Signalling pathways in alcohol-induced liver inflammation.

scientific article published on 28 March 2009

Signalling pathways in alcohol-induced liver inflammation. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.JHEP.2009.03.007
P932PMC publication ID3342816
P698PubMed publication ID19398236
P5875ResearchGate publication ID24365332

P50authorPranoti S. MandrekarQ68342340
P2093author name stringGyongyi Szabo
P2860cites workMD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4Q22009943
Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in miceQ24170238
Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophagesQ24296276
Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4Q24555143
TLR signaling pathwaysQ24570127
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIFQ24672442
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteinsQ27860890
Pathogen recognition and innate immunityQ27861084
Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa BQ28118928
Signaling through the JAK/STAT pathway, recent advances and future challengesQ28201804
Toll-like receptors in innate immunityQ28297257
Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stabilityQ28508664
Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stressQ28512203
ERK1/2 and Egr-1 contribute to increased TNF-alpha production in rat Kupffer cells after chronic ethanol feedingQ28572528
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathwayQ28592087
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformationQ29400446
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding proteinQ29615189
AP-1 in cell proliferation and survivalQ29615217
Negative regulation of toll-like receptor-mediated immune responsesQ29619019
Regulation of inducible gene expression by the transcription factor NF-kappaB.Q33736018
Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytesQ33977596
Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosisQ34072530
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Recent insights into the role of the innate immune system in the development of alcoholic liver disease.Q35216526
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Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expressionQ38324517
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Tumor necrosis factor in alcohol enhanced endotoxin liver injuryQ41914272
Acetaldehyde induces c-fos and c-jun proto-oncogenes in fat-storing cell cultures through protein kinase C activation.Q42282216
Increased tumor necrosis factor production by monocytes in alcoholic hepatitisQ42505321
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Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF-kappaB activation and cytokine production.Q43580537
Ethanol inhibits the JAK-STAT signaling pathway in freshly isolated rat hepatocytes but not in cultured hepatocytes or HepG2 cells: evidence for a lack of involvement of ethanol metabolismQ43641253
Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in miceQ43657691
A role for interleukin-10 in alcohol-induced liver sensitization to bacterial lipopolysaccharideQ43872901
Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in miceQ43909493
Dilinoleoylphosphatidylcholine decreases LPS-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats: respective roles of MAPKs and NF-kappaB.Q44025407
Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?Q44219386
Up-regulation of CD14 in liver caused by acute ethanol involves oxidant-dependent AP-1 pathwayQ44249788
In vivo ethanol exposure down-regulates TLR2-, TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activationQ45195947
CD14 is required for MyD88-independent LPS signaling.Q45990170
The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.Q46367336
Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokinesQ46414361
Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10.Q46909253
Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxinQ47787116
Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis.Q48007469
Essential role of MD-2 in LPS responsiveness and TLR4 distribution.Q50109313
II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin.Q50864303
TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes.Q51807119
Alcohol-induced regulation of nuclear regulatory factor-kappa beta in human monocytes.Q52527307
Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytesQ57375031
Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patientsQ68198337
Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta productionQ71672956
Human monocyte IL-10 production is increased by acute ethanol treatmentQ71725675
Cytokines and alcoholic liver diseaseQ72847010
Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the ratQ73023401
Inhibition of lipopolysaccharide-mediated NFkappaB activation by ethanol in human monocytesQ73142401
Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor-associated kinaseQ73149415
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cellsQ73322874
Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relation to severity of liver disturbanceQ73769805
Increased monocyte nuclear factor-kappaB activation and tumor necrosis factor production in alcoholic hepatitisQ73792877
Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the ratQ73939862
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genesQ77137033
Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytesQ80058051
Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liverQ83182716
P433issue6
P921main subjectinflammationQ101991
P304page(s)1258-1266
P577publication date2009-03-28
P1433published inJournal of HepatologyQ15724402
P1476titleSignalling pathways in alcohol-induced liver inflammation
P478volume50

Reverse relations

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