Assembly of an export-competent mRNP is needed for efficient release of the 3'-end processing complex after polyadenylation

scientific article published on 27 July 2009

Assembly of an export-competent mRNP is needed for efficient release of the 3'-end processing complex after polyadenylation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.00468-09
P932PMC publication ID2747973
P698PubMed publication ID19635808

P50authorSøren Lykke-AndersenQ55136794
Edouard BertrandQ57645202
Torben Heick JensenQ42334328
P2093author name stringClaire Moore
Xiangping Qu
Cyril Saguez
Tommy Nasser
P2860cites workTREX is a conserved complex coupling transcription with messenger RNA exportQ24295211
Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicingQ24317157
The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255pQ24529891
Molecular dissection of mRNA poly(A) tail length control in yeastQ24646300
Role of polyadenylation in nucleocytoplasmic transport of mRNAQ24650446
Structure of the N-Terminal Mlp1-Binding Domain of the Saccharomyces cerevisiae mRNA-Binding Protein, Nab2Q27649526
A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiaeQ27929512
The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instabilityQ27929526
Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1pQ27929754
Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3'-end formation in yeastQ27930053
Pta1, a component of yeast CF II, is required for both cleavage and poly(A) addition of mRNA precursorQ27930178
A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA exportQ27931607
The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear poresQ27931766
Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylationQ27931769
The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activityQ27931926
General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutantsQ27932821
Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutantsQ27932830
Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I.Q27933038
A genetic screen in Saccharomyces cerevisiae identifies new genes that interact with mex67-5, a temperature-sensitive allele of the gene encoding the mRNA export receptor.Q27933172
Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA exportQ27933519
Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA exportQ27933999
Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP.Q27934062
Comprehensive analysis of diverse ribonucleoprotein complexes.Q27934310
Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA exportQ27934431
Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to exportQ27934476
Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores.Q27934517
Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear exportQ27934522
A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexesQ27934541
Npl3 is an antagonist of mRNA 3' end formation by RNA polymerase II.Q27935622
Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA exportQ27935795
A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.Q27936954
A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombinationQ27937094
Effects of mutations in the Saccharomyces cerevisiae RNA14, RNA15, and PAP1 genes on polyadenylation in vivoQ27937493
Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA exportQ27937989
Functional specificity of shuttling hnRNPs revealed by genome-wide analysis of their RNA binding profilesQ27938114
Messenger RNAs are recruited for nuclear export during transcriptionQ27938581
Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradationQ27938985
Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1pQ27939091
The DECD box putative ATPase Sub2p is an early mRNA export factorQ27939448
Polyadenylation site choice in yeast is affected by competition between Npl3 and polyadenylation factor CFI.Q27939878
Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1.Q27939910
Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear poresQ27940054
The tandem affinity purification (TAP) method: a general procedure of protein complex purificationQ28131621
Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288CQ28131625
The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNAQ75399914
Assembly of export-competent mRNP: it's all about being connectedQ83283711
Exporting RNA from the nucleus to the cytoplasmQ28245155
Transitions in RNA polymerase II elongation complexes at the 3' ends of genesQ29614767
The essential N terminus of the Pta1 scaffold protein is required for snoRNA transcription termination and Ssu72 function but is dispensable for pre-mRNA 3'-end processing.Q30663144
Mutations in the yeast RNA14 and RNA15 genes result in an abnormal mRNA decay rate; sequence analysis reveals an RNA-binding domain in the RNA15 proteinQ33245533
A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcriptionQ33945461
A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcriptQ33983114
Coupling of termination, 3' processing, and mRNA exportQ34325429
Pre-mRNA processing factors are required for nuclear exportQ34363202
T7 RNA polymerase-directed transcripts are processed in yeast and link 3' end formation to mRNA nuclear exportQ34364453
Localization of nuclear retained mRNAs in Saccharomyces cerevisiaeQ34365269
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factorsQ34419716
The role of Rat1 in coupling mRNA 3'-end processing to transcription termination: implications for a unified allosteric-torpedo modelQ34511126
Ubiquitin-associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcriptionQ35133832
The transcriptional cycle of HIV-1 in real-time and live cells.Q36119592
Connections between mRNA 3' end processing and transcription terminationQ36131487
PCF11 encodes a third protein component of yeast cleavage and polyadenylation factor I.Q36565604
The nuclear envelope and transcriptional control.Q36840615
Functional significance of the interaction between the mRNA-binding protein, Nab2, and the nuclear pore-associated protein, Mlp1, in mRNA exportQ36914437
Protein factors in pre-mRNA 3'-end processing.Q37044967
Regulation of mRNP dynamics along the export pathwayQ37131104
Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleusQ37144184
mRNA journey to the cytoplasm: attire requiredQ37163404
Quality control of mRNP in the nucleusQ37194592
mRNA nuclear export at a glanceQ37506920
Rna15 interaction with the A-rich yeast polyadenylation signal is an essential step in mRNA 3'-end formationQ39529058
The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instabilityQ40444246
Separation of factors required for cleavage and polyadenylation of yeast pre-mRNAQ40655774
Inefficient processing impairs release of RNA from the site of transcriptionQ40954153
Biochemical analysis of TREX complex recruitment to intronless and intron-containing yeast genesQ41062668
Cotranscriptional recruitment of the mRNA export factor Yra1 by direct interaction with the 3' end processing factor Pcf11.Q41920187
Role of poly (A) tail as an identity element for mRNA nuclear exportQ43042769
Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3'-end formation of nascent transcriptsQ43206826
The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim.Q46093228
The DEAD-box protein Dbp5 controls mRNA export by triggering specific RNA:protein remodeling eventsQ46848532
Elongator interactions with nascent mRNA revealed by RNA immunoprecipitationQ47587838
THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association.Q50336097
Regulation of yeast mRNA 3' end processing by phosphorylation.Q53658895
Yeast mRNA Poly(A) tail length control can be reconstituted in vitro in the absence of Pab1p-dependent Poly(A) nuclease activity.Q53675884
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)5327-5338
P577publication date2009-07-27
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleAssembly of an export-competent mRNP is needed for efficient release of the 3'-end processing complex after polyadenylation
P478volume29

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