Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats.

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Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2147/DDDT.S116192
P932PMC publication ID5135077
P698PubMed publication ID27932863

P50authorGniewomir LataczQ57909458
Katarzyna Kiec-KononowiczQ58970601
Agnieszka OlejarzQ59691295
Kamil KuderQ81936180
Tadeusz KarczQ117266307
P2093author name stringHolger Stark
Ali Saad
Bassem Sadek
P2860cites workILAE official report: a practical clinical definition of epilepsyQ27009103
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracyQ28251042
Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonistQ28288221
The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neuronsQ28292338
Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domainQ28344970
Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexesQ29616736
Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screeningQ29617343
The physiology of brain histamine.Q31875011
Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugsQ33756749
Involvement of central histamine in amygdaloid kindled seizures in ratsQ34097939
Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugsQ34162438
Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptorQ34249836
S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonistQ34250754
Modifying effects of histamine on circadian rhythms and neuronal excitabilityQ34407480
The histamine H3 receptor: from discovery to clinical trials with pitolisantQ34629532
Histamine in the nervous systemQ34795903
Current use and future potential of organometallic radiopharmaceuticals.Q34979217
Bodilisant-a novel fluorescent, highly affine histamine h3 receptor ligandQ35181936
Bioorganometallic chemistry of ferroceneQ35976166
Luminogenic cytochrome P450 assaysQ36543124
Histamine H3 receptor antagonists go to clinicsQ37337876
Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?Q37944920
Histamine H3 receptor antagonists in relation to epilepsy and neurodegeneration: a systemic consideration of recent progress and perspectives.Q38023551
Cherry-picked ligands at histamine receptor subtypes.Q38637712
Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseasesQ38882359
Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands.Q38977969
The study of cellular cytotoxicity of argireline - an anti-aging peptideQ39014003
Effects of antihistamines on the function of human α7-nicotinic acetylcholine receptors.Q39090568
Anticonvulsant properties of histamine H3 receptor ligands belonging to N-substituted carbamates of imidazopropanolQ39377196
Kojic acid derivatives as histamine H(3) receptor ligandsQ39647030
Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H3 receptor antagonistsQ40318984
Seizure susceptibility due to antihistamines in febrile seizuresQ40363396
Histamine in cerebrospinal fluid of children with febrile convulsionsQ40688399
Is histamine an anticonvulsive inhibitory transmitter?Q42059596
Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and ratsQ42205553
Drug-likeness approach of 2-aminopyrimidines as histamine H3 receptor ligands.Q42921406
Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in ratsQ43095470
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure modelsQ43464905
Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonistsQ43625285
Sensitive radioimmunoassays for histamine and tele-methylhistamine in the brainQ44298077
Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: dose-dependent effects in the human photosensitivity modelQ44449222
Effects of endogenous histamine on seizure development of pentylenetetrazole-induced kindling in rats.Q44529329
Development of amygdaloid kindling in histidine decarboxylase-deficient and histamine H1 receptor-deficient miceQ44805056
Role of histaminergic neurons in development of epileptic seizures in EL miceQ45153402
Fluorinated non-imidazole histamine H3 receptor antagonistsQ46088221
Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profilesQ46509579
MetaSite: understanding metabolism in human cytochromes from the perspective of the chemistQ46775772
Anticonvulsant activity of the methanolic extract of Justicia extensa T. AndersQ47257639
Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents.Q47934602
Anticonvulsant, neuroprotective and behavioral effects of organic and conventional yerba mate (Ilex paraguariensis St. Hil.) on pentylenetetrazol-induced seizures in Wistar ratsQ48238572
Dual localization of histamine in an ascending neuronal pathway and in non-neuronal cells evidenced by lesions in the lateral hypothalamic areaQ48392299
The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in ratsQ48395108
Histaminergic mechanisms in amygdaloid-kindled seizures in ratsQ48433993
Mechanism of imipramine-induced seizures in amygdala-kindled ratsQ48445673
Effects of alpha-fluoromethylhistidine on locomotor activity, brain histamine and catecholamine contents in ratsQ48512875
Pentylenetetrazol-induced kindling in rats: Effect of GABA function inhibitorsQ48646145
Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats.Q50551591
The novel non-imidazole histamine H3 receptor antagonist DL77 reduces voluntary alcohol intake and ethanol-induced conditioned place preference in mice.Q50578120
Anticonvulsive effect of nonimidazole histamine H3 receptor antagonists.Q51091396
(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands.Q51334897
Non-imidazole histamine H3 receptor ligands incorporating antiepileptic moieties.Q51749619
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure modelsQ67994775
[125I]iodoproxyfan, a new antagonist to label and visualize cerebral histamine H3 receptorsQ72818403
Planar chromatographyQ74386385
Highly potent fluorescence-tagged nonimidazole histamine H3 receptor ligandsQ79956903
Receptor-specific functional efficacies of alkyl imidazoles as dual histamine H3/H4 receptor ligandsQ83211003
Seizure-modifying potential of histamine H1 antagonists: a clinical observationQ83284712
Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental modelsQ86033464
Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanismsQ87535408
Commentary: Consciousness of epilepsyQ95420094
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectseizureQ6279182
P304page(s)3879-3898
P577publication date2016-11-25
P1433published inDrug Design, Development and TherapyQ2566724
P1476titleNon-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats
P478volume10

Reverse relations

cites work (P2860)
Q49167073Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice.
Q48316817Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish.
Q89729736Betahistine, prevents kindling, ameliorates the behavioral comorbidities and neurodegeneration induced by pentylenetetrazole
Q47833839In the search for a lead structure among series of potent and selective hydantoin 5-HT7 R agents: The drug-likeness in vitro study.
Q90399887Influence of the Novel Histamine H3 Receptor Antagonist/Inverse Agonist M39 on Gastroprotection and PGE2 Production Induced by (R)-Alpha-Methylhistamine in C57BL/6 Mice
Q96953395Role of Neuroinflammation in Autism Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD?
Q47239447Selenazolinium Salts as "Small Molecule Catalysts" with High Potency against ESKAPE Bacterial Pathogens.
Q58103536Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats
Q47996823Study on the effect of EMD386088, a 5-HT6 receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats.
Q42691812The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats

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