Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.

scientific article published on 06 August 2009

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/JAPPLPHYSIOL.91393.2008
P932PMC publication ID2763842
P698PubMed publication ID19661445
P5875ResearchGate publication ID26723463

P50authorJae Hyung KimQ64482272
Young Jun OhQ79250623
Gautam SikkaQ117789925
P2093author name stringDavid W Christianson
Lakshmi Santhanam
Kevin G Soucy
Sungwoo Ryoo
Hunter C Champion
Trinity J Bivalacqua
Dan E Berkowitz
Daniel Nyhan
Jae Hyung Kim
Artin A Shoukas
Andre Camara
Monica Ilies
Lukasz J Bugaj
Alanah Webb
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Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2.Q40047128
Improved arterial compliance by a novel advanced glycation end-product crosslink breakerQ40684856
Diabetes-induced coronary vascular dysfunction involves increased arginase activityQ41817278
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Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunctionQ43605519
Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal studyQ43859232
Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar functionQ44028489
NAD(P)H oxidase-generated superoxide anion accounts for reduced control of myocardial O2 consumption by NO in old Fischer 344 ratsQ44547281
Arginase and autoimmune inflammation in the central nervous systemQ44563491
Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood VesselsQ44601105
Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells.Q44772508
Involvement of increased arginase activity in impaired cavernous relaxation with aging in the rabbitQ44940159
Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterinQ45023381
Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arteriolesQ45113050
Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertensionQ45182794
Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginaseQ45863383
Endothelial arginase II: a novel target for the treatment of atherosclerosisQ46726767
Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arteriolesQ46862881
Knockdown of arginase I restores NO signaling in the vasculature of old rats.Q46870256
Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: role of transglutaminasesQ46979575
Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function.Q50336020
Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness.Q51104632
Oxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signaling.Q52573945
Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging.Q53850917
Arterial Stiffness and Risk of Coronary Heart Disease and StrokeQ57781936
Relation of pulse pressure and blood pressure reduction to the incidence of myocardial infarctionQ72286695
Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging ratsQ77114829
Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of ageQ77350579
Superoxide anion production is increased in a model of genetic hypertension: role of the endotheliumQ77894868
Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2AQ80161975
Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with ageQ80281483
P4510describes a project that usesImageJQ1659584
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)1249-1257
P577publication date2009-08-06
P1433published inJournal of Applied PhysiologyQ1091719
P1476titleArginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats
P478volume107

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