A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani

scientific article published on December 2016

A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1009300404
P356DOI10.1186/S13071-016-1904-8
P8608Fatcat IDrelease_ehc3g4uowzbrvaro3tpkzq53le
P932PMC publication ID5133764
P698PubMed publication ID27906059

P2093author name stringB Norris-Mullins
E S Carlson
M A Morales
P Vacchina
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Expression of a mitochondrial peroxiredoxin prevents programmed cell death in Leishmania donovaniQ34601641
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Regulation of Leishmania (L.) amazonensis protein expression by host T cell dependent responses: differential expression of oligopeptidase B, tryparedoxin peroxidase and HSP70 isoforms in amastigotes isolated from BALB/c and BALB/c nude miceQ35097514
Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantumQ35129032
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Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone FunctionsQ36058976
Mechanism of regulation of hsp70 chaperones by DnaJ cochaperonesQ36351463
S-Adenosylmethionine in protozoan parasites: functions, synthesis and regulationQ36695448
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Genomic Appraisal of the Multifactorial Basis for In Vitro Acquisition of Miltefosine Resistance in Leishmania donovaniQ37023262
Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic TrypanosomatidsQ37090590
In vitro screening test using Leishmania promastigotes stably expressing mCherry proteinQ38324287
Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations.Q38904942
Miltefosine resistance in Leishmania donovani involves suppression of oxidative stress-induced programmed cell death.Q39106618
Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine).Q39444314
Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drugQ39792515
Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarraysQ39982163
The role of pH and temperature in the development of Leishmania parasitesQ40572964
Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movementQ41940537
The heat shock protein HSP70 and heat shock cognate protein HSC70 contribute to antimony tolerance in the protozoan parasite leishmaniaQ41959907
Expression of a mitochondrial stress protein in the protozoan parasite Leishmania major.Q42612753
Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drugQ43113859
Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistanceQ44599854
Distinct mitochondrial HSP70 homologues conserved in various Leishmania species suggest novel biological functions.Q44913904
Synthesis of BODIPY-labeled alkylphosphocholines with leishmanicidal activity, as fluorescent analogues of miltefosineQ46259580
A novel ATP-binding cassette transporter, ABCG6 is involved in chemoresistance of LeishmaniaQ46776164
An in vitro system for developmental and genetic studies of Leishmania donovani phosphoglycans.Q47450122
Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.Q48086647
The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity.Q48243238
A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.Q50680649
Prefractionation by digitonin extraction increases representation of the cytosolic and intracellular proteome of Leishmania infantum.Q50724361
HSP70 phylogeny and the relationship between archaebacteria, eubacteria, and eukaryotes.Q52367909
Use of the green fluorescent protein as a marker in transfected LeishmaniaQ71479108
Characterization and cellular distribution of heat-shock proteins HSP70 and HSP60 in Trypanosoma cruziQ71571865
Molecular Comparison of the Mitochondrial and Cytoplasmic hsp 70 of Trypanosoma cruzi, Trypanosoma brucei and Leishmania majorQ71793697
Molecular and biochemical comparison of the 70-kDa heat shock proteins of Trypanosoma cruziQ72237994
Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of useQ84100557
Differential expression of proteins in antimony-susceptible and -resistant isolates of Leishmania donovaniQ84517685
P4510describes a project that usesImageQuantQ112270642
P433issue1
P921main subjectmiltefosineQ411787
Leishmania donovaniQ1950752
P304page(s)621
P577publication date2016-12-01
P1433published inParasites and VectorsQ7135941
P1476titleA mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani
P478volume9

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cites work (P2860)
Q64055381Genome-wide analysis of HSP70 family genes in cabbage (Brassica oleracea var. capitata) reveals their involvement in floral development
Q33797614Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress
Q88540303Understanding Leishmania parasites through proteomics and implications for the clinic

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