Anti-β2GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathway

scientific article published on 16 August 2013

Anti-β2GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2013-03-490318
P932PMC publication ID3843239
P698PubMed publication ID23954892
P5875ResearchGate publication ID255975197

P2093author name stringBelinda Willard
Venkaiah Betapudi
Keith R McCrae
Meifang Wu
George Lominadze
Linda Hsi
P2860cites workHigh affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin IIQ22254095
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Non-muscle myosin II takes centre stage in cell adhesion and migrationQ28262326
International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)Q28292418
Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146.Q30164911
Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective mannerQ30304130
A novel pathway for human endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodiesQ30422807
Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motilityQ30471919
Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.Q30497721
Activation of cultured vascular endothelial cells by antiphospholipid antibodies.Q33488617
Antiphospholipid syndrome: a comprehensive review of a complex and multisystemic disease.Q35004519
Endothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factorsQ35067429
Endothelial microparticles as markers of endothelial dysfunctionQ35672659
Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assayQ35792021
Current concepts on the pathogenesis of the antiphospholipid syndromeQ36598158
Microparticles as mediators of cellular cross-talk in inflammatory diseaseQ36687910
Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patientsQ36947164
Nonmuscle myosin II is responsible for maintaining endothelial cell basal tone and stress fiber integrityQ36955846
Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanismsQ37249524
Are endothelial microparticles potential markers of vascular dysfunction in the antiphospholipid syndrome?Q37510353
The role of LRP8 (ApoER2') in the pathophysiology of the antiphospholipid syndromeQ37721602
Microparticles in physiological and in pathological conditionsQ37799778
Cellular mechanisms underlying the formation of circulating microparticlesQ37821168
Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosisQ37922118
Recent developments in our understanding of the antiphospholipid syndromeQ37991066
The significance of autoantibodies against β2-glycoprotein I.Q38007155
Cooperation between β- and γ-cytoplasmic actins in the mechanical regulation of endothelial microparticle formation.Q39243315
Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2.Q40276225
Distinct roles of nonmuscle myosin II isoforms in the regulation of MDA-MB-231 breast cancer cell spreading and migrationQ40285029
Antiphospholipid antibodies, thrombin and LPS activate brain endothelial cells and Ras-dependent pathways through distinct mechanismsQ40344286
In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant.Q40851071
Human beta 2-glycoprotein I binds to endothelial cells through a cluster of lysine residues that are critical for anionic phospholipid binding and offers epitopes for anti-beta 2-glycoprotein I antibodiesQ48032183
Endothelial Microparticle Formation by Angiotensin II Is Mediated via Ang II Receptor Type I/NADPH Oxidase/ Rho Kinase Pathways Targeted to Lipid RaftsQ56991404
Annexin A2 mediates endothelial cell activation by antiphospholipid/anti- 2 glycoprotein I antibodiesQ57374964
Endothelial cells as target for antiphospholipid antibodies. Human Polyclonal and Monoclonal Anti-β2-Glycoprotein I Antibodies React In Vitro with Endothelial Cells Through Adherent β2-Glycoprotein I and Induce Endothelial ActivationQ62395215
Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactorQ68090535
Induction of endothelial cell tissue factor activity by sera from patients with antiphospholipid syndrome: a possible mechanism of thrombosisQ70529807
Relationship between anti-phospholipid and anti-endothelial cell antibodies III: beta 2 glycoprotein I mediates the antibody binding to endothelial membranes and induces the expression of adhesion moleculesQ71707854
Antiphospholipid antibodies activate vascular endothelial cellsQ71747732
Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectinQ73396795
Endothelial microparticles: a potential contribution to the thrombotic complications of the antiphospholipid syndromeQ79826484
Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activationQ80851651
Antiphospholipid antibodies from patients with the antiphospholipid syndrome induce monocyte tissue factor expression through the simultaneous activation of NF-kappaB/Rel proteins via the p38 mitogen-activated protein kinase pathway, and of the MEK-Q82132738
Antiphospholipid antibodies and the protein C pathwayQ83954291
The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter studyQ84438431
MP's and VTE's: Fact or fictionQ84980460
Endothelial microparticle release is stimulated in vitro by purified IgG from patients with the antiphospholipid syndromeQ85437025
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
endotheliumQ111140
P304page(s)3808-3817
P577publication date2013-08-16
P1433published inBloodQ885070
P1476titleAnti-β2GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathway
P478volume122

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cites work (P2860)
Q89509404A Comprehensive Picture of Extracellular Vesicles and Their Contents. Molecular Transfer to Cancer Cells
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Q34684028Changes in regulation of human monocyte proteins in response to IgG from patients with antiphospholipid syndrome
Q47982275Diagnosis and management of the antiphospholipid syndrome
Q91715341Insight into the Role of Extracellular Vesicles in Lysosomal Storage Disorders
Q54277572NMMHC IIA inhibition impedes tissue factor expression and venous thrombosis via Akt/GSK3β-NF-κB signalling pathways in the endothelium.
Q57177487The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases
Q51064693Vitamin D suppresses oxidative stress-induced microparticle release by human umbilical vein endothelial cells.

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