Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats

scientific article

Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M509552200
P698PubMed publication ID16221665

P2093author name stringRobert S Haltiwanger
Raajit Rampal
Daniel J Moloney
Kelvin B Luther
Aleksandra Nita-Lazar
Annie S Y Li
Stephanie A Georgiou
P2860cites workGenomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genesQ22009900
Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferaseQ24291613
Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domainsQ24318707
O-fucosylation of notch occurs in the endoplasmic reticulumQ24338227
Notch signaling: cell fate control and signal integration in developmentQ27861061
Fringe is a glycosyltransferase that modifies NotchQ28143123
Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulationQ28188343
Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cellsQ28266420
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1Q28509366
Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant miceQ28512351
Sequence and embryonic expression of three zebrafish fringe genes: lunatic fringe, radical fringe, and manic fringeQ31113247
Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1Q33949989
Glycosyltransferase structure and mechanismQ34066499
O-glycosylation of EGF repeats: identification and initial characterization of a UDP-glucose: protein O-glucosyltransferaseQ34162112
Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex regionQ34165262
Glycosylation regulates Notch signalling.Q34271410
Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferaseQ34989571
Differential terminal fucosylation of N-linked glycans versus protein O-fucosylation in leukocyte adhesion deficiency type II (CDG IIc).Q40649000
O-linked fucose and other post-translational modifications unique to EGF modulesQ40838885
Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modulesQ40891320
Highly conserved O-fucose sites have distinct effects on Notch1 functionQ41842411
Complementation between mutants of CHO cells resistant to a variety of plant lectinsQ41902100
fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development.Q42694998
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.Q45345395
Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limbQ46444960
CADASIL mutations impair Notch3 glycosylation by FringeQ46460917
Defects in somite formation in lunatic fringe-deficient miceQ47741558
Studies on the N-glycosylation of the subunits of oligosaccharyl transferase in Saccharomyces cerevisiae.Q52086236
Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock.Q52110194
The O-linked fucose glycosylation pathway. Evidence for protein-specific elongation of o-linked fucose in Chinese hamster ovary cells.Q52193411
Fringe modulates Notch-ligand interactions.Q52194027
P433issue51
P407language of work or nameEnglishQ1860
P304page(s)42454-42463
P577publication date2005-10-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleLunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats
P478volume280

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cites work (P2860)
Q364917726-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2.
Q37405136A Notch updated
Q52691671A Putative Protein O-Fucosyltransferase Facilitates Pollen Tube Penetration through the Stigma-Style Interface.
Q89233181A potential role for protein O-fucosylation during pollen-pistil interactions
Q40036216Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands
Q42987220Deletion of Pofut1 in Mouse Skeletal Myofibers Induces Muscle Aging-Related Phenotypes in cis and in trans
Q27683660Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands
Q34566205Fucosylation in prokaryotes and eukaryotes
Q35643741Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling
Q59806973Glycans as Key Checkpoints of T Cell Activity and Function
Q28267777Identification and characterization of abeta1,3-glucosyltransferase that synthesizes the Glc-beta1,3-Fuc disaccharide on thrombospondin type 1 repeats
Q24321548Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats
Q90370645Identification of novel LFNG mutations in spondylocostal dysostosis
Q35002856Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome.
Q36630292Lunatic Fringe Enhances Competition for Delta-Like Notch Ligands but Does Not Overcome Defective Pre-TCR Signaling during Thymocyte β-Selection In Vivo
Q36389083Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development
Q37145399MFng is dispensable for mouse pancreas development and function
Q37421674Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain
Q36667093Methods for analysis of O-linked modifications on epidermal growth factor-like and thrombospondin type 1 repeats
Q24323154Mutation of the fucose-specific beta1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine
Q37861191NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of rapamycin (mTOR) signaling in T-cell development and T-cell acute lymphoblastic leukemia
Q42109253Notch signalling stabilises boundary formation at the midbrain-hindbrain organiser.
Q41685413O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking
Q46294775O-fucosylation of an antibody light chain: characterization of a modification occurring on an IgG1 molecule
Q28295699O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily
Q35213076O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1.
Q34773949O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein).
Q34745434Protein O-fucosyltransferase 1 expression impacts myogenic C2C12 cell commitment via the Notch signaling pathway
Q36276095Regulation of Notch signaling by glycosylation
Q37785139Regulation of notch signaling via O-glucosylation insights from Drosophila studies
Q34030111Role of glycans and glycosyltransferases in the regulation of Notch signaling
Q33969519Role of glycosylation of Notch in development
Q37308624Role of unusual O-glycans in intercellular signaling
Q34023789Roles of Glycosylation in Notch Signaling
Q34585462Roles of O-fucose glycans in notch signaling revealed by mutant mice.
Q34744616Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.
Q38218592Significance of glycosylation in Notch signaling
Q36298276Site-specific O-glucosylation of the epidermal growth factor-like (EGF) repeats of notch: efficiency of glycosylation is affected by proper folding and amino acid sequence of individual EGF repeats
Q41773509Structural and mechanistic insights into lunatic fringe from a kinetic analysis of enzyme mutants
Q37607556The Golgi apparatus: lessons from Drosophila
Q35703104The N-acetyl-binding pocket of N-acetylglucosaminyltransferases also accommodates a sugar analog with a chemical handle at C2.
Q36446371The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development
Q90366123The acquisition of positional information across the radial axis of the cochlea
Q40132697The threonine that carries fucose, but not fucose, is required for Cripto to facilitate Nodal signaling
Q33364683Turn It Down a Notch
Q45345744Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats

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