Utah. Short communications and abstracts
Q35997819A Drosophila protein homologous to the human p70 Ku autoimmune antigen interacts with the P transposable element inverted repeats
Q38306266A Ku80 fragment with dominant negative activity imparts a radiosensitive phenotype to CHO-K1 cells
Q34656593A central region of Ku80 mediates interaction with Ku70 in vivo
Q32150396A low-pH culture condition enhances the radiosensitizing effect of wortmannin
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Q36777827A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining
Q64388179A method to detect particle-specific antibodies against Ku and the DNA-dependent protein kinase catalytic subunit in autoimmune sera
Q48002807A somatostatin analogue induces translocation of Ku 86 autoantigen from the cytosol to the nucleus in colon tumour cells
Q29547883ATR: an essential regulator of genome integrity
Q36364964Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis
Q41368190Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line
Q33786814An alternate form of Ku80 is required for DNA end-binding activity in mammalian mitochondria
Q36684796An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells
Q46107069Antigen receptor gene rearrangement
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Q37353084Autoantibodies to DNA-dependent protein kinase. Probes for the catalytic subunit
Q34157808Autoantibodies to RNA polymerase II are common in systemic lupus erythematosus and overlap syndrome. Specific recognition of the phosphorylated (IIO) form by a subset of human sera
Q38301372Autoantigen Ku protein is involved in DNA binding proteins which recognize the U5 repressive element of human T-cell leukemia virus type I long terminal repeat
Q27919629Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
Q44490255Bacterial and eukaryotic systems collide in the three Rs of Methanococcus.
Q26827232Beyond DNA repair: DNA-PK function in cancer
Q24678907Biochemical evidence for Ku-independent backup pathways of NHEJ
Q71525106CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme
Q35855807CREB-binding protein is a mediator of neuroblastoma cell death induced by the histone deacetylase inhibitor trichostatin A.
Q41191958Characterization of a Ku86 variant protein that results in altered DNA binding and diminished DNA-dependent protein kinase activity
Q41116291Characterization of two DNA double-stranded break repair-deficient cell lines that express inactive DNA-dependent protein kinase catalytic subunits
Q28623271Common and unique transcription factor requirements of human U1 and U6 snRNA genes
Q24653672Common mechanisms of PIKK regulation
Q34746959Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen
Q29614218Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
Q44290667Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
Q41044013Cutting apart V(D)J recombination
Q47070264DNA binding specificities of YPF1, a Drosophila homolog to the DNA binding subunit of human DNA-dependent protein kinase, Ku.
Q26829155DNA damage response and prostate cancer: defects, regulation and therapeutic implications
Q90055320DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR
Q39876259DNA double-strand break repair functions defend against parvovirus infection.
Q35965069DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae
Q36144172DNA ends alter the molecular composition and localization of Ku multicomponent complexes
Q28143901DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system
Q36126604DNA looping by Ku and the DNA-dependent protein kinase
Q34880194DNA structure-specific priming of ATR activation by DNA-PKcs
Q33181420DNA-Dependent protein kinase is not required for efficient lentivirus integration
Q40315391DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner
Q90628309DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer
Q34367487DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex
Q41513507DNA-PK: at the cross-roads of biochemistry and genetics
Q38852980DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis
Q35603296DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.
Q36371923DNA-dependent protein kinase activity is not required for immunoglobulin class switching
Q35899741DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis
Q64388891DNA-dependent protein kinase protects against heat-induced apoptosis
Q34519398DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.
Q35739034DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
Q37308089Defective signal joint recombination in fanconi anemia fibroblasts reveals a role for Rad50 in V(D)J recombination
Q36887381Defining the minimal domain of Ku80 for interaction with Ku70.
Q36430308Dimerization and DNA binding alter phosphorylation of Fos and Jun.
Q44548807Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation
Q47996057Double-strand break repair mediated by DNA end-joining
Q24608343Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
Q36252549Engagement of Components of DNA-Break Repair Complex and NFκB in Hsp70A1A Transcription Upregulation by Heat Shock
Q34999232Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation
Q50926972Ensemble and Single-Molecule Analysis of Non-Homologous End Joining in Frog Egg Extracts.
Q33702830Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.
Q24649590Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes
Q36580698Evidence for Ku70/Ku80 association with full-length RAG1.
Q64387979Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma
Q31861467Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues.
Q28284325Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element
Q33770481Functional characterization of a novel Ku70/80 pause site at the H19/Igf2 imprinting control region
Q73877076Functional properties of the separate subunits of human DNA helicase II/Ku autoantigen
Q24564348Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8
Q92513981Genetic expression signatures of oral submucous fibrosis and oral cancer-A preliminary microarray report
Q52522266HDF2, the second subunit of the Ku homologue from Saccharomyces cerevisiae.
Q38329558Hairpin coding end opening is mediated by RAG1 and RAG2 proteins
Q39716405Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination
Q42800551Heat and chemical shock potentiation of glucocorticoid receptor transactivation requires heat shock factor (HSF) activity. Modulation of HSF by vanadate and wortmannin
Q28250857Heat shock transcription factor 1 binds selectively in vitro to Ku protein and the catalytic subunit of the DNA-dependent protein kinase
Q34626147Heat-shock inactivation of the TFIIH-associated kinase and change in the phosphorylation sites on the C-terminal domain of RNA polymerase II.
Q35845807Herpes simplex virus immediate-early protein ICP22 is required for viral modification of host RNA polymerase II and establishment of the normal viral transcription program
Q24336453Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen
Q71143177Human Ku autoantigen binds cisplatin-damaged DNA but fails to stimulate human DNA-activated protein kinase
Q64387661Human neutrophils isolated from peripheral blood contain Ku protein but not DNA-dependent protein kinase
Q39576173Hypersensitivity of Ku-deficient cells toward the DNA topoisomerase II inhibitor ICRF-193 suggests a novel role for Ku antigen during the G2 and M phases of the cell cycle
Q42831224Hypoxia-activated ligand HAL-1/13 is lupus autoantigen Ku80 and mediates lymphoid cell adhesion in vitro
Q58244290Identification of Ku70/Ku80 as ADD1/SREBP1c interacting proteins
Q36820879Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse
Q34966793Impact of DNA ligase IV on the fidelity of end joining in human cells
Q24294826In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex
Q32119114In vitro-activated human lupus T cells express normal estrogen receptor proteins which bind to the estrogen response element
Q39265275In vivo association of Ku with mammalian origins of DNA replication
Q39945316Increased expression of HSP27 linked to vincristine resistance in human gastric cancer cell line
Q39574798Inhibition of HTLV-1 transcription by cyclin dependent kinase inhibitors
Q33818265Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)
Q33570316Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2
Q28608946Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids
Q24290239Interaction of human Ku70 with TRF2
Q40408378Interactions of USF and Ku antigen with a human DNA region containing a replication origin
Q38321453Involvement of DNA end-binding protein Ku in Ty element retrotransposition
Q52519451Involvement of the Saccharomyces cerevisiae HDF1 gene in DNA double-strand break repair and recombination.
Q38287589KAP-2, a protein that binds to the H-box in a bean chalcone synthase promoter, is a novel plant transcription factor with sequence identity to the large subunit of human Ku autoantigen
Q24532230KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity
Q43613070Ku antigen is required to relieve G2 arrest caused by inhibition of DNA topoisomerase II activity by the bisdioxopiperazine ICRF-193.
Q40473460Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.
Q28137885Ku, a DNA repair protein with multiple cellular functions?
Q52549796Ku-related antigens are associated with transcriptionally active loci in Chironomus polytene chromosomes.
Q33935153Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors
Q36380622Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo
Q42647102Ku80 facilitates chromatin binding of the telomere binding protein, TRF2
Q41081073Ku80 gene expression is Sp1-dependent and sensitive to CpG methylation within a novel cis element
Q38337002Ku80 is required but not sufficient for Galpha13-mediated endodermal differentiation in P19 embryonic carcinoma cells
Q24527652Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element
Q24670086Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus recruits uracil DNA glycosylase 2 at the terminal repeats and is important for latent persistence of the virus
Q78805217Lethality in PARP-1/Ku80 double mutant mice reveals physiological synergy during early embryogenesis
Q34419609Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells
Q28282983MDC1 regulates DNA-PK autophosphorylation in response to DNA damage
Q24548851Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
Q41049010Mechanism of V(D)J recombination
Q39982082Modification of the ionizing radiation response in living cells by an scFv against the DNA-dependent protein kinase
Q37473890Modifying the function of DNA repair nanomachines for therapeutic benefit
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Q40021061Molecular and biochemical characterization of xrs mutants defective in Ku80.
Q40468515Molecular structure and function of autoantigens in systemic sclerosis.
Q41551864Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens
Q33854272Non-homologous end joining: emerging themes and unanswered questions
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Q38289667Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene
Q38327349OBA/Ku86: DNA binding specificity and involvement in mammalian DNA replication
Q34093159Phosphorylation in transcription: the CTD and more
Q34604946Phosphorylation of human replication protein A by the DNA-dependent protein kinase is involved in the modulation of DNA replication
Q36565906Phosphorylation of the RNA polymerase II largest subunit during Xenopus laevis oocyte maturation
Q40401377Production and characterization of recombinant human Ku antigen
Q24293029Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells
Q40015992Proximal sequence element-binding transcription factor (PTF) is a multisubunit complex required for transcription of both RNA polymerase II- and RNA polymerase III-dependent small nuclear RNA genes
Q30845708Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase
Q24568357Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen
Q42099538RNA polymerase II C-terminal heptarepeat domain Ser-7 phosphorylation is established in a mediator-dependent fashion
Q33905060RNA polymerase II carboxy-terminal domain kinases: emerging clues to their function
Q36627034RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection
Q41430421Recent advances in understanding V(D)J recombination.
Q40499369Recombination and repair. Ku starts at the end.
Q33559700Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction
Q42811268Reduced sulphydryl groups are required for DNA binding of Ku protein
Q34816680Regulation of transcription elongation by phosphorylation
Q35466760Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair
Q71785541Relationship between estrogen structure and conformational changes in estrogen receptor/DNA complexes
Q28076969Replication fork instability and the consequences of fork collisions from rereplication
Q29618204Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair
Q41211021Role of protein kinase activity in apoptosis.
Q24561996Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways
Q72180517Similar DNA binding properties of free P70 (KU) subunit and P70/P80 heterodimer
Q72465867Stimulation of the DNA-dependent protein kinase by RNA polymerase II transcriptional activator proteins
Q24644339Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4
Q33914715Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time
Q37021606Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex
Q24537786Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites.
Q38359074Suppression of a DNA double-strand break repair gene, Ku70, increases radio- and chemosensitivity in a human lung carcinoma cell line
Q52558943TET1 deficiency attenuates the DNA damage response and promotes resistance to DNA damaging agents.
Q38008913TFIIH: when transcription met DNA repair.
Q37379581The 86-kD subunit of Ku autoantigen mediates homotypic and heterotypic adhesion of multiple myeloma cells
Q24554509The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit
Q38314660The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity
Q34315021The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication
Q29465403The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae
Q34009427The DNA-damage response: new molecular insights and new approaches to cancer therapy
Q64389407The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit
Q41263744The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight
Q28081821The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis
Q41066922The DNA-dependent protein kinase: a matter of life and (cell) death
Q37259294The Ku-like protein from Saccharomyces cerevisiae is required in vitro for the assembly of a stable multiprotein complex at a eukaryotic origin of replication
Q77388156The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase
Q41951178The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain
Q40406792The nucleolar transcription activator UBF relieves Ku antigen-mediated repression of mouse ribosomal gene transcription
Q24310169The promoters for human DNA-PKcs (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11
Q49906238The role of DNA-PK in aging and energy metabolism
Q28296356The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control
Q36418531The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage
Q40639070The role of multisite phosphorylation in the regulation of RNA polymerase II activity
Q41412080The salivary gland 42-kDa phosphoprotein is a single-stranded DNA-binding protein with characteristics of the epithelial casein kinase N42 in Chironomus tentans
Q38196597The spatial organization of non-homologous end joining: from bridging to end joining
Q40856128Transcription by RNA polymerase II in DNA-PK deficient scid mouse cells
Q37082620Tumor Suppressors and Endodermal Differentiation of P19 Embryonic Stem Cells
Q30729763Two-Stage Synapsis of DNA Ends during Non-homologous End Joining
Q35159001Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination
Q41888313Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling
Q36011232Up-regulation of the Ku heterodimer in Drosophila testicular cyst cells
Q41134314V(D)J recombination pathology.
Q34333584Visualization of inositol phosphate-dependent mobility of Ku: depletion of the DNA-PK cofactor InsP6 inhibits Ku mobility
Q42850240Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system
Q24568188cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein
Q36555430scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase

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