Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain

scientific article published on July 2009

Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/DVDY.21982
P932PMC publication ID2777648
P698PubMed publication ID19479951
P5875ResearchGate publication ID26250941

P50authorJennifer L. MoranQ37651649
P2093author name stringShyamala Mani
John M Levorse
Thomas F Vogt
Dawn M Walker
Susan E Cole
Emily T Shifley
Ariadna Perez-Balaguer
Kristin Ostmann
P2860cites workA family of mammalian Fringe genes implicated in boundary determination and the Notch pathwayQ24310459
The mouse Engrailed-1 gene and ventral limb patterningQ24336735
Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in DrosophilaQ28115115
Fringe is a glycosyltransferase that modifies NotchQ28143123
Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulationQ28188343
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiencyQ28203380
The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryoQ28302373
Wnt-3a regulates somite and tailbud formation in the mouse embryoQ28504870
Lunatic fringe null female mice are infertile due to defects in meiotic maturationQ28506185
Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial nichesQ28508335
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1Q28509366
Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeletonQ28510529
Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant miceQ28512351
Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceQ28593600
Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrainQ28594355
Efficient in vivo manipulation of mouse genomic sequences at the zygote stageQ29547306
Sonic hedgehog mediates the polarizing activity of the ZPAQ29616565
Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex regionQ34165262
Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternumQ34323246
Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.Q34343668
Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse.Q34561526
Mouse duplicate genes are as essential as singletonsQ34636141
A deficiency of lunatic fringe is associated with cystic dilation of the rete testisQ34830849
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturationQ36229695
Of chicken wings and frog legs: a smorgasbord of evolutionary variation in mechanisms of tetrapod limb development.Q36295692
MFng is dispensable for mouse pancreas development and functionQ37145399
Role of unusual O-glycans in intercellular signalingQ37308624
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.Q40862987
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.Q45345395
Modulation of Notch Signaling During SomitogenesisQ46419557
Lunatic fringe protein processing by proprotein convertases may contribute to the short protein half-life in the segmentation clockQ46427203
Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limbQ46444960
Regions of Drosophila Notch that contribute to ligand binding and the modulatory influence of Fringe.Q46580662
Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeatsQ46749922
The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation.Q46783801
Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrainQ47073773
lunatic fringe is an essential mediator of somite segmentation and patterningQ47741550
Defects in somite formation in lunatic fringe-deficient miceQ47741558
Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud.Q48037226
Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation.Q48052345
Segmental and neuronal architecture of the hindbrain of Krox-20 mouse mutants.Q48783715
Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches.Q50937939
Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1.Q51063485
Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype.Q51946283
Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT).Q52166624
Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs.Q52188267
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.Q52223119
Distributed robustness versus redundancy as causes of mutational robustness.Q52654713
Limbs move beyond the Radical fringeQ58997355
Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acidQ68317251
P433issue7
P304page(s)1803-1812
P577publication date2009-07-01
P1433published inDevelopmental DynamicsQ59752
P1476titleManic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain
P478volume238

Reverse relations

cites work (P2860)
Q30442278A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins
Q40036216Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands
Q50426445Do as I say, Not(ch) as I do: Lateral control of cell fate.
Q56890487Evolutionary emergence of the // regulatory cluster refined mechanisms for hindbrain boundaries formation
Q37560132Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates
Q36389083Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development
Q37052329Notch signaling during cell fate determination in the inner ear.
Q35030924Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions
Q55168104Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis.
Q34030111Role of glycans and glycosyltransferases in the regulation of Notch signaling
Q64979292Roles for Golgi Glycans in Oogenesis and Spermatogenesis.
Q34023789Roles of Glycosylation in Notch Signaling
Q39752995Sequential Notch activation regulates ventricular chamber development
Q24299571Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells
Q38116930The molecular basis of human congenital limb malformations
Q38547337The multiple roles of epidermal growth factor repeat O-glycans in animal development
Q38796983What Have We Learned from Glycosyltransferase Knockouts in Mice?