Molecular mechanisms responsible for the atheroprotective effects of laminar shear stress.

scientific article published on July 2009

Molecular mechanisms responsible for the atheroprotective effects of laminar shear stress. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1089/ARS.2009.2487
P932PMC publication ID2842586
P698PubMed publication ID19309258
P5875ResearchGate publication ID24222452

P50authorShi PanQ41903771
P2093author name stringShi Pan
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Upregulation of superoxide dismutase and nitric oxide synthase mediates the apoptosis-suppressive effects of shear stress on endothelial cellsQ28371345
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Glycocalyx modulates the motility and proliferative response of vascular endothelium to fluid shear stressQ51015457
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Shear stress induces transforming growth factor-beta 1 release by arterial endothelial cellsQ74239591
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Mechanosensitive endothelial gene expression profiles: scripts for the role of hemodynamics in atherogenesis?Q77500810
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Shear stress regulates the endothelial Kir2.1 ion channelQ34065567
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Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cellsQ34229735
Is PECAM-1 a mechanoresponsive molecule?Q34246895
Nitrosylation. the prototypic redox-based signaling mechanism.Q34381833
Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitrationQ34433509
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Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genesQ35085085
The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchangeQ35090750
Cellular mechanics and gene expression in blood vesselsQ35106977
Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinasesQ35192636
The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation.Q35193982
Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endotheliumQ35265510
Thioredoxin: a key regulator of cardiovascular homeostasisQ35596367
Turbulent fluid shear stress induces vascular endothelial cell turnover in vitroQ35597409
Endothelial cell adhesion in real time. Measurements in vitro by tandem scanning confocal image analysisQ35610952
Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidationQ35611252
Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokinesQ35749970
Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid compositionQ35924452
Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory crosstalk among MAPK family membersQ35949976
Reduced release of nitric oxide to shear stress in mesenteric arteries of aged ratsQ35954835
Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow.Q36095665
Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?Q36325631
Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP.Q36388240
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activationQ36399199
Endothelial mechanotransduction, nitric oxide and vascular inflammation.Q36440491
Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stressQ36495182
The Ras-JNK pathway is involved in shear-induced gene expressionQ36563260
Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta.Q36602479
Elevated blood pressures in mice lacking endothelial nitric oxide synthase.Q36689446
Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery diseaseQ36753752
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Molecular cloning and expression of a bovine endothelial inward rectifier potassium channelQ36868000
Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitrationQ36922288
Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear strQ37341184
Nitric oxide synthases: which, where, how, and why?Q37374087
Nitric oxide: an endogenous modulator of leukocyte adhesionQ37519420
Cutting edge: heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cellsQ37877296
Shear stress inhibits adhesion of cultured mouse endothelial cells to lymphocytes by downregulating VCAM-1 expressionQ38305078
Role of endothelial MCP-1 in monocyte adhesion to inflamed human endothelium under physiological flowQ38361790
Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor.Q39821682
Effect on endothelial cell gene expression of shear stress, oxygen concentration, and low-density lipoprotein as studied by a novel flow cell culture systemQ40529651
Temporal gradient in shear but not steady shear stress induces PDGF-A and MCP-1 expression in endothelial cells: role of NO, NF kappa B, and egr-1.Q41644604
Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc.Q41673423
A flow-activated chloride-selective membrane current in vascular endothelial cellsQ41698008
Effect of inhibition of nitric oxide synthesis on the uptake of LDL and fibrinogen by arterial walls and other organs of the ratQ42114569
Hypertension in mice lacking the gene for endothelial nitric oxide synthaseQ42478091
Lateral zone of cell-cell adhesion as the major fluid shear stress-related signal transduction siteQ42484466
Fluid flow stimulates tissue plasminogen activator secretion by cultured human endothelial cellsQ42489921
Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2.Q42507272
Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein couplingQ42508047
Endothelial cell morphology in areas of in vivo Evans blue uptake in the aorta of young pigs. II. Ultrastructure of the intima in areas of differing permeability to proteinsQ42588488
Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinaseQ43568413
Shear stress-induced release of nitric oxide from endothelial cells grown on beadsQ43650148
Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathwaysQ43805171
Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A.Q43812771
Shear stress activation of SREBP1 in endothelial cells is mediated by integrinsQ43852804
Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesisQ44121998
Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanismQ44182985
Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanismQ44184055
Fluid flow rapidly activates G proteins in human endothelial cells. Involvement of G proteins in mechanochemical signal transductionQ44337534
Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthaseQ44534254
Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammationQ44567761
Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stressQ44575134
Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesionQ44575257
Shear stress increases the amount of S-nitrosylated molecules in endothelial cells: important role for signal transductionQ44579163
Heparan Sulfate Proteoglycan Is a Mechanosensor on Endothelial CellsQ44620897
Shear stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor kappaB binding.Q44626801
Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosisQ44690015
Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidaseQ45075488
Pulsatile flow increases the expression of eNOS, ET-1, and prostacyclin in a novel in vitro coculture model of the retinal vasculatureQ45205314
Flow-activated chloride channels in vascular endothelium. Shear stress sensitivity, desensitization dynamics, and physiological implications.Q45984520
Mechanism of temporal gradients in shear-induced ERK1/2 activation and proliferation in endothelial cellsQ46482935
A mechanosensory complex that mediates the endothelial cell response to fluid shear stressQ46494451
The role of the multidrug resistance protein-1 in modulation of endothelial cell oxidative stressQ46670070
Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress.Q47334929
Genetic analysis of NOS isoforms using nNOS and eNOS knockout animals.Q48291000
P433issue7
P304page(s)1669-1682
P577publication date2009-07-01
P1433published inAntioxidants & Redox SignalingQ4775078
P1476titleMolecular mechanisms responsible for the atheroprotective effects of laminar shear stress
P478volume11

Reverse relations

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