Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis

scientific article published on October 2009

Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI38674
P932PMC publication ID2769194
P698PubMed publication ID19805911

P50authorPaul WebsterQ85708745
P2093author name stringFred S Gorelick
Samuel W French
Stephen J Pandol
Nobuhiko Katunuma
Kip Hermann
Anna S Gukovskaya
Ilya Gukovsky
Olga A Mareninova
Ann H Erickson
Mark S O'Konski
P2860cites workGuidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesQ23757358
Inhibition of macroautophagy triggers apoptosisQ24338482
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome markerQ24633015
Biochemical models of hereditary pancreatitisQ24675973
Autophagy in the Pathogenesis of DiseaseQ27860558
Autophagy fights disease through cellular self-digestionQ27860902
At the acidic edge: emerging functions for lysosomal membrane proteinsQ28182104
Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomesQ28267732
Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitisQ28363504
Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitisQ28566885
Autophagosome formation: core machinery and adaptationsQ29547417
Rab7: a key to lysosome biogenesisQ29620369
Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cellsQ30479173
Vacuolar ATPase regulates zymogen activation in pancreatic aciniQ33757539
Disease model: LAMP-2 enlightens Danon diseaseQ34294228
Processing and activation of lysosomal proteinasesQ35055169
Intracellular vacuoles in experimental acute pancreatitis in rats and mice are an acidified compartmentQ35585377
Methods for monitoring autophagyQ35869399
Why does pancreatic overstimulation cause pancreatitis?Q36632168
Pancreatic acinar ultrastructure in human acute pancreatitisQ36668513
Proteases and proteolysis in the lysosomeQ36777562
Cysteine cathepsins: cellular roadmap to different functionsQ36934250
Neurodegenerative lysosomal disorders: a continuum from development to late age.Q37170688
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's diseaseQ37178375
Involvement of autophagy in trypsinogen activation within the pancreatic acinar cellsQ37203732
Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cellsQ37284059
Biosynthesis of lysosomal endopeptidasesQ38660008
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitisQ40735691
Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenineQ41710692
Degradation of short and long lived proteins in isolated rat liver lysosomes. Effects of pH, temperature, and proteolytic inhibitorsQ41917062
Regulation of microautophagy and basal protein turnover in rat liver. Effects of short-term starvationQ42515727
Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzymeQ42792985
The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis.Q42856794
Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitisQ43634098
Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitisQ43946815
Role of S-adenosylmethionine in two experimental models of pancreatitisQ44211044
Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cellsQ44755679
Improved retention of zymogen granules in cultured murine pancreatic acinar cells and induction of acinar-ductal transdifferentiation in vitroQ45267736
Cell death in pancreatitis: caspases protect from necrotizing pancreatitisQ46091205
Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.Q46499913
Subcellular fractionation of the pancreasQ46850169
Rat procathepsin B. Proteolytic processing to the mature form in vitro.Q47856856
Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells.Q50709677
Regression of autophagic vacuoles in pancreatic acinar, seminal vesicle epithelial, and liver parenchymal cells: a comparative morphometric study of the effect of vinblastine and leupeptin followed by cycloheximide treatmentQ68248998
Biosyntheses and processing of lysosomal cysteine proteinases in rat macrophagesQ68325544
In vivo rat pancreatic acinar cell function during supramaximal stimulation with caeruleinQ68951595
Subcellular redistribution of lysosomal enzymes during caerulein-induced pancreatitisQ69808490
Pancreatic effects of ethionine: blockade of exocytosis and appearance of crinophagy and autophagy precede cellular necrosisQ70302410
A morphometric study of 24-hour variations in subcellular structures of the rat pancreatic acinar cellQ70508265
Alteration of membrane fusion as a cause of acute pancreatitis in the ratQ70510595
Human acute pancreatitis: a light and electron microscopic studyQ70532207
Diurnal variation in secretory components of the rat parotid glandQ70977121
Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitisQ71345530
Ultrastructure of early development of acute pancreatitis in the ratQ71652941
Influence of ductal pressure and infusates on activity and subcellular distribution of lysosomal enzymes in the rat pancreasQ71890565
Lysosomal enzymes and pancreatitisQ71890589
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytesQ73067976
Early events in acute pancreatitisQ73075153
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivoQ73077056
Lysosomal cysteine protease, cathepsin B, is targeted to lysosomes by the mannose 6-phosphate-independent pathway in rat hepatocytes: site-specific phosphorylation in oligosaccharides of the proregionQ73943379
Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic aciniQ77307036
Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitisQ77551309
The activation of trypsinogen by cathepsin BQ79317421
Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitisQ79856720
Microwave-assisted processing and embedding for transmission electron microscopyQ80683933
Early events in acute pancreatitisQ81481271
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectvacuoleQ127702
autophagyQ288322
P304page(s)3340-3355
P577publication date2009-10-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleImpaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis
P478volume119

Reverse relations

cites work (P2860)
Q36574193A Study on Subchronic Inhalation Toxicity of 1-Chloropropane
Q30276361A small molecule inhibitor of NFκB blocks ER stress and the NLRP3 inflammasome and prevents progression of pancreatitis
Q42238474ADP-ribosylation factor 1 protein regulates trypsinogen activation via organellar trafficking of procathepsin B protein and autophagic maturation in acute pancreatitis
Q37578687Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats.
Q47109916Acinar injury and early cytokine response in human acute biliary pancreatitis
Q36109742Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells
Q38938667Acute acinar pancreatitis blocks vesicle-associated membrane protein 8 (VAMP8)-dependent secretion, resulting in intracellular trypsin accumulation.
Q84101842Acute pancreatitis
Q26766670Alcoholic pancreatitis: New insights into the pathogenesis and treatment
Q51620499Asparaginase-associated pancreatitis: a study on phenotype and genotype in the NOPHO ALL2008 protocol.
Q93047724Autophagy and inflammation in ischemic stroke
Q36454316Autophagy and pancreatitis
Q34014519Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets
Q36235457Autophagy in immunity: implications in etiology of autoimmune/autoinflammatory diseases
Q36135812Autophagy in pancreatic cancer pathogenesis and treatment
Q39675853Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice.
Q46828081Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis.
Q37969122Autophagy: a primer for the gastroenterologist/hepatologist
Q95840706BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux
Q36300434Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress
Q35707173Blockade of Multidrug Resistance-Associated Proteins Aggravates Acute Pancreatitis and Blunts Atrial Natriuretic Factor's Beneficial Effect in Rats: Role of MRP4 (ABCC4).
Q35245361Calcium and reactive oxygen species in acute pancreatitis: friend or foe?
Q37876199Cardiocirculatory pathophysiological mechanisms in severe acute pancreatitis
Q41862502Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis.
Q47305008Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis.
Q35019204Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose
Q26994999Cell death and DAMPs in acute pancreatitis
Q34180057Cholinergic mediation of alcohol-induced experimental pancreatitis
Q37189451Cluster of differentiation 38 (CD38) mediates bile acid-induced acinar cell injury and pancreatitis through cyclic ADP-ribose and intracellular calcium release
Q42375433Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo
Q99710688Critical thresholds: key to unlocking the door to the prevention and specific treatments for acute pancreatitis
Q42220118Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models
Q38656177Do Animal Models of Acute Pancreatitis Reproduce Human Disease?
Q36310514Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells
Q40895281Effect of the manipulation of the duodenal papilla during double balloon enteroscopy.
Q42037739Evidences supporting the vascular etiology of post-double balloon enteroscopy pancreatitis: Study in porcine model
Q52900571Ex vivo human pancreatic slice preparations offer a valuable model for studying pancreatic exocrine biology.
Q36119410Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine hearts
Q26801332Framework for interpretation of trypsin-antitrypsin imbalance and genetic heterogeneity in pancreatitis
Q36948885Functions of autophagy in hepatic and pancreatic physiology and disease
Q48247460Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis.
Q35028058Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity.
Q37074271Genetic variants associated with Crohn's disease
Q46513078Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis.
Q37466767Hydrogen sulphide exacerbates acute pancreatitis by over-activating autophagy via AMPK/mTOR pathway
Q38266870Immune-modulating therapy in acute pancreatitis: fact or fiction
Q92508594Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis
Q37982804Impaired autophagy and organellar dysfunction in pancreatitis
Q42535631Impaired autophagy triggers chronic pancreatitis: lessons from pancreas-specific atg5 knockout mice
Q64079362Inhibition of miR-155 reduces impaired autophagy and improves prognosis in an experimental pancreatitis mouse model
Q34028895Interleukin-1β induces autophagy by affecting calcium homeostasis and trypsinogen activation in pancreatic acinar cells
Q35673533Interleukin-22 ameliorates cerulein-induced pancreatitis in mice by inhibiting the autophagic pathway
Q37662678Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice
Q55514770Intracellular rupture, exocytosis and actin interaction of endocytic vacuoles in pancreatic acinar cells: initiating events in acute pancreatitis.
Q34936085Intragenic duplication: a novel mutational mechanism in hereditary pancreatitis
Q34872933Investigating the pathobiology of alcoholic pancreatitis
Q35875403Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity.
Q35593014Loss of Bace1 in mice does not alter the severity of caerulein induced pancreatitis
Q36793423Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice
Q36357685Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis
Q42322457Lysosome-Associated Membrane Protein-2: A Major Player in the Pathogenesis of Chronic Pancreatitis
Q37037412Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP.
Q26766654Mechanisms of interleukin-22's beneficial effects in acute pancreatitis
Q46289111Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models.
Q34501606Molecular and cellular mechanisms of pancreatic injury
Q38240876Molecular mechanisms of alcohol associated pancreatitis
Q37918238Molecular mechanisms of pancreatic injury
Q90286159Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival
Q47248825Munc18c depletion attenuates caerulein hyperstimulation induced pancreatitis
Q37602778New insights into the pathogenesis of pancreatitis
Q38900762New insights into the pathways initiating and driving pancreatitis.
Q39304611Noggin attenuates cerulein-induced acute pancreatitis and impaired autophagy
Q37413840Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome
Q35816569Obesity, autophagy and the pathogenesis of liver and pancreatic cancers
Q37915531Organellar dysfunction in the pathogenesis of pancreatitis
Q58554308PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer
Q35832384PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis
Q49841510Pancreatitis-induced Depletion of Syntaxin 2 Promotes Autophagy and Increases Basolateral Exocytosis
Q38034035Pathogenic mechanisms of acute pancreatitis
Q38840155Pathophysiological mechanisms in acute pancreatitis: Current understanding
Q90689845Quantitative Ultrasound and the Pancreas: Demonstration of Early Detection Capability
Q58712490RB1CC1-enhanced autophagy facilitates PSCs activation and pancreatic fibrogenesis in chronic pancreatitis
Q93022937Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders
Q90095290Reciprocal Feedback Loop of the MALAT1-MicroRNA-194-YAP1 Pathway Regulates Progression of Acute Pancreatitis
Q35178638Redox signaling in acute pancreatitis
Q52599334Regulation of Autophagy Affects the Prognosis of Mice with Severe Acute Pancreatitis.
Q41642231Release of Cathepsin B in Cytosol Causes Cell Death in Acute Pancreatitis
Q42356670Reply to: "The autophagic response to alcohol toxicity: the missing layer".
Q89425551Resolvin D1 Resolve Inflammation in Experimental Acute Pancreatitis by Restoring Autophagic Flux
Q27001120Review of experimental animal models of biliary acute pancreatitis and recent advances in basic research
Q34400723Risk factors for pancreatic cancer: underlying mechanisms and potential targets
Q49910118SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation
Q37370518Spautin-1 Ameliorates Acute Pancreatitis via Inhibiting Impaired Autophagy and Alleviating Calcium Overload
Q37797839Specialized roles for cysteine cathepsins in health and disease.
Q46092740Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas
Q38776190TRAM1 protects AR42J cells from caerulein-induced acute pancreatitis through ER stress-apoptosis pathway
Q36905963The Receptor for Advanced Glycation End Products Activates the AIM2 Inflammasome in Acute Pancreatitis.
Q34915977The conspiracy of autophagy, stress and inflammation in acute pancreatitis
Q37840892The multiple roles of autophagy in cancer
Q38090903The role of protein synthesis and digestive enzymes in acinar cell injury
Q35058693The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity
Q42155388Trypsinogen activation in acute and chronic pancreatitis: is it a prerequisite?
Q55001730Using CRISPR/Cas9 to Knock out Amylase in Acinar Cells Decreases Pancreatitis-Induced Autophagy.
Q42604284Which way to die: the regulation of acinar cell death in pancreatitis by mitochondria, calcium, and reactive oxygen species
Q39617768Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death
Q42540810Zymophagy: selective autophagy of secretory granules
Q52655067miR-352 participates in the regulation of trypsinogen activation in pancreatic acinar cells by influencing the function of autophagic lysosomes.

Search more.