| P50 | author | Maikel Wijtmans | Q88406952 |
| P2093 | author name string | Iwan J P de Esch | |
| | Rob Leurs | |
| | Sebastiaan Kuhne | |
| | Herman D Lim | |
| P2860 | cites work | Structure of the human histamine H1 receptor complex with doxepin | Q24595968 |
| | Correlation between ex vivo receptor occupancy and wake-promoting activity of selective H3 receptor antagonists | Q28270462 |
| | GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models | Q28574369 |
| | High constitutive activity of native H3 receptors regulates histamine neurons in brain. | Q33929208 |
| | Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. | Q34002822 |
| | Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists | Q34113362 |
| | Discovery of Histamine H3 Antagonists for the Treatment of Cognitive Disorders and Alzheimer's Disease | Q34139724 |
| | Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor | Q34249836 |
| | The histamine H3 receptor: from gene cloning to H3 receptor drugs | Q34387276 |
| | Keynote review: histamine H3 receptor antagonists reach out for the clinic | Q34479438 |
| | BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology | Q34569432 |
| | The histamine H3 receptor: from discovery to clinical trials with pitolisant | Q34629532 |
| | Highly potent and selective ligands for histamine H3-receptors | Q34661299 |
| | Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain | Q34731433 |
| | An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients | Q34754308 |
| | Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice | Q34979043 |
| | The histamine H3 receptor as a therapeutic drug target for CNS disorders | Q34980219 |
| | The role of histamine and the tuberomamillary nucleus in the nervous system | Q35058506 |
| | Genetic and pharmacological aspects of histamine H3 receptor heterogeneity | Q35556324 |
| | Molecular aspects of the histamine H3 receptor | Q36727499 |
| | Histamine H3 receptor ligands break ground in a remarkable plethora of therapeutic areas | Q36861579 |
| | Histamine H3 receptor antagonists go to clinics | Q37337876 |
| | Molecular and biochemical pharmacology of the histamine H4 receptor | Q37469102 |
| | Major advances in the development of histamine H4 receptor ligands | Q37499295 |
| | Recent advances in histamine H3 receptor antagonists/inverse agonists. | Q37780549 |
| | Histamine and H3 receptor in alcohol-related behaviors | Q37791774 |
| | Histamine H3 Receptor as a Drug Discovery Target | Q37808205 |
| | Histamine receptors in the CNS as targets for therapeutic intervention. | Q37842889 |
| | New H1/H3 antagonists for treating allergic rhinitis: WO2010094643. | Q37845843 |
| | En route to new blockbuster anti-histamines: surveying the offspring of the expanding histamine receptor family | Q37854214 |
| | Design, synthesis, and structure-activity relationships of novel non-imidazole histamine H(3) receptor antagonists | Q38526228 |
| | Cloning and characterization of the monkey histamine H3 receptor isoforms | Q39922557 |
| | Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists | Q39965762 |
| | An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity | Q40080977 |
| | Cloning and pharmacological characterization of the monkey histamine H3 receptor | Q40609951 |
| | The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis | Q42747107 |
| | Acute alertness-promoting effects of a novel histamine subtype-3 receptor inverse agonist in healthy sleep-deprived male volunteers | Q42845521 |
| | Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems | Q42947904 |
| | Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development | Q43012622 |
| | Evaluation of 11C-GSK189254 as a novel radioligand for the H3 receptor in humans using PET. | Q43017039 |
| | Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists | Q43625285 |
| | Species-related pharmacological heterogeneity of histamine H(3) receptors | Q43832373 |
| | Coordination of histamine H3 receptor antagonists with human adrenal cytochrome P450 enzymes | Q44174454 |
| | Molecular and pharmacological characterization of the mouse histamine H3 receptor | Q44410722 |
| | Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine | Q44461769 |
| | Activation of histamine H3 receptors in human nasal mucosa inhibits sympathetic vasoconstriction | Q44732616 |
| | 4-acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H3 receptor antagonists | Q46871864 |
| | Cloning and cerebral expression of the guinea pig histamine H3 receptor: evidence for two isoforms | Q46872768 |
| | Identification of zebrafish histamine H1, H2 and H3 receptors and effects of histaminergic ligands on behavior | Q47073518 |
| | Synthesis of potent non-imidazole histamine H3-receptor antagonists | Q48297634 |
| | Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers | Q48317899 |
| | Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-human primates. | Q48899369 |
| | JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. | Q51895488 |
| | 4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration. | Q53582667 |
| | H 3 receptor antagonism increases methylhistamine levels in the cerebrospinal fluid of dogs and healthy human volunteers | Q56767378 |
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1629-1648 | |
| P577 | publication date | 2011-10-13 | |
| P1433 | published in | Expert Opinion on Investigational Drugs | Q5421208 |
| P1476 | title | Several down, a few to go: histamine H3 receptor ligands making the final push towards the market? | |
| P478 | volume | 20 | |