Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice

scientific journal article

Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/GENE.10081
P698PubMed publication ID12001066

P2093author name stringNian Zhang
Thomas Gridley
Christine R. Norton
P2860cites workFringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in DrosophilaQ28115115
Fringe is a glycosyltransferase that modifies NotchQ28143123
Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulationQ28188343
Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factorsQ28510928
Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesodermQ28585594
Defects in limb, craniofacial, and thymic development in Jagged2 mutant miceQ28586431
Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1Q28589104
Dynamic expression and essential functions of Hes7 in somite segmentationQ28593057
The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD.Q33909902
Somite formation and patterningQ33914527
Notch signalling and the synchronization of the somite segmentation clockQ33926876
Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1Q33949989
A molecular clock involved in somite segmentation.Q34173684
Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.Q34343668
Maintenance of somite borders in mice requires the Delta homologue DII1.Q34422203
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.Q40862987
Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modulesQ40891320
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.Q45345395
A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous systemQ47681842
Defects in somite formation in lunatic fringe-deficient miceQ47741558
The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundariesQ47852383
Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesisQ48041941
Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiationQ48047260
Homologues of c-hairy1 (her9) and lunatic fringe in zebrafish are expressed in the developing central nervous system, but not in the presomitic mesodermQ48333698
Zebrafish lunatic fringe demarcates segmental boundaries.Q52133312
Mesp2 initiates somite segmentation through the Notch signalling pathway.Q52166230
Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation.Q52179113
The lunatic fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos.Q52184463
Waves of mouse Lunatic fringe expression, in four-hour cycles at two-hour intervals, precede somite boundary formation.Q52184506
Fringe modulates Notch-ligand interactions.Q52194027
Notch1 is essential for postimplantation development in mice.Q52512097
Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouseQ57315074
Galaxy clusters: Well of darknessQ57746408
A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochleaQ73849637
P433issue1
P921main subjectphenotypeQ104053
Delta like canonical Notch ligand 1Q21982911
Delta like canonical Notch ligand 3Q21982924
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseQ21986096
Notch 1Q21986193
P304page(s)21–28
P577publication date2002-05-01
P1433published inGenesisQ5532784
P1476titleSegmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice
P478volume33

Reverse relations

cites work (P2860)
Q37405136A Notch updated
Q28742953A survey of small RNAs in human sperm
Q36821431Anabolic actions of Notch on mature bone
Q51946283Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype.
Q28589511Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes
Q35101893Fine-tuning Notch1 activation by endocytosis and glycosylation
Q28509366Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1
Q34492882Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts
Q46749922Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats
Q36389083Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development
Q37145399MFng is dispensable for mouse pancreas development and function
Q37421674Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain
Q46419557Modulation of Notch Signaling During Somitogenesis
Q24540500Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype
Q24323154Mutation of the fucose-specific beta1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine
Q32874834Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis
Q46795621Notch Signaling in Development, Tissue Homeostasis, and Disease
Q35858248Notch signaling in mammary development and oncogenesis
Q36140085Notch signaling in the mammalian central nervous system: insights from mouse mutants
Q28587727Notch signaling regulates left-right asymmetry determination by inducing Nodal expression
Q28504465Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development
Q28512806Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis
Q28545998O-fucosylation of DLL3 is required for its function during somitogenesis
Q24677654Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways
Q36382727Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions
Q33969519Role of glycosylation of Notch in development
Q37308624Role of unusual O-glycans in intercellular signaling
Q34023789Roles of Glycosylation in Notch Signaling
Q34585462Roles of O-fucose glycans in notch signaling revealed by mutant mice.
Q41773509Structural and mechanistic insights into lunatic fringe from a kinetic analysis of enzyme mutants
Q28584296The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
Q52009415The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3.
Q36488814The long and short of it: somite formation in mice
Q37256458The many facets of Notch ligands
Q37888532The mouse notches up another success: understanding the causes of human vertebral malformation.
Q62555277The mouse rib-vertebrae mutation is a hypomorphic Tbx6 allele
Q38547337The multiple roles of epidermal growth factor repeat O-glycans in animal development
Q34116042The search for glycan function: fucosylation of the TGF-beta1 receptor is required for receptor activation
Q24672577Transcriptional oscillation of lunatic fringe is essential for somitogenesis

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