Diagnosis and management of the antiphospholipid syndrome

scientific article published on 30 July 2017

Diagnosis and management of the antiphospholipid syndrome is …
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P356DOI10.1016/J.BLRE.2017.07.006
P932PMC publication ID5714279
P698PubMed publication ID28784423

P50authorShruti ChaturvediQ59679810
Keith R McCraeQ60839328
P2093author name stringKeith R McCrae
Shruti Chaturvedi
P2860cites workCatastrophic antiphospholipid syndrome: international consensus statement on classification criteria and treatment guidelinesQ22255576
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E-Selectin mediates pathogenic effects of antiphospholipid antibodiesQ33349081
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Release of neutrophil extracellular traps by neutrophils stimulated with antiphospholipid antibodies: a newly identified mechanism of thrombosis in the antiphospholipid syndrome.Q41818166
Hydroxychloroquine reverses thrombogenic properties of antiphospholipid antibodies in miceQ41927420
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Antibodies to domain I of β-2-glycoprotein I and IgA antiphospholipid antibodies in patients with 'seronegative' antiphospholipid syndromeQ43090289
In vitro model of annexin A5 crystallization on natural phospholipid bilayers observed by atomic force microscopyQ43265575
Thrombotic risk assessment in the antiphospholipid syndrome requires more than the quantification of lupus anticoagulantsQ43463817
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Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control study.Q43626449
Detection of endothelial cell-reactive immunoglobulin in patients with anti-phospholipid antibodiesQ43719415
Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotypeQ43837381
Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivoQ44106531
A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndromeQ44588720
Comparison of different kits in the detection of autoantibodies to cardiolipin and beta2glycoprotein 1Q44636973
Antithrombotic effects of hydroxychloroquine in primary antiphospholipid syndrome patientsQ44830352
GAPSS: the Global Anti-Phospholipid Syndrome ScoreQ44993606
Unreliability of international normalized ratio for monitoring warfarin therapy in patients with lupus anticoagulantQ45013061
beta2-glycoprotein I-dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndromeQ45021710
Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cellsQ45033718
Assessing the variation in antiphospholipid antibody (APA) assays: comparison of results from 10 centersQ45041423
Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activationQ45111033
IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosisQ45126748
The global anti-phospholipid syndrome score in primary APS.Q45130401
Frequent false-positive results of lupus anticoagulant tests in plasmas of patients receiving the new oral anticoagulants and enoxaparinQ45220126
Update on the catastrophic antiphospholipid syndrome and the "CAPS Registry".Q45780878
The utility of the Taipan snake venom assay in assessing lupus anticoagulant status in individuals receiving or not receiving an oral vitamin K antagonist.Q45967639
Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA TrialQ46125985
Correlation between the potency of a beta2-glycoprotein I-dependent lupus anticoagulant and the level of resistance to activated protein C.Q46252581
Long-duration therapy with low molecular weight heparin in patients with antiphospholipid antibody syndrome resistant to warfarin therapy.Q46651769
Warfarin and the antiphospholipid syndrome: does one size fit all?Q46873547
In vivo effects of an inhibitor of nuclear factor-kappa B on thrombogenic properties of antiphospholipid antibodiesQ46982839
Innate immune response gene expression profiles characterize primary antiphospholipid syndrome.Q47743642
Pregnancy complications in women with recurrent miscarriage associated with antiphospholipid antibodies treated with low dose aspirin and heparinQ47868175
Role of anti-domain 1-β2 glycoprotein I antibodies in the diagnosis and risk stratification of antiphospholipid syndromeQ49042052
Eculizumab Induces Sustained Remission in a Patient With Refractory Primary Catastrophic Antiphospholipid SyndromeQ50172456
Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies.Q50196335
Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study.Q50619255
Diagnosis and management of non-criteria obstetric antiphospholipid syndrome.Q53082840
Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis.Q53190445
Anticardiolipin antibodies predict early recurrence of thromboembolism and death among patients with venous thromboembolism following anticoagulant therapy. Duration of Anticoagulation Study Group.Q53354829
Thrombin generation and factor X assays for the assessment of warfarin anticoagulation in thrombotic antiphospholipid syndrome.Q53533989
A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways.Q53598537
Acquired activated protein C resistance associated with IgG antibodies against beta2-glycoprotein I and prothrombin as a strong risk factor for venous thromboembolism.Q53874974
Annexin A2 mediates endothelial cell activation by antiphospholipid/anti- 2 glycoprotein I antibodiesQ57374964
Complement activation in patients with isolated antiphospholipid antibodies or primary antiphospholipid syndromeQ57624160
Failure of dabigatran and rivaroxaban to prevent thromboembolism in antiphospholipid syndrome: a case series of three patientsQ57907773
Induction of anti-β2-glycoprotein I autoantibodies in mice by protein H of Streptococcus pyogenesQ57983447
Eculizumab Prevents Recurrent Antiphospholipid Antibody Syndrome and Enables Successful Renal TransplantationQ58048140
Immune responses against domain I of β2-glycoprotein I are driven by conformational changes: Domain I of β2-glycoprotein I harbors a cryptic immunogenic epitopeQ58895662
Anti–β2-glycoprotein I antibodies induce monocyte release of tumor necrosis factor α and tissue factor by signal transduction pathways involving lipid raftsQ59140753
Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drugQ33747286
β₂-Glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model.Q33796355
Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways.Q33967600
Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expressionQ34003992
The anticoagulant and anti-inflammatory roles of the protein C anticoagulant pathwayQ34021223
On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodiesQ34195707
beta2-glycoprotein i is a cofactor for tissue plasminogen activator-mediated plasminogen activationQ34245642
The pathogenesis of the antiphospholipid syndromeQ34332601
A role for Toll-like receptor mediated signals in neutrophils in the pathogenesis of the anti-phospholipid syndromeQ34364580
14th International Congress on Antiphospholipid Antibodies: task force report on antiphospholipid syndrome treatment trendsQ34400373
Monitoring warfarin therapy in patients with lupus anticoagulantsQ34434408
Viral infections and antiphospholipid antibodiesQ34522953
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.Q34566135
Clinical significance of different antiphospholipid antibodies in the WAPS (warfarin in the antiphospholipid syndrome) studyQ34619943
A non-complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome.Q35124036
CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosisQ35746486
Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assayQ35792021
Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndromeQ35849691
Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndromeQ35874202
Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modification of the major autoantigen β2-glycoprotein I.Q35895238
Anti-beta2GPI-antibody-induced endothelial cell gene expression profiling reveals induction of novel pro-inflammatory genes potentially involved in primary antiphospholipid syndromeQ35953541
Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injuryQ36007691
Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studiesQ36013878
Identification of a region of beta 2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activityQ36157442
Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)Q36242479
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.Q36403678
Hydroxychloroquine directly reduces the binding of antiphospholipid antibody-beta2-glycoprotein I complexes to phospholipid bilayersQ36843689
Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndromeQ36890849
A novel pathway of cellular activation mediated by antiphospholipid antibody-induced extracellular vesiclesQ36928587
The antiphospholipid syndrome: still an enigmaQ36928593
Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cellsQ37059648
Rivaroxaban - a safe therapeutic option in patients with antiphospholipid syndrome? Our experience in 23 casesQ37141430
Rivaroxaban versus warfarin to treat patients with thrombotic antiphospholipid syndrome, with or without systemic lupus erythematosus (RAPS): a randomised, controlled, open-label, phase 2/3, non-inferiority trialQ37230504
Pediatric antiphospholipid antibodies and antiphospholipid syndromeQ37249533
Anti-β2GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathwayQ37349421
Mechanisms of antiphospholipid-induced thrombosis: effects on the protein C systemQ37378113
Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndromeQ37473270
A prospective open-label pilot study of fluvastatin on proinflammatory and prothrombotic biomarkers in antiphospholipid antibody positive patientsQ37702168
The mosaic of "seronegative" antiphospholipid syndromeQ37704857
Isolated IgA anti- β2 glycoprotein I antibodies in patients with clinical criteria for antiphospholipid syndromeQ37704874
The dual role of innate immunity in the antiphospholipid syndromeQ37721589
Challenges in the diagnosis of the antiphospholipid syndromeQ37723113
Heparin treatment in antiphospholipid syndrome with recurrent pregnancy loss: a systematic review and meta-analysisQ37760751
Use of hydroxychloroquine to prevent thrombosis in systemic lupus erythematosus and in antiphospholipid antibody-positive patientsQ37803363
Antiphospholipid antibodies--we are not quite there yet.Q37829519
Clinical manifestations of antiphospholipid syndrome (APS) with and without antiphospholipid antibodies (the so-called 'seronegative APS').Q37939702
The contribution of antiphosphatidylethanolamine antibodies in the diagnosis of the antiphospholipid syndromeQ38013586
Seronegative antiphospholipid syndromeQ38090375
Novel anticoagulants and laboratory testingQ38099419
Antiphospholipid antibodies and the risk of recurrence after a first episode of venous thromboembolism: a systematic reviewQ38113968
Rituximab use in the catastrophic antiphospholipid syndrome: descriptive analysis of the CAPS registry patients receiving rituximabQ38115382
Standardization of antiphospholipid antibody testing--historical perspectives and ongoing initiativesQ38182509
Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplicationQ38313174
Primary prophylaxis to prevent obstetric complications in asymptomatic women with antiphospholipid antibodies: a systematic reviewQ38392607
Safety and efficacy of oral direct inhibitors of thrombin and factor Xa in antiphospholipid syndrome.Q38416654
The IgG and IgM isotypes of anti-annexin A5 antibodies: relevance for primary antiphospholipid syndrome.Q38866404
Catastrophic antiphospholipid syndrome (CAPS): Descriptive analysis of 500 patients from the International CAPS RegistryQ38957667
Persistent antiphospholipid antibody (aPL) in asymptomatic carriers as a risk factor for future thrombotic events: a nationwide prospective studyQ39138695
Anti-β(2)GPI/β(2)GPI induced TF and TNF-α expression in monocytes involving both TLR4/MyD88 and TLR4/TRIF signaling pathwaysQ39281957
Long-term use of hydroxychloroquine reduces antiphospholipid antibodies levels in patients with primary antiphospholipid syndromeQ39608521
Clinical course of high-risk patients diagnosed with antiphospholipid syndromeQ39934417
Direct oral anticoagulants in antiphospholipid syndrome: a real life case seriesQ40131133
The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies.Q40474976
Factor H Autoantibodies in Patients with Antiphospholipid Syndrome and ThrombosisQ40639743
CIRCULATING MICROPARTICLES, BLOOD CELLS, AND ENDOTHELIUM INDUCE PROCOAGULANT ACTIVITY IN SEPSIS THROUGH PHOSPHATIDYLSERINE EXPOSURE.Q40932437
Pregnancy Loss in the Antiphospholipid-Antibody Syndrome — A Possible Thrombogenic MechanismQ41099260
Increased mortality in patients with the lupus anticoagulant: the Vienna Lupus Anticoagulant and Thrombosis Study (LATS).Q41157732
A case of relapsing and refractory catastrophic anti-phospholipid syndrome successfully managed with eculizumab, a complement 5 inhibitorQ41211826
Rivaroxaban and false positive lupus anticoagulant testingQ60619095
Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophiliaQ61415575
Activation of complement mediates antiphospholipid antibody-induced pregnancy lossQ61415576
IgA anticardiolipin and IgA anti-β2 glycoprotein I antibody positivity determined by fluorescence enzyme immunoassay in primary antiphospholipid syndromeQ61649470
Treatment of 139 Pregnancies in Antiphospholipid-positive Women Not Fulfilling Criteria for Antiphospholipid Syndrome: A Retrospective StudyQ61649488
Antiphospholipid and antiprotein syndromes in non-thrombotic, non-autoimmune women with unexplained recurrent primary early foetal loss. The Nîmes Obstetricians and Haematologists Study--NOHAQ61853593
Endothelial cells as target for antiphospholipid antibodies. Human Polyclonal and Monoclonal Anti-β2-Glycoprotein I Antibodies React In Vitro with Endothelial Cells Through Adherent β2-Glycoprotein I and Induce Endothelial ActivationQ62395215
Platelet adhesion to dimeric β2-glycoprotein I under conditions of flow is mediated by at least two receptors: glycoprotein Ibαand apolipoprotein E receptor 2′Q63346659
Thrombotic events in patients with antiphospholipid syndrome treated with rivaroxaban: a series of eight cases.Q64897464
Lupus anticoagulant IgG's (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombinQ67866864
Immunoglobulin fractions isolated from patients with antiphospholipid antibodies prevent the inactivation of factor Va by activated protein C on human endothelial cellsQ67939870
Impaired catalytic function of activated protein C: a new in vitro manifestation of lupus anticoagulantQ69241643
Induction of endothelial cell tissue factor activity by sera from patients with antiphospholipid syndrome: a possible mechanism of thrombosisQ70529807
Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTHQ70897451
Antiphosphatidylethanolamine antibodies as the only antiphospholipid antibodies. I. Association with thrombosis and vascular cutaneous diseasesQ71654278
Reduction of annexin-V (placental anticoagulant protein-I) on placental villi of women with antiphospholipid antibodies and recurrent spontaneous abortionQ72361563
Autoantibodies to heparin from patients with antiphospholipid antibody syndrome inhibit formation of antithrombin III-thrombin complexesQ72384713
Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin aloneQ73143663
Systemic endothelial cell markers in primary antiphospholipid syndromeQ73322507
High levels of coagulation factor XI as a risk factor for venous thrombosisQ73520981
Laboratory diagnosis of lupus anticoagulants for patients on oral anticoagulant treatment. Performance of dilute Russell viper venom test and silica clotting time in comparison with Staclot LAQ78321143
Anti-beta(2)-glycoprotein I antibody-mediated inhibition of activated protein C requires binding of beta(2)-glycoprotein I to phospholipidsQ78321169
Decreased anticoagulant response to tissue factor pathway inhibitor type 1 in plasmas from patients with lupus anticoagulantsQ79339543
Endothelial microparticles: a potential contribution to the thrombotic complications of the antiphospholipid syndromeQ79826484
Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-VQ79992039
Anti-annexin II antibodies in systemic autoimmune diseases and antiphospholipid syndromeQ80826802
Lupus anticoagulants and the risk of a first episode of deep venous thrombosisQ81064718
Anti-prothrombin IgG from patients with anti-phospholipid antibodies inhibits the inactivation of factor Va by activated protein CQ81620372
Laboratory detection of the antiphospholipid syndrome via calibrated automated thrombographyQ83162733
Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at the 13th International Congress on antiphospholipid antibodiesQ83389363
Antiphospholipid antibodies and the protein C pathwayQ83954291
The role of antiphospholipid antibodies toward the protein C/protein S system in venous thromboembolic diseaseQ84143873
Risk factors for pregnancy failure in patients with anti-phospholipid syndrome treated with conventional therapies: a multicentre, case-control studyQ84302565
Detection of lupus anticoagulant in the presence of rivaroxaban using Taipan snake venom timeQ84349009
Factor XI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosisQ84390547
The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter studyQ84438431
Antiphospholipid antibodies induce translocation of TLR7 and TLR8 to the endosome in human monocytes and plasmacytoid dendritic cellsQ84513241
Efficacy of the antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic eventsQ85002100
An international multicentre‐laboratory evaluation of a new assay to detect specifically lupus anticoagulants dependent on the presence of anti‐beta2‐glycoprotein autoantibodiesQ85100865
Prevalence of antibodies to prothrombin in solid phase (aPT) and to phosphatidylserine-prothrombin complex (aPS/PT) in patients with and without lupus anticoagulantQ85743774
An independent validation of the Global Anti-Phospholipid Syndrome Score in a Japanese cohort of patients with autoimmune diseasesQ86077231
Antiphospholipid syndrome: antibodies to Domain 1 of β2-glycoprotein 1 correctly classify patients at riskQ86646346
The use of rivaroxaban in patients with antiphospholipid syndrome: A series of 12 casesQ86704919
Rivaroxaban use in patients with antiphospholipid syndrome and previous venous thromboembolismQ87211442
New oral anticoagulants may not be effective to prevent venous thromboembolism in patients with antiphospholipid syndromeQ87417887
P433issue6
P304page(s)406-417
P577publication date2017-07-30
P1433published inBlood ReviewsQ15724415
P1476titleDiagnosis and management of the antiphospholipid syndrome
P478volume31

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cites work (P2860)
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