Molecular and biochemical pharmacology of the histamine H4 receptor

scientific article published on May 2009

Molecular and biochemical pharmacology of the histamine H4 receptor is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1476-5381.2009.00250.X
P932PMC publication ID2697796
P698PubMed publication ID19413568
P5875ResearchGate publication ID24399936

P2093author name stringIwan J P de Esch
Rob Leurs
Paul L Chazot
Fiona C Shenton
Herman D Lim
P2860cites workEvaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonistQ34425247
Keynote review: histamine H3 receptor antagonists reach out for the clinicQ34479438
Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonistQ34588721
Cloning and characterization of dominant negative splice variants of the human histamine H4 receptorQ34656212
Receptors mediating some actions of histamineQ34794929
Cloning and pharmacological characterization of the dog histamine H4 receptorQ34798053
Histamine induces cytoskeletal changes in human eosinophils via the H4 receptorQ35045875
Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C miceQ35047117
The regulatory mechanisms of export trafficking of G protein-coupled receptors.Q36192980
The histamine H4 receptor as a new therapeutic target for inflammationQ36212654
The selective eosinophil chemotactic activity of histamineQ36358850
Molecular aspects of the histamine H3 receptorQ36727499
Histamine H3 receptor ligands break ground in a remarkable plethora of therapeutic areasQ36861579
The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistaminesQ37049023
Discovery of naturally occurring splice variants of the rat histamine H3 receptor that act as dominant-negative isoformsQ38316776
Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430.Q39857276
Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptorsQ39960108
Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculationsQ39972386
Functional expression of H4 histamine receptor in human natural killer cells, monocytes, and dendritic cells.Q40048266
Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivativesQ40253729
Probing the importance of N-glycosylation for [(3)H] clobenpropit binding to human H (3) receptors expressed in HEK 293 cells . 3. Molecular and chemical aspects of the histamine receptorsQ40302123
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonistsQ40338159
Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.Q40509880
Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulationQ40558411
The first potent and selective non-imidazole human histamine H4 receptor antagonistsQ40638111
The medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor.Q40937038
The histamine H4 receptor is functionally expressed on neurons in the mammalian CNSQ41420104
Importance of N-glycosylation positioning for cell-surface expression, targeting, affinity and quality control of the human AT1 receptorQ42912360
Identification of rat H3 receptor isoforms with different brain expression and signaling properties.Q43513207
The role of transmembrane helix 5 in agonist binding to the human H3 receptorQ43964575
Immunohistochemical localization of histamine receptor subtypes in human inferior turbinatesQ44993372
Localization of histamine H4 receptors in the central nervous system of human and rat.Q46153368
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesiaQ46265556
Comparative study of histamine H4 receptor expression in human dermal fibroblastsQ46338219
Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation modelsQ46347020
Histamine H4 receptors modulate dendritic cell migration through skin--immunomodulatory role of histamineQ46377867
Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cellsQ46448103
Molecular cloning of monkey histamine H4 receptorQ46557938
Histamine H3 and H4 receptors are expressed on distinct endocrine cell types in the rat fundic mucosaQ46697957
Definition and antagonism of histamine H 2 -receptorsQ46704110
Human inflammatory dendritic epidermal cells express a functional histamine H4 receptorQ46779260
Histamine-induced actin polymerization in human eosinophils: an imaging approach for histamine H4 receptorQ46830111
Linking agonist binding to histamine H1 receptor activationQ46890983
Pharmacologic characterization of a novel histamine receptor on human eosinophilsQ71996703
Histamine downregulates monocyte CCL2 production through the histamine H4 receptorQ80345603
Oligomerization of recombinant and endogenously expressed human histamine H(4) receptorsQ83214912
Cloning and functional expression of the human histamine H3 receptorQ22009916
Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytesQ24290193
Molecular cloning and characterization of a new human histamine receptor, HH4RQ24290633
Molecular cloning of the human histamine H2 receptorQ24322916
Genomic organization and characterization of splice variants of the human histamine H3 receptorQ24532634
The histamine H3 receptor: an attractive target for the treatment of cognitive disordersQ24654788
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptorQ24657484
Crystal structure of rhodopsin: A G protein-coupled receptorQ27625972
Structure of a beta1-adrenergic G-protein-coupled receptorQ27651011
Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell linesQ28114776
The challenge of drug discovery of a GPCR target: analysis of preclinical pharmacology of histamine H3 antagonists/inverse agonistsQ28300005
Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variationQ28566917
A potent and selective histamine H4 receptor antagonist with anti-inflammatory propertiesQ28571371
Structure and expression of the human histamine H4-receptor gene.Q30676263
cDNA cloning and characterization of porcine histamine H4 receptorQ31059304
Genomics meets histamine receptors: new subtypes, new receptors.Q31941904
Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrowQ31941917
Discovery of a novel member of the histamine receptor familyQ31941930
Cloning, expression, and pharmacological characterization of a novel human histamine receptor.Q31941941
Cloning and characterization of a novel human histamine receptorQ31963519
Immunological identification of the mammalian H3 histamine receptor in the mouse brainQ32037199
Expression cloning of a cDNA encoding the bovine histamine H1 receptorQ33269233
H3 receptor gene is cloned at lastQ33818927
Molecular modeling and site-specific mutagenesis of the histamine-binding site of the histamine H4 receptor.Q34133464
Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cellsQ34182519
A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidineQ34208818
Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptorQ34249836
Critical role of L-selectin and histamine H4 receptor in zymosan-induced neutrophil recruitment from the bone marrow: comparison with carrageenanQ34302701
The histamine H3 receptor: from gene cloning to H3 receptor drugsQ34387276
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpharmacologyQ128406
P304page(s)14-23
P577publication date2009-05-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleMolecular and biochemical pharmacology of the histamine H4 receptor
P478volume157

Reverse relations

cites work (P2860)
Q58694870A Selective Histamine H Receptor Antagonist, JNJ7777120, Is Protective in a Rat Model of Transient Cerebral Ischemia
Q48491449A search for functional histamine H4 receptors in the human, guinea pig and mouse brain
Q43110514Advances in histamine pharmacology reveal new drug targets
Q37553620Aryl-1,3,5-triazine ligands of histamine H4 receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide
Q37551908Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and Pathology
Q39445688Commercially available antibodies against human and murine histamine H₄-receptor lack specificity
Q42020167Comparison of the pharmacological properties of human and rat histamine H3-receptors
Q38152336Current and emerging options for the drug treatment of narcolepsy
Q39204577Detailed analysis of biased histamine H₄ receptor signalling by JNJ 7777120 analogues
Q39323929Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling
Q47845214Effects of histamine H4 receptor ligands in a mouse model of gastric ulceration.
Q38160491Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia
Q39584467Expression and functional properties of canine, rat, and murine histamine H₄ receptors in Sf9 insect cells.
Q42182992Facilitation of short-term memory by histaminergic neurons in the nucleus accumbens is independent of cholinergic and glutamatergic transmission
Q42951309GPCR theme editorial
Q37598261Histamine H3 and H4 receptors as novel drug targets.
Q38023551Histamine H3 receptor antagonists in relation to epilepsy and neurodegeneration: a systemic consideration of recent progress and perspectives.
Q39166397Histamine H4 receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress
Q33752485Histamine H4 receptor antagonism inhibits allergen-specific T-cell responses mediated by human dendritic cells
Q34025192Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration
Q38264340Histamine H₄ receptors in the gastrointestinal tract.
Q26799561Histamine and Skin Barrier: Are Histamine Antagonists Useful for the Prevention or Treatment of Atopic Dermatitis?
Q26798112Histamine and the striatum
Q38024865Histamine in brain development
Q39639684Histamine modulates γδ-T lymphocyte migration and cytotoxicity, via Gi and Gs protein-coupled signalling pathways.
Q37954375Histamine pharmacology and new CNS drug targets.
Q34356076Histamine receptors and cancer pharmacology
Q33688711Histamine therapeutic efficacy in metastatic melanoma: Role of histamine H4 receptor agonists and opportunity for combination with radiation.
Q33574684Histamine: a new immunomodulatory player in the neuron-glia crosstalk
Q37995651Histamine: an undercover agent in multiple rare diseases?
Q64059638Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus
Q90399887Influence of the Novel Histamine H3 Receptor Antagonist/Inverse Agonist M39 on Gastroprotection and PGE2 Production Induced by (R)-Alpha-Methylhistamine in C57BL/6 Mice
Q41684431Lack of Histamine H4-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice.
Q28536518Luciferase reporter gene assay on human, murine and rat histamine H4 receptor orthologs: correlations and discrepancies between distal and proximal readouts
Q91871611Mast Cells May Differentially Regulate Growth of Lymphoid Neoplasms by Opposite Modulation of Histamine Receptors
Q42554178Molecular determinants for the high constitutive activity of the human histamine H4 receptor: functional studies on orthologues and mutants
Q92970095Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications
Q50875481Pharmacological targeting of histamine H4 receptor in periodontal disease.
Q35161152Physiological implications of biased signaling at histamine H2 receptors
Q34902203Protection of radiation-induced damage to the hematopoietic system, small intestine and salivary glands in rats by JNJ7777120 compound, a histamine H4 ligand.
Q39498635Role of the second and third extracellular loops of the histamine H(4) receptor in receptor activation
Q37944920Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?
Q64061747Structure-Activity Relationship of Hetarylpropylguanidines Aiming at the Development of Selective Histamine Receptor Ligands
Q43097783TRPV1 and PLC Participate in Histamine H4 Receptor-Induced Itch
Q58785720The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets
Q54383765The expression of histamine H4 receptor mRNA in the skin and other tissues of normal dogs.
Q37151169Therapeutic potential of histamine H₄ receptor agonists in triple-negative human breast cancer experimental model.