Cellular and Molecular Mechanisms of Anti-Phospholipid Syndrome.

scientific article published on 7 May 2018

Cellular and Molecular Mechanisms of Anti-Phospholipid Syndrome. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2018.00969
P8608Fatcat IDrelease_n3ol57dluzc2hpquouso3j6vdu
P932PMC publication ID5949565
P698PubMed publication ID29867951

P50authorMarko RadicQ57542832
P2093author name stringDebendra Pattanaik
P2860cites workAnti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)Q24558202
Extracellular DNA traps promote thrombosis.Q24613579
Molecular analysis of major histocompatibility complex alleles associated with the lupus anticoagulantQ24633473
Crystal structure of human β2-glycoprotein I: implications for phospholipid binding and the antiphospholipid syndromeQ27620388
Mechanisms of thrombosis in systemic lupus erythematosus and antiphospholipid syndromeQ47311173
HLA-DRB1 alleles and beta 2 glycoprotein I-dependent anticardiolipin antibodies in Japanese patients with systemic lupus erythematosus.Q47677888
Monoclonal antibodies from NZW x BXSB F1 mice to beta2 glycoprotein I and cardiolipin. Species specificity and charge-dependent binding.Q48065124
Antiphospholipid antibody-mediated effects in an arterial model of thrombosis are dependent on Toll-like receptor 4.Q48074369
Familial anticardiolipin antibodies and C4 deficiency genotypes that coexist with MHC DQB1 risk factors.Q49185648
Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study.Q50619255
Activation of mTOR is involved in anti-β2GPI/β2GPI-induced expression of tissue factor and IL-8 in monocytes.Q52567143
NF-κB is activated from endosomal compartments in antiphospholipid antibodies-treated human monocytes.Q53063239
A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways.Q53598537
PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis.Q53609970
Anti-phospholipid antibodies in HIV infection and SLE with or without anti-phospholipid syndrome: comparisons of phospholipid specificity, avidity and reactivity with beta2-GPI.Q54073056
Impaired expression of endometrial differentiation markers and complement regulatory proteins in patients with recurrent pregnancy loss associated with antiphospholipid syndrome.Q54599187
Inhibition of the mTORC pathway in the antiphospholipid syndrome.Q55072769
[Antiphospholipid antibodies, antiphospholipid syndrome and viral infections].Q55239351
Familial antiphospholipid antibody syndrome: Criteria for disease and evidence for autosomal dominant inheritanceQ57186231
Complement activation in patients with isolated antiphospholipid antibodies or primary antiphospholipid syndromeQ57624160
Major histocompatibility complex associations with primary antiphospholipid syndromeQ58143748
Neutrophil extracellular traps kill bacteriaQ27860996
HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosusQ28138464
Antiphospholid antibodies regulate the expression of trophoblast cell adhesion moleculesQ28213303
Brief report: induction of sustained remission in recurrent catastrophic antiphospholipid syndrome via inhibition of terminal complement with eculizumabQ28260452
Eculizumab and renal transplantation in a patient with CAPSQ28281405
International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)Q28292418
Anti-phospholipid antibodies and biological false positive serological test for syphilis in patients with systemic lupus erythematosusQ28365920
Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factorQ28565242
Neutrophil recruitment and function in health and inflammationQ29616689
Histone deimination as a response to inflammatory stimuli in neutrophils.Q30367246
Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.Q30497721
Neutrophil extracellular traps: is immunity the second function of chromatin?Q30524665
Complement C3 activation is required for antiphospholipid antibody-induced fetal lossQ33340713
Bacterial induction of autoantibodies to beta2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndromeQ33341518
E-Selectin mediates pathogenic effects of antiphospholipid antibodiesQ33349081
The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosusQ33360375
Anticardiolipin antibodies in NZW x BXSB F1 mice. A model of antiphospholipid syndromeQ33369548
Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodiesQ33384065
Non-criteria manifestations of antiphospholipid syndromeQ33388991
High incidence of anticardiolipin antibodies in relatives of patients with systemic lupus erythematosusQ33455163
A family study of anticardiolipin antibodies and associated clinical conditionsQ33487561
Multigenic control of lupus-associated antiphospholipid syndrome in a model of (NZW x BXSB) F1 miceQ33503790
Thrombosis: tangled up in NETsQ33556910
Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome.Q33576496
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndromeQ33630007
β₂-Glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model.Q33796355
The role of neutrophils and NETosis in autoimmune and renal diseasesQ33904653
Platelets are required for enhanced activation of the endothelium and fibrinogen in a mouse thrombosis model of APS.Q33948737
Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cellsQ33950104
Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways.Q33967600
The neutrophil as a cellular source of chemokinesQ34118783
Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients.Q34296850
The pathogenesis of the antiphospholipid syndromeQ34332601
Immune responses against domain I of β2-glycoprotein I are driven by conformational changes: Domain I of β2-glycoprotein I harbors a cryptic immunogenic epitopeQ58895662
Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent plateletsQ59065667
Toll-like receptor 4 and β2 glycoprotein I interaction on endothelial cellsQ60547104
Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophiliaQ61415575
Human Cytomegalovirus Induces Systemic Immune Activation Characterized by a Type 1 Cytokine SignatureQ61863439
Associations of anti-beta2-glycoprotein I autoantibodies with HLA class II alleles in three ethnic groupsQ61943923
Human monoclonal anti-phospholipid antibodies selectively bind to membrane phospholipid and beta2-glycoprotein I (beta2-GPI) on apoptotic cells.Q64966940
Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactorQ68090535
Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: a model for autoimmune fetal lossQ68528823
Thrombogenic properties of murine anti-cardiolipin antibodies induced by beta 2 glycoprotein 1 and human immunoglobulin G antiphospholipid antibodiesQ71613866
Connective tissue disease and the chronic biologic false-positive test for syphilis (BFP reaction)Q72190106
HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patientsQ73395887
Blebs and apoptotic bodies are B cell autoantigensQ74334880
The antiphospholipid syndromeQ77739053
A role for the polymorphism at position 247 of the beta2-glycoprotein I gene in the generation of anti-beta2-glycoprotein I antibodies in the antiphospholipid syndromeQ78124733
A peptide that mimics the Vth region of beta-2-glycoprotein I reverses antiphospholipid-mediated thrombosis in miceQ79869726
The antiphospholipid syndromeQ79870443
The placental bed in pregnancies complicated by primary antiphospholipid syndromeQ80349512
Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activationQ80851651
TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy lossQ81178348
Complement activation in patients with primary antiphospholipid syndromeQ81638094
Anti-phospholipid antibody mediated fetal loss: still an open question from a pathogenic point of viewQ83954324
Antibodies to Domain I of β(2)Glycoprotein I are in close relation to patients risk categories in Antiphospholipid Syndrome (APS)Q84212281
Phagocytosis of platelet microvesicles and beta2- glycoprotein IQ84388641
The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter studyQ84438431
Antiphospholipid syndrome: antibodies to Domain 1 of β2-glycoprotein 1 correctly classify patients at riskQ86646346
Cellular signaling by antiphospholipid antibodiesQ87418426
Pathogenesis of the antiphospholipid syndrome revisited: time to challenge the dogmaQ87506720
MHC Class II Alleles influence Induction of Pathogenic Antiphospholipid Antibodies in a Thrombosis Mouse ModelQ38699947
Pathogenesis and management of antiphospholipid syndromeQ39198671
In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody-Mediated Venous ThrombosisQ39328138
Clinical course of high-risk patients diagnosed with antiphospholipid syndromeQ39934417
In vivo inhibition of antiphospholipid antibody-induced pathogenicity utilizing the antigenic target peptide domain I of beta2-glycoprotein I: proof of conceptQ40002234
Cofactor-independent human antiphospholipid antibodies induce venous thrombosis in miceQ40087226
Endothelial cells as a target for antiphospholipid antibodies: role of anti-beta 2 glycoprotein I antibodies.Q41084661
Release of neutrophil extracellular traps by neutrophils stimulated with antiphospholipid antibodies: a newly identified mechanism of thrombosis in the antiphospholipid syndrome.Q41818166
Activated signature of antiphospholipid syndrome neutrophils reveals potential therapeutic targetQ42162703
V gene analysis of anticardiolipin antibodies from MRL-lpr/lpr miceQ42799873
Residues that mediate DNA binding of autoimmune antibodiesQ42799912
Complement C5-inhibitor rEV576 (coversin) ameliorates in-vivo effects of antiphospholipid antibodies.Q43984230
Thrombogenicity of beta 2-glycoprotein I-dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamsterQ44189585
Valine/valine genotype at position 247 of the beta2-glycoprotein I gene in Mexican patients with primary antiphospholipid syndrome: association with anti-beta2-glycoprotein I antibodiesQ44305352
beta2-glycoprotein I-dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndromeQ45021710
Characterization of estrogen-induced autoantibodies to cardiolipin in non-autoimmune miceQ45105184
Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activationQ45111033
Rivaroxaban limits complement activation compared with warfarin in antiphospholipid syndrome patients with venous thromboembolismQ45857473
Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsiaQ47105114
Oxidation of β2-glycoprotein I associates with IgG antibodies to domain I in patients with antiphospholipid syndromeQ47116452
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727.Q47233334
Emerging concepts in the molecular pathogenesis of systemic lupus erythematosusQ34578430
Heterogeneity of laboratory test results for antiphospholipid antibodies in patients treated with chlorpromazine and other phenothiazinesQ35000251
Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in miceQ35070716
β2-Glycoprotein I-specific T cells are associated with epitope spread to lupus-related autoantibodiesQ35126642
Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of β2-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosisQ35214636
Pathophysiology of the antiphospholipid antibody syndromeQ35309024
Theodore E. Woodward Award: antiphospholipid syndrome revisited: a disorder initiated by inflammationQ35778578
Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6.Q35844573
Anti-phospholipid induced murine fetal loss: novel protective effect of a peptide targeting the β2 glycoprotein I phospholipid-binding site. Implications for human fetal loss.Q35854768
Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndromeQ35874202
Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modification of the major autoantigen β2-glycoprotein I.Q35895238
The Effects of NF-κB and c-Jun/AP-1 on the Expression of Prothrombotic and Proinflammatory Molecules Induced by Anti-β2GPI in MouseQ35909733
N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trialQ36139749
Current trends in drug-induced autoimmunityQ36180084
Immunization with an apoptotic cell-binding protein recapitulates the nephritis and sequential autoantibody emergence of systemic lupus erythematosusQ36227184
Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restrictionQ36228832
Antiphospholipid syndrome associated with infections: clinical and microbiological characteristicsQ36329966
Complement activation in anti-phospholipid syndrome: a clue for an inflammatory process?Q36785674
Antiphospholipid syndrome (APS): where does it come from?Q37027969
Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanismsQ37249524
Anti-β2GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathwayQ37349421
Antiphospholipid syndrome and systemic lupus erythematosus: are they separate entities or just clinical presentations on the same scale?Q37547996
Inhibition of thrombotic properties of persistent autoimmune anti-β2GPI antibodies in the mouse model of antiphospholipid syndromeQ37585221
The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: role in pregnancy losses and thrombosisQ37721612
Pathogenesis of antiphospholipid syndrome: understanding the antibodiesQ37873720
Molecular pathophysiology of the antiphospholipid syndrome: the role of oxidative post-translational modification of beta 2 glycoprotein I.Q37903952
Pathophysiology of thrombotic APS: where do we stand?Q38013582
The protein arginine deiminases: Structure, function, inhibition, and disease.Q38061870
From antibody to clinical phenotype, the black box of the antiphospholipid syndrome: pathogenic mechanisms of the antiphospholipid syndromeQ38130022
Citrullination of autoantigens implicates NETosis in the induction of autoimmunity.Q38167579
Risk of venous and arterial thrombosis according to type of antiphospholipid antibodies in adults without systemic lupus erythematosus: a systematic review and meta-analysisQ38177962
Clearance of Apoptotic Bodies, NETs, and Biofilm DNA: Implications for AutoimmunityQ38240144
Citrullinated Autoantigens: From Diagnostic Markers to Pathogenetic Mechanisms.Q38263755
Vasculitis in antiphospholipid syndromeQ38268555
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectthrombosisQ261327
globulinsQ321710
cellQ7868
blood proteinsQ425056
antiphospholipid syndromeQ582207
P304page(s)969
P577publication date2018-05-07
P1433published inFrontiers in ImmunologyQ27723748
P1476titleCellular and Molecular Mechanisms of Anti-Phospholipid Syndrome
P478volume9

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cites work (P2860)
Q94683713COVID-19 and ischemic stroke: Should we systematically look for lupus anticoagulant and antiphospholipid antibodies?
Q64981840Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues.
Q91868696Neutrophils-Important Communicators in Systemic Lupus Erythematosus and Antiphospholipid Syndrome
Q90230532Structural and functional characterization of β2 -glycoprotein I domain 1 in anti-melanoma cell migration
Q60961044β2-Glycoprotein I-Reactive T Cells in Autoimmune Disease

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